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Protein

Signal transducer and activator of transcription 5B

Gene

STAT5B

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer and activator of transcription 5B
Gene namesi
Name:STAT5B
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Translocated into the nucleus in response to phosphorylation.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 787787Signal transducer and activator of transcription 5BPRO_0000182428Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei90 – 901PhosphotyrosineBy similarity
Modified residuei128 – 1281PhosphoserineBy similarity
Modified residuei682 – 6821PhosphotyrosineBy similarity
Modified residuei699 – 6991Phosphotyrosine; by HCK, JAK and PTK6By similarity

Post-translational modificationi

Tyrosine phosphorylated. Tyrosine phosphorylated in response to signaling via activated FLT3 and KIT, resulting in translocation to the nucleus. Alternatively, can be phosphorylated by JAK2 (By similarity). Phosphorylation at Tyr-699 by PTK6 or HCK leads to an increase of its transcriptional activity (By similarity). Dephosphorylation on tyrosine residues by PTPN2 negatively regulates prolactin signaling pathway (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9TUM3.
PRIDEiQ9TUM3.

Expressioni

Gene expression databases

BgeeiENSBTAG00000010125.

Interactioni

Subunit structurei

Forms a homodimer or a heterodimer with a related family member. Binds NR3C1. Interacts with NCOA1 and SOCS7 (By similarity). Interacts (via SH2 domain) with INSR (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012497.

Structurei

3D structure databases

ProteinModelPortaliQ9TUM3.
SMRiQ9TUM3. Positions 138-686.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini589 – 68698SH2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the transcription factor STAT family.Curated
Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG3667. Eukaryota.
ENOG410XPN8. LUCA.
HOGENOMiHOG000230988.
HOVERGENiHBG107486.
InParanoidiQ9TUM3.
KOiK11224.
TreeFamiTF318648.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view]
PANTHERiPTHR11801. PTHR11801. 2 hits.
PfamiPF00017. SH2. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
[Graphical view]
SUPFAMiSSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9TUM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVWIQAQQL QGDALHQMQA LYGQHFPIEV RHYLSQWIEG QAWDSIDLDN
60 70 80 90 100
PQENIKATQL LEGLVQELQK KAEHQVGEDG FLLKIKLGHY ATQLQNTYDR
110 120 130 140 150
CPMELVRCIR HILYNEQRLV REANNGTSPA GSLADAMSQK HLQINQTFEE
160 170 180 190 200
LRLVTQDTEN ELKKLQQTQE YFIIQYQESL RIQAQFAQLA QLNPQERLSR
210 220 230 240 250
ETALQQKQLS LEAWLQREAQ TLQQYRVELA EKHQKTLQLL RKQQTIILDD
260 270 280 290 300
ELIQWKRRQQ LAGNGGPPEG SLDVLQSWCE KLAEIIWQNR QQIRRAEHFC
310 320 330 340 350
QQLPIPGPVE EMLAEVNATI TDIISALVTS TFIIEKQPPQ VLKTQTKFAA
360 370 380 390 400
TVRLLVGGKL NVHMNPPQVK ATIISEQQAK SLLKNENTRN DYSGEILNNC
410 420 430 440 450
CVMEYHQATG TLSAHFRNMS LKRIKRSDRR GAESVTEEKF TILFESQFSV
460 470 480 490 500
GGNELVFQVK TLSLPVVVIV HGSQDNNATA TVLWDNAFAE PGRVPFAVPD
510 520 530 540 550
KVLWPQLCEA LNMKFKAEVQ SNRGLTKENL VFLAQKLFNS SSSHLEDYNG
560 570 580 590 600
MSVSWSQFNR ENLPGRNYTF WQWFDGVMEV LKKHLKPHWN DGAILGFVNK
610 620 630 640 650
QQAHDLLINK PDGTFLLRFS DSEIGGITIA WKFDSQERMF WNLMPFTTRD
660 670 680 690 700
FSIRSLADRL GDLSYLIYVF PDRPKDEVYS KYYTPVPCEP ATAKAVDGYV
710 720 730 740 750
KPQIKQVVPE FVSASADSAG GSATYMDQAP SPAVCPQPHY NMYPQNPDPV
760 770 780
LDNDGDFDLD DTIDVARRVE ELLGRPMDSQ WIPHAQS
Length:787
Mass (Da):89,991
Last modified:April 27, 2001 - v2
Checksum:i121C9CD9794E3A9A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti133 – 1331L → F in CAB51845 (PubMed:10835485).Curated
Sequence conflicti209 – 2091L → V in CAB51845 (PubMed:10835485).Curated
Sequence conflicti209 – 2091L → V in AAI12569 (Ref. 2) Curated
Sequence conflicti299 – 2991F → L in CAB51845 (PubMed:10835485).Curated
Sequence conflicti299 – 2991F → L in AAI12569 (Ref. 2) Curated
Sequence conflicti611 – 6111P → S in CAB51845 (PubMed:10835485).Curated
Sequence conflicti636 – 6361Missing in CAB52172 (PubMed:10835485).Curated
Sequence conflicti693 – 6931Missing in CAB52172 (PubMed:10835485).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ237933 mRNA. Translation: CAB51845.1.
AJ237934, AJ237935, AJ237936 Genomic DNA. Translation: CAB52172.1.
BC112568 mRNA. Translation: AAI12569.1.
AJ005638 Genomic DNA. Translation: CAA06641.1.
RefSeqiNP_777042.2. NM_174617.4.
XP_005220730.1. XM_005220673.3.
XP_005220731.1. XM_005220674.3.
UniGeneiBt.20143.

Genome annotation databases

GeneIDi282376.
KEGGibta:282376.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ237933 mRNA. Translation: CAB51845.1.
AJ237934, AJ237935, AJ237936 Genomic DNA. Translation: CAB52172.1.
BC112568 mRNA. Translation: AAI12569.1.
AJ005638 Genomic DNA. Translation: CAA06641.1.
RefSeqiNP_777042.2. NM_174617.4.
XP_005220730.1. XM_005220673.3.
XP_005220731.1. XM_005220674.3.
UniGeneiBt.20143.

3D structure databases

ProteinModelPortaliQ9TUM3.
SMRiQ9TUM3. Positions 138-686.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012497.

Proteomic databases

PaxDbiQ9TUM3.
PRIDEiQ9TUM3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi282376.
KEGGibta:282376.

Organism-specific databases

CTDi6777.

Phylogenomic databases

eggNOGiKOG3667. Eukaryota.
ENOG410XPN8. LUCA.
HOGENOMiHOG000230988.
HOVERGENiHBG107486.
InParanoidiQ9TUM3.
KOiK11224.
TreeFamiTF318648.

Gene expression databases

BgeeiENSBTAG00000010125.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view]
PANTHERiPTHR11801. PTHR11801. 2 hits.
PfamiPF00017. SH2. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
[Graphical view]
SUPFAMiSSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTA5B_BOVIN
AccessioniPrimary (citable) accession number: Q9TUM3
Secondary accession number(s): O77702, Q2KIP0, Q9TUM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: September 7, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.