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Protein

Potassium channel toxin alpha-KTx 2.4

Gene
N/A
Organism
Centruroides noxius (Mexican scorpion)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Blocks voltage-gated non-inactivating potassium channels (Kv) and unblocks inactivating potassium channels blocked by alpha-dendrotoxin in synaptosomes. It is not toxic to mice and crustaceans, but has a paralysing effect on crickets.1 Publication

Miscellaneous

NTX2 has a thousandfold less affinity than NTX, for the potassium channels (Kv) of synaptosomes. In addition, it shows a lower potency (over two logarithm units) than noxiustoxin (AC P08815) in producing 50% blockade of the probability of opening small conductance calcium-activated potassium (KCa) (obtained from cultured bovine aortic endothelial cells).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei27Basic residue of the functional dyadBy similarity1
Sitei36Aromatic residue of the functional dyadBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin alpha-KTx 2.4
Alternative name(s):
Noxiustoxin-21 Publication
Short name:
NTx21 Publication
OrganismiCentruroides noxius (Mexican scorpion)
Taxonomic identifieri6878 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeCentruroides

Subcellular locationi

  • Secreted 1 Publication

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000449061 – 38Potassium channel toxin alpha-KTx 2.41 PublicationAdd BLAST38

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi7 ↔ 28By similarity
Disulfide bondi13 ↔ 33By similarity
Disulfide bondi17 ↔ 35By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ9TXD1.
SMRiQ9TXD1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Has the structural arrangement of an alpha-helix connected to a beta-sheet by disulfide bonds (CSalpha/beta).By similarity
The N-terminus is probably essential for channel affinity.1 Publication

Sequence similaritiesi

Family and domain databases

Gene3Di3.30.30.10. 1 hit.
InterProiView protein in InterPro
IPR003614. Scorpion_toxin-like.
IPR001947. Scorpion_toxinS_K_inh.
PfamiView protein in Pfam
PF00451. Toxin_2. 1 hit.
PRINTSiPR00286. CHARYBDTOXIN.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003586. Scorpion_toxinS. 1 hit.
SUPFAMiSSF57095. SSF57095. 1 hit.
PROSITEiView protein in PROSITE
PS01138. SCORP_SHORT_TOXIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9TXD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
TIINEKCFAT SQCWTPCKKA IGSLQSKCMN GKCKCYNG
Length:38
Mass (Da):4,189
Last modified:May 1, 2000 - v1
Checksum:i64E3A9BA12C8B8BA
GO

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKAX24_CENNO
AccessioniPrimary (citable) accession number: Q9TXD1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: May 1, 2000
Last modified: July 5, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families