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Protein

Probable cyclin-dependent kinase 9

Gene

cdk-9

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) and spt-5.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei114ATPPROSITE-ProRule annotation1
Active sitei217Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi91 – 99ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • embryo development ending in birth or egg hatching Source: UniProtKB
  • germ cell development Source: UniProtKB
  • nematode larval development Source: UniProtKB
  • phosphorylation of RNA polymerase II C-terminal domain Source: GO_Central
  • positive regulation of transcription by RNA polymerase II Source: GO_Central
  • regulation of histone H3-K36 trimethylation Source: UniProtKB
  • regulation of phosphorylation of RNA polymerase II C-terminal domain Source: UniProtKB
  • transcription elongation from RNA polymerase II promoter Source: GO_Central

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processTranscription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-674695 RNA Polymerase II Pre-transcription Events
R-CEL-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-CEL-6807505 RNA polymerase II transcribes snRNA genes
R-CEL-75955 RNA Polymerase II Transcription Elongation
R-CEL-9018519 Estrogen-dependent gene expression
SignaLinkiQ9TVL3

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cyclin-dependent kinase 9 (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
Cell division protein kinase 9
Gene namesi
Name:cdk-9
ORF Names:H25P06.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi

Organism-specific databases

WormBaseiH25P06.2a ; CE37838 ; WBGene00000410 ; cdk-9
H25P06.2b ; CE37839 ; WBGene00000410 ; cdk-9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000858071 – 478Probable cyclin-dependent kinase 9Add BLAST478

Proteomic databases

EPDiQ9TVL3
PaxDbiQ9TVL3
PeptideAtlasiQ9TVL3
PRIDEiQ9TVL3

PTM databases

iPTMnetiQ9TVL3

Expressioni

Gene expression databases

BgeeiWBGene00000410

Interactioni

Subunit structurei

Associates with cyclin-T (cit-1.1 or cit-1.2) to form P-TEFb.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi38431, 1 interactor
IntActiQ9TVL3, 2 interactors
STRINGi6239.H25P06.2b

Structurei

3D structure databases

ProteinModelPortaliQ9TVL3
SMRiQ9TVL3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 413Protein kinasePROSITE-ProRule annotationAdd BLAST329

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0600 Eukaryota
ENOG410XPIR LUCA
GeneTreeiENSGT00890000139396
HOGENOMiHOG000233024
InParanoidiQ9TVL3
KOiK02211
OMAiSASCHEM
OrthoDBiEOG091G08Z8
PhylomeDBiQ9TVL3

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform b (identifier: Q9TVL3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAQNYHAGL HQSSTQRPPK RPNTEHAQEP PKRALIGGQT TPSSSGGGQT
60 70 80 90 100
PNGTNYELEV KQQLSNYQKL FDQATYPFIR DVSTYEKLNK IGQGTFGEVF
110 120 130 140 150
KARCKNTGRM VALKKILMEN EKEGFPITAL REVKMLEQLK HPNITDLIEV
160 170 180 190 200
CSAKSTGTTG SKDRATFYLV MALCAHDLAG LLSNPKIRMS LVHIKTMMKH
210 220 230 240 250
LMSGLNKLHR SKILHRDMKA ANVLISKDGI LKLADFGLAR PFVQRENGAG
260 270 280 290 300
PRPLYTNRVV TLWYRPPELL LGDRQYGTKI DVWGAGCIMA EMWTRQPIMQ
310 320 330 340 350
GDTEQKQLQL ISGLCGSINK DVWPNCVNMP LWSAMSSEPN SALPQGKYRI
360 370 380 390 400
LPNKMKNLMK FDAPDSKTDP FGKNVKQHDS ATDDDALHLL EILLAIDPDK
410 420 430 440 450
RPTSDEAEDD IWFFKDPVPM ANVQDLMDTI PNSQFEYTVG KGAHANRGRH
460 470
QNAQQRPNQQ QARPSNAIPA GQYRDTIF
Note: Gene prediction based on EST data.
Length:478
Mass (Da):53,593
Last modified:March 1, 2005 - v2
Checksum:iC8E307EA3465E36B
GO
Isoform a (identifier: Q9TVL3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     432-445: NSQFEYTVGKGAHA → VRKFEAKWLKKREK
     446-478: Missing.

Note: Gene prediction based on EST data. No experimental confirmation available.
Show »
Length:445
Mass (Da):50,130
Checksum:i2EB98637B821C984
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016291432 – 445NSQFE…KGAHA → VRKFEAKWLKKREK in isoform a. CuratedAdd BLAST14
Alternative sequenceiVSP_016292446 – 478Missing in isoform a. CuratedAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z92797, Z83118 Genomic DNA Translation: CAB07237.2
Z92797, Z83118 Genomic DNA Translation: CAB07238.3
PIRiF87920
T23123
T23124
RefSeqiNP_492906.2, NM_060505.3 [Q9TVL3-1]
NP_492907.2, NM_060506.3 [Q9TVL3-2]
UniGeneiCel.8202

Genome annotation databases

EnsemblMetazoaiH25P06.2b; H25P06.2b; WBGene00000410 [Q9TVL3-1]
GeneIDi173023
KEGGicel:CELE_H25P06.2
UCSCiH25P06.2b c. elegans [Q9TVL3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Entry informationi

Entry nameiCDK9_CAEEL
AccessioniPrimary (citable) accession number: Q9TVL3
Secondary accession number(s): Q9XTH5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: March 1, 2005
Last modified: May 23, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

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