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Protein

Serine/threonine-protein kinase par-1

Gene

par-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for cytoplasmic partitioning and asymmetric cell division in early embryogenesis (PubMed:7758115). Phosphorylates and restricts the asymmetry effector mex-5 (and possibly also mex-6) to the anterior cytoplasm of the zygote (PubMed:18842813). Regulates mes-1 expression during early embryogenesis (PubMed:11003841). Critical role in postembryonic vulval morphogenesis (PubMed:12490197). Involved in the establishment of neuronal polarity (PubMed:20023164).5 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei199ATPPROSITE-ProRule annotationBy similarity1
Active sitei292Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi176 – 184ATPPROSITE-ProRule annotationBy similarity9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • myosin II tail binding Source: WormBase
  • protein serine/threonine kinase activity Source: WormBase
  • ubiquitin protein ligase binding Source: WormBase

GO - Biological processi

  • asymmetric neuroblast division Source: WormBase
  • asymmetric protein localization involved in cell fate determination Source: WormBase
  • embryonic pattern specification Source: WormBase
  • establishment of cell polarity Source: WormBase
  • establishment or maintenance of cell polarity Source: WormBase
  • microtubule cytoskeleton organization Source: InterPro
  • peptidyl-serine phosphorylation Source: WormBase
  • polarity specification of anterior/posterior axis Source: WormBase
  • protein phosphorylation Source: WormBase
  • vulval development Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-5673000. RAF activation.
R-CEL-5674135. MAP2K and MAPK activation.
R-CEL-5675221. Negative regulation of MAPK pathway.
SignaLinkiQ9TW45.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase par-11 PublicationImported (EC:2.7.11.1)
Gene namesi
Name:par-1Imported
ORF Names:H39E23.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiH39E23.1a; CE23838; WBGene00003916; par-1.
H39E23.1b; CE27768; WBGene00003916; par-1.
H39E23.1c; CE40085; WBGene00003916; par-1.
H39E23.1d; CE44808; WBGene00003916; par-1.
H39E23.1e; CE44733; WBGene00003916; par-1.
H39E23.1f; CE45159; WBGene00003916; par-1.
H39E23.1g; CE45263; WBGene00003916; par-1.
H39E23.1h; CE45267; WBGene00003916; par-1.
H39E23.1i; CE45299; WBGene00003916; par-1.
H39E23.1j; CE46555; WBGene00003916; par-1.
H39E23.1k; CE46628; WBGene00003916; par-1.
H39E23.1l; CE48381; WBGene00003916; par-1.

Subcellular locationi

  • Cytoplasmcell cortex 1 Publication

  • Note: Colocalizes with germ granules (P granules).1 Publication

GO - Cellular componenti

  • cell cortex Source: WormBase
  • cell periphery Source: WormBase
  • cytoplasm Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Maternal effect lethality. Blastomeres cleave synchronously until the fourth or fifth round, when synchrony breaks down. Cells also fail to segregate P granules. Terminal stage embryos fail to produce intestinal cells. Disruption post-hatching results in a protruding vulva, the two mirror-symmetric halves of the vulva fail to join into a single, coherent organ.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003833221 – 1192Serine/threonine-protein kinase par-1Add BLAST1192

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei325Phosphothreonine1 Publication1

Post-translational modificationi

Phosphorylated at Thr-325 probably by par-4.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9TW45.
PaxDbiQ9TW45.
PeptideAtlasiQ9TW45.
PRIDEiQ9TW45.

PTM databases

iPTMnetiQ9TW45.

Expressioni

Tissue specificityi

Asymmetrically localized to the posterior of the zygote before mitotic division, then differentially distributed to the germline precursor cells (at protein level).1 Publication

Developmental stagei

Maternally expressed.1 Publication

Gene expression databases

BgeeiWBGene00003916.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
let-99Q213412EBI-1811687,EBI-1811800

GO - Molecular functioni

  • myosin II tail binding Source: WormBase
  • ubiquitin protein ligase binding Source: WormBase

Protein-protein interaction databases

IntActiQ9TW45. 2 interactors.
STRINGi6239.H39E23.1d.

Structurei

3D structure databases

ProteinModelPortaliQ9TW45.
SMRiQ9TW45.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini170 – 421Protein kinasePROSITE-ProRule annotationAdd BLAST252
Domaini440 – 482UBAPROSITE-ProRule annotationAdd BLAST43
Domaini1143 – 1192KA1PROSITE-ProRule annotationAdd BLAST50

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi24 – 156Ser-richSequence analysisAdd BLAST133
Compositional biasi498 – 584Ser-richSequence analysisAdd BLAST87
Compositional biasi737 – 743Poly-SerSequence analysis7
Compositional biasi871 – 972Ser-richSequence analysisAdd BLAST102

Sequence similaritiesi

Contains 1 KA1 (kinase-associated) domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 UBA domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0586. Eukaryota.
ENOG410XNQ0. LUCA.
GeneTreeiENSGT00790000122947.
HOGENOMiHOG000233025.
InParanoidiQ9TW45.
KOiK08798.
OMAiIFILMEY.
OrthoDBiEOG091G0D1E.
PhylomeDBiQ9TW45.

Family and domain databases

Gene3Di3.30.310.80. 1 hit.
InterProiIPR028375. KA1/Ssp2_C.
IPR001772. KA1_dom.
IPR011009. Kinase-like_dom.
IPR033624. MARK/par1.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR015940. UBA.
[Graphical view]
PANTHERiPTHR24346. PTHR24346. 3 hits.
PfamiPF02149. KA1. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF103243. SSF103243. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50032. KA1. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50030. UBA. 1 hit.
[Graphical view]

Sequences (12)i

Sequence statusi: Complete.

This entry describes 12 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a2 Publications (identifier: Q9TW45-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSASVGKKP EHVNTPPGDN QQKSSKENQK SNKDKQSSNQ PPGQIPHSTN
60 70 80 90 100
SGTRKSSGSG LKTANLKHPA RPSTESSTSS SHHRRPAQEM NGTSTATATG
110 120 130 140 150
GGGTSGATTT ASSGAPAASS GGSSARYSSS GRSHPTSGSS SSHARSTGQS
160 170 180 190 200
GMSSRSAARR NDQDVHVGKY KLLKTIGKGN FAKVKLAKHV ITGHEVAIKI
210 220 230 240 250
IDKTALNPSS LQKLFREVKI MKQLDHPNIV KLYQVMETEQ TLYLVLEYAS
260 270 280 290 300
GGEVFDYLVA HGRMKEKEAR AKFRQIVSAV QYLHSKNIIH RDLKAENLLL
310 320 330 340 350
DQDMNIKIAD FGFSNTFSLG NKLDTFCGSP PYAAPELFSG KKYDGPEVDV
360 370 380 390 400
WSLGVILYTL VSGSLPFDGQ NLKELRERVL RGKYRIPFYM STDCENLLKK
410 420 430 440 450
FLVINPQRRS SLDNIMKDRW MNVGYEDDEL KPFIEPPKDQ IDEQRIEKLI
460 470 480 490 500
QIFQLGFNKA AILESVEKEK FEDIHATYLL LGERKSDMDA SEITMAQSLL
510 520 530 540 550
SHSSINVSSS LGQHPAGVIT REHVTSSSAS GSSASPSRYS RSSATATGAS
560 570 580 590 600
ITAGSALASA ANAQKHQQSS AAPSSGSSSS RRSSQNDAAA TAAGGTVVMS
610 620 630 640 650
GTRHGGVQMR AQPTSRQATI SLLQPPSYKP SSNTTQIAQI PPLFNRNSTA
660 670 680 690 700
TSSAAQPSTG ITGTRKIADP KGRIPLNSTA VQGHRTATGA VAANNGGIPS
710 720 730 740 750
HRDHAQQQQY MNQLTSSTMM SKLINKTPAA GGTAATSSSS SSSATSTAPL
760 770 780 790 800
QKSGSQISHA PTEPVIREDD DENNSENQNG NVPLIGGVGP QTSPAVQVPT
810 820 830 840 850
EDATSSSDKE QQQQKASSET PKESKPSMIH QSPSMPPSQM MTAMESLKLS
860 870 880 890 900
ESGQTGGPTV ATGGPPQRAT SQQMSRSATT NSANMGASSG GAAAAASATN
910 920 930 940 950
QLSGAPSSTG ASSQQYHPKA PSSSSSSSTN PPHQHQLTHN ASFSVTPSSY
960 970 980 990 1000
QIPTSTAVNV TSTGMPTSSS SSAFPRNTRN RQTFHGKTEK DKGGDDSSDE
1010 1020 1030 1040 1050
IGETPGNVSI GATGPSANNA EATIWSKLSK LTRRDHNRES MTQPVSGRAG
1060 1070 1080 1090 1100
TIGASQGQQT AAALAAIREQ SGPIAPGAGQ VAPSLPIHEG DVKPRSLRFT
1110 1120 1130 1140 1150
WSMKTTSSLA PDDMMREIRK VLDANGCDYE QRERYMILCV HGDPNTDSLV
1160 1170 1180 1190
QWEMEVCKLP RLSLNGVRFK RISGTSIGFK NIASKIAQEL NL
Length:1,192
Mass (Da):126,349
Last modified:May 1, 2000 - v1
Checksum:i32517D17BCAB46E0
GO
Isoform b1 Publication (identifier: Q9TW45-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: Missing.
     50-66: NSGTRKSSGSGLKTANL → MSRVSGYFMGISKKNGQK
     488-535: Missing.

Show »
Length:1,096
Mass (Da):116,654
Checksum:iB15A1CB5AFA6C77C
GO
Isoform c1 Publication (identifier: Q9TW45-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-130: Missing.
     131-139: GRSHPTSGS → MKFMWKPPD

Note: No experimental confirmation available.Curated
Show »
Length:1,062
Mass (Da):113,668
Checksum:iA24E250456BEC7DA
GO
Isoform d1 Publication (identifier: Q9TW45-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-64: Missing.
     65-139: NLKHPARPST...SGRSHPTSGS → MFNAAYSSLL...GDHVTHNRKN
     1034-1034: R → RSSTAAAHQP...LSEEAMAIRR

Note: No experimental confirmation available.Curated
Show »
Length:1,216
Mass (Da):130,022
Checksum:iC13854BDB8F84C23
GO
Isoform e (identifier: Q9TW45-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-64: Missing.
     65-139: NLKHPARPST...SGRSHPTSGS → MFNAAYSSLL...GDHVTHNRKN
     825-1030: KPSMIHQSPS...EATIWSKLSK → NPIVWQNLHL...TANVSFGNNQ
     1031-1192: Missing.

Note: No experimental confirmation available.
Show »
Length:966
Mass (Da):104,589
Checksum:i8292B7DAB7DDB85A
GO
Isoform f (identifier: Q9TW45-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: Missing.

Note: No experimental confirmation available.
Show »
Length:1,103
Mass (Da):116,884
Checksum:i80C69107E7DE45DC
GO
Isoform g (identifier: Q9TW45-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-151: Missing.

Note: No experimental confirmation available.
Show »
Length:1,041
Mass (Da):111,363
Checksum:i82EEE97D3213595F
GO
Isoform h (identifier: Q9TW45-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-487: Missing.

Note: No experimental confirmation available.
Show »
Length:705
Mass (Da):72,747
Checksum:iE4ACBB4CC93FA144
GO
Isoform i (identifier: Q9TW45-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-963: Missing.
     964-1032: GMPTSSSSSA...TIWSKLSKLT → MSMTQSPSQL...RKLSEEAMAI

Note: No experimental confirmation available.
Show »
Length:229
Mass (Da):24,898
Checksum:i3B801C2D7C89D8BD
GO
Isoform j (identifier: Q9TW45-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     535-535: S → SVSDHHHPY

Note: No experimental confirmation available.
Show »
Length:1,200
Mass (Da):127,322
Checksum:i7CDD3EAA316C2BD8
GO
Isoform k (identifier: Q9TW45-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-598: Missing.

Note: No experimental confirmation available.
Show »
Length:594
Mass (Da):62,027
Checksum:i1A1CD6AD60BB535A
GO
Isoform l (identifier: Q9TW45-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-86: Missing.
     87-138: AQEMNGTSTA...SSGRSHPTSG → MTKKSYAFAL...RTFFPEYELT

Note: No experimental confirmation available.
Show »
Length:1,106
Mass (Da):118,634
Checksum:i2E9CD90B86AF78D6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti84R → Q in AAA97437 (PubMed:7758115).Curated1
Sequence conflicti96A → P in AAA97437 (PubMed:7758115).Curated1
Sequence conflicti1141H → Y in AAA97437 (PubMed:7758115).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0536341 – 963Missing in isoform i. CuratedAdd BLAST963
Alternative sequenceiVSP_0536351 – 598Missing in isoform k. CuratedAdd BLAST598
Alternative sequenceiVSP_0536361 – 487Missing in isoform h. CuratedAdd BLAST487
Alternative sequenceiVSP_0536371 – 151Missing in isoform g. CuratedAdd BLAST151
Alternative sequenceiVSP_0531401 – 130Missing in isoform c. 1 PublicationAdd BLAST130
Alternative sequenceiVSP_0536381 – 89Missing in isoform f. CuratedAdd BLAST89
Alternative sequenceiVSP_0536391 – 86Missing in isoform l. CuratedAdd BLAST86
Alternative sequenceiVSP_0531411 – 64Missing in isoform d and isoform e. CuratedAdd BLAST64
Alternative sequenceiVSP_0531421 – 49Missing in isoform b. 2 PublicationsAdd BLAST49
Alternative sequenceiVSP_05314350 – 66NSGTR…KTANL → MSRVSGYFMGISKKNGQK in isoform b. 2 PublicationsAdd BLAST17
Alternative sequenceiVSP_05314465 – 139NLKHP…PTSGS → MFNAAYSSLLARFMCQPSSS SVTPIPEEEESLIPKRKVSE VVTTAPMAPTLTSSGKRRTV KVSPDGDHVTHNRKN in isoform d and isoform e. CuratedAdd BLAST75
Alternative sequenceiVSP_05364087 – 138AQEMN…HPTSG → MTKKSYAFALDLDDLCCDDH PYSYSPPSTSSRHSAYYPSQ QPRTFFPEYELT in isoform l. CuratedAdd BLAST52
Alternative sequenceiVSP_053145131 – 139GRSHPTSGS → MKFMWKPPD in isoform c. 1 Publication9
Alternative sequenceiVSP_053146488 – 535Missing in isoform b. 2 PublicationsAdd BLAST48
Alternative sequenceiVSP_053641535S → SVSDHHHPY in isoform j. Curated1
Alternative sequenceiVSP_053642825 – 1030KPSMI…SKLSK → NPIVWQNLHLNSLLKSLLDS SAATSYETPRRPGIAGRRSE PSAATPRRRHQTMVVDARHL QTPPDTDRPYHFEDTTLDRQ MRALYVSTASSRMTRGVLPT PPTSNSTSSSFIVEPLTHVA AASPDITTTTPTKSTVTTSP YFRRTPSFRMAVDDPPISIN ASITDDDCDGIIEIEREWSN GGTDSGDGRSTTTSHITANV SFGNNQ in isoform e. CuratedAdd BLAST206
Alternative sequenceiVSP_053643964 – 1032GMPTS…LSKLT → MSMTQSPSQLSSRFTSNYVA PIVRSKPPAPVSTPAAPSAT APIPVIVSPAVTKMLKENRR KLSEEAMAI in isoform i. CuratedAdd BLAST69
Alternative sequenceiVSP_0536441031 – 1192Missing in isoform e. CuratedAdd BLAST162
Alternative sequenceiVSP_0531481034R → RSSTAAAHQPRGSSLHHSMS MTQSPSQLSSRFTSNYVAPI VRSKPPAPVSTPAAPSATAP IPVIVSPAVTKMLKENRRKL SEEAMAIRR in isoform d. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22183 mRNA. Translation: AAA97437.1.
U40858 mRNA. Translation: AAA83272.1.
Z96102, Z81027 Genomic DNA. Translation: CAB54262.2.
Z96102, Z81027 Genomic DNA. Translation: CAB54263.1.
Z96102, Z81027 Genomic DNA. Translation: CAJ85756.1.
Z96102, Z81027 Genomic DNA. Translation: CAQ16148.2.
Z96102, Z81027 Genomic DNA. Translation: CBL43447.1.
Z96102, Z81027 Genomic DNA. Translation: CBO24859.1.
Z96102 Genomic DNA. Translation: CBW44387.1.
Z96102 Genomic DNA. Translation: CBW44388.1.
Z96102 Genomic DNA. Translation: CBW48399.1.
Z96102 Genomic DNA. Translation: CCE71393.1.
Z96102, Z81027 Genomic DNA. Translation: CCE71394.1.
Z96102, Z81027 Genomic DNA. Translation: CCW45975.1.
PIRiT18611.
RefSeqiNP_001024018.1. NM_001028847.2. [Q9TW45-1]
NP_001024019.1. NM_001028848.2. [Q9TW45-2]
NP_001041145.1. NM_001047680.2. [Q9TW45-3]
NP_001122967.2. NM_001129495.2. [Q9TW45-4]
NP_001256559.1. NM_001269630.1. [Q9TW45-6]
NP_001256560.1. NM_001269631.1. [Q9TW45-10]
NP_001256561.1. NM_001269632.1. [Q9TW45-7]
NP_001256562.1. NM_001269633.1. [Q9TW45-8]
NP_001256563.1. NM_001269634.1. [Q9TW45-11]
NP_001256564.1. NM_001269635.1. [Q9TW45-9]
NP_001256565.1. NM_001269636.1. [Q9TW45-5]
NP_001294690.1. NM_001307761.1. [Q9TW45-12]
UniGeneiCel.6280.

Genome annotation databases

EnsemblMetazoaiH39E23.1a; H39E23.1a; WBGene00003916. [Q9TW45-1]
GeneIDi179912.
KEGGicel:CELE_H39E23.1.
UCSCiH39E23.1b. c. elegans.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22183 mRNA. Translation: AAA97437.1.
U40858 mRNA. Translation: AAA83272.1.
Z96102, Z81027 Genomic DNA. Translation: CAB54262.2.
Z96102, Z81027 Genomic DNA. Translation: CAB54263.1.
Z96102, Z81027 Genomic DNA. Translation: CAJ85756.1.
Z96102, Z81027 Genomic DNA. Translation: CAQ16148.2.
Z96102, Z81027 Genomic DNA. Translation: CBL43447.1.
Z96102, Z81027 Genomic DNA. Translation: CBO24859.1.
Z96102 Genomic DNA. Translation: CBW44387.1.
Z96102 Genomic DNA. Translation: CBW44388.1.
Z96102 Genomic DNA. Translation: CBW48399.1.
Z96102 Genomic DNA. Translation: CCE71393.1.
Z96102, Z81027 Genomic DNA. Translation: CCE71394.1.
Z96102, Z81027 Genomic DNA. Translation: CCW45975.1.
PIRiT18611.
RefSeqiNP_001024018.1. NM_001028847.2. [Q9TW45-1]
NP_001024019.1. NM_001028848.2. [Q9TW45-2]
NP_001041145.1. NM_001047680.2. [Q9TW45-3]
NP_001122967.2. NM_001129495.2. [Q9TW45-4]
NP_001256559.1. NM_001269630.1. [Q9TW45-6]
NP_001256560.1. NM_001269631.1. [Q9TW45-10]
NP_001256561.1. NM_001269632.1. [Q9TW45-7]
NP_001256562.1. NM_001269633.1. [Q9TW45-8]
NP_001256563.1. NM_001269634.1. [Q9TW45-11]
NP_001256564.1. NM_001269635.1. [Q9TW45-9]
NP_001256565.1. NM_001269636.1. [Q9TW45-5]
NP_001294690.1. NM_001307761.1. [Q9TW45-12]
UniGeneiCel.6280.

3D structure databases

ProteinModelPortaliQ9TW45.
SMRiQ9TW45.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9TW45. 2 interactors.
STRINGi6239.H39E23.1d.

PTM databases

iPTMnetiQ9TW45.

Proteomic databases

EPDiQ9TW45.
PaxDbiQ9TW45.
PeptideAtlasiQ9TW45.
PRIDEiQ9TW45.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiH39E23.1a; H39E23.1a; WBGene00003916. [Q9TW45-1]
GeneIDi179912.
KEGGicel:CELE_H39E23.1.
UCSCiH39E23.1b. c. elegans.

Organism-specific databases

CTDi2768852.
WormBaseiH39E23.1a; CE23838; WBGene00003916; par-1.
H39E23.1b; CE27768; WBGene00003916; par-1.
H39E23.1c; CE40085; WBGene00003916; par-1.
H39E23.1d; CE44808; WBGene00003916; par-1.
H39E23.1e; CE44733; WBGene00003916; par-1.
H39E23.1f; CE45159; WBGene00003916; par-1.
H39E23.1g; CE45263; WBGene00003916; par-1.
H39E23.1h; CE45267; WBGene00003916; par-1.
H39E23.1i; CE45299; WBGene00003916; par-1.
H39E23.1j; CE46555; WBGene00003916; par-1.
H39E23.1k; CE46628; WBGene00003916; par-1.
H39E23.1l; CE48381; WBGene00003916; par-1.

Phylogenomic databases

eggNOGiKOG0586. Eukaryota.
ENOG410XNQ0. LUCA.
GeneTreeiENSGT00790000122947.
HOGENOMiHOG000233025.
InParanoidiQ9TW45.
KOiK08798.
OMAiIFILMEY.
OrthoDBiEOG091G0D1E.
PhylomeDBiQ9TW45.

Enzyme and pathway databases

ReactomeiR-CEL-5673000. RAF activation.
R-CEL-5674135. MAP2K and MAPK activation.
R-CEL-5675221. Negative regulation of MAPK pathway.
SignaLinkiQ9TW45.

Miscellaneous databases

PROiQ9TW45.

Gene expression databases

BgeeiWBGene00003916.

Family and domain databases

Gene3Di3.30.310.80. 1 hit.
InterProiIPR028375. KA1/Ssp2_C.
IPR001772. KA1_dom.
IPR011009. Kinase-like_dom.
IPR033624. MARK/par1.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR015940. UBA.
[Graphical view]
PANTHERiPTHR24346. PTHR24346. 3 hits.
PfamiPF02149. KA1. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF103243. SSF103243. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50032. KA1. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50030. UBA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPAR1_CAEEL
AccessioniPrimary (citable) accession number: Q9TW45
Secondary accession number(s): B1Q266
, E0AHE2, E0AHE3, E1B6W1, G5EE60, G5EE76, H2L2K6, H2L2K7, N1NTJ6, Q17346, Q17368, Q1ZXR3, Q9TVG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.