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Protein

Pulmonary surfactant-associated protein A

Gene

SFTPA1

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi215CalciumBy similarity1
Metal bindingi217Calcium; via carbonyl oxygenBy similarity1
Metal bindingi234CalciumBy similarity1
Metal bindingi235CalciumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processGaseous exchange
LigandCalcium, Lectin, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pulmonary surfactant-associated protein A
Short name:
PSAP
Short name:
PSP-A
Short name:
SP-A
Gene namesi
Name:SFTPA1
Synonyms:SFTPA
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted, Surface film

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000004668921 – 248Pulmonary surfactant-associated protein AAdd BLAST228

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26InterchainPROSITE-ProRule annotation
Disulfide bondi155 ↔ 246PROSITE-ProRule annotation
Glycosylationi207N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi224 ↔ 238PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Gene expression databases

BgeeiENSMMUG00000009795

Interactioni

Subunit structurei

Oligomeric complex of 6 set of homotrimers.By similarity

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000012817

Structurei

3D structure databases

SMRiQ9TUC5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 100Collagen-likeAdd BLAST70
Domaini134 – 247C-type lectinPROSITE-ProRule annotationAdd BLAST114

Sequence similaritiesi

Belongs to the SFTPA family.Curated

Keywords - Domaini

Collagen, Signal

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
HOGENOMiHOG000085660
HOVERGENiHBG108270
InParanoidiQ9TUC5
KOiK10067
OMAiTWNDKNC
OrthoDBiEOG091G0PU5
TreeFamiTF330481

Family and domain databases

CDDicd03591 CLECT_collectin_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR033990 Collectin_CTLD
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9TUC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLCPLALTL TLMAASGAAC EVKDICVGSP GIPGTPGSHG LPGRDGRDGV
60 70 80 90 100
KGDPGPPGPM GPPGDMPCFP GNDGLPGAPG IPGECGEKGE PGERGPPGLP
110 120 130 140 150
AHLDEELQAT LHDFRHQILQ TRGALSLQES ILAIGGKVFS TNGQSATFDA
160 170 180 190 200
IQEACARAGG HIAVPRSPEE NEAIASFVKK YNTYAYVGLT EGPSPGDFRY
210 220 230 240
SDGTPVNYTN WYPGEPAGRG TEQCVEMYTD GRWNDRNCLY NRLTICEF
Length:248
Mass (Da):26,086
Last modified:November 28, 2012 - v2
Checksum:iDCEDB793CCDDC11F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti213P → R in AAF02223 (PubMed:10074480).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087691 mRNA Translation: AAF02223.1
RefSeqiNP_001182305.1, NM_001195376.1
XP_015002613.1, XM_015147127.1
XP_015002614.1, XM_015147128.1
UniGeneiMmu.3533

Genome annotation databases

GeneIDi574108
KEGGimcc:574108

Similar proteinsi

Entry informationi

Entry nameiSFTPA_MACMU
AccessioniPrimary (citable) accession number: Q9TUC5
Secondary accession number(s): F6Y0S1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: November 28, 2012
Last modified: March 28, 2018
This is version 97 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health