Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Calcium-transporting ATPase

Gene

mca-2

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.UniRule annotation

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotation

Keywords - Biological processi

Calcium transportUniRule annotation, Ion transport, Transport

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Calcium, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-418359. Reduction of cytosolic Ca++ levels.
R-CEL-5578775. Ion homeostasis.
R-CEL-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPaseUniRule annotation (EC:3.6.3.8UniRule annotation)
Gene namesi
Name:mca-2Imported
ORF Names:CELE_R05C11.3Imported, R05C11.3Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiR05C11.3; CE28747; WBGene00019875; mca-2.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei85 – 104HelicalUniRule annotationAdd BLAST20
Transmembranei124 – 144HelicalUniRule annotationAdd BLAST21
Transmembranei319 – 345HelicalUniRule annotationAdd BLAST27
Transmembranei365 – 392HelicalUniRule annotationAdd BLAST28
Transmembranei821 – 843HelicalUniRule annotationAdd BLAST23
Transmembranei849 – 868HelicalUniRule annotationAdd BLAST20
Transmembranei889 – 911HelicalUniRule annotationAdd BLAST23
Transmembranei931 – 950HelicalUniRule annotationAdd BLAST20
Transmembranei970 – 988HelicalUniRule annotationAdd BLAST19
Transmembranei1000 – 1023HelicalUniRule annotationAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

EPDiQ9TYP9.
PaxDbiQ9TYP9.
PeptideAtlasiQ9TYP9.

Expressioni

Gene expression databases

BgeeiWBGene00019875.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi6239.R05C11.3.2.

Structurei

3D structure databases

ProteinModelPortaliQ9TYP9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 106Cation_ATPase_NInterPro annotationAdd BLAST75

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0204. Eukaryota.
ENOG410XNNC. LUCA.
GeneTreeiENSGT00510000046331.
InParanoidiQ9TYP9.
KOiK01537.
OMAiLEMFITA.
OrthoDBiEOG091G057D.
PhylomeDBiQ9TYP9.

Family and domain databases

Gene3Di1.20.1110.10. 3 hits.
InterProiIPR022141. ATP_Ca_trans_C.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006408. P-type_ATPase_IIB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF12424. ATP_Ca_trans_C. 1 hit.
PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 2 hits.
PF08282. Hydrolase_3. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01517. ATPase-IIB_Ca. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9TYP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSSDDYDCS ISELKLLMEL RGAEALEKVN STYNGVEGLC RKLKTDPING
60 70 80 90 100
LPNDTKELEH RRTAFGKNEI PPAPSKSFFR LAWEALQDIT LVILLVAALV
110 120 130 140 150
SLGLSFYKPP AEHASNDSSE SEAGWIEGVA ILVAVLVVVL VTALNDWTKE
160 170 180 190 200
KQFRGLQSKI ETEHKFSVIR GGEPLDIVVN ELVVGDIARV KYGDLLPADG
210 220 230 240 250
LLIQSNDLKI DESSLTGESD LIRKSEEFDP VLLSGTHAME GSGRFLVTAV
260 270 280 290 300
GLNSQTGIIM SLLGAAKEKK DDKKEEPTTL TNGNHMNGLG NGVDKAAELP
310 320 330 340 350
VPEEEEVGRM SKSVLQTKLS NLALQIGYIG SIVAAATVLI LIIRHCISKY
360 370 380 390 400
AIEGKSFEAS DISHFVNFII IGVTVLVIAV PEGLPLAITL ALTYSVKKMM
410 420 430 440 450
KDNNLVRHLD ACETMGNATS ICSDKTGTLT TNRMTCVQQY INSEFYKGNA
460 470 480 490 500
PKYEQMDPST RDILFNGIVI NSGYNSTVVT PKNPGEQRGQ IGNKTECSLL
510 520 530 540 550
GFIMDSGRSY EDLRRQFPEE KLYKVYTFNS SRKSMMTVIE LGDKKYRIYA
560 570 580 590 600
KGASEIILTR CNYIFGKSGK IEQFGPKEAA VMTKNVIEPM ASDGLRTIGL
610 620 630 640 650
AFKDLVPAGS KKYEYEEEYD GEIDWEDEEK IREGQTVIAV MGIQDPVRPE
660 670 680 690 700
VPAAIAKCQK AGITVRMVTG DNINTARSIA TQCGIMQPGG DFLALEGKEF
710 720 730 740 750
NARIRDADGK VNQQKFDAIW PKLRVLARAQ PSDKYVLVKG IIESTVTKNR
760 770 780 790 800
EVVAVTGDGT NDAPALKKAD VGFAMGIAGT DVAKEASDII LTDDNFSSIV
810 820 830 840 850
KAVMWGRNVY DSIAKFLQFQ LTVNVVAVTI AFIGACAISD SPLKAVQMLW
860 870 880 890 900
VNLIMDTLAS LALATEMPTE DLLNRKPYGR TKSLISRTMV KNIVGHAVYQ
910 920 930 940 950
LAILFAIMFW GDKLIPNTPS GRNAELGSPP SAHFTIIFNA FVLMTLVNEI
960 970 980 990 1000
NARKIHGERN VFKGIFTNPI FCVIWITTLI SHILIVQFGG QWFSTAPLDL
1010 1020 1030 1040 1050
TQWIICICCG VGELFWGQII NCIPASILPK SFRFGKGDVQ PTSIMLSGEY
1060 1070 1080 1090 1100
DMPSTASTLP MKDGAAADHQ RAGQSLWLLG LTRLQTQIRV VKAFQSVNDD
1110 1120 1130 1140 1150
SHPNSLTTST ADRLRASYRR LRIARELEQQ KRAGGLRASG QVYSTETNAK

DTSGIRFA
Length:1,158
Mass (Da):126,921
Last modified:October 1, 2001 - v2
Checksum:iE73043B418C2CA40
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CCD65358.1.
PIRiT33877.
RefSeqiNP_500161.1. NM_067760.3.
UniGeneiCel.18184.

Genome annotation databases

EnsemblMetazoaiR05C11.3; R05C11.3; WBGene00019875.
GeneIDi177004.
KEGGicel:CELE_R05C11.3.
UCSCiR05C11.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CCD65358.1.
PIRiT33877.
RefSeqiNP_500161.1. NM_067760.3.
UniGeneiCel.18184.

3D structure databases

ProteinModelPortaliQ9TYP9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.R05C11.3.2.

Proteomic databases

EPDiQ9TYP9.
PaxDbiQ9TYP9.
PeptideAtlasiQ9TYP9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiR05C11.3; R05C11.3; WBGene00019875.
GeneIDi177004.
KEGGicel:CELE_R05C11.3.
UCSCiR05C11.3. c. elegans.

Organism-specific databases

CTDi177004.
WormBaseiR05C11.3; CE28747; WBGene00019875; mca-2.

Phylogenomic databases

eggNOGiKOG0204. Eukaryota.
ENOG410XNNC. LUCA.
GeneTreeiENSGT00510000046331.
InParanoidiQ9TYP9.
KOiK01537.
OMAiLEMFITA.
OrthoDBiEOG091G057D.
PhylomeDBiQ9TYP9.

Enzyme and pathway databases

ReactomeiR-CEL-418359. Reduction of cytosolic Ca++ levels.
R-CEL-5578775. Ion homeostasis.
R-CEL-936837. Ion transport by P-type ATPases.

Gene expression databases

BgeeiWBGene00019875.

Family and domain databases

Gene3Di1.20.1110.10. 3 hits.
InterProiIPR022141. ATP_Ca_trans_C.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006408. P-type_ATPase_IIB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF12424. ATP_Ca_trans_C. 1 hit.
PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 2 hits.
PF08282. Hydrolase_3. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01517. ATPase-IIB_Ca. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9TYP9_CAEEL
AccessioniPrimary (citable) accession number: Q9TYP9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: October 1, 2001
Last modified: November 30, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.