Unreviewed, UniProtKB/TrEMBL Q9TYY1 (Q9TYY1_CAEEL)

Names and origin

Protein names

Submitted name:
    DNA-binding protein LAG-1 EMBL AAB03859.1
Submitted name:
    Lag-1 protein EMBL AAB03858.1
    Lin-12 and glp-1 phenotype protein 1, isoform a EMBL AAC68978.3

Gene names

Name:	lag-1 EMBL AAC68978.3 WormBase WBGene00002245 WormPep K08B4.1a
ORF Names:	K08B4.1 EMBL AAC68978.3 WormPep K08B4.1a

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	673 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

Ontologies

Keywords
Ligand	DNA-binding EMBL AAB03859.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	collagen and cuticulin-based cuticle development Inferred from mutant phenotype. Source: WormBase embryonic development ending in birth or egg hatching Inferred from mutant phenotype. Source: WormBase hermaphrodite genitalia development Inferred from mutant phenotype. Source: WormBase molting cycle, collagen and cuticulin-based cuticle Inferred from mutant phenotype. Source: WormBase nematode larval development Inferred from mutant phenotype. Source: WormBase positive regulation of growth rate Inferred from mutant phenotype. Source: WormBase regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	nucleus Inferred from electronic annotation. Source: InterPro
Molecular function	protein binding Inferred from physical interaction. Source: IntAct transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9TYY1-1 [UniParc]. Last modified October 1, 2001. Version 2. Checksum: 72B236C29ECAE0B6	FASTA	673	74,947
	10 20 30 40 50 60 MPLAYSTHDN FYESPKTPQP TWDHVHAQFP LGEPARNLDK FIVPEAMFQS VSPLAGVAAA 70 80 90 100 110 120 PSQIAALQQI QALMTFQMQQ NNLFPKIDTI SKSPTPELAS PSAKRMRLSP STSSHSDVAS 130 140 150 160 170 180 TSKGTNGQDQ SKNSPTNSDP FYTIGQSTPN TSSFLDTSNS SFGAPSTVVA NPMTNYQLAF 190 200 210 220 230 240 QAKLGSLHSL IGDSVQSLTS DRMIDFLSNK EKYECVISIF HAKVAQKSYG NEKRFFCPPP 250 260 270 280 290 300 CIYLIGQGWK LKKDRVAQLY KTLKASAQKD AAIENDPIHE QQATELVAYI GIGSDTSERQ 310 320 330 340 350 360 QLDFSTGKVR HPGDQRQDPN IYDYCAAKTL YISDSDKRKY FDLNAQFFYG CGMEIGGFVS 370 380 390 400 410 420 QRIKVISKPS KKKQSMKNTD CKYLCIASGT KVALFNRLRS QTVSTRYLHV EGNAFHASST 430 440 450 460 470 480 KWGAFTIHLF DDERGLQETD NFAVRDGFVY YGSVVKLVDS VTGIALPRLR IRKVDKQQVI 490 500 510 520 530 540 LDASCSEEPV SQLHKCAFQM IDNELVYLCL SHDKIIQHQA TAINEHRHQI NDGAAWTIIS 550 560 570 580 590 600 TDKAEYRFFE AMGQVANPIS PCPVVGSLEV DGHGEASRVE LHGRDFKPNL KVWFGATPVE 610 620 630 640 650 660 TTFRSEESLH CSIPPVSQVR NEQTHWMFTN RTTGDVEVPI SLVRDDGVVY SSGLTFSYKS 670 LERHGPCRIV SNY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[2]	"lag-1, a gene required for lin-12 and glp-1 signaling in Caenorhabditis elegans, is homologous to human CBF1 and Drosophila Su(H)." Christensen S., Kodoyianni V., Bosenberg M., Friedman L., Kimble J. Development 122:1373-1383(1996) [PubMed: 8625826] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: N2 EMBL AAB03858.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

U49794 mRNA. Translation: AAB03858.1.
U49795 Genomic DNA. Translation: AAB03859.1.
AF100663 Genomic DNA. Translation: AAC68978.3.

PIR

T33741.

RefSeq

NP_741410.1.

UniGene

Cel.18193

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1TTU	X-ray	2.85	A	192-663	[»]
3BRD	X-ray	2.21	A	192-663	[»]
3BRF	X-ray	2.47	A	192-663	[»]

ModBase

Search...

Protein-protein interaction databases

DIP

DIP:26205N.

IntAct

Q9TYY1. 15 interactions.

STRING

Q9TYY1.

Proteomic databases

PRIDE

Q9TYY1.

Genome annotation databases

Ensembl

K08B4.1a; K08B4.1a; K08B4.1; Caenorhabditis elegans. [Genome view]

GeneID

177373.

UCSC

K08B4.1a. c. elegans.

Organism-specific databases

CTD

177373.

WormBase

WBGene00002245. lag-1.

WormPep

K08B4.1a. CE28839. [WorfDB]

Phylogenomic databases

OMA

TELVAYI

PhylomeDB

Q9TYY1.

Gene expression databases

ArrayExpress

Q9TYY1.

Family and domain databases

InterPro

IPR015350. Beta-trefoil.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT_TIG_rcpt.
IPR015351. LAG1_DNA_bd.
IPR008967. p53-like_TF_DNA-bd.
[Graphical view]

Gene3D

G3DSA:2.60.40.10. Ig-like_fold. 1 hit.

Pfam

PF09270. Beta-trefoil. 1 hit.
PF09271. LAG1-DNAbind. 1 hit.
PF01833. TIG. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

896516.

Entry information

Entry name

Q9TYY1_CAEEL

Accession

Primary (citable) accession number: Q9TYY1
Secondary accession number(s): Q27427

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	October 1, 2001
Last modified:	November 24, 2009
This is version 61 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)