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Protein

Perilipin-2

Gene

PLIN2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in development and maintenance of adipose tissue.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Perilipin-2
Alternative name(s):
Adipophilin
Adipose differentiation-related protein
Short name:
ADRP
Gene namesi
Name:PLIN2
Synonyms:ADFP, ADRP
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Unplaced

Subcellular locationi

Membrane By similarity; Peripheral membrane protein By similarity

GO - Cellular componenti

  1. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 450449Perilipin-2PRO_0000099887Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9TUM6.
PRIDEiQ9TUM6.

Expressioni

Tissue specificityi

Milk lipid globules.

Family & Domainsi

Sequence similaritiesi

Belongs to the perilipin family.Curated

Phylogenomic databases

eggNOGiNOG68493.
HOGENOMiHOG000033816.
HOVERGENiHBG002935.
InParanoidiQ9TUM6.
KOiK17284.

Family and domain databases

InterProiIPR004279. Perilipin.
[Graphical view]
PANTHERiPTHR14024. PTHR14024. 1 hit.
PfamiPF03036. Perilipin. 1 hit.
[Graphical view]
PIRSFiPIRSF036881. PAT. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9TUM6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASVAVEPQL SVVTRVANLP LVSSTYDLVS SAYISRKDQY PYLKSLCEMA
60 70 80 90 100
EKGMKTITSV AVTSALPIIQ KLEPQIAVAN TYACKGLDRI EEKLPILNQP
110 120 130 140 150
TNQVVANAKG AMTGAKDAVT TTVTGAKDSV ASTITGVVDR TKGAVTGSVE
160 170 180 190 200
KTKSVVSGSI NTVLRSRVMQ LMSSGVENAL TKSELLVDQY LPLTKDELEK
210 220 230 240 250
EAKKVEGFDM VQKPSYYVRL GSLSTKLRSR AYQQALCRVE EAKRKGQETI
260 270 280 290 300
SQLHSAFNLS ELARKNVHNA NQKIQDAQDK LYLSWLEWKR SIGYDDTDES
310 320 330 340 350
HCAEHIESRT LAIARNLTQQ LQTMCHTLLS NIQGLPQNIQ DRANHLGVMA
360 370 380 390 400
GDIYSVFRNA ASFKEVSDGL LASSKGQLQK MKESLDDVMD YLVNNTPLNW
410 420 430 440 450
LVGPFYPQVT ESESAQAPGT TRRPGRWSRK HPKPVPVSNA EGSQPDDSSS
Length:450
Mass (Da):49,368
Last modified:May 1, 2000 - v1
Checksum:iA5026FF11969A885
GO
Isoform 2 (identifier: Q9TUM6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     402-450: VGPFYPQVTE...EGSQPDDSSS → ALDFSITDFT...EPSQGKMLNN

Note: No experimental confirmation available.

Show »
Length:447
Mass (Da):49,102
Checksum:i9BDC82ECADB0FCEB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti54 – 541M → T in AAI02212 (Ref. 2) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei402 – 45049VGPFY…DDSSS → ALDFSITDFTSETDEIPDII ALEEEDGPNHSHANGPEPSQ GKMLNN in isoform 2. 1 PublicationVSP_019867Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011680 mRNA. Translation: CAB53860.1.
BC102211 mRNA. Translation: AAI02212.1.
RefSeqiNP_776405.1. NM_173980.2. [Q9TUM6-1]
UniGeneiBt.2568.

Genome annotation databases

GeneIDi280981.
KEGGibta:280981.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011680 mRNA. Translation: CAB53860.1.
BC102211 mRNA. Translation: AAI02212.1.
RefSeqiNP_776405.1. NM_173980.2. [Q9TUM6-1]
UniGeneiBt.2568.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ9TUM6.
PRIDEiQ9TUM6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi280981.
KEGGibta:280981.

Organism-specific databases

CTDi123.

Phylogenomic databases

eggNOGiNOG68493.
HOGENOMiHOG000033816.
HOVERGENiHBG002935.
InParanoidiQ9TUM6.
KOiK17284.

Miscellaneous databases

NextBioi20805082.

Family and domain databases

InterProiIPR004279. Perilipin.
[Graphical view]
PANTHERiPTHR14024. PTHR14024. 1 hit.
PfamiPF03036. Perilipin. 1 hit.
[Graphical view]
PIRSFiPIRSF036881. PAT. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of adipophilin and butyrophilin from bovine milk and characterization of a cDNA encoding adipophilin."
    Nielsen R.L., Andersen M.H., Mabhout P., Berglund L., Petersen T.E., Rasmussen J.T.
    J. Dairy Sci. 82:2543-2549(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Mammary gland.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiPLIN2_BOVIN
AccessioniPrimary (citable) accession number: Q9TUM6
Secondary accession number(s): Q3T0Y0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: April 1, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.