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Protein

Claudin

Gene

PCLN-1

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.UniRule annotation

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
ClaudinUniRule annotation
Gene namesi
Name:PCLN-1Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 26HelicalUniRule annotationAdd BLAST20
Transmembranei80 – 106HelicalUniRule annotationAdd BLAST27
Transmembranei118 – 140HelicalUniRule annotationAdd BLAST23
Transmembranei167 – 190HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Cell junction, Cell membraneUniRule annotationSAAS annotation, Membrane, Tight junctionUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiQ9TUF7.

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IEIE. Eukaryota.
ENOG410XP0E. LUCA.
HOVERGENiHBG050987.

Family and domain databases

InterProiView protein in InterPro
IPR006187. Claudin.
IPR003927. Claudin16.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
PANTHERiPTHR12002. PTHR12002. 1 hit.
PTHR12002:SF56. PTHR12002:SF56. 1 hit.
PfamiView protein in Pfam
PF00822. PMP22_Claudin. 1 hit.
PRINTSiPR01447. CLAUDIN16.
PROSITEiView protein in PROSITE
PS01346. CLAUDIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9TUF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDLLQYVAC FFAFFSAGFL VVATWTDCWM VNADDSLEVS TKCRGLWWEC
60 70 80 90 100
VTNAFDGIRT CDEYDSILAE HSLKLVVTRA LMITADILAG FGFITLLLGL
110 120 130 140 150
DCVKFLPDEP YIKVRISFVA GTTLLIAGAP GIIGSVWYAV DVYVERSSLV
160 170 180 190 200
LHNIFLGIQY KFGWSCWLGM AGSLGCFLAG AILTCCLYLF KDVGPERSYP
210 220 230
YSTRKAYSTT AVSMPRSHAI PRTQTAKMYA VDTRV
Length:235
Mass (Da):26,112
Last modified:May 1, 2000 - v1
Checksum:iAE3B52A63C6EACD4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035210 mRNA. Translation: BAA87045.1.
UniGeneiBt.483.

Similar proteinsi

Entry informationi

Entry nameiQ9TUF7_BOVIN
AccessioniPrimary (citable) accession number: Q9TUF7
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: October 25, 2017
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)