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Protein

Serine-repeat antigen protein

Gene

SERA

Organism
Plasmodium falciparum (isolate 3D7)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

It may function at the red blood cell membrane, perhaps as a component that influences the invasion process.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei596 – 5961Ancestral active siteBy similarity
Active sitei762 – 7621By similarity
Active sitei787 – 7871By similarity

GO - Molecular functioni

  • cysteine-type endopeptidase activity Source: GO_Central
  • cysteine-type peptidase activity Source: GeneDB

GO - Biological processi

  • immunoglobulin production Source: GeneDB
  • proteolysis Source: GeneDB
  • proteolysis involved in cellular protein catabolic process Source: GO_Central
  • regulation of immune response Source: GeneDB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Protein family/group databases

MEROPSiC01.984.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine-repeat antigen protein
Alternative name(s):
111 kDa antigen
p126
Gene namesi
Name:SERA
ORF Names:PFB0340c
OrganismiPlasmodium falciparum (isolate 3D7)
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0207600.

Subcellular locationi

  • Parasitophorous vacuole By similarity

  • Note: Exported antigen that accumulates in the parasitophorous vacuole.By similarity

GO - Cellular componenti

  • extracellular space Source: GO_Central
  • lysosome Source: GO_Central
  • symbiont-containing vacuole Source: GeneDB
Complete GO annotation...

Pathology & Biotechi

Keywords - Diseasei

Malaria

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Chaini17 – 997981Serine-repeat antigen proteinPRO_0000026479Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence analysis
Glycosylationi318 – 3181N-linked (GlcNAc...)Sequence analysis
Glycosylationi828 – 8281N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Contains numerous possible O-linked glycosylation and serine phosphorylation sites.

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9TY95.

PTM databases

SwissPalmiQ9TY95.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PfSUB1Q8I0V03EBI-826913,EBI-1568896

Protein-protein interaction databases

BioGridi1207988. 24 interactions.
IntActiQ9TY95. 24 interactions.
MINTiMINT-1557980.

Structurei

Secondary structure

1
997
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi566 – 5705Combined sources
Helixi574 – 5763Combined sources
Helixi582 – 5843Combined sources
Beta strandi592 – 5943Combined sources
Helixi596 – 61116Combined sources
Helixi621 – 6266Combined sources
Beta strandi629 – 6313Combined sources
Turni635 – 6373Combined sources
Helixi642 – 65211Combined sources
Helixi658 – 6603Combined sources
Helixi665 – 6673Combined sources
Turni682 – 6854Combined sources
Beta strandi702 – 7076Combined sources
Helixi708 – 7114Combined sources
Helixi715 – 72915Combined sources
Beta strandi732 – 7365Combined sources
Helixi738 – 7414Combined sources
Beta strandi750 – 7523Combined sources
Beta strandi762 – 77312Combined sources
Beta strandi779 – 7868Combined sources
Beta strandi791 – 7933Combined sources
Beta strandi798 – 8047Combined sources
Beta strandi810 – 8134Combined sources
Beta strandi816 – 8205Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3CH2X-ray1.80X564-828[»]
3CH3X-ray1.79X564-828[»]
ProteinModelPortaliQ9TY95.
SMRiQ9TY95. Positions 563-827.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9TY95.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni579 – 997419Thiol-protease-likeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi46 – 10358Ser-richAdd
BLAST
Compositional biasi205 – 23531Poly-SerAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000284262.
InParanoidiQ9TY95.
PhylomeDBiQ9TY95.

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 2 hits.
PfamiPF00112. Peptidase_C1. 1 hit.
[Graphical view]
SMARTiSM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9TY95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSYISLFFI LCVIFNKNVI KCTGESQTGN TGGGQAGNTG GDQAGSTGGS
60 70 80 90 100
PQGSTGASPQ GSTGASPQGS TGASQPGSSE PSNPVSSGHS VSTVSVSQTS
110 120 130 140 150
TSSEKQDTIQ VKSALLKDYM GLKVTGPCNE NFIMFLVPHI YIDVDTEDTN
160 170 180 190 200
IELRTTLKKT NNAISFESNS GSLEKKKYVK LPSNGTTGEQ GSSTGTVRGD
210 220 230 240 250
TEPISDSSSS SSSSSSSSSS SSSSSSSSSS SSSESLPANG PDSPTVKPPR
260 270 280 290 300
NLQNICETGK NFKLVVYIKE NTLILKWKVY GETKDTTENN KVDVRKYLIN
310 320 330 340 350
EKETPFTNIL IHAYKEHNGT NLIESKNYAI GSDIPEKCDT LASNCFLSGN
360 370 380 390 400
FNIEKCFQCA LLVEKENKND VCYKYLSEDI VSKFKEIKAE TEDDDEDDYT
410 420 430 440 450
EYKLTESIDN ILVKMFKTNE NNDKSELIKL EEVDDSLKLE LMNYCSLLKD
460 470 480 490 500
VDTTGTLDNY GMGNEMDIFN NLKRLLIYHS EENINTLKNK FRNAAVCLKN
510 520 530 540 550
VDDWIVNKRG LVLPELNYDL EYFNEHLYND KNSPEDKDNK GKGVVHVDTT
560 570 580 590 600
LEKEDTLSYD NSDNMFCNKE YCNRLKDENN CISNLQVEDQ GNCDTSWIFA
610 620 630 640 650
SKYHLETIRC MKGYEPTKIS ALYVANCYKG EHKDRCDEGS SPMEFLQIIE
660 670 680 690 700
DYGFLPAESN YPYNYVKVGE QCPKVEDHWM NLWDNGKILH NKNEPNSLDG
710 720 730 740 750
KGYTAYESER FHDNMDAFVK IIKTEVMNKG SVIAYIKAEN VMGYEFSGKK
760 770 780 790 800
VQNLCGDDTA DHAVNIVGYG NYVNSEGEKK SYWIVRNSWG PYWGDEGYFK
810 820 830 840 850
VDMYGPTHCH FNFIHSVVIF NVDLPMNNKT TKKESKIYDY YLKASPEFYH
860 870 880 890 900
NLYFKNFNVG KKNLFSEKED NENNKKLGNN YIIFGQDTAG SGQSGKESNT
910 920 930 940 950
ALESAGTSNE VSERVHVYHI LKHIKDGKIR MGMRKYIDTQ DVNKKHSCTR
960 970 980 990
SYAFNPENYE KCVNLCNVNW KTCEEKTSPG LCLSKLDTNN ECYFCYV
Length:997
Mass (Da):111,768
Last modified:May 1, 2000 - v1
Checksum:iCF26A8A03E512ED5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001362 Genomic DNA. Translation: AAC71857.1.
PIRiB71617.
RefSeqiXP_001349586.1. XM_001349550.1.

Genome annotation databases

EnsemblProtistsiPFB0340c:mRNA; PFB0340c:pep; PFB0340c.
GeneDBiPF3D7_0207600.1:pep.
GeneIDi812668.
KEGGipfa:PFB0340c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001362 Genomic DNA. Translation: AAC71857.1.
PIRiB71617.
RefSeqiXP_001349586.1. XM_001349550.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3CH2X-ray1.80X564-828[»]
3CH3X-ray1.79X564-828[»]
ProteinModelPortaliQ9TY95.
SMRiQ9TY95. Positions 563-827.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1207988. 24 interactions.
IntActiQ9TY95. 24 interactions.
MINTiMINT-1557980.

Protein family/group databases

MEROPSiC01.984.

PTM databases

SwissPalmiQ9TY95.

Proteomic databases

PRIDEiQ9TY95.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiPFB0340c:mRNA; PFB0340c:pep; PFB0340c.
GeneDBiPF3D7_0207600.1:pep.
GeneIDi812668.
KEGGipfa:PFB0340c.

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0207600.

Phylogenomic databases

HOGENOMiHOG000284262.
InParanoidiQ9TY95.
PhylomeDBiQ9TY95.

Miscellaneous databases

EvolutionaryTraceiQ9TY95.

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 2 hits.
PfamiPF00112. Peptidase_C1. 1 hit.
[Graphical view]
SMARTiSM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate 3D7.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate 3D7.

Entry informationi

Entry nameiSERA_PLAF7
AccessioniPrimary (citable) accession number: Q9TY95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: May 1, 2000
Last modified: February 17, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.