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Q9TUL9 (TIMP3_HORSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Metalloproteinase inhibitor 3
Alternative name(s):
Tissue inhibitor of metalloproteinases 3
Short name=TIMP-3
Gene names
Name:TIMP3
OrganismEquus caballus (Horse) [Reference proteome]
Taxonomic identifier9796 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus

Protein attributes

Sequence length211 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli.

Subunit structure

Interacts with EFEMP1 By similarity.

Subcellular location

Secretedextracellular spaceextracellular matrix By similarity.

Sequence similarities

Belongs to the protease inhibitor I35 (TIMP) family. [View classification]

Contains 1 NTR domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 211188Metalloproteinase inhibitor 3
PRO_0000034340

Regions

Domain24 – 143120NTR
Region24 – 285Involved in metalloproteinase-binding By similarity
Region88 – 892Involved in metalloproteinase-binding By similarity
Region105 – 18884Mediates interaction with EFEMP1 By similarity

Sites

Metal binding241Zinc; via amino nitrogen and carbonyl oxygen; shared with metalloproteinase partner By similarity

Amino acid modifications

Glycosylation2071N-linked (GlcNAc...) Potential
Disulfide bond24 ↔ 91 By similarity
Disulfide bond26 ↔ 118 By similarity
Disulfide bond36 ↔ 143 By similarity
Disulfide bond145 ↔ 192 By similarity
Disulfide bond150 ↔ 155 By similarity
Disulfide bond163 ↔ 184 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9TUL9 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 1E9C5A6D2FC766DF

FASTA21124,147
        10         20         30         40         50         60 
MTPWLGLVVL LGSWSLGDWG AEACTCSPSH PQDAFCNSDI VIRAKVVGKK LVKEGPFGTL 

        70         80         90        100        110        120 
VYTIKQMKMY RGFTKMPHVQ YIHTEASESL CGLKLEVNKY QYLLTGRVYD GKMYTGLCNF 

       130        140        150        160        170        180 
VERWDQLTLS QRKGLNYRYH LGCNCKIKSC YYLPCYVTSK NECLWTDMLS NFGYPGYQSK 

       190        200        210 
HYACIRQKGG YCSWYRGWAP PDKSIINATD P 

« Hide

References

[1]"Molecular cloning and sequencing of the cDNA encoding equine tissue inhibitor of metalloproteinase-3 (TIMP-3)."
Kyaw-Tanner M.T., Mungall B.A., Pollitt C.C.
Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ243283 mRNA. Translation: CAB51854.1.
RefSeqNP_001075339.1. NM_001081870.1.
UniGeneEca.12656.

3D structure databases

ProteinModelPortalQ9TUL9.
SMRQ9TUL9. Positions 24-144.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9796.ENSECAP00000015840.

Protein family/group databases

MEROPSI35.003.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSECAT00000019359; ENSECAP00000015840; ENSECAG00000018314.
GeneID100033947.
KEGGecb:100033947.

Organism-specific databases

CTD7078.

Phylogenomic databases

eggNOGNOG250837.
GeneTreeENSGT00390000004555.
HOGENOMHOG000285981.
HOVERGENHBG068749.
InParanoidQ9TUL9.
KOK16866.
OMAKEGYCSW.
OrthoDBEOG79GT74.
TreeFamTF317409.

Family and domain databases

Gene3D3.90.370.10. 1 hit.
InterProIPR001134. Netrin_domain.
IPR001820. Prot_inh_TIMP.
IPR008993. TIMP-like_OB-fold.
IPR027465. TIMP_C_dom.
IPR015612. Tissue_inhib_metalloprotease_3.
[Graphical view]
PANTHERPTHR11844. PTHR11844. 1 hit.
PTHR11844:SF6. PTHR11844:SF6. 1 hit.
PfamPF00965. TIMP. 1 hit.
[Graphical view]
SMARTSM00206. NTR. 1 hit.
[Graphical view]
SUPFAMSSF50242. SSF50242. 1 hit.
PROSITEPS50189. NTR. 1 hit.
PS00288. TIMP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTIMP3_HORSE
AccessionPrimary (citable) accession number: Q9TUL9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families