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Q9TUM6

- PLIN2_BOVIN

UniProt

Q9TUM6 - PLIN2_BOVIN

Protein

Perilipin-2

Gene

PLIN2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    May be involved in development and maintenance of adipose tissue.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Perilipin-2
    Alternative name(s):
    Adipophilin
    Adipose differentiation-related protein
    Short name:
    ADRP
    Gene namesi
    Name:PLIN2
    Synonyms:ADFP, ADRP
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Membrane By similarity; Peripheral membrane protein By similarity

    GO - Cellular componenti

    1. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 450449Perilipin-2PRO_0000099887Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ9TUM6.
    PRIDEiQ9TUM6.

    Expressioni

    Tissue specificityi

    Milk lipid globules.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9TUM6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the perilipin family.Curated

    Phylogenomic databases

    eggNOGiNOG68493.
    HOGENOMiHOG000033816.
    HOVERGENiHBG002935.
    InParanoidiQ9TUM6.
    KOiK17284.

    Family and domain databases

    InterProiIPR004279. Perilipin.
    [Graphical view]
    PANTHERiPTHR14024. PTHR14024. 1 hit.
    PfamiPF03036. Perilipin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036881. PAT. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9TUM6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASVAVEPQL SVVTRVANLP LVSSTYDLVS SAYISRKDQY PYLKSLCEMA    50
    EKGMKTITSV AVTSALPIIQ KLEPQIAVAN TYACKGLDRI EEKLPILNQP 100
    TNQVVANAKG AMTGAKDAVT TTVTGAKDSV ASTITGVVDR TKGAVTGSVE 150
    KTKSVVSGSI NTVLRSRVMQ LMSSGVENAL TKSELLVDQY LPLTKDELEK 200
    EAKKVEGFDM VQKPSYYVRL GSLSTKLRSR AYQQALCRVE EAKRKGQETI 250
    SQLHSAFNLS ELARKNVHNA NQKIQDAQDK LYLSWLEWKR SIGYDDTDES 300
    HCAEHIESRT LAIARNLTQQ LQTMCHTLLS NIQGLPQNIQ DRANHLGVMA 350
    GDIYSVFRNA ASFKEVSDGL LASSKGQLQK MKESLDDVMD YLVNNTPLNW 400
    LVGPFYPQVT ESESAQAPGT TRRPGRWSRK HPKPVPVSNA EGSQPDDSSS 450
    Length:450
    Mass (Da):49,368
    Last modified:May 1, 2000 - v1
    Checksum:iA5026FF11969A885
    GO
    Isoform 2 (identifier: Q9TUM6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         402-450: VGPFYPQVTE...EGSQPDDSSS → ALDFSITDFT...EPSQGKMLNN

    Note: No experimental confirmation available.

    Show »
    Length:447
    Mass (Da):49,102
    Checksum:i9BDC82ECADB0FCEB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti54 – 541M → T in AAI02212. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei402 – 45049VGPFY…DDSSS → ALDFSITDFTSETDEIPDII ALEEEDGPNHSHANGPEPSQ GKMLNN in isoform 2. 1 PublicationVSP_019867Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ011680 mRNA. Translation: CAB53860.1.
    BC102211 mRNA. Translation: AAI02212.1.
    RefSeqiNP_776405.1. NM_173980.2. [Q9TUM6-1]
    UniGeneiBt.2568.

    Genome annotation databases

    GeneIDi280981.
    KEGGibta:280981.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ011680 mRNA. Translation: CAB53860.1 .
    BC102211 mRNA. Translation: AAI02212.1 .
    RefSeqi NP_776405.1. NM_173980.2. [Q9TUM6-1 ]
    UniGenei Bt.2568.

    3D structure databases

    ProteinModelPortali Q9TUM6.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q9TUM6.
    PRIDEi Q9TUM6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 280981.
    KEGGi bta:280981.

    Organism-specific databases

    CTDi 123.

    Phylogenomic databases

    eggNOGi NOG68493.
    HOGENOMi HOG000033816.
    HOVERGENi HBG002935.
    InParanoidi Q9TUM6.
    KOi K17284.

    Miscellaneous databases

    NextBioi 20805082.

    Family and domain databases

    InterProi IPR004279. Perilipin.
    [Graphical view ]
    PANTHERi PTHR14024. PTHR14024. 1 hit.
    Pfami PF03036. Perilipin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036881. PAT. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of adipophilin and butyrophilin from bovine milk and characterization of a cDNA encoding adipophilin."
      Nielsen R.L., Andersen M.H., Mabhout P., Berglund L., Petersen T.E., Rasmussen J.T.
      J. Dairy Sci. 82:2543-2549(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Mammary gland.
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: Crossbred X Angus.
      Tissue: Ileum.

    Entry informationi

    Entry nameiPLIN2_BOVIN
    AccessioniPrimary (citable) accession number: Q9TUM6
    Secondary accession number(s): Q3T0Y0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3