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Q9TUC5

- SFTPA_MACMU

UniProt

Q9TUC5 - SFTPA_MACMU

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Protein
Pulmonary surfactant-associated protein A
Gene
SFTPA1, SFTPA
Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi215 – 2151Calcium By similarity
Metal bindingi217 – 2171Calcium; via carbonyl oxygen By similarity
Metal bindingi234 – 2341Calcium By similarity
Metal bindingi235 – 2351Calcium By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. respiratory gaseous exchange Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Gaseous exchange

Keywords - Ligandi

Calcium, Lectin, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pulmonary surfactant-associated protein A
Short name:
PSAP
Short name:
PSP-A
Short name:
SP-A
Gene namesi
Name:SFTPA1
Synonyms:SFTPA
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
ProteomesiUP000006718: Chromosome 9

Subcellular locationi

GO - Cellular componenti

  1. collagen trimer Source: UniProtKB-KW
  2. extracellular space Source: UniProtKB-SubCell
  3. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted, Surface film

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 248228Pulmonary surfactant-associated protein A
PRO_0000046689Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 – 26Interchain By similarity
Disulfide bondi155 ↔ 246 By similarity
Glycosylationi207 – 2071N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi224 ↔ 238 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Oligomeric complex of 6 set of homotrimers By similarity.

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000012817.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 10070Collagen-like
Add
BLAST
Domaini134 – 247114C-type lectin
Add
BLAST

Sequence similaritiesi

Belongs to the SFTPA family.

Keywords - Domaini

Collagen, Signal

Phylogenomic databases

eggNOGiNOG315755.
GeneTreeiENSGT00700000104102.
HOGENOMiHOG000085660.
HOVERGENiHBG108270.
InParanoidiQ9TUC5.
KOiK10067.
OMAiEMYTDGK.
OrthoDBiEOG7HXCVB.
TreeFamiTF330481.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR008160. Collagen.
[Graphical view]
PfamiPF01391. Collagen. 1 hit.
PF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9TUC5-1 [UniParc]FASTAAdd to Basket

« Hide

MWLCPLALTL TLMAASGAAC EVKDICVGSP GIPGTPGSHG LPGRDGRDGV    50
KGDPGPPGPM GPPGDMPCFP GNDGLPGAPG IPGECGEKGE PGERGPPGLP 100
AHLDEELQAT LHDFRHQILQ TRGALSLQES ILAIGGKVFS TNGQSATFDA 150
IQEACARAGG HIAVPRSPEE NEAIASFVKK YNTYAYVGLT EGPSPGDFRY 200
SDGTPVNYTN WYPGEPAGRG TEQCVEMYTD GRWNDRNCLY NRLTICEF 248
Length:248
Mass (Da):26,086
Last modified:November 28, 2012 - v2
Checksum:iDCEDB793CCDDC11F
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti213 – 2131P → R in AAF02223. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF087691 mRNA. Translation: AAF02223.1.
RefSeqiNP_001182305.1. NM_001195376.1.
UniGeneiMmu.3533.

Genome annotation databases

EnsembliENSMMUT00000013677; ENSMMUP00000012817; ENSMMUG00000009795.
GeneIDi574108.
KEGGimcc:574108.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF087691 mRNA. Translation: AAF02223.1 .
RefSeqi NP_001182305.1. NM_001195376.1.
UniGenei Mmu.3533.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9544.ENSMMUP00000012817.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMMUT00000013677 ; ENSMMUP00000012817 ; ENSMMUG00000009795 .
GeneIDi 574108.
KEGGi mcc:574108.

Organism-specific databases

CTDi 653509.

Phylogenomic databases

eggNOGi NOG315755.
GeneTreei ENSGT00700000104102.
HOGENOMi HOG000085660.
HOVERGENi HBG108270.
InParanoidi Q9TUC5.
KOi K10067.
OMAi EMYTDGK.
OrthoDBi EOG7HXCVB.
TreeFami TF330481.

Miscellaneous databases

NextBioi 19975046.

Family and domain databases

Gene3Di 3.10.100.10. 1 hit.
InterProi IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR008160. Collagen.
[Graphical view ]
Pfami PF01391. Collagen. 1 hit.
PF00059. Lectin_C. 1 hit.
[Graphical view ]
SMARTi SM00034. CLECT. 1 hit.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 1 hit.
PROSITEi PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Evolutionary and biomedical insights from the rhesus macaque genome."
    Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C., Makova K.D., Miller W., Milosavljevic A.
    , Palermo R.E., Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., Zwieg A.S.
    Science 316:222-234(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Prenatal nicotine increases pulmonary alpha7 nicotinic receptor expression and alters fetal lung development in monkeys."
    Sekhon H.S., Jia Y., Raab R., Kuryatov A., Pankow J.F., Whitsett J.A., Lindstrom J., Spindel E.R.
    J. Clin. Invest. 103:637-647(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 49-213.

Entry informationi

Entry nameiSFTPA_MACMU
AccessioniPrimary (citable) accession number: Q9TUC5
Secondary accession number(s): F6Y0S1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: November 28, 2012
Last modified: July 9, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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