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Protein

Galactoside 2-alpha-L-fucosyltransferase 1

Gene

FUT1

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.69. 4497.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT11. Glycosyltransferase Family 11.

Names & Taxonomyi

Protein namesi
Recommended name:
Galactoside 2-alpha-L-fucosyltransferase 1 (EC:2.4.1.69)
Alternative name(s):
Alpha(1,2)FT 1
Fucosyltransferase 1
GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1
Gene namesi
Name:FUT1
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 88CytoplasmicSequence analysis
Transmembranei9 – 2517Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini26 – 366341LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 366366Galactoside 2-alpha-L-fucosyltransferase 1PRO_0000149099Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi66 – 661N-linked (GlcNAc...)Sequence analysis
Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence analysis
Glycosylationi328 – 3281N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9TUD6.

Interactioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000019304.

Structurei

3D structure databases

ProteinModelPortaliQ9TUD6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 11 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFKR. Eukaryota.
ENOG4111HG3. LUCA.
HOGENOMiHOG000261621.
HOVERGENiHBG004338.
InParanoidiQ9TUD6.
KOiK00718.

Family and domain databases

InterProiIPR002516. Glyco_trans_11.
[Graphical view]
PANTHERiPTHR11927. PTHR11927. 1 hit.
PfamiPF01531. Glyco_transf_11. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9TUD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWPPSHRQLC LAFLLVCVLS VISFFLHIHQ DSFPHGLGLS ILCPDRGLVT
60 70 80 90 100
PPVAIFCLPG TAMGPNASSS CPQHPASLSG TWTVYPNGRF GNQMGQYATL
110 120 130 140 150
LALAQLNGRR AFILPAMHAA LAPVFRITLP VLAPEADSRT PWRELQLHDW
160 170 180 190 200
MSEEYADLRD PFLKLSGFPC SWTFFHHLRE QIRREFTLHD HLREEAQSVL
210 220 230 240 250
GQLRLGRTGD RPRTFVGVHV RRGDYLQVMP QRWKGVVGDS AYLRQAMDWF
260 270 280 290 300
RARHEAPVFV VTSNGMEWCK ENIDTSQGDV TFAGDGQEAT PWKDFALLTQ
310 320 330 340 350
CNHTIMTIGT FGFWAAYLAG GDTVYLANFT LPDSEFLKIF KPEAAFLPEW
360
VGINADLSSL WTLAKP
Length:366
Mass (Da):41,126
Last modified:May 1, 2000 - v1
Checksum:i7B021F32A16EC676
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080603 Genomic DNA. Translation: AAF14065.1.
RefSeqiNP_001009121.1. NM_001009121.1.
UniGeneiPtr.6206.

Genome annotation databases

GeneIDi468947.
KEGGiptr:468947.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080603 Genomic DNA. Translation: AAF14065.1.
RefSeqiNP_001009121.1. NM_001009121.1.
UniGeneiPtr.6206.

3D structure databases

ProteinModelPortaliQ9TUD6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000019304.

Protein family/group databases

CAZyiGT11. Glycosyltransferase Family 11.

Proteomic databases

PaxDbiQ9TUD6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi468947.
KEGGiptr:468947.

Organism-specific databases

CTDi2523.

Phylogenomic databases

eggNOGiENOG410IFKR. Eukaryota.
ENOG4111HG3. LUCA.
HOGENOMiHOG000261621.
HOVERGENiHBG004338.
InParanoidiQ9TUD6.
KOiK00718.

Enzyme and pathway databases

UniPathwayiUPA00378.
BRENDAi2.4.1.69. 4497.

Family and domain databases

InterProiIPR002516. Glyco_trans_11.
[Graphical view]
PANTHERiPTHR11927. PTHR11927. 1 hit.
PfamiPF01531. Glyco_transf_11. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evolution of alpha 2-fucosyltransferase genes in primates: relation between an intronic Alu-Y element and red cell expression of ABH antigens."
    Apoil P.-A., Roubinet F., Despiau S., Mollicone R., Oriol R., Blancher A.
    Mol. Biol. Evol. 17:337-351(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Isolate CH16.

Entry informationi

Entry nameiFUT1_PANTR
AccessioniPrimary (citable) accession number: Q9TUD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.