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Protein

C-X-C chemokine receptor type 6

Gene

CXCR6

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 6
Short name:
CXC-R6
Short name:
CXCR-6
Alternative name(s):
G-protein coupled receptor STRL33
G-protein coupled receptor bonzo
CD_antigen: CD186
Gene namesi
Name:CXCR6
Synonyms:BONZO, STRL33
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 3

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232ExtracellularSequence analysisAdd
BLAST
Transmembranei33 – 5927Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini60 – 689CytoplasmicSequence analysis
Transmembranei69 – 8921Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini90 – 10314ExtracellularSequence analysisAdd
BLAST
Transmembranei104 – 12522Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini126 – 14318CytoplasmicSequence analysisAdd
BLAST
Transmembranei144 – 16421Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini165 – 18723ExtracellularSequence analysisAdd
BLAST
Transmembranei188 – 21528Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini216 – 23116CytoplasmicSequence analysisAdd
BLAST
Transmembranei232 – 25928Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini260 – 27516ExtracellularSequence analysisAdd
BLAST
Transmembranei276 – 29318Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini294 – 34249CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 342342C-X-C chemokine receptor type 6PRO_0000069369Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi16 – 161N-linked (GlcNAc...)Sequence analysis
Disulfide bondi102 ↔ 180PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9TV16.

Interactioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000054532.

Structurei

3D structure databases

ProteinModelPortaliQ9TV16.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiQ9TV16.
KOiK04191.
OMAiTPFNLVK.
OrthoDBiEOG091G0D3V.
TreeFamiTF330966.

Family and domain databases

InterProiIPR002235. Chemokine_CXCR6.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01105. CXCCHMKINER6.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9TV16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEHDYHEDY GFNSFNDSSQ EEHQDFLQFS KVFLPCMYLV VFVCGLVGNS
60 70 80 90 100
LVLVISIFYH KLQSLTDVFL VNLPLADLVF VCTLPFWAYA GIHEWVFGQV
110 120 130 140 150
MCKSLLGIYT INFYTSMLIL TCITVDRFIV VVKATKAYNQ QAKRMTWGKV
160 170 180 190 200
TSLLIWVISL LVSLPQIIYG NVFNLDKLIC GYHDEAISTV VLATQMTLGF
210 220 230 240 250
FLPLLTMIVC YSVIIKTLLH AGGFQKHRSL KIIFLVMAVF LLTQMPFNLM
260 270 280 290 300
KLIRSTHWEY YAMTSFHYTI MVTEAIAYLR ACLNPVLYAF VSLKFRKNFW
310 320 330 340
KLVKDIGCLP YLGVSHQWKS SEDNSKTFSA SHNVEATSMF QL
Length:342
Mass (Da):39,273
Last modified:May 1, 2000 - v1
Checksum:i5B58003797806B2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF084229 mRNA. Translation: AAD52041.1.
RefSeqiNP_001009051.1. NM_001009051.1.
UniGeneiPtr.6411.

Genome annotation databases

EnsembliENSPTRT00000061984; ENSPTRP00000054532; ENSPTRG00000014843.
GeneIDi450138.
KEGGiptr:450138.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF084229 mRNA. Translation: AAD52041.1.
RefSeqiNP_001009051.1. NM_001009051.1.
UniGeneiPtr.6411.

3D structure databases

ProteinModelPortaliQ9TV16.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000054532.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ9TV16.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPTRT00000061984; ENSPTRP00000054532; ENSPTRG00000014843.
GeneIDi450138.
KEGGiptr:450138.

Organism-specific databases

CTDi10663.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiQ9TV16.
KOiK04191.
OMAiTPFNLVK.
OrthoDBiEOG091G0D3V.
TreeFamiTF330966.

Family and domain databases

InterProiIPR002235. Chemokine_CXCR6.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01105. CXCCHMKINER6.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXCR6_PANTR
AccessioniPrimary (citable) accession number: Q9TV16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.