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Protein
Submitted name:

HAlF transporter (PGP related)

Gene

haf-4

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • lipid metabolic process Source: WormBase
  • lysosomal transport Source: WormBase
  • multicellular organism growth Source: WormBase
  • transmembrane transport Source: GO_Central
Complete GO annotation...

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-382556. ABC-family proteins mediated transport.
R-CEL-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Submitted name:
HAlF transporter (PGP related)Imported
Gene namesi
Name:haf-4Imported
ORF Names:CELE_W04C9.1Imported, W04C9.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiW04C9.1a; CE28355; WBGene00001814; haf-4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 33HelicalSequence analysisAdd BLAST22
Transmembranei53 – 75HelicalSequence analysisAdd BLAST23
Transmembranei87 – 106HelicalSequence analysisAdd BLAST20
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Transmembranei179 – 202HelicalSequence analysisAdd BLAST24
Transmembranei222 – 243HelicalSequence analysisAdd BLAST22
Transmembranei322 – 344HelicalSequence analysisAdd BLAST23
Transmembranei400 – 425HelicalSequence analysisAdd BLAST26

GO - Cellular componenti

  • integral component of membrane Source: GO_Central
  • lysosomal membrane Source: WormBase
  • membrane Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

EPDiQ9TZD9.
PaxDbiQ9TZD9.
PeptideAtlasiQ9TZD9.

Expressioni

Gene expression databases

BgeeiWBGene00001814.
ExpressionAtlasiQ9TZD9. differential.

Interactioni

Protein-protein interaction databases

STRINGi6239.W04C9.1.

Structurei

3D structure databases

ProteinModelPortaliQ9TZD9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini185 – 465ABC transmembrane type-1InterPro annotationAdd BLAST281
Domaini498 – 733ABC transporterInterPro annotationAdd BLAST236

Sequence similaritiesi

Contains 1 ABC transporter domain.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0058. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00550000074497.
InParanoidiQ9TZD9.
KOiK05656.
OMAiTHRTWIS.
OrthoDBiEOG091G0HVA.
PhylomeDBiQ9TZD9.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR013305. ABC_Tap-like.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR00958. 3a01208. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9TZD9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSTVASRFS WGLILASIDF LACLLFACLH DGTFKFANFT SQFGDFSFFT
60 70 80 90 100
STIDLFLLQF FRFALWMVPA AIHVANKADT LTMWKEPIFC SALLICAASP
110 120 130 140 150
TKLLLLTEKL KPDEFLTFGD TAFLVWNFIS AIILNSSWTR YFSRTPSSYI
160 170 180 190 200
ILEDEDLEVA PKQTFELIFR LLQYCKREWL WHISGFSWLF IYSITRIFVP
210 220 230 240 250
YYTGQVIATV VATKSYPALS NAVYIMTIIS LVSAVAAGFR GGSFEYAYAR
260 270 280 290 300
IQRAIRYDLF HGLVKQDVAF YDAHKTGEVT SRLAADCQTM SDTVALNVNV
310 320 330 340 350
FLRNCVMLLG SMIFMMKLSW RLSLVTFILV PIIFVASKIF GTYYDLLSER
360 370 380 390 400
TQDTIAESND VAEEVLSTMR TVRSFSCENV EADRFYGKLT HTLDVTRTKA
410 420 430 440 450
IAYIGFLWVS ELFQSFIIVS VLWYGGHLVL TQKMKGDLLV SFLLYQMQLG
460 470 480 490 500
DNLRQMGEVW TGLMQSVGAS RKVFEYIDRE PQIQHNGEYM PENVVGKIEF
510 520 530 540 550
RNVHFSYPTR SDQPILKDLS FTVEPGETVA LVGPSGSGKS SCISLLENFY
560 570 580 590 600
VPNAGQVLVD GVPLEEFEHH YIHKKIALVG QEPVLFARSV MENVRYGVEV
610 620 630 640 650
ADTEIIRSCE MANAHGFIMQ TTLKYETNVG EKGTQMSGGQ KQRIAIARAL
660 670 680 690 700
VREPAILLLD EATSALDTES EHLVQEAIYK NLDGKSVILI AHRLSTVEKA
710 720 730 740 750
DKIVVINKGR VEQIGNHETL LKDTNGTYAK LVQRQMMGDQ KPRKRPAVAR
760 770 780
SGPQPAASIN VAGPSQGNAM SLLSTSFSQS ASSVTSH
Length:787
Mass (Da):88,276
Last modified:October 1, 2001 - v2
Checksum:i739536AA8EFAE7A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CCD73387.1.
PIRiT33559.
RefSeqiNP_001021666.1. NM_001026495.4.
UniGeneiCel.7790.

Genome annotation databases

EnsemblMetazoaiW04C9.1a; W04C9.1a; WBGene00001814.
GeneIDi171639.
KEGGicel:CELE_W04C9.1.
UCSCiW04C9.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CCD73387.1.
PIRiT33559.
RefSeqiNP_001021666.1. NM_001026495.4.
UniGeneiCel.7790.

3D structure databases

ProteinModelPortaliQ9TZD9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.W04C9.1.

Proteomic databases

EPDiQ9TZD9.
PaxDbiQ9TZD9.
PeptideAtlasiQ9TZD9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiW04C9.1a; W04C9.1a; WBGene00001814.
GeneIDi171639.
KEGGicel:CELE_W04C9.1.
UCSCiW04C9.1. c. elegans.

Organism-specific databases

CTDi171639.
WormBaseiW04C9.1a; CE28355; WBGene00001814; haf-4.

Phylogenomic databases

eggNOGiKOG0058. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00550000074497.
InParanoidiQ9TZD9.
KOiK05656.
OMAiTHRTWIS.
OrthoDBiEOG091G0HVA.
PhylomeDBiQ9TZD9.

Enzyme and pathway databases

ReactomeiR-CEL-382556. ABC-family proteins mediated transport.
R-CEL-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Gene expression databases

BgeeiWBGene00001814.
ExpressionAtlasiQ9TZD9. differential.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR013305. ABC_Tap-like.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR00958. 3a01208. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9TZD9_CAEEL
AccessioniPrimary (citable) accession number: Q9TZD9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: October 1, 2001
Last modified: November 30, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.