Q9TUM6 (PLIN2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Perilipin-2

Alternative name(s):
Adipophilin
Adipose differentiation-related protein
Short name=ADRP

Gene names

Name:	PLIN2
Synonyms:	ADFP, ADRP

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	450 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in development and maintenance of adipose tissue By similarity.
Subcellular location	Membrane; Peripheral membrane protein By similarity.
Tissue specificity	Milk lipid globules.
Sequence similarities	Belongs to the perilipin family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9TUM6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9TUM6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     402-450: VGPFYPQVTE...EGSQPDDSSS → ALDFSITDFT...EPSQGKMLNN

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 450	450	Perilipin-2		PRO_0000099887
Natural variations
	Alternative sequence	402 – 450	49	VGPFY…DDSSS → ALDFSITDFTSETDEIPDII ALEEEDGPNHSHANGPEPSQ GKMLNN in isoform 2.		VSP_019867
Experimental info
	Sequence conflict	54	1	M → T in AAI02212. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: A5026FF11969A885	FASTA	450	49,368
	10 20 30 40 50 60 MASVAVEPQL SVVTRVANLP LVSSTYDLVS SAYISRKDQY PYLKSLCEMA EKGMKTITSV 70 80 90 100 110 120 AVTSALPIIQ KLEPQIAVAN TYACKGLDRI EEKLPILNQP TNQVVANAKG AMTGAKDAVT 130 140 150 160 170 180 TTVTGAKDSV ASTITGVVDR TKGAVTGSVE KTKSVVSGSI NTVLRSRVMQ LMSSGVENAL 190 200 210 220 230 240 TKSELLVDQY LPLTKDELEK EAKKVEGFDM VQKPSYYVRL GSLSTKLRSR AYQQALCRVE 250 260 270 280 290 300 EAKRKGQETI SQLHSAFNLS ELARKNVHNA NQKIQDAQDK LYLSWLEWKR SIGYDDTDES 310 320 330 340 350 360 HCAEHIESRT LAIARNLTQQ LQTMCHTLLS NIQGLPQNIQ DRANHLGVMA GDIYSVFRNA 370 380 390 400 410 420 ASFKEVSDGL LASSKGQLQK MKESLDDVMD YLVNNTPLNW LVGPFYPQVT ESESAQAPGT 430 440 450 TRRPGRWSRK HPKPVPVSNA EGSQPDDSSS
	Isoform 2 [UniParc]. Checksum: 9BDC82ECADB0FCEB	FASTA	447	49,102
	10 20 30 40 50 60 MASVAVEPQL SVVTRVANLP LVSSTYDLVS SAYISRKDQY PYLKSLCEMA EKGMKTITSV 70 80 90 100 110 120 AVTSALPIIQ KLEPQIAVAN TYACKGLDRI EEKLPILNQP TNQVVANAKG AMTGAKDAVT 130 140 150 160 170 180 TTVTGAKDSV ASTITGVVDR TKGAVTGSVE KTKSVVSGSI NTVLRSRVMQ LMSSGVENAL 190 200 210 220 230 240 TKSELLVDQY LPLTKDELEK EAKKVEGFDM VQKPSYYVRL GSLSTKLRSR AYQQALCRVE 250 260 270 280 290 300 EAKRKGQETI SQLHSAFNLS ELARKNVHNA NQKIQDAQDK LYLSWLEWKR SIGYDDTDES 310 320 330 340 350 360 HCAEHIESRT LAIARNLTQQ LQTMCHTLLS NIQGLPQNIQ DRANHLGVMA GDIYSVFRNA 370 380 390 400 410 420 ASFKEVSDGL LASSKGQLQK MKESLDDVMD YLVNNTPLNW LALDFSITDF TSETDEIPDI 430 440 IALEEEDGPN HSHANGPEPS QGKMLNN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of adipophilin and butyrophilin from bovine milk and characterization of a cDNA encoding adipophilin." Nielsen R.L., Andersen M.H., Mabhout P., Berglund L., Petersen T.E., Rasmussen J.T. J. Dairy Sci. 82:2543-2549(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Mammary gland.
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Strain: Crossbred X Angus. Tissue: Ileum.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ011680 mRNA. Translation: CAB53860.1. BC102211 mRNA. Translation: AAI02212.1.
IPI	IPI00716572. IPI00782891.
RefSeq	NP_776405.1. NM_173980.2.
UniGene	Bt.2568.
3D structure databases
ProteinModelPortal	Q9TUM6.
ModBase	Search...
Proteomic databases
PaxDb	Q9TUM6.
PRIDE	Q9TUM6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	280981.
KEGG	bta:280981.
Organism-specific databases
CTD	123.
Phylogenomic databases
eggNOG	NOG68493.
HOGENOM	HOG000033816.
HOVERGEN	HBG002935.
InParanoid	Q9TUM6.
Family and domain databases
InterPro	IPR004279. Perilipin. [Graphical view]
PANTHER	PTHR14024. PTHR14024. 1 hit.
Pfam	PF03036. Perilipin. 1 hit. [Graphical view]
PIRSF	PIRSF036881. PAT. 1 hit.
ProtoNet	Search...
Other
NextBio	20805082.

Entry information

Entry name

PLIN2_BOVIN

Accession

Primary (citable) accession number: Q9TUM6
Secondary accession number(s): Q3T0Y0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	May 1, 2000
Last modified:	April 3, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program