Q9TZH6 (PHS_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative pterin-4-alpha-carbinolamine dehydratase
Short name=PHS
EC=4.2.1.96

Alternative name(s):
4-alpha-hydroxy-tetrahydropterin dehydratase
Pterin carbinolamine dehydratase
Short name=PCD

Gene names

Name:	pcbd-1
ORF Names:	T10B11.1

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	142 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O.
Sequence similarities	Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	striated muscle myosin thick filament assembly Inferred from mutant phenotype. Source: WormBase tetrahydrobiopterin biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	4-alpha-hydroxytetrahydrobiopterin dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 142	142	Putative pterin-4-alpha-carbinolamine dehydratase		PRO_0000063060

Sequences

	Sequence		Length	Mass (Da)
	Q9TZH6 [UniParc]. Last modified June 26, 2007. Version 3. Checksum: 8AD47F7D814E8EEF	FASTA	142	16,255
	10 20 30 40 50 60 MHSSYSHFLQ RLRTSVSYLS VSHFPSTSSH RLFSTTIGVF ARKKMPLLTE SERTEQLSGL 70 80 90 100 110 120 KTAGWKLVEG RDAIQKEFHF KDFNEAFGFM TRVGLKAEKM DHHPEWFNVY NKVDITLSTH 130 140 DCGGLSPNDV KLATFIESIV KK

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FO080731 Genomic DNA. Translation: CCD66239.1.
PIR	T33522.
RefSeq	NP_491982.2. NM_059581.4.
UniGene	Cel.16765.
3D structure databases
ProteinModelPortal	Q9TZH6.
SMR	Q9TZH6. Positions 48-137.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9TZH6.
Proteomic databases
PRIDE	Q9TZH6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	T10B11.1; T10B11.1; T10B11.1.
GeneID	188368.
KEGG	cel:T10B11.1.
NMPDR	fig|6239.3.peg.1757.
UCSC	T10B11.1. c. elegans.
Organism-specific databases
CTD	188368.
WormBase	T10B11.1; CE39768; WBGene00020397; pcbd-1.
Phylogenomic databases
eggNOG	meNOG19676.
GeneTree	EMGT00050000016529.
HOGENOM	HBG705804.
InParanoid	Q9TZH6.
OMA	FANGWAM.
PhylomeDB	Q9TZH6.
Gene expression databases
ArrayExpress	Q9TZH6.
Family and domain databases
InterPro	IPR001533. Trans/pterin_deHydtase. [Graphical view]
Gene3D	G3DSA:3.30.1360.20. Trans_pterinDh. 1 hit.
KO	K01724.
PANTHER	PTHR12599. Trans_pterinDh. 1 hit.
Pfam	PF01329. Pterin_4a. 1 hit. [Graphical view]
SUPFAM	SSF55248. Trans_pterinDh. 1 hit.
ProtoNet	Search...
Other
NextBio	938540.

Entry information

Entry name

PHS_CAEEL

Accession

Primary (citable) accession number: Q9TZH6

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2001
Last sequence update:	June 26, 2007
Last modified:	December 14, 2011
This is version 67 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project