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Q9TVL3

- CDK9_CAEEL

UniProt

Q9TVL3 - CDK9_CAEEL

Protein

Probable cyclin-dependent kinase 9

Gene

cdk-9

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 2 (01 Mar 2005)
      Previous versions | rss
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    Functioni

    Essential member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) and spt-5.1 Publication

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.
    ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei114 – 1141ATPPROSITE-ProRule annotation
    Active sitei217 – 2171Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi91 – 999ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
    3. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiQ9TVL3.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable cyclin-dependent kinase 9 (EC:2.7.11.22, EC:2.7.11.23)
    Alternative name(s):
    Cell division protein kinase 9
    Gene namesi
    Name:cdk-9
    ORF Names:H25P06.2
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome I

    Organism-specific databases

    WormBaseiH25P06.2a; CE37838; WBGene00000410; cdk-9.
    H25P06.2b; CE37839; WBGene00000410; cdk-9.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. chromosome Source: WormBase
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 478478Probable cyclin-dependent kinase 9PRO_0000085807Add
    BLAST

    Proteomic databases

    PaxDbiQ9TVL3.
    PRIDEiQ9TVL3.

    Interactioni

    Subunit structurei

    Associates with cyclin-T (cit-1.1 or cit-1.2) to form P-TEFb.By similarity

    Protein-protein interaction databases

    BioGridi38431. 1 interaction.
    IntActiQ9TVL3. 2 interactions.
    STRINGi6239.H25P06.2b.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9TVL3.
    SMRiQ9TVL3. Positions 55-419.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini85 – 413329Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00740000114964.
    HOGENOMiHOG000233024.
    InParanoidiQ9TVL3.
    KOiK02211.
    OMAiMSLVHIK.
    OrthoDBiEOG76DTSM.
    PhylomeDBiQ9TVL3.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 2 hits.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform b (identifier: Q9TVL3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSAQNYHAGL HQSSTQRPPK RPNTEHAQEP PKRALIGGQT TPSSSGGGQT    50
    PNGTNYELEV KQQLSNYQKL FDQATYPFIR DVSTYEKLNK IGQGTFGEVF 100
    KARCKNTGRM VALKKILMEN EKEGFPITAL REVKMLEQLK HPNITDLIEV 150
    CSAKSTGTTG SKDRATFYLV MALCAHDLAG LLSNPKIRMS LVHIKTMMKH 200
    LMSGLNKLHR SKILHRDMKA ANVLISKDGI LKLADFGLAR PFVQRENGAG 250
    PRPLYTNRVV TLWYRPPELL LGDRQYGTKI DVWGAGCIMA EMWTRQPIMQ 300
    GDTEQKQLQL ISGLCGSINK DVWPNCVNMP LWSAMSSEPN SALPQGKYRI 350
    LPNKMKNLMK FDAPDSKTDP FGKNVKQHDS ATDDDALHLL EILLAIDPDK 400
    RPTSDEAEDD IWFFKDPVPM ANVQDLMDTI PNSQFEYTVG KGAHANRGRH 450
    QNAQQRPNQQ QARPSNAIPA GQYRDTIF 478

    Note: Gene prediction based on EST data.

    Length:478
    Mass (Da):53,593
    Last modified:March 1, 2005 - v2
    Checksum:iC8E307EA3465E36B
    GO
    Isoform a (identifier: Q9TVL3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         432-445: NSQFEYTVGKGAHA → VRKFEAKWLKKREK
         446-478: Missing.

    Note: Gene prediction based on EST data. No experimental confirmation available.

    Show »
    Length:445
    Mass (Da):50,130
    Checksum:i2EB98637B821C984
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei432 – 44514NSQFE…KGAHA → VRKFEAKWLKKREK in isoform a. CuratedVSP_016291Add
    BLAST
    Alternative sequencei446 – 47833Missing in isoform a. CuratedVSP_016292Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z92797, Z83118 Genomic DNA. Translation: CAB07237.2.
    Z92797, Z83118 Genomic DNA. Translation: CAB07238.3.
    PIRiF87920.
    T23123.
    T23124.
    RefSeqiNP_492906.2. NM_060505.3. [Q9TVL3-1]
    NP_492907.2. NM_060506.3. [Q9TVL3-2]
    UniGeneiCel.8202.

    Genome annotation databases

    EnsemblMetazoaiH25P06.2b; H25P06.2b; WBGene00000410. [Q9TVL3-1]
    GeneIDi173023.
    KEGGicel:CELE_H25P06.2.
    UCSCiH25P06.2b. c. elegans. [Q9TVL3-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z92797 , Z83118 Genomic DNA. Translation: CAB07237.2 .
    Z92797 , Z83118 Genomic DNA. Translation: CAB07238.3 .
    PIRi F87920.
    T23123.
    T23124.
    RefSeqi NP_492906.2. NM_060505.3. [Q9TVL3-1 ]
    NP_492907.2. NM_060506.3. [Q9TVL3-2 ]
    UniGenei Cel.8202.

    3D structure databases

    ProteinModelPortali Q9TVL3.
    SMRi Q9TVL3. Positions 55-419.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 38431. 1 interaction.
    IntActi Q9TVL3. 2 interactions.
    STRINGi 6239.H25P06.2b.

    Proteomic databases

    PaxDbi Q9TVL3.
    PRIDEi Q9TVL3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai H25P06.2b ; H25P06.2b ; WBGene00000410 . [Q9TVL3-1 ]
    GeneIDi 173023.
    KEGGi cel:CELE_H25P06.2.
    UCSCi H25P06.2b. c. elegans. [Q9TVL3-1 ]

    Organism-specific databases

    CTDi 173023.
    WormBasei H25P06.2a ; CE37838 ; WBGene00000410 ; cdk-9.
    H25P06.2b ; CE37839 ; WBGene00000410 ; cdk-9.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00740000114964.
    HOGENOMi HOG000233024.
    InParanoidi Q9TVL3.
    KOi K02211.
    OMAi MSLVHIK.
    OrthoDBi EOG76DTSM.
    PhylomeDBi Q9TVL3.

    Enzyme and pathway databases

    SignaLinki Q9TVL3.

    Miscellaneous databases

    NextBioi 877955.
    PROi Q9TVL3.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 2 hits.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
      Strain: Bristol N2.
    2. "CDK-9/cyclin T (P-TEFb) is required in two postinitiation pathways for transcription in the C. elegans embryo."
      Shim E.Y., Walker A.K., Shi Y., Blackwell T.K.
      Genes Dev. 16:2135-2146(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiCDK9_CAEEL
    AccessioniPrimary (citable) accession number: Q9TVL3
    Secondary accession number(s): Q9XTH5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3