Q9TUD4 (FUT1_GORGO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Galactoside 2-alpha-L-fucosyltransferase 1
EC=2.4.1.69

Alternative name(s):
Alpha(1,2)FT 1
Fucosyltransferase 1
GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1

Gene names

Name:

FUT1

Organism

Gorilla gorilla gorilla (Lowland gorilla) [Complete proteome]

Taxonomic identifier

9595 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Gorilla

Protein attributes

Sequence length	366 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.
Pathway	Protein modification; protein glycosylation.
Subcellular location	Golgi apparatus › Golgi stack membrane; Single-pass type II membrane protein By similarity. Note: Membrane-bound form in trans cisternae of Golgi By similarity.
Sequence similarities	Belongs to the glycosyltransferase 11 family.

Ontologies

Keywords
Cellular component	Golgi apparatus Membrane
Domain	Signal-anchor Transmembrane Transmembrane helix
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	Golgi cisterna membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	galactoside 2-alpha-L-fucosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 366	366	Galactoside 2-alpha-L-fucosyltransferase 1		PRO_0000149094
Regions
	Topological domain	1 – 8	8	Cytoplasmic Potential
	Transmembrane	9 – 25	17	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	26 – 366	341	Lumenal Potential
Amino acid modifications
	Glycosylation	66	1	N-linked (GlcNAc...) Potential
	Glycosylation	302	1	N-linked (GlcNAc...) Potential
	Glycosylation	328	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9TUD4 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 6605B34B6E98DAE1	FASTA	366	41,241
	10 20 30 40 50 60 MWPPSHRQLC RAFLLVCVFS VISFFLHIHQ DSFPHGLGLS ILCPDRRLVT PPVAIFCLPG 70 80 90 100 110 120 TAMGPNASSS CPQHPASLSG TWTVYPNGRF GNQMGQYATL LALAQLNGRR AFILPAMHAA 130 140 150 160 170 180 LAPVFRITLP VLAPEVDSRT PWRELQLHDW MSEEYADLGD PFLKLSGFPC SWTFFHHLRE 190 200 210 220 230 240 QIRREFTLHD HLREEAQSVL GQLRLGRTGD RPRTFVGVHV RRGDYLQVMP QRWKGVVGDS 250 260 270 280 290 300 AYLRQAMDWF RARHEAPVFV VTSNGMEWCK ENIDTSQGDV TFAGDGQEAT PWKDFALLTQ 310 320 330 340 350 360 CNHTIMTIGT FGFWAAYLAG GDTVYLANFT LPDSEFLKIF KPEAAFLPEW VGINADLSPL WTLAKP

References

[1]

"Evolution of alpha 2-fucosyltransferase genes in primates: relation between an intronic Alu-Y element and red cell expression of ABH antigens." Apoil P.-A., Roubinet F., Despiau S., Mollicone R., Oriol R., Blancher A. Mol. Biol. Evol. 17:337-351(2000) [PubMed: 10723735] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Isolate Alexis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF080605 Genomic DNA. Translation: AAF14067.1.
3D structure databases
ProteinModelPortal	Q9TUD4.
ModBase	Search...
Protein family/group databases
CAZy	GT11. Glycosyltransferase Family 11.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG004338.
Family and domain databases
InterPro	IPR002516. Glyco_trans_11. [Graphical view]
PANTHER	PTHR11927. Glyco_trans_11. 1 hit.
Pfam	PF01531. Glyco_transf_11. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FUT1_GORGO

Accession

Primary (citable) accession number: Q9TUD4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2005
Last sequence update:	May 1, 2000
Last modified:	November 16, 2011
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program