Reviewed, UniProtKB/Swiss-Prot Q9TUD6 (FUT1_PANTR)

Names and origin

Protein names

Recommended name:
    Galactoside 2-alpha-L-fucosyltransferase 1
    EC=2.4.1.69
Alternative name(s):
    GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1
    Alpha(1,2)FT 1
    Fucosyltransferase 1

Gene names

Name:

FUT1

Organism

Pan troglodytes (Chimpanzee)

Taxonomic identifier

9598 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan

Protein attributes

Sequence length	366 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.
Pathway	Protein modification; protein glycosylation.
Subcellular location	Golgi apparatus › Golgi stack membrane; Single-pass type II membrane protein By similarity. Note: Membrane-bound form in trans cisternae of Golgi By similarity.
Sequence similarities	Belongs to the glycosyltransferase 11 family.

Ontologies

Keywords
Cellular component	Golgi apparatus Membrane
Domain	Signal-anchor Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	galactoside 2-alpha-L-fucosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 366	366	Galactoside 2-alpha-L-fucosyltransferase 1		PRO_0000149099
Regions
	Topological domain	1 – 8	8	Cytoplasmic Potential
	Transmembrane	9 – 25	17	Signal-anchor for type II membrane protein Potential
	Topological domain	26 – 366	341	Lumenal Potential
Amino acid modifications
	Glycosylation	66	1	N-linked (GlcNAc...) Potential
	Glycosylation	302	1	N-linked (GlcNAc...) Potential
	Glycosylation	328	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9TUD6-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 7B021F32A16EC676	FASTA	366	41,126
	10 20 30 40 50 60 MWPPSHRQLC LAFLLVCVLS VISFFLHIHQ DSFPHGLGLS ILCPDRGLVT PPVAIFCLPG 70 80 90 100 110 120 TAMGPNASSS CPQHPASLSG TWTVYPNGRF GNQMGQYATL LALAQLNGRR AFILPAMHAA 130 140 150 160 170 180 LAPVFRITLP VLAPEADSRT PWRELQLHDW MSEEYADLRD PFLKLSGFPC SWTFFHHLRE 190 200 210 220 230 240 QIRREFTLHD HLREEAQSVL GQLRLGRTGD RPRTFVGVHV RRGDYLQVMP QRWKGVVGDS 250 260 270 280 290 300 AYLRQAMDWF RARHEAPVFV VTSNGMEWCK ENIDTSQGDV TFAGDGQEAT PWKDFALLTQ 310 320 330 340 350 360 CNHTIMTIGT FGFWAAYLAG GDTVYLANFT LPDSEFLKIF KPEAAFLPEW VGINADLSSL WTLAKP

References

[1]

"Evolution of alpha 2-fucosyltransferase genes in primates: relation between an intronic Alu-Y element and red cell expression of ABH antigens." Apoil P.-A., Roubinet F., Despiau S., Mollicone R., Oriol R., Blancher A. Mol. Biol. Evol. 17:337-351(2000) [PubMed: 10723735] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Isolate CH16.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF080603 Genomic DNA. Translation: AAF14065.1.
RefSeq	NP_001009121.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9TUD6.
Protein family/group databases
CAZy	GT11. Glycosyltransferase Family 11.
Genome annotation databases
Ensembl	ENSPTRT00000020911; ENSPTRP00000019304; ENSPTRG00000011256; Pan troglodytes. [Genome view]
GeneID	468947.
KEGG	ptr:468947.
Organism-specific databases
CTD	468947.
Phylogenomic databases
HOVERGEN	Q9TUD6.
Enzyme and pathway databases
BRENDA	2.4.1.69. 264977.
Family and domain databases
InterPro	IPR002516. Glyco_trans_11. [Graphical view]
PANTHER	PTHR11927. Glyco_trans_11. 1 hit.
Pfam	PF01531. Glyco_transf_11. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FUT1_PANTR

Accession

Primary (citable) accession number: Q9TUD6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2003
Last sequence update:	May 1, 2000
Last modified:	October 13, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)