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Protein

Transcription elongation factor SPT4

Gene

spt-4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May function as a component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. DSIF may enhance transcriptional pausing at sites proximal to the promoter, which may in turn facilitate the assembly of an elongation competent RNA polymerase II complex.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri15 – 35C4-typeSequence analysisAdd BLAST21

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-CEL-113418 Formation of the Early Elongation Complex
R-CEL-674695 RNA Polymerase II Pre-transcription Events
R-CEL-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-CEL-75955 RNA Polymerase II Transcription Elongation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation factor SPT4
Alternative name(s):
DRB sensitivity-inducing factor small subunit
Short name:
DSIF small subunit
Gene namesi
Name:spt-4
ORF Names:F54C4.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF54C4.2 ; CE19891 ; WBGene00005014 ; spt-4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002103341 – 120Transcription elongation factor SPT4Add BLAST120

Proteomic databases

EPDiQ9TZ93
PaxDbiQ9TZ93
PeptideAtlasiQ9TZ93
PRIDEiQ9TZ93

Expressioni

Gene expression databases

BgeeiWBGene00005014

Interactioni

Subunit structurei

Interacts with spt-5 to form DSIF. DSIF interacts with RNA polymerase II and with the positive transcription elongation factor b complex (P-TEFb complex), which is composed of cdk-9 and cyclin-T (cit-1.1 or cit-1.2) (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi40448, 1 interactor
DIPiDIP-25841N
STRINGi6239.F54C4.2

Structurei

3D structure databases

ProteinModelPortaliQ9TZ93
SMRiQ9TZ93
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 39Interaction with spt-5By similarityAdd BLAST39

Sequence similaritiesi

Belongs to the SPT4 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri15 – 35C4-typeSequence analysisAdd BLAST21

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3490 Eukaryota
COG5204 LUCA
GeneTreeiENSGT00390000018559
HOGENOMiHOG000172685
InParanoidiQ9TZ93
KOiK15171
OMAiVRGMYAV
OrthoDBiEOG091G0NIU
PhylomeDBiQ9TZ93

Family and domain databases

CDDicd07973 Spt4, 1 hit
Gene3Di3.30.40.210, 1 hit
InterProiView protein in InterPro
IPR029040 RPABC4/Spt4
IPR009287 Spt4
IPR022800 Spt4/RpoE2_Znf
IPR038510 Spt4_sf
PANTHERiPTHR12882 PTHR12882, 1 hit
PfamiView protein in Pfam
PF06093 Spt4, 1 hit
PIRSFiPIRSF025023 Spt4, 1 hit
SMARTiView protein in SMART
SM01389 Spt4, 1 hit
SUPFAMiSSF63393 SSF63393, 1 hit

Sequencei

Sequence statusi: Complete.

Q9TZ93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSASVPADLR NLRACLLCSL VKSVESFQKE GCENCEDVLH LKGDEEKVYD
60 70 80 90 100
CTSANYDGMI AAMSNNESWV CKWQKMQRKV KGMYAISVSG VLPNNIVSEL
110 120
KSLGVRYKPN QRDYSTQFKK
Length:120
Mass (Da):13,536
Last modified:May 1, 2000 - v1
Checksum:iE48D2A78789D5467
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080712 Genomic DNA Translation: CCD66087.1
PIRiT33605
RefSeqiNP_497135.1, NM_064734.4
UniGeneiCel.20527

Genome annotation databases

EnsemblMetazoaiF54C4.2; F54C4.2; WBGene00005014
GeneIDi175172
KEGGicel:CELE_F54C4.2
UCSCiF54C4.2 c. elegans

Similar proteinsi

Entry informationi

Entry nameiSPT4H_CAEEL
AccessioniPrimary (citable) accession number: Q9TZ93
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

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