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Protein

Signal transducer and activator of transcription 5B

Gene

STAT5B

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer and activator of transcription 5B
Gene namesi
Name:STAT5B
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001824281 – 787Signal transducer and activator of transcription 5BAdd BLAST787

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei90PhosphotyrosineBy similarity1
Modified residuei128PhosphoserineBy similarity1
Modified residuei699Phosphotyrosine; by HCK, JAK and PTK6By similarity1

Post-translational modificationi

Tyrosine phosphorylated in response to signaling via activated KIT, resulting in translocation to the nucleus. Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3. Alternatively, can be phosphorylated by JAK2. Phosphorylation at Tyr-699 by PTK6 or HCK leads to an increase of its transcriptional activity.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9TUM3.
PRIDEiQ9TUM3.

Interactioni

Subunit structurei

Forms a homodimer or a heterodimer with a related family member. Binds NR3C1. Interacts with NCOA1. Interacts with NMI. Interacts with SOCS7. Interacts (via SH2 domain) with INSR. Interacts with CPEB3; this inhibits STAT5B-mediated transcriptional activation.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012497.

Structurei

3D structure databases

ProteinModelPortaliQ9TUM3.
SMRiQ9TUM3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini589 – 686SH2PROSITE-ProRule annotationAdd BLAST98

Sequence similaritiesi

Belongs to the transcription factor STAT family.Curated

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG3667. Eukaryota.
ENOG410XPN8. LUCA.
HOGENOMiHOG000230988.
HOVERGENiHBG107486.
InParanoidiQ9TUM3.
KOiK11224.
TreeFamiTF318648.

Family and domain databases

CDDicd10420. SH2_STAT5b. 1 hit.
Gene3Di1.10.532.10. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProiView protein in InterPro
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR036860. SH2_dom_sf.
IPR001217. STAT.
IPR035858. STAT5a/5b.
IPR035886. STAT5b_SH2.
IPR036535. STAT_N_sf.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
PANTHERiPTHR11801. PTHR11801. 1 hit.
PTHR11801:SF39. PTHR11801:SF39. 1 hit.
PfamiView protein in Pfam
PF00017. SH2. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
SMARTiView protein in SMART
SM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
SUPFAMiSSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiView protein in PROSITE
PS50001. SH2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9TUM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVWIQAQQL QGDALHQMQA LYGQHFPIEV RHYLSQWIEG QAWDSIDLDN
60 70 80 90 100
PQENIKATQL LEGLVQELQK KAEHQVGEDG FLLKIKLGHY ATQLQNTYDR
110 120 130 140 150
CPMELVRCIR HILYNEQRLV REANNGTSPA GSLADAMSQK HLQINQTFEE
160 170 180 190 200
LRLVTQDTEN ELKKLQQTQE YFIIQYQESL RIQAQFAQLA QLNPQERLSR
210 220 230 240 250
ETALQQKQLS LEAWLQREAQ TLQQYRVELA EKHQKTLQLL RKQQTIILDD
260 270 280 290 300
ELIQWKRRQQ LAGNGGPPEG SLDVLQSWCE KLAEIIWQNR QQIRRAEHFC
310 320 330 340 350
QQLPIPGPVE EMLAEVNATI TDIISALVTS TFIIEKQPPQ VLKTQTKFAA
360 370 380 390 400
TVRLLVGGKL NVHMNPPQVK ATIISEQQAK SLLKNENTRN DYSGEILNNC
410 420 430 440 450
CVMEYHQATG TLSAHFRNMS LKRIKRSDRR GAESVTEEKF TILFESQFSV
460 470 480 490 500
GGNELVFQVK TLSLPVVVIV HGSQDNNATA TVLWDNAFAE PGRVPFAVPD
510 520 530 540 550
KVLWPQLCEA LNMKFKAEVQ SNRGLTKENL VFLAQKLFNS SSSHLEDYNG
560 570 580 590 600
MSVSWSQFNR ENLPGRNYTF WQWFDGVMEV LKKHLKPHWN DGAILGFVNK
610 620 630 640 650
QQAHDLLINK PDGTFLLRFS DSEIGGITIA WKFDSQERMF WNLMPFTTRD
660 670 680 690 700
FSIRSLADRL GDLSYLIYVF PDRPKDEVYS KYYTPVPCEP ATAKAVDGYV
710 720 730 740 750
KPQIKQVVPE FVSASADSAG GSATYMDQAP SPAVCPQPHY NMYPQNPDPV
760 770 780
LDNDGDFDLD DTIDVARRVE ELLGRPMDSQ WIPHAQS
Length:787
Mass (Da):89,991
Last modified:April 27, 2001 - v2
Checksum:i121C9CD9794E3A9A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti133L → F in CAB51845 (PubMed:10835485).Curated1
Sequence conflicti209L → V in CAB51845 (PubMed:10835485).Curated1
Sequence conflicti209L → V in AAI12569 (Ref. 2) Curated1
Sequence conflicti299F → L in CAB51845 (PubMed:10835485).Curated1
Sequence conflicti299F → L in AAI12569 (Ref. 2) Curated1
Sequence conflicti611P → S in CAB51845 (PubMed:10835485).Curated1
Sequence conflicti636Missing in CAB52172 (PubMed:10835485).Curated1
Sequence conflicti693Missing in CAB52172 (PubMed:10835485).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ237933 mRNA. Translation: CAB51845.1.
AJ237934, AJ237935, AJ237936 Genomic DNA. Translation: CAB52172.1.
BC112568 mRNA. Translation: AAI12569.1.
AJ005638 Genomic DNA. Translation: CAA06641.1.
RefSeqiNP_777042.2. NM_174617.4.
XP_005220730.1. XM_005220673.3.
XP_005220731.1. XM_005220674.3.
UniGeneiBt.20143.

Genome annotation databases

GeneIDi282376.
KEGGibta:282376.

Similar proteinsi

Entry informationi

Entry nameiSTA5B_BOVIN
AccessioniPrimary (citable) accession number: Q9TUM3
Secondary accession number(s): O77702, Q2KIP0, Q9TUM2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: October 25, 2017
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families