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Protein

Apelin

Gene

APLN

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Endogenous ligand for the apelin receptor (APLNR) (PubMed:9792798). Drives internalization of APLNR (By similarity). Apelin-36 dissociates more hardly than (pyroglu)apelin-13 from APLNR (By similarity). Hormone involved in the regulation of cardiac precursor cell movements during gastrulation and heart morphogenesis (By similarity). Has an inhibitory effect on cytokine production in response to T-cell receptor/CD3 cross-linking; the oral intake of apelin in the colostrum and the milk might therefore modulate immune responses in neonates (By similarity). Plays a role in early coronary blood vessels formation (By similarity). Mediates myocardial contractility in an ERK1/2-dependent manner (By similarity). May also have a role in the central control of body fluid homeostasis by influencing vasopressin release and drinking behavior (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Hormone
Biological processAngiogenesis, Gastrulation

Enzyme and pathway databases

ReactomeiR-BTA-375276 Peptide ligand-binding receptors
R-BTA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Apelin
Alternative name(s):
APJ endogenous ligand
Cleaved into the following 4 chains:
Gene namesi
Name:APLN
Synonyms:APEL
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome X

Organism-specific databases

VGNCiVGNC:26017 APLN

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000000175423 – 411 PublicationAdd BLAST19
PeptideiPRO_000000175542 – 77Apelin-36Add BLAST36
PeptideiPRO_000000175647 – 77Apelin-31Add BLAST31
PeptideiPRO_000000175750 – 77Apelin-28Add BLAST28
PeptideiPRO_000000175865 – 77Apelin-13Add BLAST13

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei65Pyrrolidone carboxylic acid1 Publication1

Post-translational modificationi

At least 5 active peptides may be produced by proteolytic processing of the peptide precursor (PubMed:9792798).1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiQ9TUI9

Expressioni

Gene expression databases

BgeeiENSBTAG00000019993

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000026630

Structurei

3D structure databases

SMRiQ9TUI9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the apelin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J5ST Eukaryota
ENOG410ZHPP LUCA
GeneTreeiENSGT00390000014020
HOGENOMiHOG000033992
HOVERGENiHBG018249
InParanoidiQ9TUI9
KOiK05225
OMAiPMASTEH
OrthoDBiEOG091G19F6
TreeFamiTF339660

Family and domain databases

InterProiView protein in InterPro
IPR026155 Apelin
PANTHERiPTHR15953 PTHR15953, 1 hit
PfamiView protein in Pfam
PF15360 Apelin, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9TUI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLRRCVQAL LLLWLCLSAV CGGPLLQTSD GKEMEEGTIR YLVQPRGPRS
60 70
GPGPWQGGRR KFRRQRPRLS HKGPMPF
Length:77
Mass (Da):8,743
Last modified:May 1, 2000 - v1
Checksum:i013D4C55E363E694
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023492 mRNA Translation: BAA84974.1
RefSeqiNP_776928.1, NM_174503.1
XP_005227542.1, XM_005227485.3
XP_010819696.1, XM_010821394.2
UniGeneiBt.495

Genome annotation databases

EnsembliENSBTAT00000026630; ENSBTAP00000026630; ENSBTAG00000019993
GeneIDi282143
KEGGibta:282143

Similar proteinsi

Entry informationi

Entry nameiAPEL_BOVIN
AccessioniPrimary (citable) accession number: Q9TUI9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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