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Protein

Adenosine kinase

Gene

AK

Organism
Toxoplasma gondii
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

ATP-dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. It is a key purine metabolic enzyme in the opportunistic parasitic protozoan toxoplasma gondii as it cannot synthesize purines de novo.

Catalytic activityi

ATP + adenosine = ADP + AMP.

Cofactori

Mg2+Note: Binds 1 Mg2+ ion per subunit.

Pathwayi: AMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes AMP from adenosine.
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosine kinase (AK)
This subpathway is part of the pathway AMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from adenosine, the pathway AMP biosynthesis via salvage pathway and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi185Magnesium; via carbonyl oxygen1
Metal bindingi188Magnesium; via carbonyl oxygen1
Metal bindingi191Magnesium; via carbonyl oxygen1
Active sitei3181

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Purine salvage

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.20. 6411.
UniPathwayiUPA00588; UER00659.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine kinase (EC:2.7.1.20)
Short name:
AK
Alternative name(s):
Adenosine 5'-phosphotransferase
Gene namesi
Name:AK
OrganismiToxoplasma gondii
Taxonomic identifieri5811 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaSarcocystidaeToxoplasma

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2982.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000800561 – 363Adenosine kinaseAdd BLAST363

Interactioni

Protein-protein interaction databases

STRINGi5811.TGME49_050880.

Chemistry databases

BindingDBiQ9TVW2.

Structurei

Secondary structure

1363
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi15 – 18Combined sources4
Beta strandi22 – 28Combined sources7
Helixi31 – 36Combined sources6
Beta strandi44 – 46Combined sources3
Helixi49 – 56Combined sources8
Helixi58 – 61Combined sources4
Beta strandi64 – 69Combined sources6
Helixi70 – 82Combined sources13
Beta strandi87 – 94Combined sources8
Helixi98 – 110Combined sources13
Beta strandi113 – 118Combined sources6
Beta strandi125 – 132Combined sources8
Beta strandi135 – 141Combined sources7
Helixi143 – 147Combined sources5
Helixi154 – 157Combined sources4
Turni158 – 160Combined sources3
Beta strandi163 – 167Combined sources5
Helixi168 – 171Combined sources4
Helixi176 – 186Combined sources11
Beta strandi188 – 190Combined sources3
Beta strandi192 – 196Combined sources5
Helixi200 – 205Combined sources6
Helixi207 – 215Combined sources9
Beta strandi218 – 223Combined sources6
Helixi224 – 234Combined sources11
Helixi239 – 241Combined sources3
Helixi249 – 264Combined sources16
Beta strandi274 – 278Combined sources5
Beta strandi284 – 289Combined sources6
Turni291 – 293Combined sources3
Beta strandi295 – 300Combined sources6
Helixi307 – 309Combined sources3
Helixi316 – 329Combined sources14
Helixi334 – 349Combined sources16
Beta strandi351 – 353Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DGMX-ray1.80A1-363[»]
1LIIX-ray1.73A1-363[»]
1LIJX-ray1.86A1-363[»]
1LIKX-ray2.55A1-363[»]
1LIOX-ray2.50A1-363[»]
2A9YX-ray1.35A1-363[»]
2A9ZX-ray1.35A1-363[»]
2AA0X-ray1.75A1-363[»]
2AB8X-ray1.75A1-363[»]
2ABSX-ray1.10A1-363[»]
ProteinModelPortaliQ9TVW2.
SMRiQ9TVW2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9TVW2.

Family & Domainsi

Sequence similaritiesi

Belongs to the carbohydrate kinase PfkB family.Curated

Phylogenomic databases

eggNOGiKOG2854. Eukaryota.
COG0524. LUCA.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
InterProiIPR001805. Adenokinase.
IPR002173. Carboh/pur_kinase_PfkB_CS.
IPR011611. PfkB_dom.
IPR029056. Ribokinase-like.
[Graphical view]
PANTHERiPTHR10584:SF24. PTHR10584:SF24. 1 hit.
PfamiPF00294. PfkB. 1 hit.
[Graphical view]
PRINTSiPR00989. ADENOKINASE.
SUPFAMiSSF53613. SSF53613. 1 hit.
PROSITEiPS00584. PFKB_KINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9TVW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVDSSNSAT GPMRVFAIGN PILDLVAEVP SSFLDEFFLK RGDATLATPE
60 70 80 90 100
QMRIYSTLDQ FNPTSLPGGS ALNSVRVVQK LLRKPGSAGY MGAIGDDPRG
110 120 130 140 150
QVLKELCDKE GLATRFMVAP GQSTGVCAVL INEKERTLCT HLGACGSFRL
160 170 180 190 200
PEDWTTFASG ALIFYATAYT LTATPKNALE VAGYAHGIPN AIFTLNLSAP
210 220 230 240 250
FCVELYKDAM QSLLLHTNIL FGNEEEFAHL AKVHNLVAAE KTALSTANKE
260 270 280 290 300
HAVEVCTGAL RLLTAGQNTG ATKLVVMTRG HNPVIAAEQT ADGTVVVHEV
310 320 330 340 350
GVPVVAAEKI VDTNGAGDAF VGGFLYALSQ GKTVKQCIMC GNACAQDVIQ
360
HVGFSLSFTS LPC
Length:363
Mass (Da):38,356
Last modified:May 1, 2000 - v1
Checksum:i6C621C7D5A56739C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF128274 Genomic DNA. Translation: AAF01261.1.
AF128275 mRNA. Translation: AAF01262.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF128274 Genomic DNA. Translation: AAF01261.1.
AF128275 mRNA. Translation: AAF01262.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DGMX-ray1.80A1-363[»]
1LIIX-ray1.73A1-363[»]
1LIJX-ray1.86A1-363[»]
1LIKX-ray2.55A1-363[»]
1LIOX-ray2.50A1-363[»]
2A9YX-ray1.35A1-363[»]
2A9ZX-ray1.35A1-363[»]
2AA0X-ray1.75A1-363[»]
2AB8X-ray1.75A1-363[»]
2ABSX-ray1.10A1-363[»]
ProteinModelPortaliQ9TVW2.
SMRiQ9TVW2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5811.TGME49_050880.

Chemistry databases

BindingDBiQ9TVW2.
ChEMBLiCHEMBL2982.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG2854. Eukaryota.
COG0524. LUCA.

Enzyme and pathway databases

UniPathwayiUPA00588; UER00659.
BRENDAi2.7.1.20. 6411.

Miscellaneous databases

EvolutionaryTraceiQ9TVW2.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
InterProiIPR001805. Adenokinase.
IPR002173. Carboh/pur_kinase_PfkB_CS.
IPR011611. PfkB_dom.
IPR029056. Ribokinase-like.
[Graphical view]
PANTHERiPTHR10584:SF24. PTHR10584:SF24. 1 hit.
PfamiPF00294. PfkB. 1 hit.
[Graphical view]
PRINTSiPR00989. ADENOKINASE.
SUPFAMiSSF53613. SSF53613. 1 hit.
PROSITEiPS00584. PFKB_KINASES_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADK_TOXGO
AccessioniPrimary (citable) accession number: Q9TVW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.