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Protein

Apelin

Gene

APLN

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Endogenous ligand for APJ. The oral intake in the colostrum and the milk could have a role in the modulation of the immune responses in neonates. May also have a role in the central control of body fluid homeostasis by influencing AVP release and drinking behavior (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-BTA-375276. Peptide ligand-binding receptors.
R-BTA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Apelin
Alternative name(s):
APJ endogenous ligand
Cleaved into the following 4 chains:
Gene namesi
Name:APLN
Synonyms:APEL
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome X

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Propeptidei23 – 41191 PublicationPRO_0000001754Add
BLAST
Peptidei42 – 7736Apelin-36PRO_0000001755Add
BLAST
Peptidei47 – 7731Apelin-31PRO_0000001756Add
BLAST
Peptidei50 – 7728Apelin-28PRO_0000001757Add
BLAST
Peptidei65 – 7713Apelin-13PRO_0000001758Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei65 – 651Pyrrolidone carboxylic acidCurated

Post-translational modificationi

At least 5 active peptides may be produced by proteolytic processing of the peptide precursor.

Keywords - PTMi

Cleavage on pair of basic residues, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiQ9TUI9.

Expressioni

Tissue specificityi

Large amount secreted by the mammary gland in the colostrum. Lower levels in milk. Decreases rapidly within several days after parturition in milk, but is still detectable even in commercial milk.

Gene expression databases

BgeeiENSBTAG00000019993.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000026630.

Family & Domainsi

Sequence similaritiesi

Belongs to the apelin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J5ST. Eukaryota.
ENOG410ZHPP. LUCA.
GeneTreeiENSGT00390000014020.
HOGENOMiHOG000033992.
HOVERGENiHBG018249.
InParanoidiQ9TUI9.
KOiK05225.
OMAiMRYLVKP.
OrthoDBiEOG091G19F6.
TreeFamiTF339660.

Family and domain databases

InterProiIPR026155. Apelin.
[Graphical view]
PANTHERiPTHR15953. PTHR15953. 1 hit.
PfamiPF15360. Apelin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9TUI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLRRCVQAL LLLWLCLSAV CGGPLLQTSD GKEMEEGTIR YLVQPRGPRS
60 70
GPGPWQGGRR KFRRQRPRLS HKGPMPF
Length:77
Mass (Da):8,743
Last modified:May 1, 2000 - v1
Checksum:i013D4C55E363E694
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023492 mRNA. Translation: BAA84974.1.
RefSeqiNP_776928.1. NM_174503.1.
XP_005227542.1. XM_005227485.3.
XP_010819696.1. XM_010821394.2.
UniGeneiBt.495.

Genome annotation databases

EnsembliENSBTAT00000026630; ENSBTAP00000026630; ENSBTAG00000019993.
GeneIDi282143.
KEGGibta:282143.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023492 mRNA. Translation: BAA84974.1.
RefSeqiNP_776928.1. NM_174503.1.
XP_005227542.1. XM_005227485.3.
XP_010819696.1. XM_010821394.2.
UniGeneiBt.495.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000026630.

Proteomic databases

PaxDbiQ9TUI9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000026630; ENSBTAP00000026630; ENSBTAG00000019993.
GeneIDi282143.
KEGGibta:282143.

Organism-specific databases

CTDi8862.

Phylogenomic databases

eggNOGiENOG410J5ST. Eukaryota.
ENOG410ZHPP. LUCA.
GeneTreeiENSGT00390000014020.
HOGENOMiHOG000033992.
HOVERGENiHBG018249.
InParanoidiQ9TUI9.
KOiK05225.
OMAiMRYLVKP.
OrthoDBiEOG091G19F6.
TreeFamiTF339660.

Enzyme and pathway databases

ReactomeiR-BTA-375276. Peptide ligand-binding receptors.
R-BTA-418594. G alpha (i) signalling events.

Gene expression databases

BgeeiENSBTAG00000019993.

Family and domain databases

InterProiIPR026155. Apelin.
[Graphical view]
PANTHERiPTHR15953. PTHR15953. 1 hit.
PfamiPF15360. Apelin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAPEL_BOVIN
AccessioniPrimary (citable) accession number: Q9TUI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.