Q9TUI5 (MT4_CANFA) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 77.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Metallothionein-4 Short name=MT-4 Alternative name(s): Metallothionein-IV Short name=MT-IV | ||
| Gene names |
| ||
| Organism | Canis familiaris (Dog) (Canis lupus familiaris) [Reference proteome] | ||
| Taxonomic identifier | 9615 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis ›  |
Protein attributes
| Sequence length | 62 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia By similarity. |
| Sequence similarities | Belongs to the metallothionein superfamily. Type 1 family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | Copper Metal-binding Metal-thiolate cluster Zinc |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | cellular metal ion homeostasis Inferred from electronic annotation. Source: Compara |
| Molecular_function | metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 62 | 62 | Metallothionein-4 | PRO_0000197254 | |||||
Sites | |||||||||
| Metal binding | 6 | 1 | Divalent metal cation; cluster B By similarity | ||||||
| Metal binding | 8 | 1 | Divalent metal cation; cluster B By similarity | ||||||
| Metal binding | 14 | 1 | Divalent metal cation; cluster B By similarity | ||||||
| Metal binding | 16 | 1 | Divalent metal cation; cluster B By similarity | ||||||
| Metal binding | 20 | 1 | Divalent metal cation; cluster B By similarity | ||||||
| Metal binding | 22 | 1 | Divalent metal cation; cluster B By similarity | ||||||
| Metal binding | 25 | 1 | Divalent metal cation; cluster B By similarity | ||||||
| Metal binding | 27 | 1 | Divalent metal cation; cluster B By similarity | ||||||
| Metal binding | 30 | 1 | Divalent metal cation; cluster B By similarity | ||||||
| Metal binding | 34 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 35 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 37 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 38 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 42 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 45 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 49 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 51 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 58 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 60 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 61 | 1 | Divalent metal cation; cluster A By similarity | ||||||
Sequences
References
| [1] | "Molecular cloning and expression of metallothionein-IV." Kobayashi K., Morita T., Shimada A. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Beagle. Tissue: Tongue. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AB028041 mRNA. Translation: BAA87326.1. |
| RefSeq | NP_001003150.1. NM_001003150.1. |
| UniGene | Cfa.3632. |
3D structure databases | |
| ProteinModelPortal | Q9TUI5. |
| SMR | Q9TUI5. Positions 32-62. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSCAFT00000014504; ENSCAFP00000013416; ENSCAFG00000009118. |
| GeneID | 403769. |
| KEGG | cfa:403769. |
Organism-specific databases | |
| CTD | 84560. |
Phylogenomic databases | |
| eggNOG | NOG69278. |
| GeneTree | ENSGT00390000010461. |
| HOGENOM | HOG000236262. |
| InParanoid | Q9TUI5. |
| KO | K14741. |
| OMA | CTNCNCK. |
| OrthoDB | EOG4M91T8. |
Family and domain databases | |
| Gene3D | 4.10.10.10. 1 hit. |
| InterPro | IPR017854. Metalthion_dom. IPR023587. Metalthion_dom_vert. IPR003019. Metalthion_sfam_euk. IPR000006. Metalthion_vert. IPR018064. Metalthion_vert_metal_BS. [Graphical view] |
| PANTHER | PTHR23299. PTHR23299. 1 hit. |
| Pfam | PF00131. Metallothio. 1 hit. [Graphical view] |
| PRINTS | PR00860. MTVERTEBRATE. |
| SUPFAM | SSF57868. Metallothionein_sfam. 1 hit. |
| PROSITE | PS00203. METALLOTHIONEIN_VRT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 20817269. |
Entry information
| Entry name | MT4_CANFA | ||||||||
| Accession | Primary (citable) accession number: Q9TUI5 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| Metallothioneins Classification of metallothioneins and list of entries |
| SIMILARITY comments Index of protein domains and families |