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Protein

Galactoside 2-alpha-L-fucosyltransferase 1

Gene

FUT1

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Gal-beta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway.By similarity

Catalytic activityi

GDP-beta-L-fucose + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R.By similarity

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.69. 4497.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT11. Glycosyltransferase Family 11.

Names & Taxonomyi

Protein namesi
Recommended name:
Galactoside 2-alpha-L-fucosyltransferase 1 (EC:2.4.1.344By similarity)
Alternative name(s):
Alpha(1,2)FT 1
Fucosyltransferase 1
GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1
Gene namesi
Name:FUT1
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicSequence analysis8
Transmembranei9 – 25Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST17
Topological domaini26 – 366LumenalSequence analysisAdd BLAST341

GO - Cellular componenti

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001490991 – 366Galactoside 2-alpha-L-fucosyltransferase 1Add BLAST366

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi302N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi328N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9TUD6.

Interactioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000019304.

Structurei

3D structure databases

ProteinModelPortaliQ9TUD6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 11 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFKR. Eukaryota.
ENOG4111HG3. LUCA.
HOGENOMiHOG000261621.
HOVERGENiHBG004338.
InParanoidiQ9TUD6.
KOiK00718.

Family and domain databases

InterProiView protein in InterPro
IPR002516. Glyco_trans_11.
PANTHERiPTHR11927. PTHR11927. 1 hit.
PfamiView protein in Pfam
PF01531. Glyco_transf_11. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9TUD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWPPSHRQLC LAFLLVCVLS VISFFLHIHQ DSFPHGLGLS ILCPDRGLVT
60 70 80 90 100
PPVAIFCLPG TAMGPNASSS CPQHPASLSG TWTVYPNGRF GNQMGQYATL
110 120 130 140 150
LALAQLNGRR AFILPAMHAA LAPVFRITLP VLAPEADSRT PWRELQLHDW
160 170 180 190 200
MSEEYADLRD PFLKLSGFPC SWTFFHHLRE QIRREFTLHD HLREEAQSVL
210 220 230 240 250
GQLRLGRTGD RPRTFVGVHV RRGDYLQVMP QRWKGVVGDS AYLRQAMDWF
260 270 280 290 300
RARHEAPVFV VTSNGMEWCK ENIDTSQGDV TFAGDGQEAT PWKDFALLTQ
310 320 330 340 350
CNHTIMTIGT FGFWAAYLAG GDTVYLANFT LPDSEFLKIF KPEAAFLPEW
360
VGINADLSSL WTLAKP
Length:366
Mass (Da):41,126
Last modified:May 1, 2000 - v1
Checksum:i7B021F32A16EC676
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080603 Genomic DNA. Translation: AAF14065.1.
RefSeqiNP_001009121.1. NM_001009121.1.
UniGeneiPtr.6206.

Genome annotation databases

GeneIDi468947.
KEGGiptr:468947.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiFUT1_PANTR
AccessioniPrimary (citable) accession number: Q9TUD6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: May 1, 2000
Last modified: May 10, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families