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Q9TUL9

- TIMP3_HORSE

UniProt

Q9TUL9 - TIMP3_HORSE

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Protein
Metalloproteinase inhibitor 3
Gene
TIMP3
Organism
Equus caballus (Horse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi24 – 241Zinc; via amino nitrogen and carbonyl oxygen; shared with metalloproteinase partner By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase inhibitor activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. cellular response to organic substance Source: Ensembl
  2. negative regulation of membrane protein ectodomain proteolysis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Metalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiI35.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Metalloproteinase inhibitor 3
Alternative name(s):
Tissue inhibitor of metalloproteinases 3
Short name:
TIMP-3
Gene namesi
Name:TIMP3
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
ProteomesiUP000002281: Chromosome 28

Subcellular locationi

GO - Cellular componenti

  1. basement membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 211188Metalloproteinase inhibitor 3
PRO_0000034340Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 91 By similarity
Disulfide bondi26 ↔ 118 By similarity
Disulfide bondi36 ↔ 143 By similarity
Disulfide bondi145 ↔ 192 By similarity
Disulfide bondi150 ↔ 155 By similarity
Disulfide bondi163 ↔ 184 By similarity
Glycosylationi207 – 2071N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Interacts with EFEMP1 By similarity.

Protein-protein interaction databases

STRINGi9796.ENSECAP00000015840.

Structurei

3D structure databases

ProteinModelPortaliQ9TUL9.
SMRiQ9TUL9. Positions 24-144.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 143120NTR
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni24 – 285Involved in metalloproteinase-binding By similarity
Regioni88 – 892Involved in metalloproteinase-binding By similarity
Regioni105 – 18884Mediates interaction with EFEMP1 By similarity
Add
BLAST

Sequence similaritiesi

Contains 1 NTR domain.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG250837.
GeneTreeiENSGT00390000004555.
HOGENOMiHOG000285981.
HOVERGENiHBG068749.
InParanoidiQ9TUL9.
KOiK16866.
OMAiKEGYCSW.
OrthoDBiEOG79GT74.
TreeFamiTF317409.

Family and domain databases

Gene3Di3.90.370.10. 1 hit.
InterProiIPR001134. Netrin_domain.
IPR001820. Prot_inh_TIMP.
IPR008993. TIMP-like_OB-fold.
IPR027465. TIMP_C_dom.
IPR015612. Tissue_inhib_metalloprotease_3.
[Graphical view]
PANTHERiPTHR11844. PTHR11844. 1 hit.
PTHR11844:SF6. PTHR11844:SF6. 1 hit.
PfamiPF00965. TIMP. 1 hit.
[Graphical view]
SMARTiSM00206. NTR. 1 hit.
[Graphical view]
SUPFAMiSSF50242. SSF50242. 1 hit.
PROSITEiPS50189. NTR. 1 hit.
PS00288. TIMP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9TUL9-1 [UniParc]FASTAAdd to Basket

« Hide

MTPWLGLVVL LGSWSLGDWG AEACTCSPSH PQDAFCNSDI VIRAKVVGKK    50
LVKEGPFGTL VYTIKQMKMY RGFTKMPHVQ YIHTEASESL CGLKLEVNKY 100
QYLLTGRVYD GKMYTGLCNF VERWDQLTLS QRKGLNYRYH LGCNCKIKSC 150
YYLPCYVTSK NECLWTDMLS NFGYPGYQSK HYACIRQKGG YCSWYRGWAP 200
PDKSIINATD P 211
Length:211
Mass (Da):24,147
Last modified:May 1, 2000 - v1
Checksum:i1E9C5A6D2FC766DF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ243283 mRNA. Translation: CAB51854.1.
RefSeqiNP_001075339.1. NM_001081870.1.
UniGeneiEca.12656.

Genome annotation databases

EnsembliENSECAT00000019359; ENSECAP00000015840; ENSECAG00000018314.
GeneIDi100033947.
KEGGiecb:100033947.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ243283 mRNA. Translation: CAB51854.1 .
RefSeqi NP_001075339.1. NM_001081870.1.
UniGenei Eca.12656.

3D structure databases

ProteinModelPortali Q9TUL9.
SMRi Q9TUL9. Positions 24-144.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9796.ENSECAP00000015840.

Protein family/group databases

MEROPSi I35.003.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSECAT00000019359 ; ENSECAP00000015840 ; ENSECAG00000018314 .
GeneIDi 100033947.
KEGGi ecb:100033947.

Organism-specific databases

CTDi 7078.

Phylogenomic databases

eggNOGi NOG250837.
GeneTreei ENSGT00390000004555.
HOGENOMi HOG000285981.
HOVERGENi HBG068749.
InParanoidi Q9TUL9.
KOi K16866.
OMAi KEGYCSW.
OrthoDBi EOG79GT74.
TreeFami TF317409.

Family and domain databases

Gene3Di 3.90.370.10. 1 hit.
InterProi IPR001134. Netrin_domain.
IPR001820. Prot_inh_TIMP.
IPR008993. TIMP-like_OB-fold.
IPR027465. TIMP_C_dom.
IPR015612. Tissue_inhib_metalloprotease_3.
[Graphical view ]
PANTHERi PTHR11844. PTHR11844. 1 hit.
PTHR11844:SF6. PTHR11844:SF6. 1 hit.
Pfami PF00965. TIMP. 1 hit.
[Graphical view ]
SMARTi SM00206. NTR. 1 hit.
[Graphical view ]
SUPFAMi SSF50242. SSF50242. 1 hit.
PROSITEi PS50189. NTR. 1 hit.
PS00288. TIMP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and sequencing of the cDNA encoding equine tissue inhibitor of metalloproteinase-3 (TIMP-3)."
    Kyaw-Tanner M.T., Mungall B.A., Pollitt C.C.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiTIMP3_HORSE
AccessioniPrimary (citable) accession number: Q9TUL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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