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Protein

T-cell surface glycoprotein CD3 zeta chain

Gene

CD247

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell surface glycoprotein CD3 zeta chain
Alternative name(s):
T-cell receptor T3 zeta chain
CD_antigen: CD247
Gene namesi
Name:CD247
Synonyms:CD3Z
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 30ExtracellularSequence analysis9
Transmembranei31 – 51HelicalSequence analysisAdd BLAST21
Topological domaini52 – 165CytoplasmicSequence analysisAdd BLAST114

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000001649722 – 165T-cell surface glycoprotein CD3 zeta chainAdd BLAST144

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32InterchainSequence analysis
Modified residuei72PhosphotyrosinePROSITE-ProRule annotationBy similarity1
Modified residuei83PhosphotyrosinePROSITE-ProRule annotationBy similarity1
Modified residuei110PhosphotyrosinePROSITE-ProRule annotationBy similarity1
Modified residuei122PhosphotyrosinePROSITE-ProRule annotationBy similarity1
Modified residuei143PhosphotyrosinePROSITE-ProRule annotationBy similarity1
Modified residuei154PhosphotyrosinePROSITE-ProRule annotationBy similarity1

Post-translational modificationi

Phosphorylated on Tyr residues after T-cell receptor triggering.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Interactioni

Subunit structurei

The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta.By similarity

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000020187.

Structurei

3D structure databases

ProteinModelPortaliQ9TUF8.
SMRiQ9TUF8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 89ITAM 1PROSITE-ProRule annotationAdd BLAST29
Domaini99 – 127ITAM 2PROSITE-ProRule annotationAdd BLAST29
Domaini132 – 160ITAM 3PROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the CD3Z/FCER1G family.Curated
Contains 3 ITAM domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0ID. Eukaryota.
ENOG411241T. LUCA.
HOGENOMiHOG000234398.
HOVERGENiHBG005280.
InParanoidiQ9TUF8.
KOiK06453.

Family and domain databases

InterProiIPR021663. CD3_zeta/IgE_Fc_rcpt_gamma.
IPR003110. Phos_immunorcpt_sig_ITAM.
IPR024128. T-cell_CD3_zeta.
[Graphical view]
PANTHERiPTHR10035. PTHR10035. 1 hit.
PfamiPF02189. ITAM. 3 hits.
PF11628. TCR_zetazeta. 1 hit.
[Graphical view]
SMARTiSM00077. ITAM. 3 hits.
[Graphical view]
PROSITEiPS51055. ITAM_1. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9TUF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKWKVLVIAA VLKAHFPVTE AHIFGLLDPK LCYLLDGILF LYGVIVTALY
60 70 80 90 100
LRAKFSRGED VPVSPQGHTQ LYNELNIGRR EEYDVLDKRR GRDPEMGGKQ
110 120 130 140 150
RRKNPQEGLY NALQKDKMAE AYSEIGMKGE NQRRRGKGHD GLYQGLSAAT
160
KDTYDALHMQ TLPPR
Length:165
Mass (Da):18,773
Last modified:May 1, 2000 - v1
Checksum:i3183136130BAA4F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035152 mRNA. Translation: BAA86994.1.
RefSeqiNP_001075471.1. NM_001082002.1.
UniGeneiOcu.2398.

Genome annotation databases

GeneIDi100008617.
KEGGiocu:100008617.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035152 mRNA. Translation: BAA86994.1.
RefSeqiNP_001075471.1. NM_001082002.1.
UniGeneiOcu.2398.

3D structure databases

ProteinModelPortaliQ9TUF8.
SMRiQ9TUF8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000020187.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100008617.
KEGGiocu:100008617.

Organism-specific databases

CTDi919.

Phylogenomic databases

eggNOGiENOG410J0ID. Eukaryota.
ENOG411241T. LUCA.
HOGENOMiHOG000234398.
HOVERGENiHBG005280.
InParanoidiQ9TUF8.
KOiK06453.

Family and domain databases

InterProiIPR021663. CD3_zeta/IgE_Fc_rcpt_gamma.
IPR003110. Phos_immunorcpt_sig_ITAM.
IPR024128. T-cell_CD3_zeta.
[Graphical view]
PANTHERiPTHR10035. PTHR10035. 1 hit.
PfamiPF02189. ITAM. 3 hits.
PF11628. TCR_zetazeta. 1 hit.
[Graphical view]
SMARTiSM00077. ITAM. 3 hits.
[Graphical view]
PROSITEiPS51055. ITAM_1. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD3Z_RABIT
AccessioniPrimary (citable) accession number: Q9TUF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.