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Q9TXD1 (KAX24_CENNO) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium channel toxin alpha-KTx 2.4
Alternative name(s):
Noxiustoxin-2
Short name=NTx-2
Short name=NTx2
OrganismCentruroides noxius (Mexican scorpion)
Taxonomic identifier6878 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeCentruroides

Protein attributes

Sequence length38 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Blocks voltage-gated non-inactivating potassium channels and unblocks inactivating potassium channels blocked by alpha-dendrotoxin in synaptosomes. Has some paralyzing effect on crickets. Ref.1

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Domain

The N-terminus is probably essential for channel affinity.

Miscellaneous

Is less effective than NTX.

Sequence similarities

Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 2 subfamily.

Ontologies

Keywords
   Cellular componentSecreted
   Molecular functionIon channel impairing toxin
Neurotoxin
Potassium channel impairing toxin
Toxin
   PTMDisulfide bond
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processdefense response

Inferred from electronic annotation. Source: InterPro

pathogenesis

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionion channel inhibitor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Peptide1 – 3838Potassium channel toxin alpha-KTx 2.4
PRO_0000044906

Sites

Site271Basic residue of the functional dyad By similarity
Site361Aromatic residue of the functional dyad By similarity

Amino acid modifications

Disulfide bond7 ↔ 28 By similarity
Disulfide bond13 ↔ 33 By similarity
Disulfide bond17 ↔ 35 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9TXD1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 64E3A9BA12C8B8BA

FASTA384,189
        10         20         30 
TIINEKCFAT SQCWTPCKKA IGSLQSKCMN GKCKCYNG 

« Hide

References

[1]"Noxiustoxin 2, a novel K+ channel blocking peptide from the venom of the scorpion Centruroides noxius Hoffmann."
Nieto A.R., Gurrola G.B., Vaca L., Possani L.D.
Toxicon 34:913-922(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, FUNCTION.
Tissue: Venom.

Cross-references

3D structure databases

ProteinModelPortalQ9TXD1.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.30.30.10. 1 hit.
InterProIPR003614. Scorpion_toxin-like.
IPR001947. Scorpion_toxinS_K_inh.
[Graphical view]
PfamPF00451. Toxin_2. 1 hit.
[Graphical view]
PRINTSPR00286. CHARYBDTOXIN.
ProDomPD003586. Scorpion_toxinS. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF57095. SSF57095. 1 hit.
PROSITEPS01138. SCORP_SHORT_TOXIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKAX24_CENNO
AccessionPrimary (citable) accession number: Q9TXD1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: May 1, 2000
Last modified: October 16, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Scorpion potassium channel toxins

Nomenclature of scorpion potassium channel toxins and list of entries