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Q9TUL9

- TIMP3_HORSE

UniProt

Q9TUL9 - TIMP3_HORSE

Protein

Metalloproteinase inhibitor 3

Gene

TIMP3

Organism
Equus caballus (Horse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi24 – 241Zinc; via amino nitrogen and carbonyl oxygen; shared with metalloproteinase partnerBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. metalloendopeptidase inhibitor activity Source: UniProtKB-KW

    GO - Biological processi

    1. cellular response to organic substance Source: Ensembl
    2. negative regulation of membrane protein ectodomain proteolysis Source: Ensembl

    Keywords - Molecular functioni

    Metalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiI35.003.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metalloproteinase inhibitor 3
    Alternative name(s):
    Tissue inhibitor of metalloproteinases 3
    Short name:
    TIMP-3
    Gene namesi
    Name:TIMP3
    OrganismiEquus caballus (Horse)
    Taxonomic identifieri9796 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
    ProteomesiUP000002281: Chromosome 28

    Subcellular locationi

    GO - Cellular componenti

    1. basement membrane Source: Ensembl

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 211188Metalloproteinase inhibitor 3PRO_0000034340Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi24 ↔ 91PROSITE-ProRule annotation
    Disulfide bondi26 ↔ 118PROSITE-ProRule annotation
    Disulfide bondi36 ↔ 143PROSITE-ProRule annotation
    Disulfide bondi145 ↔ 192PROSITE-ProRule annotation
    Disulfide bondi150 ↔ 155PROSITE-ProRule annotation
    Disulfide bondi163 ↔ 184PROSITE-ProRule annotation
    Glycosylationi207 – 2071N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Subunit structurei

    Interacts with EFEMP1.By similarity

    Protein-protein interaction databases

    STRINGi9796.ENSECAP00000015840.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9TUL9.
    SMRiQ9TUL9. Positions 24-144.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 143120NTRPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni24 – 285Involved in metalloproteinase-bindingBy similarity
    Regioni88 – 892Involved in metalloproteinase-bindingBy similarity
    Regioni105 – 18884Mediates interaction with EFEMP1By similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 1 NTR domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG250837.
    GeneTreeiENSGT00390000004555.
    HOGENOMiHOG000285981.
    HOVERGENiHBG068749.
    InParanoidiQ9TUL9.
    KOiK16866.
    OMAiKEGYCSW.
    OrthoDBiEOG79GT74.
    TreeFamiTF317409.

    Family and domain databases

    Gene3Di3.90.370.10. 1 hit.
    InterProiIPR001134. Netrin_domain.
    IPR001820. Prot_inh_TIMP.
    IPR008993. TIMP-like_OB-fold.
    IPR027465. TIMP_C_dom.
    IPR015612. Tissue_inhib_metalloprotease_3.
    [Graphical view]
    PANTHERiPTHR11844. PTHR11844. 1 hit.
    PTHR11844:SF6. PTHR11844:SF6. 1 hit.
    PfamiPF00965. TIMP. 1 hit.
    [Graphical view]
    SMARTiSM00206. NTR. 1 hit.
    [Graphical view]
    SUPFAMiSSF50242. SSF50242. 1 hit.
    PROSITEiPS50189. NTR. 1 hit.
    PS00288. TIMP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9TUL9-1 [UniParc]FASTAAdd to Basket

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    MTPWLGLVVL LGSWSLGDWG AEACTCSPSH PQDAFCNSDI VIRAKVVGKK    50
    LVKEGPFGTL VYTIKQMKMY RGFTKMPHVQ YIHTEASESL CGLKLEVNKY 100
    QYLLTGRVYD GKMYTGLCNF VERWDQLTLS QRKGLNYRYH LGCNCKIKSC 150
    YYLPCYVTSK NECLWTDMLS NFGYPGYQSK HYACIRQKGG YCSWYRGWAP 200
    PDKSIINATD P 211
    Length:211
    Mass (Da):24,147
    Last modified:May 1, 2000 - v1
    Checksum:i1E9C5A6D2FC766DF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ243283 mRNA. Translation: CAB51854.1.
    RefSeqiNP_001075339.1. NM_001081870.1.
    UniGeneiEca.12656.

    Genome annotation databases

    EnsembliENSECAT00000019359; ENSECAP00000015840; ENSECAG00000018314.
    GeneIDi100033947.
    KEGGiecb:100033947.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ243283 mRNA. Translation: CAB51854.1 .
    RefSeqi NP_001075339.1. NM_001081870.1.
    UniGenei Eca.12656.

    3D structure databases

    ProteinModelPortali Q9TUL9.
    SMRi Q9TUL9. Positions 24-144.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9796.ENSECAP00000015840.

    Protein family/group databases

    MEROPSi I35.003.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSECAT00000019359 ; ENSECAP00000015840 ; ENSECAG00000018314 .
    GeneIDi 100033947.
    KEGGi ecb:100033947.

    Organism-specific databases

    CTDi 7078.

    Phylogenomic databases

    eggNOGi NOG250837.
    GeneTreei ENSGT00390000004555.
    HOGENOMi HOG000285981.
    HOVERGENi HBG068749.
    InParanoidi Q9TUL9.
    KOi K16866.
    OMAi KEGYCSW.
    OrthoDBi EOG79GT74.
    TreeFami TF317409.

    Family and domain databases

    Gene3Di 3.90.370.10. 1 hit.
    InterProi IPR001134. Netrin_domain.
    IPR001820. Prot_inh_TIMP.
    IPR008993. TIMP-like_OB-fold.
    IPR027465. TIMP_C_dom.
    IPR015612. Tissue_inhib_metalloprotease_3.
    [Graphical view ]
    PANTHERi PTHR11844. PTHR11844. 1 hit.
    PTHR11844:SF6. PTHR11844:SF6. 1 hit.
    Pfami PF00965. TIMP. 1 hit.
    [Graphical view ]
    SMARTi SM00206. NTR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50242. SSF50242. 1 hit.
    PROSITEi PS50189. NTR. 1 hit.
    PS00288. TIMP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and sequencing of the cDNA encoding equine tissue inhibitor of metalloproteinase-3 (TIMP-3)."
      Kyaw-Tanner M.T., Mungall B.A., Pollitt C.C.
      Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiTIMP3_HORSE
    AccessioniPrimary (citable) accession number: Q9TUL9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2002
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3