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Protein

P granule abnormality protein 1

Gene

pgl-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential role in male and female postembryonic germline development; maternally provided protein maintains a population of proliferating germ cells and zygotic expression is required for correct oogenesis. Predicted to bind RNA.1 Publication

GO - Molecular functioni

  • ATP-dependent RNA helicase activity Source: GO_Central
  • protein self-association Source: WormBase
  • RNA binding Source: WormBase

GO - Biological processi

  • gamete generation Source: WormBase
  • germ-line stem cell division Source: WormBase
  • oogenesis Source: WormBase
  • P granule organization Source: WormBase
  • regulation of gene expression Source: GO_Central
  • reproduction Source: WormBase
  • RNA secondary structure unwinding Source: GO_Central
  • translational initiation Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Oogenesis

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
P granule abnormality protein 1
Gene namesi
Name:pgl-1
ORF Names:ZK381.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiZK381.4a; CE25689; WBGene00003992; pgl-1.

Subcellular locationi

GO - Cellular componenti

  • P granule Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Mutants display temperature-sensitive maternal- effect and zygotic sterility. The temperature-sensitive period extends from mid-larvae to young adults.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 730730P granule abnormality protein 1PRO_0000058357Add
BLAST

Proteomic databases

EPDiQ9TZQ3.
PaxDbiQ9TZQ3.
PRIDEiQ9TZQ3.

Expressioni

Tissue specificityi

Expressed in germ granules (P granules).1 Publication

Developmental stagei

Expressed both maternally and zygotically throughout development. Levels are low in young larvae but increase at the end of larval development.1 Publication

Gene expression databases

ExpressionAtlasiQ9TZQ3. baseline.

Interactioni

Subunit structurei

Interacts with ife-1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ife-1O455512EBI-332200,EBI-330148

GO - Molecular functioni

  • protein self-association Source: WormBase

Protein-protein interaction databases

BioGridi42581. 4 interactions.
DIPiDIP-26042N.
IntActiQ9TZQ3. 2 interactions.
MINTiMINT-1037921.
STRINGi6239.ZK381.4b.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5CV1X-ray3.60A205-447[»]
ProteinModelPortaliQ9TZQ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati674 – 682911 Publication
Repeati685 – 693921 Publication
Repeati695 – 703931 Publication
Repeati706 – 714941 Publication
Repeati715 – 723951 Publication
Repeati724 – 730761 Publication

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni674 – 730576 X 9 AA approximate repeats of R-G-G-R-G-G-Y-G-GAdd
BLAST

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410KABH. Eukaryota.
ENOG4110IF4. LUCA.
GeneTreeiENSGT00390000008064.
HOGENOMiHOG000017375.
InParanoidiQ9TZQ3.

Sequencei

Sequence statusi: Complete.

Q9TZQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEANKREIVD FGGLRSYFFP NLAHYITKND EELFNNTSQA NKLAAFVLGA
60 70 80 90 100
SKDAPGDEDI LEMILPNDAN AAVIAAGMDV CLLLGDKFRP KFDAAAEKLS
110 120 130 140 150
GLGHAHDLVS VIDDDKKLGM LARKAKLKKT EDAKILQALL KVIAIDDAAE
160 170 180 190 200
KFVELTELVS QLDLDFDVYV LTKILGLISE ETSDEVDIIR DNVVNAFDSC
210 220 230 240 250
KPLLKQLMLD GPKSEPADPF ISLLMDPLEE SVGKVVNHIA QLFEEASKNE
260 270 280 290 300
GDESLVLRSQ LGYQLFFLIV RSLADGKREV SKKILSGIPT SVRAEVFPGL
310 320 330 340 350
QRSVYKSAVF LGNHIIQVLL GSKKSFEDWD VVGVAKDLES AWKRRAIAEL
360 370 380 390 400
IKKFQVSILE QCFDKPVPLI PQSPLNNDAV IDNVNKALQF ALWLTEFYGS
410 420 430 440 450
ENETEALGEL RFLDSTSKNL LVDSFKKFVQ GINSKTHVTR IVESLEKCCL
460 470 480 490 500
SDTPSGRKSN VQPSTSQQQD SAYTKEEMTT VHNTYSVNTK AQVLNGLSDT
510 520 530 540 550
NSSGLLVDSK DSLSLQEISC DEVDSSTLLS SSRNIGEGVT VKAVDPVPEK
560 570 580 590 600
VNDAQQQQTV NEIEMASDAN QDTSSSASPE VAPSFSTDGW DSPTKSVALP
610 620 630 640 650
PGMQQIDEEE TTVADKDSTP QPQARAETAW GSGDATPMPL PAPTNQYKVS
660 670 680 690 700
GFGEAKVAKG FGQFAPTSSA YGGGGGRGGY GGGDRGGRGG YGGDRGGRGG
710 720 730
YGGGDRGGRG GYGGDRGRGG YGGRGGRGGF
Length:730
Mass (Da):78,454
Last modified:May 1, 2000 - v1
Checksum:i779FFC6180376D7A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077868 mRNA. Translation: AAC36100.1.
FO080210 Genomic DNA. Translation: CCD62010.1.
PIRiT43317.
RefSeqiNP_001041065.1. NM_001047600.3.
UniGeneiCel.23408.

Genome annotation databases

EnsemblMetazoaiZK381.4a.1; ZK381.4a.1; WBGene00003992.
ZK381.4a.2; ZK381.4a.2; WBGene00003992.
GeneIDi177461.
UCSCiZK381.4a.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077868 mRNA. Translation: AAC36100.1.
FO080210 Genomic DNA. Translation: CCD62010.1.
PIRiT43317.
RefSeqiNP_001041065.1. NM_001047600.3.
UniGeneiCel.23408.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5CV1X-ray3.60A205-447[»]
ProteinModelPortaliQ9TZQ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi42581. 4 interactions.
DIPiDIP-26042N.
IntActiQ9TZQ3. 2 interactions.
MINTiMINT-1037921.
STRINGi6239.ZK381.4b.

Proteomic databases

EPDiQ9TZQ3.
PaxDbiQ9TZQ3.
PRIDEiQ9TZQ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZK381.4a.1; ZK381.4a.1; WBGene00003992.
ZK381.4a.2; ZK381.4a.2; WBGene00003992.
GeneIDi177461.
UCSCiZK381.4a.1. c. elegans.

Organism-specific databases

CTDi177461.
WormBaseiZK381.4a; CE25689; WBGene00003992; pgl-1.

Phylogenomic databases

eggNOGiENOG410KABH. Eukaryota.
ENOG4110IF4. LUCA.
GeneTreeiENSGT00390000008064.
HOGENOMiHOG000017375.
InParanoidiQ9TZQ3.

Miscellaneous databases

PROiQ9TZQ3.

Gene expression databases

ExpressionAtlasiQ9TZQ3. baseline.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "pgl-1, a predicted RNA-binding component of germ granules, is essential for fertility in C. elegans."
    Kawasaki I., Shim Y.-H., Kirchner J., Kaminker J., Wood W.B., Strome S.
    Cell 94:635-645(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DISRUPTION PHENOTYPE, FUNCTION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
    Strain: Bristol N21 Publication.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  3. "An isoform of eIF4E is a component of germ granules and is required for spermatogenesis in C. elegans."
    Amiri A., Keiper B.D., Kawasaki I., Fan Y., Kohara Y., Rhoads R.E., Strome S.
    Development 128:3899-3912(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH IFE-1.
    Strain: Bristol N21 Publication.

Entry informationi

Entry nameiPGL1_CAEEL
AccessioniPrimary (citable) accession number: Q9TZQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: May 1, 2000
Last modified: July 6, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.