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Protein

T-cell surface glycoprotein CD3 zeta chain

Gene

CD247

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell surface glycoprotein CD3 zeta chain
Alternative name(s):
T-cell receptor T3 zeta chain
CD_antigen: CD247
Gene namesi
Name:CD247
Synonyms:CD3Z
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 309ExtracellularSequence analysis
Transmembranei31 – 5121HelicalSequence analysisAdd
BLAST
Topological domaini52 – 165114CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121By similarityAdd
BLAST
Chaini22 – 165144T-cell surface glycoprotein CD3 zeta chainPRO_0000016497Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 – 32InterchainSequence analysis
Modified residuei72 – 721PhosphotyrosinePROSITE-ProRule annotationBy similarity
Modified residuei83 – 831PhosphotyrosinePROSITE-ProRule annotationBy similarity
Modified residuei110 – 1101PhosphotyrosinePROSITE-ProRule annotationBy similarity
Modified residuei122 – 1221PhosphotyrosinePROSITE-ProRule annotationBy similarity
Modified residuei143 – 1431PhosphotyrosinePROSITE-ProRule annotationBy similarity
Modified residuei154 – 1541PhosphotyrosinePROSITE-ProRule annotationBy similarity

Post-translational modificationi

Phosphorylated on Tyr residues after T-cell receptor triggering.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Interactioni

Subunit structurei

The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta.By similarity

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000020187.

Structurei

3D structure databases

ProteinModelPortaliQ9TUF8.
SMRiQ9TUF8. Positions 28-60.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini61 – 8929ITAM 1PROSITE-ProRule annotationAdd
BLAST
Domaini99 – 12729ITAM 2PROSITE-ProRule annotationAdd
BLAST
Domaini132 – 16029ITAM 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the CD3Z/FCER1G family.Curated
Contains 3 ITAM domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0ID. Eukaryota.
ENOG411241T. LUCA.
HOGENOMiHOG000234398.
HOVERGENiHBG005280.
InParanoidiQ9TUF8.
KOiK06453.

Family and domain databases

InterProiIPR021663. CR3_zeta/IgE_Fc_rcpt_gamma.
IPR003110. Phos_immunorcpt_sig_ITAM.
IPR024128. T-cell_CD3_zeta/eta.
[Graphical view]
PANTHERiPTHR10035. PTHR10035. 1 hit.
PfamiPF02189. ITAM. 3 hits.
PF11628. TCR_zetazeta. 1 hit.
[Graphical view]
SMARTiSM00077. ITAM. 3 hits.
[Graphical view]
PROSITEiPS51055. ITAM_1. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9TUF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKWKVLVIAA VLKAHFPVTE AHIFGLLDPK LCYLLDGILF LYGVIVTALY
60 70 80 90 100
LRAKFSRGED VPVSPQGHTQ LYNELNIGRR EEYDVLDKRR GRDPEMGGKQ
110 120 130 140 150
RRKNPQEGLY NALQKDKMAE AYSEIGMKGE NQRRRGKGHD GLYQGLSAAT
160
KDTYDALHMQ TLPPR
Length:165
Mass (Da):18,773
Last modified:May 1, 2000 - v1
Checksum:i3183136130BAA4F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035152 mRNA. Translation: BAA86994.1.
RefSeqiNP_001075471.1. NM_001082002.1.
UniGeneiOcu.2398.

Genome annotation databases

GeneIDi100008617.
KEGGiocu:100008617.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035152 mRNA. Translation: BAA86994.1.
RefSeqiNP_001075471.1. NM_001082002.1.
UniGeneiOcu.2398.

3D structure databases

ProteinModelPortaliQ9TUF8.
SMRiQ9TUF8. Positions 28-60.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000020187.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100008617.
KEGGiocu:100008617.

Organism-specific databases

CTDi919.

Phylogenomic databases

eggNOGiENOG410J0ID. Eukaryota.
ENOG411241T. LUCA.
HOGENOMiHOG000234398.
HOVERGENiHBG005280.
InParanoidiQ9TUF8.
KOiK06453.

Family and domain databases

InterProiIPR021663. CR3_zeta/IgE_Fc_rcpt_gamma.
IPR003110. Phos_immunorcpt_sig_ITAM.
IPR024128. T-cell_CD3_zeta/eta.
[Graphical view]
PANTHERiPTHR10035. PTHR10035. 1 hit.
PfamiPF02189. ITAM. 3 hits.
PF11628. TCR_zetazeta. 1 hit.
[Graphical view]
SMARTiSM00077. ITAM. 3 hits.
[Graphical view]
PROSITEiPS51055. ITAM_1. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Rabbit CD3 zeta."
    Isono T., Nishimura M.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: B/J X Chbb:HM.

Entry informationi

Entry nameiCD3Z_RABIT
AccessioniPrimary (citable) accession number: Q9TUF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 1, 2000
Last modified: December 9, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.