Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine-repeat antigen protein

Gene

SERA

Organism
Plasmodium falciparum (isolate 3D7)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

It may function at the red blood cell membrane, perhaps as a component that influences the invasion process.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei596Ancestral active siteBy similarity1
Active sitei762By similarity1
Active sitei787By similarity1

GO - Molecular functioni

  • cysteine-type endopeptidase activity Source: GO_Central
  • cysteine-type peptidase activity Source: GeneDB

GO - Biological processi

  • immunoglobulin production Source: GeneDB
  • proteolysis Source: GeneDB
  • proteolysis involved in cellular protein catabolic process Source: GO_Central
  • regulation of immune response Source: GeneDB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Protein family/group databases

MEROPSiC01.984.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine-repeat antigen protein
Alternative name(s):
111 kDa antigen
p126
Gene namesi
Name:SERA
ORF Names:PFB0340c
OrganismiPlasmodium falciparum (isolate 3D7)
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0207600.

Subcellular locationi

  • Parasitophorous vacuole By similarity

  • Note: Exported antigen that accumulates in the parasitophorous vacuole.By similarity

GO - Cellular componenti

  • extracellular space Source: GO_Central
  • lysosome Source: GO_Central
  • symbiont-containing vacuole Source: GeneDB
Complete GO annotation...

Pathology & Biotechi

Keywords - Diseasei

Malaria

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000002647917 – 997Serine-repeat antigen proteinAdd BLAST981

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi184N-linked (GlcNAc...)Sequence analysis1
Glycosylationi318N-linked (GlcNAc...)Sequence analysis1
Glycosylationi828N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Contains numerous possible O-linked glycosylation and serine phosphorylation sites.

Keywords - PTMi

Glycoprotein

PTM databases

SwissPalmiQ9TY95.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PF3D7_0507500Q8I0V03EBI-826913,EBI-1568896

Protein-protein interaction databases

BioGridi1207988. 24 interactors.
IntActiQ9TY95. 24 interactors.
MINTiMINT-1557980.

Structurei

Secondary structure

1997
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi566 – 570Combined sources5
Helixi574 – 576Combined sources3
Helixi582 – 584Combined sources3
Beta strandi592 – 594Combined sources3
Helixi596 – 611Combined sources16
Helixi621 – 626Combined sources6
Beta strandi629 – 631Combined sources3
Turni635 – 637Combined sources3
Helixi642 – 652Combined sources11
Helixi658 – 660Combined sources3
Helixi665 – 667Combined sources3
Turni682 – 685Combined sources4
Beta strandi702 – 707Combined sources6
Helixi708 – 711Combined sources4
Helixi715 – 729Combined sources15
Beta strandi732 – 736Combined sources5
Helixi738 – 741Combined sources4
Beta strandi750 – 752Combined sources3
Beta strandi762 – 773Combined sources12
Beta strandi779 – 786Combined sources8
Beta strandi791 – 793Combined sources3
Beta strandi798 – 804Combined sources7
Beta strandi810 – 813Combined sources4
Beta strandi816 – 820Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3CH2X-ray1.80X564-828[»]
3CH3X-ray1.79X564-828[»]
ProteinModelPortaliQ9TY95.
SMRiQ9TY95.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9TY95.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni579 – 997Thiol-protease-likeAdd BLAST419

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi46 – 103Ser-richAdd BLAST58
Compositional biasi205 – 235Poly-SerAdd BLAST31

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000284262.
InParanoidiQ9TY95.
PhylomeDBiQ9TY95.

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 2 hits.
PfamiPF00112. Peptidase_C1. 1 hit.
[Graphical view]
SMARTiSM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9TY95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSYISLFFI LCVIFNKNVI KCTGESQTGN TGGGQAGNTG GDQAGSTGGS
60 70 80 90 100
PQGSTGASPQ GSTGASPQGS TGASQPGSSE PSNPVSSGHS VSTVSVSQTS
110 120 130 140 150
TSSEKQDTIQ VKSALLKDYM GLKVTGPCNE NFIMFLVPHI YIDVDTEDTN
160 170 180 190 200
IELRTTLKKT NNAISFESNS GSLEKKKYVK LPSNGTTGEQ GSSTGTVRGD
210 220 230 240 250
TEPISDSSSS SSSSSSSSSS SSSSSSSSSS SSSESLPANG PDSPTVKPPR
260 270 280 290 300
NLQNICETGK NFKLVVYIKE NTLILKWKVY GETKDTTENN KVDVRKYLIN
310 320 330 340 350
EKETPFTNIL IHAYKEHNGT NLIESKNYAI GSDIPEKCDT LASNCFLSGN
360 370 380 390 400
FNIEKCFQCA LLVEKENKND VCYKYLSEDI VSKFKEIKAE TEDDDEDDYT
410 420 430 440 450
EYKLTESIDN ILVKMFKTNE NNDKSELIKL EEVDDSLKLE LMNYCSLLKD
460 470 480 490 500
VDTTGTLDNY GMGNEMDIFN NLKRLLIYHS EENINTLKNK FRNAAVCLKN
510 520 530 540 550
VDDWIVNKRG LVLPELNYDL EYFNEHLYND KNSPEDKDNK GKGVVHVDTT
560 570 580 590 600
LEKEDTLSYD NSDNMFCNKE YCNRLKDENN CISNLQVEDQ GNCDTSWIFA
610 620 630 640 650
SKYHLETIRC MKGYEPTKIS ALYVANCYKG EHKDRCDEGS SPMEFLQIIE
660 670 680 690 700
DYGFLPAESN YPYNYVKVGE QCPKVEDHWM NLWDNGKILH NKNEPNSLDG
710 720 730 740 750
KGYTAYESER FHDNMDAFVK IIKTEVMNKG SVIAYIKAEN VMGYEFSGKK
760 770 780 790 800
VQNLCGDDTA DHAVNIVGYG NYVNSEGEKK SYWIVRNSWG PYWGDEGYFK
810 820 830 840 850
VDMYGPTHCH FNFIHSVVIF NVDLPMNNKT TKKESKIYDY YLKASPEFYH
860 870 880 890 900
NLYFKNFNVG KKNLFSEKED NENNKKLGNN YIIFGQDTAG SGQSGKESNT
910 920 930 940 950
ALESAGTSNE VSERVHVYHI LKHIKDGKIR MGMRKYIDTQ DVNKKHSCTR
960 970 980 990
SYAFNPENYE KCVNLCNVNW KTCEEKTSPG LCLSKLDTNN ECYFCYV
Length:997
Mass (Da):111,768
Last modified:May 1, 2000 - v1
Checksum:iCF26A8A03E512ED5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001362 Genomic DNA. Translation: AAC71857.1.
PIRiB71617.
RefSeqiXP_001349586.1. XM_001349550.1.

Genome annotation databases

EnsemblProtistsiAAC71857; AAC71857; PFB0340c.
GeneDBiPF3D7_0207600.1:pep.
GeneIDi812668.
KEGGipfa:PFB0340c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001362 Genomic DNA. Translation: AAC71857.1.
PIRiB71617.
RefSeqiXP_001349586.1. XM_001349550.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3CH2X-ray1.80X564-828[»]
3CH3X-ray1.79X564-828[»]
ProteinModelPortaliQ9TY95.
SMRiQ9TY95.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1207988. 24 interactors.
IntActiQ9TY95. 24 interactors.
MINTiMINT-1557980.

Protein family/group databases

MEROPSiC01.984.

PTM databases

SwissPalmiQ9TY95.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiAAC71857; AAC71857; PFB0340c.
GeneDBiPF3D7_0207600.1:pep.
GeneIDi812668.
KEGGipfa:PFB0340c.

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0207600.

Phylogenomic databases

HOGENOMiHOG000284262.
InParanoidiQ9TY95.
PhylomeDBiQ9TY95.

Miscellaneous databases

EvolutionaryTraceiQ9TY95.

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 2 hits.
PfamiPF00112. Peptidase_C1. 1 hit.
[Graphical view]
SMARTiSM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSERA_PLAF7
AccessioniPrimary (citable) accession number: Q9TY95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.