Q9TYU5 (TIP60_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone acetyltransferase Tip60 homolog
EC=2.3.1.48

Alternative name(s):
Myst family histone acetyltransferase-like protein 1

Gene names

Name:	mys-1
ORF Names:	VC5.4

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	458 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probable catalytic subunit of the Tip60 chromatin-remodeling complex. May acetylate nucleosomal histone H4 and H2A. Acts in the determination of vulval cell fates. Ref.1
Catalytic activity	Acetyl-CoA + [histone] = CoA + acetyl-[histone].
Subcellular location	Nucleus By similarity.
Post-translational modification	Autoacetylation at Lys-268 is required for proper function By similarity.
Sequence similarities	Belongs to the MYST (SAS/MOZ) family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Molecular function	Acyltransferase Chromatin regulator Developmental protein Transferase
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell fate specification Inferred from mutant phenotype PubMed 20181741. Source: WormBase histone acetylation Inferred from electronic annotation. Source: GOC multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW protein localization to chromatin Inferred from genetic interaction PubMed 20181741. Source: WormBase regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	histone acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 458	458	Histone acetyltransferase Tip60 homolog		PRO_0000245807
Regions
	Region	318 – 324	7	Acetyl-CoA binding By similarity
Sites
	Active site	268	1	By similarity
	Active site	310	1	Nucleophile By similarity
	Binding site	348	1	Acetyl-CoA By similarity
Amino acid modifications
	Modified residue	268	1	N6-acetyllysine; by autocatalysis By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9TYU5 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 19D7727E5B47D10B	FASTA	458	53,143
	10 20 30 40 50 60 MTEPKKEIIE DENHGISKKI PTDPRQYEKV TEGCRLLVMM ASQEEERWAE VISRCRAANG 70 80 90 100 110 120 SIKFYVHYID CNRRLDEWVQ SDRLNLASCE LPKKGGKKGA HLREENRDSN ENEGKKSGRK 130 140 150 160 170 180 RKIPLLPMDD LKAESVDPLQ AISTMTSGST PSLRGSMSMV GHSEDAMTRI RNVECIELGR 190 200 210 220 230 240 SRIQPWYFAP YPQQLTSLDC IYICEFCLKY LKSKTCLKRH MEKCAMCHPP GNQIYSHDKL 250 260 270 280 290 300 SFFEIDGRKN KSYAQNLCLL AKLFLDHKTL YYDTDPFLFY VLTEEDEKGH HIVGYFSKEK 310 320 330 340 350 360 ESAEEYNVAC ILVLPPFQKK GYGSLLIEFS YELSKIEQKT GSPEKPLSDL GLLSYRSYWS 370 380 390 400 410 420 MAIMKELFAF KRRHPGEDIT VQDISQSTSI KREDVVSTLQ QLDLYKYYKG SYIIVISDEK 430 440 450 RQVYEKRIEA AKKKTRINPA ALQWRPKEYG KKRAQIMF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A new class of C. elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of Ras signaling." Ceol C.J., Horvitz H.R. Dev. Cell 6:563-576(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY551963 mRNA. Translation: AAS65427.1. FO081233 Genomic DNA. Translation: CCD70078.1.
PIR	T33814.
RefSeq	NP_504796.1. NM_072395.3.
UniGene	Cel.2062.
3D structure databases
ProteinModelPortal	Q9TYU5.
SMR	Q9TYU5. Positions 12-86, 169-446.
ModBase	Search...
Protein-protein interaction databases
STRING	6239.VC5.4.
Proteomic databases
PaxDb	Q9TYU5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	VC5.4.1; VC5.4.1; VC5.4. VC5.4.2; VC5.4.2; VC5.4.
GeneID	179096.
KEGG	cel:CELE_VC5.4.
UCSC	VC5.4. c. elegans.
Organism-specific databases
CTD	179096.
WormBase	VC5.4; CE21225; WBGene00007029; mys-1.
Phylogenomic databases
eggNOG	COG5027.
GeneTree	ENSGT00550000074503.
HOGENOM	HOG000182457.
InParanoid	Q9TYU5.
KO	K11304.
OMA	EEDEKGH.
Family and domain databases
Gene3D	3.40.630.30. 1 hit.
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR000953. Chromo_domain/shadow. IPR016197. Chromodomain-like. IPR002717. MOZ_SAS. IPR025995. Tudor-knot. [Graphical view]
Pfam	PF01853. MOZ_SAS. 1 hit. PF11717. Tudor-knot. 1 hit. [Graphical view]
SMART	SM00298. CHROMO. 1 hit. [Graphical view]
SUPFAM	SSF55729. Acyl_CoA_acyltransferase. 1 hit. SSF54160. Chromodomain-like. 1 hit.
ProtoNet	Search...
Other
NextBio	903906.

Entry information

Entry name

TIP60_CAEEL

Accession

Primary (citable) accession number: Q9TYU5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project