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Q9TYU5 (TIP60_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone acetyltransferase Tip60 homolog

EC=2.3.1.48
Alternative name(s):
Myst family histone acetyltransferase-like protein 1
Gene names
Name:mys-1
ORF Names:VC5.4
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length458 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable catalytic subunit of the Tip60 chromatin-remodeling complex. May acetylate nucleosomal histone H4 and H2A. Acts in the determination of vulval cell fates. Ref.1

Catalytic activity

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Subcellular location

Nucleus By similarity.

Post-translational modification

Autoacetylation at Lys-268 is required for proper function By similarity.

Sequence similarities

Belongs to the MYST (SAS/MOZ) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 458458Histone acetyltransferase Tip60 homolog
PRO_0000245807

Regions

Region318 – 3247Acetyl-CoA binding By similarity

Sites

Active site2681 By similarity
Active site3101Nucleophile By similarity
Binding site3481Acetyl-CoA By similarity

Amino acid modifications

Modified residue2681N6-acetyllysine; by autocatalysis By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9TYU5 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 19D7727E5B47D10B

FASTA45853,143
        10         20         30         40         50         60 
MTEPKKEIIE DENHGISKKI PTDPRQYEKV TEGCRLLVMM ASQEEERWAE VISRCRAANG 

        70         80         90        100        110        120 
SIKFYVHYID CNRRLDEWVQ SDRLNLASCE LPKKGGKKGA HLREENRDSN ENEGKKSGRK 

       130        140        150        160        170        180 
RKIPLLPMDD LKAESVDPLQ AISTMTSGST PSLRGSMSMV GHSEDAMTRI RNVECIELGR 

       190        200        210        220        230        240 
SRIQPWYFAP YPQQLTSLDC IYICEFCLKY LKSKTCLKRH MEKCAMCHPP GNQIYSHDKL 

       250        260        270        280        290        300 
SFFEIDGRKN KSYAQNLCLL AKLFLDHKTL YYDTDPFLFY VLTEEDEKGH HIVGYFSKEK 

       310        320        330        340        350        360 
ESAEEYNVAC ILVLPPFQKK GYGSLLIEFS YELSKIEQKT GSPEKPLSDL GLLSYRSYWS 

       370        380        390        400        410        420 
MAIMKELFAF KRRHPGEDIT VQDISQSTSI KREDVVSTLQ QLDLYKYYKG SYIIVISDEK 

       430        440        450 
RQVYEKRIEA AKKKTRINPA ALQWRPKEYG KKRAQIMF 

« Hide

References

« Hide 'large scale' references
[1]"A new class of C. elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of Ras signaling."
Ceol C.J., Horvitz H.R.
Dev. Cell 6:563-576(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
[2]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY551963 mRNA. Translation: AAS65427.1.
FO081233 Genomic DNA. Translation: CCD70078.1.
PIRT33814.
RefSeqNP_504796.1. NM_072395.3.
UniGeneCel.2062.

3D structure databases

ProteinModelPortalQ9TYU5.
SMRQ9TYU5. Positions 12-86, 169-446.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid44141. 12 interactions.
IntActQ9TYU5. 18 interactions.
STRING6239.VC5.4.

Proteomic databases

PaxDbQ9TYU5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaVC5.4.1; VC5.4.1; WBGene00007029.
VC5.4.2; VC5.4.2; WBGene00007029.
GeneID179096.
KEGGcel:CELE_VC5.4.
UCSCVC5.4. c. elegans.

Organism-specific databases

CTD179096.
WormBaseVC5.4; CE21225; WBGene00007029; mys-1.

Phylogenomic databases

eggNOGCOG5027.
GeneTreeENSGT00550000074503.
HOGENOMHOG000182457.
InParanoidQ9TYU5.
KOK11304.
OMARRLDEWI.
PhylomeDBQ9TYU5.

Family and domain databases

Gene3D3.40.630.30. 1 hit.
InterProIPR016181. Acyl_CoA_acyltransferase.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR002717. MOZ_SAS.
IPR025995. Tudor-knot.
[Graphical view]
PfamPF01853. MOZ_SAS. 1 hit.
PF11717. Tudor-knot. 1 hit.
[Graphical view]
SMARTSM00298. CHROMO. 1 hit.
[Graphical view]
SUPFAMSSF54160. SSF54160. 1 hit.
SSF55729. SSF55729. 1 hit.
ProtoNetSearch...

Other

NextBio903906.
PROQ9TYU5.

Entry information

Entry nameTIP60_CAEEL
AccessionPrimary (citable) accession number: Q9TYU5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: May 1, 2000
Last modified: June 11, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase