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Protein
Submitted name:

Long-chain 3-ketoacyl-CoA thiolase

Gene

LCTHIO

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei106Acyl-thioester intermediateUniRule annotation1
Active sitei396Proton acceptorUniRule annotation1
Active sitei426Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotationImported, Transferase

Enzyme and pathway databases

SABIO-RKiQ9TUF6.

Names & Taxonomyi

Protein namesi
Submitted name:
Long-chain 3-ketoacyl-CoA thiolaseImported (EC:2.3.1.16Imported)
Gene namesi
Name:LCTHIOImported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

PTM / Processingi

Proteomic databases

PaxDbiQ9TUF6.
PRIDEiQ9TUF6.

Expressioni

Gene expression databases

GenevisibleiQ9TUF6. SS.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000009135.

Structurei

3D structure databases

ProteinModelPortaliQ9TUF6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 292Thiolase_NInterPro annotationAdd BLAST271
Domaini299 – 438Thiolase_CInterPro annotationAdd BLAST140

Sequence similaritiesi

Belongs to the thiolase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1392. Eukaryota.
COG0183. LUCA.
HOGENOMiHOG000012240.
HOVERGENiHBG104782.
KOiK07509.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiView protein in InterPro
IPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR020615. Thiolase_acyl_enz_int_AS.
IPR020610. Thiolase_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
PfamiView protein in Pfam
PF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
PIRSFiPIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
TIGRFAMsiTIGR01930. AcCoA-C-Actrans. 1 hit.
PROSITEiView protein in PROSITE
PS00098. THIOLASE_1. 1 hit.
PS00737. THIOLASE_2. 1 hit.
PS00099. THIOLASE_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9TUF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPAVQTKS KKTLAKPNIR NIVVVDGVRI PFLQSGTSYK ELMPHDLARA
60 70 80 90 100
ALLGLLHRTS VPKDVVDYLV FGTVIQEVKT SNVAREAALG AGFSDKTPAH
110 120 130 140 150
TVTMACISSN QAMTTGVSLI ASGQFDVVVA GGVELMSDIP IRHSRKMRKM
160 170 180 190 200
MLDLNKAKTL GQRLSLISKF RLNFLSPELP AVAEFSTSET MGHSADRLAA
210 220 230 240 250
AFAVSRSEQD EYALRSHSLA KKAQDEGLLS DVVPFKVPGK DTVLKDNGIR
260 270 280 290 300
PSSLEQMAKL KPAFIKPYGT VTAANSSFLT DGASAVLIMA EEKALAMGYK
310 320 330 340 350
PKAYLRDFIY VSQDPKDQLL LGPTYATPKV LEKAGLTMND IDAFEFHEAF
360 370 380 390 400
SGQILANLKA MDSDWFAQNY MGRKAKVGSP PLEKFNNWGG SLSLGHPFGA
410 420 430 440
TGCRLVMTAA NRLRKEGGQY GLVAACAAGG QGHAMIVEAY PK
Length:442
Mass (Da):47,586
Last modified:May 1, 2000 - v1
Checksum:i6F5BC680BFD258B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF028007 mRNA. Translation: AAF04612.1.
RefSeqiNP_999131.1. NM_213966.1.
UniGeneiSsc.23043.

Genome annotation databases

GeneIDi397017.
KEGGissc:397017.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF028007 mRNA. Translation: AAF04612.1.
RefSeqiNP_999131.1. NM_213966.1.
UniGeneiSsc.23043.

3D structure databases

ProteinModelPortaliQ9TUF6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000009135.

Proteomic databases

PaxDbiQ9TUF6.
PRIDEiQ9TUF6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397017.
KEGGissc:397017.

Organism-specific databases

CTDi3032.

Phylogenomic databases

eggNOGiKOG1392. Eukaryota.
COG0183. LUCA.
HOGENOMiHOG000012240.
HOVERGENiHBG104782.
KOiK07509.

Enzyme and pathway databases

SABIO-RKiQ9TUF6.

Gene expression databases

GenevisibleiQ9TUF6. SS.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiView protein in InterPro
IPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR020615. Thiolase_acyl_enz_int_AS.
IPR020610. Thiolase_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
PfamiView protein in Pfam
PF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
PIRSFiPIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
TIGRFAMsiTIGR01930. AcCoA-C-Actrans. 1 hit.
PROSITEiView protein in PROSITE
PS00098. THIOLASE_1. 1 hit.
PS00737. THIOLASE_2. 1 hit.
PS00099. THIOLASE_3. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ9TUF6_PIG
AccessioniPrimary (citable) accession number: Q9TUF6
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: April 12, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.