Q9TXI7 (Q9TXI7_CAEEL) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Protein VPS-34, isoform a EMBL CCD61194.1

Gene names

Name:	vps-34 EMBL CCD61194.1 WormBase WBGene00006932 WormBase B0025.1a
ORF Names:	CELE_B0025.1 EMBL CCD61194.1

Organism

Caenorhabditis elegans [Reference proteome] EMBL CCD61194.1

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	901 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 PI3K/PI4K domain. SAAS SAAS018936 Contains 1 PIK helical domain. SAAS SAAS018936

Ontologies

Keywords
Ligand	ATP-binding SAAS SAAS008973 Nucleotide-binding
Molecular function	Kinase SAAS SAAS018936 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	determination of adult lifespan Inferred from genetic interaction PubMed 21906946. Source: WormBase ecdysis, collagen and cuticulin-based cuticle Inferred from mutant phenotype PubMed 11927551. Source: WormBase nematode larval development Inferred from mutant phenotype PubMed 11927551. Source: WormBase nuclear envelope organization Inferred from mutant phenotype PubMed 11927551. Source: WormBase phagosome maturation involved in apoptotic cell clearance Inferred from mutant phenotype PubMed 22272187. Source: WormBase phosphatidylinositol-mediated signaling Inferred from electronic annotation. Source: InterPro positive regulation of engulfment of apoptotic cell Inferred from mutant phenotype PubMed 21183797. Source: WormBase positive regulation of triglyceride lipase activity Inferred from mutant phenotype PubMed 21906946. Source: WormBase regulation of protein secretion Inferred from mutant phenotype PubMed 11927551. Source: WormBase reproduction Inferred from mutant phenotype PubMed 11927551. Source: WormBase
Cellular_component	nuclear outer membrane Inferred from direct assay PubMed 11927551. Source: WormBase phosphatidylinositol 3-kinase complex Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	1-phosphatidylinositol-3-kinase activity Inferred from direct assay PubMed 11927551. Source: WormBase ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9TXI7 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 3B490B64FD3F5E78	FASTA	901	103,059
	10 20 30 40 50 60 MIPGMRATPT ESFSFVYSCD LQTNVQVKVA EFEGIFRDVL NPVRRLNQLF AEITVYCNNQ 70 80 90 100 110 120 QIGYPVCTSF HTPPDSSQLA RQKLIQKWNE WLTLPIRYSD LSRDAFLHIT IWEHEDDEIV 130 140 150 160 170 180 NNSTFSRRLV AQSKLSMFSK RGILKSGVID VQMNVSTTPD PFVKQPETWK YSDAWGDEID 190 200 210 220 230 240 LLFKQVTRQS RGLVEDVPWL DPFASRRIEM IRAKYKYSSP DRHVFLVLEM AAIRLGPTFY 250 260 270 280 290 300 KVVYYEDETK NMRVSTSVNG GVGIVSACTR YCVADPELLL ESLAEVKHSA MTRRIRDVED 310 320 330 340 350 360 ERHRQVKPNK QAKDRLETIV NLPSSQVLTR EQRDLVWKFR HYLRQFPKAL NKYLRSVNWV 370 380 390 400 410 420 HPQEVKTALA LMNDWELIEA EDALELLSSA FTHPAVRAYS VSRLLEAASP EQVLLYLPQL 430 440 450 460 470 480 VQALKYEQGQ QLPEEGNPVP VVSEEEGKIP SVATTPTEEL EGRDMTVVTK KEARKAASGD 490 500 510 520 530 540 LATFLIDYAL ASPKVSNYLY WHLKTEIEST KESKEEHSKM YQNIQDRLME ALVKRPDTRA 550 560 570 580 590 600 QVDSLHQQQI FVEDLIILMN EAKARGGRLN ESKSAEFRTM LSRAKHMLDL KGVHLPLDPS 610 620 630 640 650 660 FRLSSVIPDT ASFFKSEMMP AKISFKVLQP NGKADRNIPE EYTVIFKTGD DLRQDQLIQQ 670 680 690 700 710 720 MVRLIDIILK KGQLDLKLTP YLVLSTGVGQ GFVQCIKSKP LRAIQEQYKA HKMDCIREAM 730 740 750 760 770 780 KELRPGDGPF GIEPNVIDNY VRSLAGYSVI MYILGLGDRH LDNLLLCENG KLFHVDFGFI 790 800 810 820 830 840 LGRDPKPMPP PMKLTSEMVQ VMGGVKSKQF LEFVQHVDSA YRILRRHSNV LLNLFSLMLD 850 860 870 880 890 900 AGIPDIAAEP DKAIFKIEQR LRLDLSDEAA TKHIFTQIES SLNAKMAMIS DIIHAYKQNL M

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." Caenorhabditis elegans Sequencing Consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2 EMBL CCD61194.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FO080100 Genomic DNA. Translation: CCD61194.1.
RefSeq	NP_491741.1. NM_059340.4.
3D structure databases
HSSP	HSSP built from PDB template 1HE8 based on UniProtKB P48736.
ProteinModelPortal	Q9TXI7.
SMR	Q9TXI7. Positions 306-884.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9TXI7.
Proteomic databases
PRIDE	Q9TXI7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	B0025.1a; B0025.1a; B0025.1.
GeneID	172280.
KEGG	cel:CELE_B0025.1.
UCSC	B0025.1b.2. c. elegans.
Organism-specific databases
CTD	172280.
WormBase	B0025.1a; CE24759; WBGene00006932; vps-34.
Phylogenomic databases
GeneTree	ENSGT00620000087805.
HOGENOM	HOG000174003.
InParanoid	Q9TXI7.
KO	K00914.
OMA	SAMTRRI.
Gene expression databases
ArrayExpress	Q9TXI7.
Family and domain databases
Gene3D	1.10.1070.11. 1 hit. 1.25.40.70. 2 hits.
InterPro	IPR016024. ARM-type_fold. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR011009. Kinase-like_dom. IPR000403. PI3/4_kinase_cat_dom. IPR018936. PI3/4_kinase_CS. IPR002420. PI3K_C2_dom. IPR008290. PI3K_Vps34. IPR015433. PI_Kinase. IPR001263. PInositide-3_kin_accessory_dom. [Graphical view]
PANTHER	PTHR10048. PTHR10048. 1 hit.
Pfam	PF00454. PI3_PI4_kinase. 1 hit. PF00792. PI3K_C2. 1 hit. PF00613. PI3Ka. 1 hit. [Graphical view]
PIRSF	PIRSF000587. PI3K_Vps34. 1 hit.
SMART	SM00142. PI3K_C2. 1 hit. SM00145. PI3Ka. 1 hit. SM00146. PI3Kc. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit. SSF49562. C2_CaLB. 1 hit. SSF56112. Kinase_like. 1 hit.
PROSITE	PS00915. PI3_4_KINASE_1. 1 hit. PS00916. PI3_4_KINASE_2. 1 hit. PS50290. PI3_4_KINASE_3. 1 hit. PS51547. PI3K_C2. 1 hit. PS51545. PIK_HELICAL. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	874813.

Entry information

Entry name

Q9TXI7_CAEEL

Accession

Primary (citable) accession number: Q9TXI7

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 101 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)