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Protein

Complement component C7

Gene

C7

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Complement alternate pathway, Complement pathway, Cytolysis, Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Complement component C7
Gene namesi
Name:C7
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane attack complex, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222By similarityAdd
BLAST
Chaini23 – 843821Complement component C7PRO_0000023584Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi36 – 361C-linked (Man)By similarity
Disulfide bondi85 ↔ 96By similarity
Disulfide bondi91 ↔ 109By similarity
Disulfide bondi103 ↔ 119By similarity
Disulfide bondi128 ↔ 165By similarity
Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence analysis
Disulfide bondi337 ↔ 353By similarity
Glycosylationi503 – 5031C-linked (Man)By similarity
Glycosylationi506 – 5061C-linked (Man)By similarity
Glycosylationi509 – 5091C-linked (Man)By similarity
Disulfide bondi571 ↔ 613By similarity
Disulfide bondi599 ↔ 626By similarity
Disulfide bondi631 ↔ 673By similarity
Disulfide bondi659 ↔ 688By similarity
Disulfide bondi702 ↔ 713By similarity
Disulfide bondi715 ↔ 750By similarity
Disulfide bondi721 ↔ 743By similarity
Disulfide bondi728 ↔ 763By similarity
Glycosylationi754 – 7541N-linked (GlcNAc...)Sequence analysis
Disulfide bondi773 ↔ 782By similarity
Disulfide bondi776 ↔ 789By similarity
Disulfide bondi791 ↔ 825By similarity
Disulfide bondi797 ↔ 818By similarity
Disulfide bondi805 ↔ 838By similarity

Post-translational modificationi

C7 has 28 disulfide bridges.By similarity
C- and N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9TUQ3.
PeptideAtlasiQ9TUQ3.

Expressioni

Tissue specificityi

Detected in plasma (at protein level). Bone marrow, heart, intestine, lung, spleen, kidney, liver and thymus.1 Publication

Interactioni

Subunit structurei

Monomer or dimer; as a C5b-7 complex it can also form multimeric rosettes. MAC assembly is initiated by protelytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000017865.

Structurei

3D structure databases

ProteinModelPortaliQ9TUQ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 8054TSP type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini83 – 12139LDL-receptor class APROSITE-ProRule annotationAdd
BLAST
Domaini124 – 456333MACPFPROSITE-ProRule annotationAdd
BLAST
Domaini457 – 48731EGF-likeAdd
BLAST
Domaini500 – 54950TSP type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini569 – 62860Sushi 1PROSITE-ProRule annotationAdd
BLAST
Domaini629 – 69062Sushi 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni545 – 61571CCP 1Add
BLAST
Regioni616 – 69378CCP 2Add
BLAST
Regioni695 – 77076Factor I module (FIM) 1Add
BLAST
Regioni771 – 84373Factor I module (FIM) 2Add
BLAST

Sequence similaritiesi

Belongs to the complement C6/C7/C8/C9 family.Curated
Contains 1 EGF-like domain.Curated
Contains 1 LDL-receptor class A domain.PROSITE-ProRule annotation
Contains 1 MACPF domain.PROSITE-ProRule annotation
Contains 2 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation
Contains 2 TSP type-1 domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiENOG410IDXP. Eukaryota.
ENOG410YJ70. LUCA.
HOGENOMiHOG000111868.
HOVERGENiHBG005367.
InParanoidiQ9TUQ3.
KOiK03996.

Family and domain databases

Gene3Di4.10.400.10. 1 hit.
InterProiIPR003884. FacI_MAC.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001862. MAC_perforin.
IPR020864. MACPF.
IPR020863. MACPF_CS.
IPR000436. Sushi_SCR_CCP_dom.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF00057. Ldl_recept_a. 1 hit.
PF01823. MACPF. 1 hit.
PF00084. Sushi. 2 hits.
PF00090. TSP_1. 2 hits.
[Graphical view]
PRINTSiPR00764. COMPLEMENTC9.
SMARTiSM00032. CCP. 2 hits.
SM00057. FIMAC. 2 hits.
SM00192. LDLa. 1 hit.
SM00457. MACPF. 1 hit.
SM00209. TSP1. 2 hits.
[Graphical view]
SUPFAMiSSF57424. SSF57424. 1 hit.
SSF57535. SSF57535. 2 hits.
SSF82895. SSF82895. 2 hits.
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS00279. MACPF_1. 1 hit.
PS51412. MACPF_2. 1 hit.
PS50923. SUSHI. 2 hits.
PS50092. TSP1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9TUQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAMSLVFLV GLIGEFQVFS SASSPVNCQW DSYAPWSECN GCTKTQTRRR
60 70 80 90 100
PVAVYGQYGG HPCVGSTFET QSCEPTRGCP TEEGCGERFR CFSGQCISKS
110 120 130 140 150
LVCNGDSDCE EDSADEDRCE DSESRPSCDL SKPPPNIELT GNGYNALTGQ
160 170 180 190 200
FRNRVLNTKS FGGQCRKVFS GDGRDFYRLS GNVLSYTFQV KVNNDFNYEF
210 220 230 240 250
YNSTWSYAKH TSTEHTSSSK GRVFIFSSSS SSSSYYAKTY EILKKKSYQL
260 270 280 290 300
LVVQNTVEVA QFINNNPEFL QLAESFWKEL SYLPPLYDYS AYRRLIDQYG
310 320 330 340 350
THYLQSGSLG GEYKVLFYVD SEKVAESDLG SEDKKKCASS HISFLFKSSK
360 370 380 390 400
HKCKAMEEAL KSASGTQSNV LRGVPFVRGG RPGFVSGLSY LELDNPDGNK
410 420 430 440 450
QRYSSWAGSV TDLPQVIKQK LTPLYELVKE VPCASVKRLY LKRALEEYLD
460 470 480 490 500
EFDSCHCQPC QNGGMASVEG TQCQCHCKPN TFGVACEQGV LVGDHAGGID
510 520 530 540 550
GGWSCWSSWG PCAQGKKTRS RKCNNPPPSG GGKSCIGETS ESRQCEDEDL
560 570 580 590 600
EHLRLLEPHC FPLSLVPTEF CPSPPALKDG FVQNEETTFP VGKNIVYSCN
610 620 630 640 650
EGYSLVGDPV ARCGEDLQWT VGKMHCQKIA CVLPTLMRGL QSHPQKPFYT
660 670 680 690 700
VGEKVTFSCS SGMSLEGPST FLCGSSLKWS PEMKNVQCVR KEAPLAKKVP
710 720 730 740 750
ECQLWEKLQN SKCVCKMPYE CGSSLDVCAR DERSKRILRL TVCKMHVLQC
760 770 780 790 800
QGRNYTLSVG ETCTLPGSAE KACGACPLWE KCDAQSSKCV CRAASECEEA
810 820 830 840
GFRVCVEVNG REQTMTECEA GVLRCLGLSI TVTSIRPCAP EAP
Length:843
Mass (Da):93,062
Last modified:May 1, 2000 - v1
Checksum:i0B703D93C3E5C83D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF162274 mRNA. Translation: AAD45918.1.
RefSeqiNP_999447.1. NM_214282.1.
UniGeneiSsc.5836.

Genome annotation databases

GeneIDi397526.
KEGGissc:397526.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF162274 mRNA. Translation: AAD45918.1.
RefSeqiNP_999447.1. NM_214282.1.
UniGeneiSsc.5836.

3D structure databases

ProteinModelPortaliQ9TUQ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000017865.

Proteomic databases

PaxDbiQ9TUQ3.
PeptideAtlasiQ9TUQ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397526.
KEGGissc:397526.

Organism-specific databases

CTDi730.

Phylogenomic databases

eggNOGiENOG410IDXP. Eukaryota.
ENOG410YJ70. LUCA.
HOGENOMiHOG000111868.
HOVERGENiHBG005367.
InParanoidiQ9TUQ3.
KOiK03996.

Family and domain databases

Gene3Di4.10.400.10. 1 hit.
InterProiIPR003884. FacI_MAC.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001862. MAC_perforin.
IPR020864. MACPF.
IPR020863. MACPF_CS.
IPR000436. Sushi_SCR_CCP_dom.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF00057. Ldl_recept_a. 1 hit.
PF01823. MACPF. 1 hit.
PF00084. Sushi. 2 hits.
PF00090. TSP_1. 2 hits.
[Graphical view]
PRINTSiPR00764. COMPLEMENTC9.
SMARTiSM00032. CCP. 2 hits.
SM00057. FIMAC. 2 hits.
SM00192. LDLa. 1 hit.
SM00457. MACPF. 1 hit.
SM00209. TSP1. 2 hits.
[Graphical view]
SUPFAMiSSF57424. SSF57424. 1 hit.
SSF57535. SSF57535. 2 hits.
SSF82895. SSF82895. 2 hits.
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS00279. MACPF_1. 1 hit.
PS51412. MACPF_2. 1 hit.
PS50923. SUSHI. 2 hits.
PS50092. TSP1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCO7_PIG
AccessioniPrimary (citable) accession number: Q9TUQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: May 1, 2000
Last modified: July 6, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.