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Q9TYU5

- TIP60_CAEEL

UniProt

Q9TYU5 - TIP60_CAEEL

Protein

Histone acetyltransferase Tip60 homolog

Gene

mys-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Probable catalytic subunit of the Tip60 chromatin-remodeling complex. May acetylate nucleosomal histone H4 and H2A. Acts in the determination of vulval cell fates.1 Publication

    Catalytic activityi

    Acetyl-CoA + [histone] = CoA + acetyl-[histone].

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei268 – 2681By similarity
    Active sitei310 – 3101NucleophileBy similarity
    Binding sitei348 – 3481Acetyl-CoABy similarity

    GO - Molecular functioni

    1. histone acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell fate specification Source: WormBase
    2. multicellular organismal development Source: UniProtKB-KW
    3. protein localization to chromatin Source: WormBase
    4. regulation of transcription, DNA-templated Source: UniProtKB-KW
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Acyltransferase, Chromatin regulator, Developmental protein, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone acetyltransferase Tip60 homolog (EC:2.3.1.48)
    Alternative name(s):
    Myst family histone acetyltransferase-like protein 1
    Gene namesi
    Name:mys-1
    ORF Names:VC5.4
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome V

    Organism-specific databases

    WormBaseiVC5.4; CE21225; WBGene00007029; mys-1.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 458458Histone acetyltransferase Tip60 homologPRO_0000245807Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei268 – 2681N6-acetyllysine; by autocatalysisBy similarity

    Post-translational modificationi

    Autoacetylation at Lys-268 is required for proper function.By similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ9TYU5.

    Interactioni

    Protein-protein interaction databases

    BioGridi44141. 12 interactions.
    IntActiQ9TYU5. 18 interactions.
    STRINGi6239.VC5.4.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9TYU5.
    SMRiQ9TYU5. Positions 12-86, 169-446.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini168 – 446279MYST-type HATAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni318 – 3247Acetyl-CoA bindingBy similarity

    Sequence similaritiesi

    Belongs to the MYST (SAS/MOZ) family.Curated

    Phylogenomic databases

    eggNOGiCOG5027.
    GeneTreeiENSGT00550000074503.
    HOGENOMiHOG000182457.
    InParanoidiQ9TYU5.
    KOiK11304.
    OMAiRRLDEWI.
    PhylomeDBiQ9TYU5.

    Family and domain databases

    Gene3Di3.40.630.30. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR000953. Chromo_domain/shadow.
    IPR016197. Chromodomain-like.
    IPR002717. MOZ_SAS.
    IPR025995. Tudor-knot.
    [Graphical view]
    PfamiPF01853. MOZ_SAS. 1 hit.
    PF11717. Tudor-knot. 1 hit.
    [Graphical view]
    SMARTiSM00298. CHROMO. 1 hit.
    [Graphical view]
    SUPFAMiSSF54160. SSF54160. 1 hit.
    SSF55729. SSF55729. 1 hit.
    PROSITEiPS51726. MYST_HAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9TYU5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTEPKKEIIE DENHGISKKI PTDPRQYEKV TEGCRLLVMM ASQEEERWAE    50
    VISRCRAANG SIKFYVHYID CNRRLDEWVQ SDRLNLASCE LPKKGGKKGA 100
    HLREENRDSN ENEGKKSGRK RKIPLLPMDD LKAESVDPLQ AISTMTSGST 150
    PSLRGSMSMV GHSEDAMTRI RNVECIELGR SRIQPWYFAP YPQQLTSLDC 200
    IYICEFCLKY LKSKTCLKRH MEKCAMCHPP GNQIYSHDKL SFFEIDGRKN 250
    KSYAQNLCLL AKLFLDHKTL YYDTDPFLFY VLTEEDEKGH HIVGYFSKEK 300
    ESAEEYNVAC ILVLPPFQKK GYGSLLIEFS YELSKIEQKT GSPEKPLSDL 350
    GLLSYRSYWS MAIMKELFAF KRRHPGEDIT VQDISQSTSI KREDVVSTLQ 400
    QLDLYKYYKG SYIIVISDEK RQVYEKRIEA AKKKTRINPA ALQWRPKEYG 450
    KKRAQIMF 458
    Length:458
    Mass (Da):53,143
    Last modified:May 1, 2000 - v1
    Checksum:i19D7727E5B47D10B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY551963 mRNA. Translation: AAS65427.1.
    FO081233 Genomic DNA. Translation: CCD70078.1.
    PIRiT33814.
    RefSeqiNP_504796.1. NM_072395.3.
    UniGeneiCel.2062.

    Genome annotation databases

    EnsemblMetazoaiVC5.4.1; VC5.4.1; WBGene00007029.
    VC5.4.2; VC5.4.2; WBGene00007029.
    GeneIDi179096.
    KEGGicel:CELE_VC5.4.
    UCSCiVC5.4. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY551963 mRNA. Translation: AAS65427.1 .
    FO081233 Genomic DNA. Translation: CCD70078.1 .
    PIRi T33814.
    RefSeqi NP_504796.1. NM_072395.3.
    UniGenei Cel.2062.

    3D structure databases

    ProteinModelPortali Q9TYU5.
    SMRi Q9TYU5. Positions 12-86, 169-446.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 44141. 12 interactions.
    IntActi Q9TYU5. 18 interactions.
    STRINGi 6239.VC5.4.

    Proteomic databases

    PaxDbi Q9TYU5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai VC5.4.1 ; VC5.4.1 ; WBGene00007029 .
    VC5.4.2 ; VC5.4.2 ; WBGene00007029 .
    GeneIDi 179096.
    KEGGi cel:CELE_VC5.4.
    UCSCi VC5.4. c. elegans.

    Organism-specific databases

    CTDi 179096.
    WormBasei VC5.4 ; CE21225 ; WBGene00007029 ; mys-1.

    Phylogenomic databases

    eggNOGi COG5027.
    GeneTreei ENSGT00550000074503.
    HOGENOMi HOG000182457.
    InParanoidi Q9TYU5.
    KOi K11304.
    OMAi RRLDEWI.
    PhylomeDBi Q9TYU5.

    Miscellaneous databases

    NextBioi 903906.
    PROi Q9TYU5.

    Family and domain databases

    Gene3Di 3.40.630.30. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR000953. Chromo_domain/shadow.
    IPR016197. Chromodomain-like.
    IPR002717. MOZ_SAS.
    IPR025995. Tudor-knot.
    [Graphical view ]
    Pfami PF01853. MOZ_SAS. 1 hit.
    PF11717. Tudor-knot. 1 hit.
    [Graphical view ]
    SMARTi SM00298. CHROMO. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54160. SSF54160. 1 hit.
    SSF55729. SSF55729. 1 hit.
    PROSITEi PS51726. MYST_HAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A new class of C. elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of Ras signaling."
      Ceol C.J., Horvitz H.R.
      Dev. Cell 6:563-576(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiTIP60_CAEEL
    AccessioniPrimary (citable) accession number: Q9TYU5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3