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Q9TUC5 (SFTPA_MACMU) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pulmonary surfactant-associated protein A

Short name=PSAP
Short name=PSP-A
Short name=SP-A
Gene names
Name:SFTPA1
Synonyms:SFTPA
OrganismMacaca mulatta (Rhesus macaque) [Reference proteome]
Taxonomic identifier9544 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length248 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration By similarity.

Subunit structure

Oligomeric complex of 6 set of homotrimers By similarity.

Subcellular location

Secretedextracellular spaceextracellular matrix By similarity. Secretedextracellular spacesurface film By similarity.

Sequence similarities

Belongs to the SFTPA family.

Contains 1 C-type lectin domain.

Contains 1 collagen-like domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 248228Pulmonary surfactant-associated protein A
PRO_0000046689

Regions

Domain31 – 10070Collagen-like
Domain134 – 247114C-type lectin

Sites

Metal binding2151Calcium By similarity
Metal binding2171Calcium; via carbonyl oxygen By similarity
Metal binding2341Calcium By similarity
Metal binding2351Calcium By similarity

Amino acid modifications

Glycosylation2071N-linked (GlcNAc...) Potential
Disulfide bond26Interchain By similarity
Disulfide bond155 ↔ 246 By similarity
Disulfide bond224 ↔ 238 By similarity

Experimental info

Sequence conflict2131P → R in AAF02223. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9TUC5 [UniParc].

Last modified November 28, 2012. Version 2.
Checksum: DCEDB793CCDDC11F

FASTA24826,086
        10         20         30         40         50         60 
MWLCPLALTL TLMAASGAAC EVKDICVGSP GIPGTPGSHG LPGRDGRDGV KGDPGPPGPM 

        70         80         90        100        110        120 
GPPGDMPCFP GNDGLPGAPG IPGECGEKGE PGERGPPGLP AHLDEELQAT LHDFRHQILQ 

       130        140        150        160        170        180 
TRGALSLQES ILAIGGKVFS TNGQSATFDA IQEACARAGG HIAVPRSPEE NEAIASFVKK 

       190        200        210        220        230        240 
YNTYAYVGLT EGPSPGDFRY SDGTPVNYTN WYPGEPAGRG TEQCVEMYTD GRWNDRNCLY 


NRLTICEF 

« Hide

References

« Hide 'large scale' references
[1]"Evolutionary and biomedical insights from the rhesus macaque genome."
Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C., Makova K.D., Miller W., Milosavljevic A. expand/collapse author list , Palermo R.E., Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., Zwieg A.S.
Science 316:222-234(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Prenatal nicotine increases pulmonary alpha7 nicotinic receptor expression and alters fetal lung development in monkeys."
Sekhon H.S., Jia Y., Raab R., Kuryatov A., Pankow J.F., Whitsett J.A., Lindstrom J., Spindel E.R.
J. Clin. Invest. 103:637-647(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 49-213.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF087691 mRNA. Translation: AAF02223.1.
RefSeqNP_001182305.1. NM_001195376.1.
UniGeneMmu.3533.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9544.ENSMMUP00000012817.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMMUT00000013677; ENSMMUP00000012817; ENSMMUG00000009795.
GeneID574108.
KEGGmcc:574108.

Organism-specific databases

CTD653509.

Phylogenomic databases

eggNOGNOG315755.
GeneTreeENSGT00700000104102.
HOGENOMHOG000085660.
HOVERGENHBG108270.
InParanoidQ9TUC5.
KOK10067.
OMAEMYTDGK.
OrthoDBEOG7HXCVB.
TreeFamTF330481.

Family and domain databases

Gene3D3.10.100.10. 1 hit.
InterProIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR008160. Collagen.
[Graphical view]
PfamPF01391. Collagen. 1 hit.
PF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMSSF56436. SSF56436. 1 hit.
PROSITEPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio19975046.

Entry information

Entry nameSFTPA_MACMU
AccessionPrimary (citable) accession number: Q9TUC5
Secondary accession number(s): F6Y0S1
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: November 28, 2012
Last modified: July 9, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families