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Protein

Claudin

Gene

PCLN-1

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
ClaudinUniRule annotation
Gene namesi
Name:PCLN-1Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Subcellular locationi

  • Cell membrane SAAS annotation; Multi-pass membrane protein SAAS annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2620HelicalSequence analysisAdd
BLAST
Transmembranei80 – 10627HelicalSequence analysisAdd
BLAST
Transmembranei118 – 14023HelicalSequence analysisAdd
BLAST
Transmembranei167 – 19024HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membraneUniRule annotationSAAS annotation, Membrane, Tight junctionUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiQ9TUF7.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000008509.

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IEIE. Eukaryota.
ENOG410XP0E. LUCA.
HOVERGENiHBG050987.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003927. Claudin16.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PTHR12002:SF56. PTHR12002:SF56. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01447. CLAUDIN16.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9TUF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDLLQYVAC FFAFFSAGFL VVATWTDCWM VNADDSLEVS TKCRGLWWEC
60 70 80 90 100
VTNAFDGIRT CDEYDSILAE HSLKLVVTRA LMITADILAG FGFITLLLGL
110 120 130 140 150
DCVKFLPDEP YIKVRISFVA GTTLLIAGAP GIIGSVWYAV DVYVERSSLV
160 170 180 190 200
LHNIFLGIQY KFGWSCWLGM AGSLGCFLAG AILTCCLYLF KDVGPERSYP
210 220 230
YSTRKAYSTT AVSMPRSHAI PRTQTAKMYA VDTRV
Length:235
Mass (Da):26,112
Last modified:May 1, 2000 - v1
Checksum:iAE3B52A63C6EACD4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035210 mRNA. Translation: BAA87045.1.
UniGeneiBt.483.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035210 mRNA. Translation: BAA87045.1.
UniGeneiBt.483.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000008509.

Proteomic databases

PaxDbiQ9TUF7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IEIE. Eukaryota.
ENOG410XP0E. LUCA.
HOVERGENiHBG050987.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003927. Claudin16.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PTHR12002:SF56. PTHR12002:SF56. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01447. CLAUDIN16.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A deletion of the paracellin-1 gene is responsible for renal tubular dysplasia in cattle."
    Ohba Y., Kitagawa H., Kitoh K., Sasaki Y., Takami M., Shinkai Y., Kunieda T.
    Genomics 68:229-236(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Japanese blackImported.

Entry informationi

Entry nameiQ9TUF7_BOVIN
AccessioniPrimary (citable) accession number: Q9TUF7
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: July 6, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.