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Protein

Phospholipid-transporting ATPase

Gene

tat-2

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

  • sterol metabolic process Source: WormBase

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-6798695. Neutrophil degranulation.
R-CEL-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid-transporting ATPaseUniRule annotation (EC:3.6.3.1UniRule annotation)
Gene namesi
Name:tat-2Imported
ORF Names:CELE_H06H21.10Imported, H06H21.10Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiH06H21.10a; CE45939; WBGene00019166; tat-2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei280 – 308HelicalUniRule annotationAdd BLAST29
Transmembranei335 – 360HelicalUniRule annotationAdd BLAST26
Transmembranei916 – 938HelicalUniRule annotationAdd BLAST23
Transmembranei944 – 965HelicalUniRule annotationAdd BLAST22
Transmembranei986 – 1012HelicalUniRule annotationAdd BLAST27
Transmembranei1032 – 1052HelicalUniRule annotationAdd BLAST21
Transmembranei1064 – 1089HelicalUniRule annotationAdd BLAST26
Transmembranei1109 – 1131HelicalUniRule annotationAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

EPDiQ9TXV2.
PaxDbiQ9TXV2.

Expressioni

Gene expression databases

BgeeiWBGene00019166.
ExpressionAtlasiQ9TXV2. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ9TXV2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 88PhoLip_ATPase_NInterPro annotationAdd BLAST65
Domaini881 – 1132PhoLip_ATPase_CInterPro annotationAdd BLAST252

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0206. Eukaryota.
ENOG410XPYK. LUCA.
GeneTreeiENSGT00870000136387.
HOGENOMiHOG000202528.
InParanoidiQ9TXV2.

Family and domain databases

Gene3Di3.40.1110.10. 2 hits.
InterProiView protein in InterPro
IPR030348. ATP8B4.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR036412. HAD-like_sf.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
PANTHERiPTHR24092. PTHR24092. 1 hit.
PTHR24092:SF80. PTHR24092:SF80. 1 hit.
PfamiView protein in Pfam
PF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81653. SSF81653. 2 hits.
SSF81660. SSF81660. 1 hit.
SSF81665. SSF81665. 3 hits.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEiView protein in PROSITE
PS00154. ATPASE_E1_E2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9TXV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSWLPCCSS TSNEKNAPTE RRLRANDREY NAQFKYADNV IKTSKYNIIT
60 70 80 90 100
FIPQNLFEQF QRIANFYFLV LMILQFIPQI SSISWYSTAV PLVIVLAFSA
110 120 130 140 150
IKDGYDDAQR HISDRNVNGR KSYVVRNGSL CEEDWSNVKV GDVIRMMSNQ
160 170 180 190 200
FVAADLLLLS TSEPYGVCFI ETMELDGETN LKNRAAIACT QEMGDDLDGI
210 220 230 240 250
TRFDGEIICE PPNNKLDKFN GKLIWNNHEY GVNNDNILLR GCILKNTRWC
260 270 280 290 300
YGVVVFAGKD TKLMMNSGKT KFKRTSLDRF LNILIVGIVL FLIAMCLICT
310 320 330 340 350
ILCAVWEYQT GRYFTIYLPW DDVVPSPEQR GGRQIALIAF LQFFSYIILL
360 370 380 390 400
NTVVPISLYV SVEIIRFIHS LWINYDTQMY YENGEKSVPA KAHTTTLNEE
410 420 430 440 450
LGQVQYVFSD KTGTLTRNIM TFNKCTINGI SYGDIYDHKG EVIETNDKTK
460 470 480 490 500
SLDFSWNSAS EPTFKFFDKN LVDATKRQVP EIDQFWRLLA LCHTVMPERD
510 520 530 540 550
KGQLVYQAQS PDEHALTSAA RNFGYVFRAR TPQSITIEVM GNEETHELLA
560 570 580 590 600
ILDFNNDRKR MSVIVKGPDG KIRLYCKGAD MMIMQRIHPS TSQIMRTSTN
610 620 630 640 650
THLADFANIG LRTLCLGYKD LDPAYFSDWD SRVKKASAAM QDRESAVDAL
660 670 680 690 700
YEEIEKDLIL IGATAIEDKL QDGVPEAIAR LSEANIKIWV LTGDKTETAI
710 720 730 740 750
NIAYSCRLLT DETKEIVVVD GQTDTEVEVQ LKDTRNTFEQ ILALPSPLGG
760 770 780 790 800
KPRIEIETIH EESEAISSAR SMDRNIVTPD LKSAEMAEHE SGGVALVING
810 820 830 840 850
DSLAFALGPR LERTFLEVAC MCNAVICCRV TPLQKAQVVD LVKRNKKAVT
860 870 880 890 900
LSIGDGANDV SMIKTAHIGV GISGQEGMQA VLASDYSIGQ FKYLERLLLV
910 920 930 940 950
HGRWSYIRMA KFLRYFFYKN FAFTLTNFWY SFFCGYSAQT VFDAVLIACY
960 970 980 990 1000
NLFFTALPVL AMGSLDQDVD DHYSLRYPKL YLPGQFNLFF NMRIFIYSVL
1010 1020 1030 1040 1050
HGMFSSLVIF FIPYGAFYNA AAASGKDLDD YSALAFTTFT ALVVVVTGQI
1060 1070 1080 1090 1100
AFDTSYWTAI SHFVIWGSLV LYFLVCFLLY EWLPVSWIVK TSSSISYGVA
1110 1120 1130 1140 1150
FRTMVTPHFW FSILMVSVVL LLPVMLNRFF WLDTHPSFAD RLRIRKKMGK
1160 1170 1180 1190 1200
KPSAKDDKKT AFKRTAATRR SVRGSLRSGY AFSHSQGFGE LILKGKLFKN
1210 1220 1230 1240 1250
VENLRGKNNS NAKIHPTSDD LQPMLISSVP DDSQGASSIN AMHLPMGTRP
1260 1270 1280 1290 1300
QNVPHTLNVN TDDWSQSSDF RPAYAKEPSP LQGTVIRGDG RSHRNHVYSR
1310
ETQVEEQPDV ITRL
Length:1,314
Mass (Da):148,756
Last modified:June 28, 2011 - v3
Checksum:iD570F3B97F43C726
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CCD72226.1.
RefSeqiNP_001023252.2. NM_001028081.2.
UniGeneiCel.6173.

Genome annotation databases

EnsemblMetazoaiH06H21.10a; H06H21.10a; WBGene00019166.
GeneIDi177256.
UCSCiH06H21.10b. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiQ9TXV2_CAEEL
AccessioniPrimary (citable) accession number: Q9TXV2
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: June 28, 2011
Last modified: October 25, 2017
This is version 146 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported