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Q9TUM6 (PLIN2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Perilipin-2
Alternative name(s):
Adipophilin
Adipose differentiation-related protein
Short name=ADRP
Gene names
Name:PLIN2
Synonyms:ADFP, ADRP
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length450 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in development and maintenance of adipose tissue By similarity.

Subcellular location

Membrane; Peripheral membrane protein By similarity.

Tissue specificity

Milk lipid globules.

Sequence similarities

Belongs to the perilipin family.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentmembrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9TUM6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9TUM6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     402-450: VGPFYPQVTE...EGSQPDDSSS → ALDFSITDFT...EPSQGKMLNN
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 450449Perilipin-2
PRO_0000099887

Amino acid modifications

Modified residue21N-acetylalanine By similarity

Natural variations

Alternative sequence402 – 45049VGPFY…DDSSS → ALDFSITDFTSETDEIPDII ALEEEDGPNHSHANGPEPSQ GKMLNN in isoform 2.
VSP_019867

Experimental info

Sequence conflict541M → T in AAI02212. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: A5026FF11969A885

FASTA45049,368
        10         20         30         40         50         60 
MASVAVEPQL SVVTRVANLP LVSSTYDLVS SAYISRKDQY PYLKSLCEMA EKGMKTITSV 

        70         80         90        100        110        120 
AVTSALPIIQ KLEPQIAVAN TYACKGLDRI EEKLPILNQP TNQVVANAKG AMTGAKDAVT 

       130        140        150        160        170        180 
TTVTGAKDSV ASTITGVVDR TKGAVTGSVE KTKSVVSGSI NTVLRSRVMQ LMSSGVENAL 

       190        200        210        220        230        240 
TKSELLVDQY LPLTKDELEK EAKKVEGFDM VQKPSYYVRL GSLSTKLRSR AYQQALCRVE 

       250        260        270        280        290        300 
EAKRKGQETI SQLHSAFNLS ELARKNVHNA NQKIQDAQDK LYLSWLEWKR SIGYDDTDES 

       310        320        330        340        350        360 
HCAEHIESRT LAIARNLTQQ LQTMCHTLLS NIQGLPQNIQ DRANHLGVMA GDIYSVFRNA 

       370        380        390        400        410        420 
ASFKEVSDGL LASSKGQLQK MKESLDDVMD YLVNNTPLNW LVGPFYPQVT ESESAQAPGT 

       430        440        450 
TRRPGRWSRK HPKPVPVSNA EGSQPDDSSS 

« Hide

Isoform 2 [UniParc].

Checksum: 9BDC82ECADB0FCEB
Show »

FASTA44749,102

References

« Hide 'large scale' references
[1]"Isolation of adipophilin and butyrophilin from bovine milk and characterization of a cDNA encoding adipophilin."
Nielsen R.L., Andersen M.H., Mabhout P., Berglund L., Petersen T.E., Rasmussen J.T.
J. Dairy Sci. 82:2543-2549(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Mammary gland.
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: Crossbred X Angus.
Tissue: Ileum.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ011680 mRNA. Translation: CAB53860.1.
BC102211 mRNA. Translation: AAI02212.1.
RefSeqNP_776405.1. NM_173980.2. [Q9TUM6-1]
UniGeneBt.2568.

3D structure databases

ProteinModelPortalQ9TUM6.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ9TUM6.
PRIDEQ9TUM6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID280981.
KEGGbta:280981.

Organism-specific databases

CTD123.

Phylogenomic databases

eggNOGNOG68493.
HOGENOMHOG000033816.
HOVERGENHBG002935.
InParanoidQ9TUM6.
KOK17284.

Family and domain databases

InterProIPR004279. Perilipin.
[Graphical view]
PANTHERPTHR14024. PTHR14024. 1 hit.
PfamPF03036. Perilipin. 1 hit.
[Graphical view]
PIRSFPIRSF036881. PAT. 1 hit.
ProtoNetSearch...

Other

NextBio20805082.

Entry information

Entry namePLIN2_BOVIN
AccessionPrimary (citable) accession number: Q9TUM6
Secondary accession number(s): Q3T0Y0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families