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Protein

Exportin-1

Gene

emb

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for the leucine-rich nuclear export signal (NES). Binds cooperatively to the NES on its target protein and to the small GTPase Ran in its active GTP-bound form. Required for the function or maintenance of certain tissues such as brain and gut. Involved in the export of dl from the nucleus to the cytoplasm.3 Publications

Miscellaneous

Activity inhibited by leptomycin B, which disrupts interaction with the NES and RanGTP.1 Publication

GO - Molecular functioni

GO - Biological processi

  • centriole replication Source: FlyBase
  • mRNA transport Source: UniProtKB-KW
  • multicellular organism development Source: UniProtKB
  • nuclear export Source: FlyBase
  • protein export from nucleus Source: FlyBase
  • protein transport Source: UniProtKB
  • regulation of cellular response to hypoxia Source: FlyBase
  • regulation of protein export from nucleus Source: GO_Central
  • ribosomal large subunit export from nucleus Source: GO_Central
  • ribosomal small subunit export from nucleus Source: FlyBase

Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-DME-3769402 Deactivation of the beta-catenin transactivating complex
R-DME-69273 Cyclin A/B1/B2 associated events during G2/M transition

Names & Taxonomyi

Protein namesi
Recommended name:
Exportin-1
Alternative name(s):
Chromosome region maintenance 1 protein
Protein embargoed
Gene namesi
Name:embImported
Synonyms:Crm1Imported
ORF Names:CG13387
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0020497 emb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002047081 – 1063Exportin-1Add BLAST1063

Proteomic databases

PaxDbiQ9TVM2
PRIDEiQ9TVM2

Expressioni

Tissue specificityi

High expression observed in the developing embryonic brain, hind gut and posterior spiracles shortly before dorsal closure; and in the ventral nerve cord, midgut and somatic musculature shortly after dorsal closure. Expression increases when the tissue is well developed.1 Publication

Developmental stagei

Highly expressed both maternally and zygotically.1 Publication

Gene expression databases

BgeeiFBgn0020497
ExpressionAtlasiQ9TVM2 differential
GenevisibleiQ9TVM2 DM

Interactioni

Subunit structurei

Interacts with Clbn (via its N-terminus) (By similarity). Interacts with mbo to form components of the nuclear pore complex, of which Nup214 is also a member. Interacts with target proteins containing NES sequences such as actin and dl.By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi60290, 14 interactors
DIPiDIP-21235N
IntActiQ9TVM2, 13 interactors
MINTiQ9TVM2
STRINGi7227.FBpp0079278

Structurei

3D structure databases

ProteinModelPortaliQ9TVM2
SMRiQ9TVM2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 109Importin N-terminalPROSITE-ProRule annotationAdd BLAST67

Sequence similaritiesi

Belongs to the exportin family.Sequence analysis

Phylogenomic databases

eggNOGiKOG2020 Eukaryota
COG5101 LUCA
GeneTreeiENSGT00390000000572
InParanoidiQ9TVM2
KOiK14290
OMAiCENNMII
OrthoDBiEOG091G013G
PhylomeDBiQ9TVM2

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR014877 CRM1_C_dom
IPR013598 Exportin-1/Importin-b-like
IPR001494 Importin-beta_N
PfamiView protein in Pfam
PF08767 CRM1_C, 1 hit
PF03810 IBN_N, 1 hit
PF08389 Xpo1, 1 hit
SMARTiView protein in SMART
SM01102 CRM1_C, 1 hit
SM00913 IBN_N, 1 hit
SUPFAMiSSF48371 SSF48371, 3 hits
PROSITEiView protein in PROSITE
PS50166 IMPORTIN_B_NT, 1 hit

Sequencei

Sequence statusi: Complete.

Q9TVM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATMLTSDEA GKLLDFSQKL DINLLDKIVE VVYTAQGEQL RLAQSILTTL
60 70 80 90 100
KEHPEAWTRV DSILEYSQNQ RTKFYALQIL EEVIKTRWKV LPRNQCEGIK
110 120 130 140 150
KYVVSLIIKT SSDPIVMEQN KVYLNKLNMI LVHILKREWP RNWETFISDI
160 170 180 190 200
VGASKTNESL CMNNMVILKN LSEEVFDFSQ GQITQTKAKH LKDTMCSEFS
210 220 230 240 250
QIFTLCSFVL ENSMNAALIH VTLETLLRFL NWIPLGYIFE TQQIETLIFK
260 270 280 290 300
FLSVPMFRNV TLKCLSEIAG LTAANYDENF ATLFKDTMVQ LEQIVGQNMN
310 320 330 340 350
MNHVFKHGSD TEQELVLNLA MFLCTFLKEH GKLVEDAKYV DYLNQALMYL
360 370 380 390 400
VMISEVEDVE VFKICLEYWN SLVEDLYNSE FFHPTLESTK RQQVYPRRRF
410 420 430 440 450
YAPILSKVRF IMISRMAKPE EVLVVENENG EVVREFMKDT NSINLYKNMR
460 470 480 490 500
ETLVFLTHLD SVDTDRIMTL KLLNQVNGSE FSWKNLNTLC WAIGSISGAF
510 520 530 540 550
CEEDEKRFLV TVIKDLLGLC EQKKGKDNKA IIASNIMYVV GQYPRFLRAH
560 570 580 590 600
WKFLKTVVNK LFEFMHETHD GVQDMACDTF IKIAIKCRRY FVTIQPNEAC
610 620 630 640 650
TFIDEILTTM SSIICDLQPQ QVHTFYEAVG YMISAQVDQV QQDVLIERYM
660 670 680 690 700
QLPNQVWDDI ISRASKNVDF LKNMTAVKQL GSILKTNVAA CKALGHAYVI
710 720 730 740 750
QLGRIYLDML NVYKITSENI IQAIEVNGVN VNNQPLIKTM HVVKKETLNL
760 770 780 790 800
ISEWVSRSND NQLVMDNFIP PLLDAILLDY QRCKVPSARE PKVLSAMAII
810 820 830 840 850
VHKLRQHITN EVPKIFDAVF ECTLDMINKN FEDFPQHRLS FYELLQAVNA
860 870 880 890 900
HCFKAFLNIP PAQFKLVFDS VVWAFKHTMR NVADMGLNIL FKMLQNLDQH
910 920 930 940 950
PGAAQSFYQT YFTDILMQIF SVVTDTSHTA GLPNHAIILA YMFSLVENRK
960 970 980 990 1000
ITVNLGPIPD NMIFIQEYVA SLLKSAFTHL SDNQVKVFVT GLFNLDENVQ
1010 1020 1030 1040 1050
AFKEHLRDFL IQIREATGED DSDLYLEERE AALAEEQSNK HQMQRNIPGM
1060
LNPHELPEDM QDE
Length:1,063
Mass (Da):122,799
Last modified:May 1, 2000 - v1
Checksum:iBBE2FF53859BD1FE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1017T → A in AAF01341 (PubMed:10636888).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF179360 mRNA Translation: AAD55778.1
AF179361 Genomic DNA Translation: AAD55780.1
AF190557 mRNA Translation: AAF01341.1
AJ249178 mRNA Translation: CAB53566.1
AE014134 Genomic DNA Translation: AAG22423.2
AY089558 mRNA Translation: AAL90296.1
RefSeqiNP_001303316.1, NM_001316387.1
NP_723391.2, NM_164818.2
UniGeneiDm.3346

Genome annotation databases

EnsemblMetazoaiFBtr0079663; FBpp0079278; FBgn0020497
FBtr0346708; FBpp0312321; FBgn0020497
GeneIDi34167
KEGGidme:Dmel_CG13387

Similar proteinsi

Entry informationi

Entry nameiXPO1_DROME
AccessioniPrimary (citable) accession number: Q9TVM2
Secondary accession number(s): Q9I7N7, Q9U699
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health