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Q9TYU5

- TIP60_CAEEL

UniProt

Q9TYU5 - TIP60_CAEEL

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Protein
Histone acetyltransferase Tip60 homolog
Gene
mys-1, VC5.4
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Probable catalytic subunit of the Tip60 chromatin-remodeling complex. May acetylate nucleosomal histone H4 and H2A. Acts in the determination of vulval cell fates.1 Publication

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei268 – 2681 By similarity
Active sitei310 – 3101Nucleophile By similarity
Binding sitei348 – 3481Acetyl-CoA By similarity

GO - Molecular functioni

  1. histone acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell fate specification Source: WormBase
  2. multicellular organismal development Source: UniProtKB-KW
  3. protein localization to chromatin Source: WormBase
  4. regulation of transcription, DNA-templated Source: UniProtKB-KW
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Chromatin regulator, Developmental protein, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase Tip60 homolog (EC:2.3.1.48)
Alternative name(s):
Myst family histone acetyltransferase-like protein 1
Gene namesi
Name:mys-1
ORF Names:VC5.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome V

Organism-specific databases

WormBaseiVC5.4; CE21225; WBGene00007029; mys-1.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 458458Histone acetyltransferase Tip60 homolog
PRO_0000245807Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei268 – 2681N6-acetyllysine; by autocatalysis By similarity

Post-translational modificationi

Autoacetylation at Lys-268 is required for proper function By similarity.

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9TYU5.

Interactioni

Protein-protein interaction databases

BioGridi44141. 12 interactions.
IntActiQ9TYU5. 18 interactions.
STRINGi6239.VC5.4.

Structurei

3D structure databases

ProteinModelPortaliQ9TYU5.
SMRiQ9TYU5. Positions 12-86, 169-446.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni318 – 3247Acetyl-CoA binding By similarity

Sequence similaritiesi

Belongs to the MYST (SAS/MOZ) family.

Phylogenomic databases

eggNOGiCOG5027.
GeneTreeiENSGT00550000074503.
HOGENOMiHOG000182457.
InParanoidiQ9TYU5.
KOiK11304.
OMAiRRLDEWI.
PhylomeDBiQ9TYU5.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR002717. MOZ_SAS.
IPR025995. Tudor-knot.
[Graphical view]
PfamiPF01853. MOZ_SAS. 1 hit.
PF11717. Tudor-knot. 1 hit.
[Graphical view]
SMARTiSM00298. CHROMO. 1 hit.
[Graphical view]
SUPFAMiSSF54160. SSF54160. 1 hit.
SSF55729. SSF55729. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9TYU5-1 [UniParc]FASTAAdd to Basket

« Hide

MTEPKKEIIE DENHGISKKI PTDPRQYEKV TEGCRLLVMM ASQEEERWAE    50
VISRCRAANG SIKFYVHYID CNRRLDEWVQ SDRLNLASCE LPKKGGKKGA 100
HLREENRDSN ENEGKKSGRK RKIPLLPMDD LKAESVDPLQ AISTMTSGST 150
PSLRGSMSMV GHSEDAMTRI RNVECIELGR SRIQPWYFAP YPQQLTSLDC 200
IYICEFCLKY LKSKTCLKRH MEKCAMCHPP GNQIYSHDKL SFFEIDGRKN 250
KSYAQNLCLL AKLFLDHKTL YYDTDPFLFY VLTEEDEKGH HIVGYFSKEK 300
ESAEEYNVAC ILVLPPFQKK GYGSLLIEFS YELSKIEQKT GSPEKPLSDL 350
GLLSYRSYWS MAIMKELFAF KRRHPGEDIT VQDISQSTSI KREDVVSTLQ 400
QLDLYKYYKG SYIIVISDEK RQVYEKRIEA AKKKTRINPA ALQWRPKEYG 450
KKRAQIMF 458
Length:458
Mass (Da):53,143
Last modified:May 1, 2000 - v1
Checksum:i19D7727E5B47D10B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY551963 mRNA. Translation: AAS65427.1.
FO081233 Genomic DNA. Translation: CCD70078.1.
PIRiT33814.
RefSeqiNP_504796.1. NM_072395.3.
UniGeneiCel.2062.

Genome annotation databases

EnsemblMetazoaiVC5.4.1; VC5.4.1; WBGene00007029.
VC5.4.2; VC5.4.2; WBGene00007029.
GeneIDi179096.
KEGGicel:CELE_VC5.4.
UCSCiVC5.4. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY551963 mRNA. Translation: AAS65427.1 .
FO081233 Genomic DNA. Translation: CCD70078.1 .
PIRi T33814.
RefSeqi NP_504796.1. NM_072395.3.
UniGenei Cel.2062.

3D structure databases

ProteinModelPortali Q9TYU5.
SMRi Q9TYU5. Positions 12-86, 169-446.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 44141. 12 interactions.
IntActi Q9TYU5. 18 interactions.
STRINGi 6239.VC5.4.

Proteomic databases

PaxDbi Q9TYU5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai VC5.4.1 ; VC5.4.1 ; WBGene00007029 .
VC5.4.2 ; VC5.4.2 ; WBGene00007029 .
GeneIDi 179096.
KEGGi cel:CELE_VC5.4.
UCSCi VC5.4. c. elegans.

Organism-specific databases

CTDi 179096.
WormBasei VC5.4 ; CE21225 ; WBGene00007029 ; mys-1.

Phylogenomic databases

eggNOGi COG5027.
GeneTreei ENSGT00550000074503.
HOGENOMi HOG000182457.
InParanoidi Q9TYU5.
KOi K11304.
OMAi RRLDEWI.
PhylomeDBi Q9TYU5.

Miscellaneous databases

NextBioi 903906.
PROi Q9TYU5.

Family and domain databases

Gene3Di 3.40.630.30. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR002717. MOZ_SAS.
IPR025995. Tudor-knot.
[Graphical view ]
Pfami PF01853. MOZ_SAS. 1 hit.
PF11717. Tudor-knot. 1 hit.
[Graphical view ]
SMARTi SM00298. CHROMO. 1 hit.
[Graphical view ]
SUPFAMi SSF54160. SSF54160. 1 hit.
SSF55729. SSF55729. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A new class of C. elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of Ras signaling."
    Ceol C.J., Horvitz H.R.
    Dev. Cell 6:563-576(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiTIP60_CAEEL
AccessioniPrimary (citable) accession number: Q9TYU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: May 1, 2000
Last modified: June 11, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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