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Q9TUI5

- MT4_CANFA

UniProt

Q9TUI5 - MT4_CANFA

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Protein

Metallothionein-4

Gene

MT4

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi6 – 61Divalent metal cation; cluster BBy similarity
Metal bindingi8 – 81Divalent metal cation; cluster BBy similarity
Metal bindingi14 – 141Divalent metal cation; cluster BBy similarity
Metal bindingi16 – 161Divalent metal cation; cluster BBy similarity
Metal bindingi20 – 201Divalent metal cation; cluster BBy similarity
Metal bindingi22 – 221Divalent metal cation; cluster BBy similarity
Metal bindingi25 – 251Divalent metal cation; cluster BBy similarity
Metal bindingi27 – 271Divalent metal cation; cluster BBy similarity
Metal bindingi30 – 301Divalent metal cation; cluster BBy similarity
Metal bindingi34 – 341Divalent metal cation; cluster ABy similarity
Metal bindingi35 – 351Divalent metal cation; cluster ABy similarity
Metal bindingi37 – 371Divalent metal cation; cluster ABy similarity
Metal bindingi38 – 381Divalent metal cation; cluster ABy similarity
Metal bindingi42 – 421Divalent metal cation; cluster ABy similarity
Metal bindingi45 – 451Divalent metal cation; cluster ABy similarity
Metal bindingi49 – 491Divalent metal cation; cluster ABy similarity
Metal bindingi51 – 511Divalent metal cation; cluster ABy similarity
Metal bindingi58 – 581Divalent metal cation; cluster ABy similarity
Metal bindingi60 – 601Divalent metal cation; cluster ABy similarity
Metal bindingi61 – 611Divalent metal cation; cluster ABy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cellular metal ion homeostasis Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Copper, Metal-binding, Metal-thiolate cluster, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-4
Short name:
MT-4
Alternative name(s):
Metallothionein-IV
Short name:
MT-IV
Gene namesi
Name:MT4
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6262Metallothionein-4PRO_0000197254Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9TUI5.
SMRiQ9TUI5. Positions 32-62.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG69278.
GeneTreeiENSGT00730000111475.
HOGENOMiHOG000236262.
InParanoidiQ9TUI5.
KOiK14741.
OMAiCICKGSS.
OrthoDBiEOG7G7KSQ.
TreeFamiTF336054.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9TUI5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDPGECTCMS GGICICGDNC KCTTCNCKTC RKSCCPCCPP GCAKCAQGCI
60
CKGGSDKCSC CA
Length:62
Mass (Da):6,249
Last modified:May 1, 2000 - v1
Checksum:i2858DA6D17AA3DC9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB028041 mRNA. Translation: BAA87326.1.
RefSeqiNP_001003150.1. NM_001003150.1.
UniGeneiCfa.3632.

Genome annotation databases

EnsembliENSCAFT00000014504; ENSCAFP00000013416; ENSCAFG00000009118.
GeneIDi403769.
KEGGicfa:403769.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB028041 mRNA. Translation: BAA87326.1 .
RefSeqi NP_001003150.1. NM_001003150.1.
UniGenei Cfa.3632.

3D structure databases

ProteinModelPortali Q9TUI5.
SMRi Q9TUI5. Positions 32-62.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCAFT00000014504 ; ENSCAFP00000013416 ; ENSCAFG00000009118 .
GeneIDi 403769.
KEGGi cfa:403769.

Organism-specific databases

CTDi 84560.

Phylogenomic databases

eggNOGi NOG69278.
GeneTreei ENSGT00730000111475.
HOGENOMi HOG000236262.
InParanoidi Q9TUI5.
KOi K14741.
OMAi CICKGSS.
OrthoDBi EOG7G7KSQ.
TreeFami TF336054.

Miscellaneous databases

NextBioi 20817269.

Family and domain databases

Gene3Di 4.10.10.10. 1 hit.
InterProi IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view ]
PANTHERi PTHR23299. PTHR23299. 1 hit.
Pfami PF00131. Metallothio. 1 hit.
[Graphical view ]
PRINTSi PR00860. MTVERTEBRATE.
SUPFAMi SSF57868. SSF57868. 1 hit.
PROSITEi PS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and expression of metallothionein-IV."
    Kobayashi K., Morita T., Shimada A.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Beagle.
    Tissue: Tongue.

Entry informationi

Entry nameiMT4_CANFA
AccessioniPrimary (citable) accession number: Q9TUI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 2000
Last modified: October 1, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3