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Q9TVW2

- ADK_TOXGO

UniProt

Q9TVW2 - ADK_TOXGO

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Protein

Adenosine kinase

Gene
AK
Organism
Toxoplasma gondii
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

ATP-dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. It is a key purine metabolic enzyme in the opportunistic parasitic protozoan toxoplasma gondii as it cannot synthesize purines de novo.

Catalytic activityi

ATP + adenosine = ADP + AMP.

Cofactori

Binds 1 magnesium ion per subunit.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi185 – 1851Magnesium; via carbonyl oxygen
Metal bindingi188 – 1881Magnesium; via carbonyl oxygen
Metal bindingi191 – 1911Magnesium; via carbonyl oxygen
Active sitei318 – 3181

GO - Molecular functioni

  1. adenosine kinase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW
  4. phosphotransferase activity, alcohol group as acceptor Source: InterPro

GO - Biological processi

  1. AMP salvage Source: UniProtKB-UniPathway
  2. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Purine salvage

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00588; UER00659.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine kinase (EC:2.7.1.20)
Short name:
AK
Alternative name(s):
Adenosine 5'-phosphotransferase
Gene namesi
Name:AK
OrganismiToxoplasma gondii
Taxonomic identifieri5811 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaSarcocystidaeToxoplasma

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 363363Adenosine kinasePRO_0000080056Add
BLAST

Interactioni

Structurei

Secondary structure

1
363
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi15 – 184
Beta strandi22 – 287
Helixi31 – 366
Beta strandi44 – 463
Helixi49 – 568
Helixi58 – 614
Beta strandi64 – 696
Helixi70 – 8213
Beta strandi87 – 948
Helixi98 – 11013
Beta strandi113 – 1186
Beta strandi125 – 1328
Beta strandi135 – 1417
Helixi143 – 1475
Helixi154 – 1574
Turni158 – 1603
Beta strandi163 – 1675
Helixi168 – 1714
Helixi176 – 18611
Beta strandi188 – 1903
Beta strandi192 – 1965
Helixi200 – 2056
Helixi207 – 2159
Beta strandi218 – 2236
Helixi224 – 23411
Helixi239 – 2413
Helixi249 – 26416
Beta strandi274 – 2785
Beta strandi284 – 2896
Turni291 – 2933
Beta strandi295 – 3006
Helixi307 – 3093
Helixi316 – 32914
Helixi334 – 34916
Beta strandi351 – 3533

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DGMX-ray1.80A1-363[»]
1LIIX-ray1.73A1-363[»]
1LIJX-ray1.86A1-363[»]
1LIKX-ray2.55A1-363[»]
1LIOX-ray2.50A1-363[»]
2A9YX-ray1.35A1-363[»]
2A9ZX-ray1.35A1-363[»]
2AA0X-ray1.75A1-363[»]
2AB8X-ray1.75A1-363[»]
2ABSX-ray1.10A1-363[»]
ProteinModelPortaliQ9TVW2.
SMRiQ9TVW2. Positions 10-359.

Miscellaneous databases

EvolutionaryTraceiQ9TVW2.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
InterProiIPR001805. Adenokinase.
IPR002173. Carboh/pur_kinase_PfkB_CS.
IPR011611. PfkB_dom.
IPR029056. Ribokinase-like.
[Graphical view]
PANTHERiPTHR10584:SF24. PTHR10584:SF24. 1 hit.
PfamiPF00294. PfkB. 1 hit.
[Graphical view]
PRINTSiPR00989. ADENOKINASE.
SUPFAMiSSF53613. SSF53613. 1 hit.
PROSITEiPS00584. PFKB_KINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9TVW2-1 [UniParc]FASTAAdd to Basket

« Hide

MAVDSSNSAT GPMRVFAIGN PILDLVAEVP SSFLDEFFLK RGDATLATPE    50
QMRIYSTLDQ FNPTSLPGGS ALNSVRVVQK LLRKPGSAGY MGAIGDDPRG 100
QVLKELCDKE GLATRFMVAP GQSTGVCAVL INEKERTLCT HLGACGSFRL 150
PEDWTTFASG ALIFYATAYT LTATPKNALE VAGYAHGIPN AIFTLNLSAP 200
FCVELYKDAM QSLLLHTNIL FGNEEEFAHL AKVHNLVAAE KTALSTANKE 250
HAVEVCTGAL RLLTAGQNTG ATKLVVMTRG HNPVIAAEQT ADGTVVVHEV 300
GVPVVAAEKI VDTNGAGDAF VGGFLYALSQ GKTVKQCIMC GNACAQDVIQ 350
HVGFSLSFTS LPC 363
Length:363
Mass (Da):38,356
Last modified:May 1, 2000 - v1
Checksum:i6C621C7D5A56739C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF128274 Genomic DNA. Translation: AAF01261.1.
AF128275 mRNA. Translation: AAF01262.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF128274 Genomic DNA. Translation: AAF01261.1 .
AF128275 mRNA. Translation: AAF01262.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1DGM X-ray 1.80 A 1-363 [» ]
1LII X-ray 1.73 A 1-363 [» ]
1LIJ X-ray 1.86 A 1-363 [» ]
1LIK X-ray 2.55 A 1-363 [» ]
1LIO X-ray 2.50 A 1-363 [» ]
2A9Y X-ray 1.35 A 1-363 [» ]
2A9Z X-ray 1.35 A 1-363 [» ]
2AA0 X-ray 1.75 A 1-363 [» ]
2AB8 X-ray 1.75 A 1-363 [» ]
2ABS X-ray 1.10 A 1-363 [» ]
ProteinModelPortali Q9TVW2.
SMRi Q9TVW2. Positions 10-359.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q9TVW2.
ChEMBLi CHEMBL2982.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00588 ; UER00659 .

Miscellaneous databases

EvolutionaryTracei Q9TVW2.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
InterProi IPR001805. Adenokinase.
IPR002173. Carboh/pur_kinase_PfkB_CS.
IPR011611. PfkB_dom.
IPR029056. Ribokinase-like.
[Graphical view ]
PANTHERi PTHR10584:SF24. PTHR10584:SF24. 1 hit.
Pfami PF00294. PfkB. 1 hit.
[Graphical view ]
PRINTSi PR00989. ADENOKINASE.
SUPFAMi SSF53613. SSF53613. 1 hit.
PROSITEi PS00584. PFKB_KINASES_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Insertional tagging of at least two loci associated with resistance to adenine arabinoside in Toxoplasma gondii, and cloning of the adenosine kinase locus."
    Sullivan W.J. Jr., Chiang C.-W., Wilson C.M., Naguib F.N.M., el Kouni M.H., Donald R.G.K., Roos D.S.
    Mol. Biochem. Parasitol. 103:1-14(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: RH.
  2. "Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding."
    Schumacher M.A., Scott D.M., Mathews I.I., Ealick S.E., Roos D.S., Ullman B., Brennan R.G.
    J. Mol. Biol. 296:549-567(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.72 ANGSTROMS).
  3. "Crystal structure of adenosine kinase from Toxoplasma gondii at 1.8 A resolution."
    Cook W.J., DeLucas L.J., Chattopadhyay D.
    Protein Sci. 9:704-712(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS).

Entry informationi

Entry nameiADK_TOXGO
AccessioniPrimary (citable) accession number: Q9TVW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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