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Protein

Probable cyclin-dependent kinase 9

Gene

cdk-9

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Essential member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) and spt-5.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei114ATPPROSITE-ProRule annotation1
Active sitei217Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi91 – 99ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-112387. Elongation arrest and recovery.
R-CEL-674695. RNA Polymerase II Pre-transcription Events.
R-CEL-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-CEL-6807505. RNA polymerase II transcribes snRNA genes.
R-CEL-75955. RNA Polymerase II Transcription Elongation.
SignaLinkiQ9TVL3.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cyclin-dependent kinase 9 (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
Cell division protein kinase 9
Gene namesi
Name:cdk-9
ORF Names:H25P06.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiH25P06.2a; CE37838; WBGene00000410; cdk-9.
H25P06.2b; CE37839; WBGene00000410; cdk-9.

Subcellular locationi

GO - Cellular componenti

  • chromosome Source: WormBase
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000858071 – 478Probable cyclin-dependent kinase 9Add BLAST478

Proteomic databases

EPDiQ9TVL3.
PaxDbiQ9TVL3.
PeptideAtlasiQ9TVL3.

PTM databases

iPTMnetiQ9TVL3.

Expressioni

Gene expression databases

BgeeiWBGene00000410.

Interactioni

Subunit structurei

Associates with cyclin-T (cit-1.1 or cit-1.2) to form P-TEFb.By similarity

Protein-protein interaction databases

BioGridi38431. 1 interactor.
IntActiQ9TVL3. 2 interactors.
STRINGi6239.H25P06.2b.

Structurei

3D structure databases

ProteinModelPortaliQ9TVL3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 413Protein kinasePROSITE-ProRule annotationAdd BLAST329

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0600. Eukaryota.
ENOG410XPIR. LUCA.
GeneTreeiENSGT00860000133755.
HOGENOMiHOG000233024.
InParanoidiQ9TVL3.
KOiK02211.
OMAiTRRIEIN.
OrthoDBiEOG091G08Z8.
PhylomeDBiQ9TVL3.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform b (identifier: Q9TVL3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAQNYHAGL HQSSTQRPPK RPNTEHAQEP PKRALIGGQT TPSSSGGGQT
60 70 80 90 100
PNGTNYELEV KQQLSNYQKL FDQATYPFIR DVSTYEKLNK IGQGTFGEVF
110 120 130 140 150
KARCKNTGRM VALKKILMEN EKEGFPITAL REVKMLEQLK HPNITDLIEV
160 170 180 190 200
CSAKSTGTTG SKDRATFYLV MALCAHDLAG LLSNPKIRMS LVHIKTMMKH
210 220 230 240 250
LMSGLNKLHR SKILHRDMKA ANVLISKDGI LKLADFGLAR PFVQRENGAG
260 270 280 290 300
PRPLYTNRVV TLWYRPPELL LGDRQYGTKI DVWGAGCIMA EMWTRQPIMQ
310 320 330 340 350
GDTEQKQLQL ISGLCGSINK DVWPNCVNMP LWSAMSSEPN SALPQGKYRI
360 370 380 390 400
LPNKMKNLMK FDAPDSKTDP FGKNVKQHDS ATDDDALHLL EILLAIDPDK
410 420 430 440 450
RPTSDEAEDD IWFFKDPVPM ANVQDLMDTI PNSQFEYTVG KGAHANRGRH
460 470
QNAQQRPNQQ QARPSNAIPA GQYRDTIF
Note: Gene prediction based on EST data.
Length:478
Mass (Da):53,593
Last modified:March 1, 2005 - v2
Checksum:iC8E307EA3465E36B
GO
Isoform a (identifier: Q9TVL3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     432-445: NSQFEYTVGKGAHA → VRKFEAKWLKKREK
     446-478: Missing.

Note: Gene prediction based on EST data. No experimental confirmation available.
Show »
Length:445
Mass (Da):50,130
Checksum:i2EB98637B821C984
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016291432 – 445NSQFE…KGAHA → VRKFEAKWLKKREK in isoform a. CuratedAdd BLAST14
Alternative sequenceiVSP_016292446 – 478Missing in isoform a. CuratedAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z92797, Z83118 Genomic DNA. Translation: CAB07237.2.
Z92797, Z83118 Genomic DNA. Translation: CAB07238.3.
PIRiF87920.
T23123.
T23124.
RefSeqiNP_492906.2. NM_060505.3. [Q9TVL3-1]
NP_492907.2. NM_060506.3. [Q9TVL3-2]
UniGeneiCel.8202.

Genome annotation databases

EnsemblMetazoaiH25P06.2b; H25P06.2b; WBGene00000410. [Q9TVL3-1]
GeneIDi173023.
KEGGicel:CELE_H25P06.2.
UCSCiH25P06.2b. c. elegans. [Q9TVL3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z92797, Z83118 Genomic DNA. Translation: CAB07237.2.
Z92797, Z83118 Genomic DNA. Translation: CAB07238.3.
PIRiF87920.
T23123.
T23124.
RefSeqiNP_492906.2. NM_060505.3. [Q9TVL3-1]
NP_492907.2. NM_060506.3. [Q9TVL3-2]
UniGeneiCel.8202.

3D structure databases

ProteinModelPortaliQ9TVL3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi38431. 1 interactor.
IntActiQ9TVL3. 2 interactors.
STRINGi6239.H25P06.2b.

PTM databases

iPTMnetiQ9TVL3.

Proteomic databases

EPDiQ9TVL3.
PaxDbiQ9TVL3.
PeptideAtlasiQ9TVL3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiH25P06.2b; H25P06.2b; WBGene00000410. [Q9TVL3-1]
GeneIDi173023.
KEGGicel:CELE_H25P06.2.
UCSCiH25P06.2b. c. elegans. [Q9TVL3-1]

Organism-specific databases

CTDi173023.
WormBaseiH25P06.2a; CE37838; WBGene00000410; cdk-9.
H25P06.2b; CE37839; WBGene00000410; cdk-9.

Phylogenomic databases

eggNOGiKOG0600. Eukaryota.
ENOG410XPIR. LUCA.
GeneTreeiENSGT00860000133755.
HOGENOMiHOG000233024.
InParanoidiQ9TVL3.
KOiK02211.
OMAiTRRIEIN.
OrthoDBiEOG091G08Z8.
PhylomeDBiQ9TVL3.

Enzyme and pathway databases

ReactomeiR-CEL-112387. Elongation arrest and recovery.
R-CEL-674695. RNA Polymerase II Pre-transcription Events.
R-CEL-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-CEL-6807505. RNA polymerase II transcribes snRNA genes.
R-CEL-75955. RNA Polymerase II Transcription Elongation.
SignaLinkiQ9TVL3.

Miscellaneous databases

PROiQ9TVL3.

Gene expression databases

BgeeiWBGene00000410.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDK9_CAEEL
AccessioniPrimary (citable) accession number: Q9TVL3
Secondary accession number(s): Q9XTH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: March 1, 2005
Last modified: November 30, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.