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Q9TUI5

- MT4_CANFA

UniProt

Q9TUI5 - MT4_CANFA

Protein

Metallothionein-4

Gene

MT4

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi6 – 61Divalent metal cation; cluster BBy similarity
    Metal bindingi8 – 81Divalent metal cation; cluster BBy similarity
    Metal bindingi14 – 141Divalent metal cation; cluster BBy similarity
    Metal bindingi16 – 161Divalent metal cation; cluster BBy similarity
    Metal bindingi20 – 201Divalent metal cation; cluster BBy similarity
    Metal bindingi22 – 221Divalent metal cation; cluster BBy similarity
    Metal bindingi25 – 251Divalent metal cation; cluster BBy similarity
    Metal bindingi27 – 271Divalent metal cation; cluster BBy similarity
    Metal bindingi30 – 301Divalent metal cation; cluster BBy similarity
    Metal bindingi34 – 341Divalent metal cation; cluster ABy similarity
    Metal bindingi35 – 351Divalent metal cation; cluster ABy similarity
    Metal bindingi37 – 371Divalent metal cation; cluster ABy similarity
    Metal bindingi38 – 381Divalent metal cation; cluster ABy similarity
    Metal bindingi42 – 421Divalent metal cation; cluster ABy similarity
    Metal bindingi45 – 451Divalent metal cation; cluster ABy similarity
    Metal bindingi49 – 491Divalent metal cation; cluster ABy similarity
    Metal bindingi51 – 511Divalent metal cation; cluster ABy similarity
    Metal bindingi58 – 581Divalent metal cation; cluster ABy similarity
    Metal bindingi60 – 601Divalent metal cation; cluster ABy similarity
    Metal bindingi61 – 611Divalent metal cation; cluster ABy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cellular metal ion homeostasis Source: Ensembl

    Keywords - Ligandi

    Copper, Metal-binding, Metal-thiolate cluster, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metallothionein-4
    Short name:
    MT-4
    Alternative name(s):
    Metallothionein-IV
    Short name:
    MT-IV
    Gene namesi
    Name:MT4
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Chromosome 2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6262Metallothionein-4PRO_0000197254Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ9TUI5.
    SMRiQ9TUI5. Positions 32-62.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG69278.
    GeneTreeiENSGT00730000111475.
    HOGENOMiHOG000236262.
    InParanoidiQ9TUI5.
    KOiK14741.
    OMAiCICKGSS.
    OrthoDBiEOG7G7KSQ.
    TreeFamiTF336054.

    Family and domain databases

    Gene3Di4.10.10.10. 1 hit.
    InterProiIPR017854. Metalthion_dom.
    IPR023587. Metalthion_dom_vert.
    IPR003019. Metalthion_sfam_euk.
    IPR000006. Metalthion_vert.
    IPR018064. Metalthion_vert_metal_BS.
    [Graphical view]
    PANTHERiPTHR23299. PTHR23299. 1 hit.
    PfamiPF00131. Metallothio. 1 hit.
    [Graphical view]
    PRINTSiPR00860. MTVERTEBRATE.
    SUPFAMiSSF57868. SSF57868. 1 hit.
    PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9TUI5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPGECTCMS GGICICGDNC KCTTCNCKTC RKSCCPCCPP GCAKCAQGCI   50
    CKGGSDKCSC CA 62
    Length:62
    Mass (Da):6,249
    Last modified:May 1, 2000 - v1
    Checksum:i2858DA6D17AA3DC9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB028041 mRNA. Translation: BAA87326.1.
    RefSeqiNP_001003150.1. NM_001003150.1.
    UniGeneiCfa.3632.

    Genome annotation databases

    EnsembliENSCAFT00000014504; ENSCAFP00000013416; ENSCAFG00000009118.
    GeneIDi403769.
    KEGGicfa:403769.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB028041 mRNA. Translation: BAA87326.1 .
    RefSeqi NP_001003150.1. NM_001003150.1.
    UniGenei Cfa.3632.

    3D structure databases

    ProteinModelPortali Q9TUI5.
    SMRi Q9TUI5. Positions 32-62.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCAFT00000014504 ; ENSCAFP00000013416 ; ENSCAFG00000009118 .
    GeneIDi 403769.
    KEGGi cfa:403769.

    Organism-specific databases

    CTDi 84560.

    Phylogenomic databases

    eggNOGi NOG69278.
    GeneTreei ENSGT00730000111475.
    HOGENOMi HOG000236262.
    InParanoidi Q9TUI5.
    KOi K14741.
    OMAi CICKGSS.
    OrthoDBi EOG7G7KSQ.
    TreeFami TF336054.

    Miscellaneous databases

    NextBioi 20817269.

    Family and domain databases

    Gene3Di 4.10.10.10. 1 hit.
    InterProi IPR017854. Metalthion_dom.
    IPR023587. Metalthion_dom_vert.
    IPR003019. Metalthion_sfam_euk.
    IPR000006. Metalthion_vert.
    IPR018064. Metalthion_vert_metal_BS.
    [Graphical view ]
    PANTHERi PTHR23299. PTHR23299. 1 hit.
    Pfami PF00131. Metallothio. 1 hit.
    [Graphical view ]
    PRINTSi PR00860. MTVERTEBRATE.
    SUPFAMi SSF57868. SSF57868. 1 hit.
    PROSITEi PS00203. METALLOTHIONEIN_VRT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and expression of metallothionein-IV."
      Kobayashi K., Morita T., Shimada A.
      Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Beagle.
      Tissue: Tongue.

    Entry informationi

    Entry nameiMT4_CANFA
    AccessioniPrimary (citable) accession number: Q9TUI5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Metallothioneins
      Classification of metallothioneins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3