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Protein
Submitted name:

NucleOLar protein

Gene

nol-2

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei337S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei382S-adenosyl-L-methioninePROSITE-ProRule annotation1
Active sitei439NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotation, RNA-bindingPROSITE-ProRule annotation, Transferase
LigandS-adenosyl-L-methioninePROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
NucleOLar proteinImported
Gene namesi
Name:nol-2Imported
Synonyms:nol-1Imported
ORF Names:CELE_W07E6.1Imported, W07E6.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiW07E6.1a; CE28259; WBGene00021073; nol-2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

EPDiQ9TYV5.
PaxDbiQ9TYV5.
PeptideAtlasiQ9TYV5.

Expressioni

Gene expression databases

BgeeiWBGene00021073.
ExpressionAtlasiQ9TYV5. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiQ9TYV5. 1 interactor.
STRINGi6239.W07E6.1.

Structurei

3D structure databases

ProteinModelPortaliQ9TYV5.
SMRiQ9TYV5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini221 – 509SAM_MT_RSMB_NOPInterPro annotationAdd BLAST289

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili519 – 548Sequence analysisAdd BLAST30

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1122. Eukaryota.
COG0144. LUCA.
GeneTreeiENSGT00660000095341.
HOGENOMiHOG000224258.
InParanoidiQ9TYV5.
KOiK14835.
OMAiLEPVGKW.
OrthoDBiEOG091G0685.
PhylomeDBiQ9TYV5.

Family and domain databases

InterProiView protein in InterPro
IPR018314. Fmu/NOL1/Nop2p_CS.
IPR031341. Methyltr_RsmF_N.
IPR001678. MeTrfase_RsmB/NOP2.
IPR011023. Nop2p.
IPR023267. RCMT.
IPR023273. RCMT_NOP2.
IPR029063. SAM-dependent_MTases.
PfamiView protein in Pfam
PF01189. Methyltr_RsmB-F. 1 hit.
PF17125. Methyltr_RsmF_N. 1 hit.
PRINTSiPR02008. RCMTFAMILY.
PR02012. RCMTNOP2.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00446. nop2p. 1 hit.
PROSITEiView protein in PROSITE
PS01153. NOL1_NOP2_SUN. 1 hit.
PS51686. SAM_MT_RSMB_NOP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9TYV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIVKKKKVS AASKAATEKP EVKKAVKRPV AETEAVTPKK KKLVKKVKKS
60 70 80 90 100
AKKAHEEEPI EQVEKLQLID DDEDGLEGLS FPGSDDEDLR DDYSDDDSDA
110 120 130 140 150
GDHLPIEKKS AALDKQKEKI IAEGEEELQL NIANQATFEL PTVEEIENEM
160 170 180 190 200
KSVPNLEIVK QRIADVIQVL GDFKNRRDPQ KSRENYVEVL KKDLCSQYGY
210 220 230 240 250
NDYLMGKFMD LFPNGAELLE FLEANDNPRP VTIRANSLKV KRRDLAKNLI
260 270 280 290 300
NRGMNVDPAA DWTKVGLVVY DSQVPVGATP EYLAGHYMIQ GLNSLLPVMA
310 320 330 340 350
LAPQPGDRVL DMCSAPGGKT SHIAALMKNS GVLFANDANF TRCRAIIGNL
360 370 380 390 400
HRLGVNNTVV CNLGGEEFSK IRPNGFDRIL LDAPCSGTGV IWKDQSVKTS
410 420 430 440 450
KDSQDVQRRH TMQRQLILSA LDSLDANSPN GGYLVYSTCS VLVEENEAVV
460 470 480 490 500
NFLLERRHCE LVPTGLSIGV DGYTRFRDYR FHPSLSMTKR YYPHVHNIDG
510 520 530 540 550
FYVAKIKKLS NAKMSKQGVM EKEKEKAAQK SQNKKNKAEA EASESSDDEE
560 570 580 590 600
EKKNGVEVNG QKKPAKKQQQ KKQKADGDDS DDDNNAPMKN IGSGARANKK
610 620 630 640 650
RRNQKKAAEK QAAVKEDDGF NTVGNVKRAK KPTQFKSKVP KRAAARTGAK
660
SVKNRRKKML AKQQ
Length:664
Mass (Da):73,905
Last modified:October 1, 2001 - v2
Checksum:iB5D2B1C00C4DFE09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA. Translation: CCD73642.1.
PIRiD88022.
T33803.
RefSeqiNP_493742.1. NM_061341.5.
UniGeneiCel.34217.

Genome annotation databases

EnsemblMetazoaiW07E6.1; W07E6.1; WBGene00021073.
GeneIDi173437.
KEGGicel:CELE_W07E6.1.
UCSCiW07E6.1. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiQ9TYV5_CAEEL
AccessioniPrimary (citable) accession number: Q9TYV5
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: October 1, 2001
Last modified: November 22, 2017
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported