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Protein

Ferritin

Gene

ftn-2

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.UniRule annotation

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.UniRule annotation

GO - Molecular functioni

  • ferric iron binding Source: InterPro
  • ferroxidase activity Source: UniProtKB-EC
  • identical protein binding Source: IntAct

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Iron storageUniRule annotationSAAS annotation

Keywords - Ligandi

Iron, Metal-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-CEL-917937. Iron uptake and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
FerritinUniRule annotation (EC:1.16.3.1UniRule annotation)
Gene namesi
Name:ftn-2Imported
ORF Names:CELE_D1037.3Imported, D1037.3Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiD1037.3; CE20622; WBGene00001501; ftn-2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiQ9TYS3.
PaxDbiQ9TYS3.
PRIDEiQ9TYS3.

Expressioni

Gene expression databases

BgeeiWBGene00001501.

Interactioni

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

DIPiDIP-27017N.
IntActiQ9TYS3. 8 interactions.
MINTiMINT-116220.
STRINGi6239.D1037.3.

Structurei

3D structure databases

ProteinModelPortaliQ9TYS3.
SMRiQ9TYS3. Positions 2-165.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 155150Ferritin-like diironInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ferritin family.UniRule annotation
Contains 1 ferritin-like diiron domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG2332. Eukaryota.
COG1528. LUCA.
GeneTreeiENSGT00760000119129.
HOGENOMiHOG000223383.
InParanoidiQ9TYS3.
KOiK00522.
OMAiEKIMTYM.
OrthoDBiEOG091G0J20.
PhylomeDBiQ9TYS3.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9TYS3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLARQNYHS EVEAAVNKQI NIELYASYVY LSMSFYFDRD DVALPNIAKF
60 70 80 90 100
FKEQSDEERE HATELMRVQN LRGGRVVLQD IQKPENDEWG TALKAFEAAL
110 120 130 140 150
ALEKFNNESL LKLHSTAGNH NDAHLTDFIE EKYLDEQVKS INEFARMVAN
160 170
LKRVGPGVGE YVFDKEHFSD
Length:170
Mass (Da):19,593
Last modified:May 1, 2000 - v1
Checksum:i7B674B7ED3831B46
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CCD68350.1.
PIRiT33854.
RefSeqiNP_491198.1. NM_058797.5.
UniGeneiCel.18344.

Genome annotation databases

EnsemblMetazoaiD1037.3; D1037.3; WBGene00001501.
GeneIDi171934.
KEGGicel:CELE_D1037.3.
UCSCiD1037.3.4. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CCD68350.1.
PIRiT33854.
RefSeqiNP_491198.1. NM_058797.5.
UniGeneiCel.18344.

3D structure databases

ProteinModelPortaliQ9TYS3.
SMRiQ9TYS3. Positions 2-165.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-27017N.
IntActiQ9TYS3. 8 interactions.
MINTiMINT-116220.
STRINGi6239.D1037.3.

Proteomic databases

EPDiQ9TYS3.
PaxDbiQ9TYS3.
PRIDEiQ9TYS3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiD1037.3; D1037.3; WBGene00001501.
GeneIDi171934.
KEGGicel:CELE_D1037.3.
UCSCiD1037.3.4. c. elegans.

Organism-specific databases

CTDi171934.
WormBaseiD1037.3; CE20622; WBGene00001501; ftn-2.

Phylogenomic databases

eggNOGiKOG2332. Eukaryota.
COG1528. LUCA.
GeneTreeiENSGT00760000119129.
HOGENOMiHOG000223383.
InParanoidiQ9TYS3.
KOiK00522.
OMAiEKIMTYM.
OrthoDBiEOG091G0J20.
PhylomeDBiQ9TYS3.

Enzyme and pathway databases

ReactomeiR-CEL-917937. Iron uptake and transport.

Gene expression databases

BgeeiWBGene00001501.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9TYS3_CAEEL
AccessioniPrimary (citable) accession number: Q9TYS3
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.