Reviewed, UniProtKB/Swiss-Prot Q9TZH6 (PHS_CAEEL)

Names and origin

Protein names

Recommended name:
    Putative pterin-4-alpha-carbinolamine dehydratase
      Short name=PHS
    EC=4.2.1.96
Alternative name(s):
    4-alpha-hydroxy-tetrahydropterin dehydratase
    Pterin carbinolamine dehydratase
      Short name=PCD

Gene names

Name:	pcbd-1
ORF Names:	T10B11.1

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	142 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O.
Sequence similarities	Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tetrahydrobiopterin biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	4-alpha-hydroxytetrahydrobiopterin dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 142	142	Putative pterin-4-alpha-carbinolamine dehydratase		PRO_0000063060

Sequences

	Sequence		Length	Mass (Da)
	Q9TZH6-1 [UniParc]. Last modified June 26, 2007. Version 3. Checksum: 8AD47F7D814E8EEF	FASTA	142	16,255
	10 20 30 40 50 60 MHSSYSHFLQ RLRTSVSYLS VSHFPSTSSH RLFSTTIGVF ARKKMPLLTE SERTEQLSGL 70 80 90 100 110 120 KTAGWKLVEG RDAIQKEFHF KDFNEAFGFM TRVGLKAEKM DHHPEWFNVY NKVDITLSTH 130 140 DCGGLSPNDV KLATFIESIV KK

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF098993 Genomic DNA. Translation: AAC67465.2.
PIR	T33522.
RefSeq	NP_491982.2.
UniGene	Cel.16765
3D structure databases
HSSP	HSSP built from PDB template 1DCO based on UniProtKB P80095.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9TZH6.
Genome annotation databases
Ensembl	T10B11.1; T10B11.1; T10B11.1; Caenorhabditis elegans. [Genome view]
GeneID	188368.
KEGG	cel:T10B11.1.
NMPDR	fig|6239.3.peg.1757.
UCSC	T10B11.1. c. elegans.
Organism-specific databases
CTD	188368.
WormBase	WBGene00020397. pcbd-1.
WormPep	T10B11.1. CE39768. [WorfDB]
Phylogenomic databases
OMA	KINGWIV.
Enzyme and pathway databases
BRENDA	4.2.1.96. 672.
Gene expression databases
ArrayExpress	Q9TZH6.
Family and domain databases
InterPro	IPR001533. Trans/pterin_deHydtase. [Graphical view]
PANTHER	PTHR12599. Trans_pterinDh. 1 hit.
Pfam	PF01329. Pterin_4a. 1 hit. [Graphical view]
ProDom	PD007262. Trans_pterinDh. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...
Other Resources
NextBio	938540.

Entry information

Entry name

PHS_CAEEL

Accession

Primary (citable) accession number: Q9TZH6

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2001
Last sequence update:	June 26, 2007
Last modified:	November 3, 2009
This is version 50 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project