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Q9TV13

- CASP1_HORSE

UniProt

Q9TV13 - CASP1_HORSE

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Protein

Caspase-1

Gene

CASP1

Organism
Equus caballus (Horse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis (By similarity).By similarity

Catalytic activityi

Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|-.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei238 – 2381By similarity
Active sitei286 – 2861By similarity

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. regulation of apoptotic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

BRENDAi3.4.22.36. 2120.

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase-1 (EC:3.4.22.36)
Short name:
CASP-1
Alternative name(s):
Interleukin-1 beta convertase
Short name:
IL-1BC
Interleukin-1 beta-converting enzyme
Short name:
ICE
Short name:
IL-1 beta-converting enzyme
p45
Cleaved into the following 2 chains:
Gene namesi
Name:CASP1
Synonyms:IL1BC
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
ProteomesiUP000002281: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. AIM2 inflammasome complex Source: UniProtKB
  2. cytoplasm Source: UniProtKB-KW
  3. IPAF inflammasome complex Source: UniProtKB
  4. NLRP1 inflammasome complex Source: UniProtKB
  5. NLRP3 inflammasome complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 119119Sequence AnalysisPRO_0000004517Add
BLAST
Chaini120 – 298179Caspase-1 subunit p20PRO_0000004518Add
BLAST
Propeptidei299 – 31719Sequence AnalysisPRO_0000004519Add
BLAST
Chaini318 – 40588Caspase-1 subunit p10PRO_0000004520Add
BLAST

Post-translational modificationi

The two subunits are derived from the precursor sequence by an autocatalytic mechanism.

Keywords - PTMi

Zymogen

Proteomic databases

PRIDEiQ9TV13.

Interactioni

Subunit structurei

Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunit. The p20 subunit can also form a heterodimer with the epsilon isoform which then has an inhibitory effect. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and NALP2 and whose function would be the activation of proinflammatory caspases. Both the p10 and p20 subunits interact with MEFV. Interacts with CARD17/INCA and CARD18 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9TV13.
SMRiQ9TV13. Positions 2-89, 127-298, 318-405.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 9191CARDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C14A family.Curated
Contains 1 CARD domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG326166.
HOGENOMiHOG000234399.
HOVERGENiHBG076981.
InParanoidiQ9TV13.
KOiK01370.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.1460. 1 hit.
InterProiIPR001315. CARD.
IPR029030. Caspase-like_dom.
IPR017350. Caspase_ICE-type.
IPR011029. DEATH-like_dom.
IPR011600. Pept_C14_caspase.
IPR001309. Pept_C14_ICE_p20.
IPR016129. Pept_C14_ICE_p20_AS.
IPR002138. Pept_C14_p10.
IPR015917. Pept_C14A_p45_core.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
PF00656. Peptidase_C14. 1 hit.
[Graphical view]
PIRSFiPIRSF038001. Caspase_ICE. 1 hit.
PRINTSiPR00376. IL1BCENZYME.
SMARTiSM00114. CARD. 1 hit.
SM00115. CASc. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9TV13-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADKVLKEKR RLFIRSVGTG TVNSLLDELL EKRVLNQEEM EKVRDENATV
60 70 80 90 100
MDKARALIDA VIRKGPQACQ IFIGHICEDD PHLAETLRLS SGPQSGNFLK
110 120 130 140 150
TQDSQAVVHS SPALQAMPDD LAKLALSGPK VSLKLCSPEV VERIWKEKSA
160 170 180 190 200
EMYPIMGKSM TRTRLALIIC NTEFDNLSRR AGAEVDIASM KVLLEGLGYS
210 220 230 240 250
VEVKENLTAL DMTTELKAFA ARPEHRSSDS TFLVFMSHGI REGICGKKFS
260 270 280 290 300
EKVPDVLEVN TIFQIFNTRN CPNLRDKPKV IIIQACRGEN QGVVWLKDST
310 320 330 340 350
GTSGNSSSLA PDDFEDDAIK KAHVEKDFIA FCSSTPDTVS WRSPTTGSVF
360 370 380 390 400
IEKLIENLQE YAWSCDLEEI FRKVRLSFEL PDARAQMPTA ERVTLTRRFY

LFPGH
Length:405
Mass (Da):45,331
Last modified:May 1, 2000 - v1
Checksum:i7CE8729BB359CC17
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti203 – 2031V → L.
Natural varianti305 – 3051N → S.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090119 mRNA. Translation: AAD46400.1.
RefSeqiNP_001075311.1. NM_001081842.1.
UniGeneiEca.13025.

Genome annotation databases

GeneIDi100033888.
KEGGiecb:100033888.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090119 mRNA. Translation: AAD46400.1 .
RefSeqi NP_001075311.1. NM_001081842.1.
UniGenei Eca.13025.

3D structure databases

ProteinModelPortali Q9TV13.
SMRi Q9TV13. Positions 2-89, 127-298, 318-405.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q9TV13.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100033888.
KEGGi ecb:100033888.

Organism-specific databases

CTDi 834.

Phylogenomic databases

eggNOGi NOG326166.
HOGENOMi HOG000234399.
HOVERGENi HBG076981.
InParanoidi Q9TV13.
KOi K01370.

Enzyme and pathway databases

BRENDAi 3.4.22.36. 2120.

Family and domain databases

Gene3Di 1.10.533.10. 1 hit.
3.40.50.1460. 1 hit.
InterProi IPR001315. CARD.
IPR029030. Caspase-like_dom.
IPR017350. Caspase_ICE-type.
IPR011029. DEATH-like_dom.
IPR011600. Pept_C14_caspase.
IPR001309. Pept_C14_ICE_p20.
IPR016129. Pept_C14_ICE_p20_AS.
IPR002138. Pept_C14_p10.
IPR015917. Pept_C14A_p45_core.
[Graphical view ]
Pfami PF00619. CARD. 1 hit.
PF00656. Peptidase_C14. 1 hit.
[Graphical view ]
PIRSFi PIRSF038001. Caspase_ICE. 1 hit.
PRINTSi PR00376. IL1BCENZYME.
SMARTi SM00114. CARD. 1 hit.
SM00115. CASc. 1 hit.
[Graphical view ]
SUPFAMi SSF47986. SSF47986. 1 hit.
PROSITEi PS50209. CARD. 1 hit.
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of equine caspase-1 cDNA."
    Wardlow S., Penha-Goncalves M.N., Argyle D.J., Onions D.E., Nicolson L.
    DNA Seq. 10:133-137(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCASP1_HORSE
AccessioniPrimary (citable) accession number: Q9TV13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3