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Protein

Pulmonary surfactant-associated protein A

Gene

SFTPA1

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi215CalciumBy similarity1
Metal bindingi217Calcium; via carbonyl oxygenBy similarity1
Metal bindingi234CalciumBy similarity1
Metal bindingi235CalciumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processGaseous exchange
LigandCalcium, Lectin, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pulmonary surfactant-associated protein A
Short name:
PSAP
Short name:
PSP-A
Short name:
SP-A
Gene namesi
Name:SFTPA1
Synonyms:SFTPA
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Extracellular matrix, Secreted, Surface film

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000004668921 – 248Pulmonary surfactant-associated protein AAdd BLAST228

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26InterchainPROSITE-ProRule annotation
Disulfide bondi155 ↔ 246PROSITE-ProRule annotation
Glycosylationi207N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi224 ↔ 238PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Gene expression databases

BgeeiENSMMUG00000009795.

Interactioni

Subunit structurei

Oligomeric complex of 6 set of homotrimers.By similarity

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000012817.

Structurei

3D structure databases

SMRiQ9TUC5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 100Collagen-likeAdd BLAST70
Domaini134 – 247C-type lectinPROSITE-ProRule annotationAdd BLAST114

Sequence similaritiesi

Belongs to the SFTPA family.Curated

Keywords - Domaini

Collagen, Signal

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
HOGENOMiHOG000085660.
HOVERGENiHBG108270.
InParanoidiQ9TUC5.
KOiK10067.
OMAiGEEECVE.
OrthoDBiEOG091G0PU5.
TreeFamiTF330481.

Family and domain databases

CDDicd03591. CLECT_collectin_like. 1 hit.
Gene3Di3.10.100.10. 1 hit.
InterProiView protein in InterPro
IPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR033990. Collectin_CTLD.
IPR016187. CTDL_fold.
PfamiView protein in Pfam
PF00059. Lectin_C. 1 hit.
SMARTiView protein in SMART
SM00034. CLECT. 1 hit.
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiView protein in PROSITE
PS50041. C_TYPE_LECTIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9TUC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLCPLALTL TLMAASGAAC EVKDICVGSP GIPGTPGSHG LPGRDGRDGV
60 70 80 90 100
KGDPGPPGPM GPPGDMPCFP GNDGLPGAPG IPGECGEKGE PGERGPPGLP
110 120 130 140 150
AHLDEELQAT LHDFRHQILQ TRGALSLQES ILAIGGKVFS TNGQSATFDA
160 170 180 190 200
IQEACARAGG HIAVPRSPEE NEAIASFVKK YNTYAYVGLT EGPSPGDFRY
210 220 230 240
SDGTPVNYTN WYPGEPAGRG TEQCVEMYTD GRWNDRNCLY NRLTICEF
Length:248
Mass (Da):26,086
Last modified:November 28, 2012 - v2
Checksum:iDCEDB793CCDDC11F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti213P → R in AAF02223 (PubMed:10074480).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087691 mRNA. Translation: AAF02223.1.
RefSeqiNP_001182305.1. NM_001195376.1.
XP_015002613.1. XM_015147127.1.
XP_015002614.1. XM_015147128.1.
UniGeneiMmu.3533.

Genome annotation databases

GeneIDi574108.
KEGGimcc:574108.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSFTPA_MACMU
AccessioniPrimary (citable) accession number: Q9TUC5
Secondary accession number(s): F6Y0S1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: November 28, 2012
Last modified: June 7, 2017
This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families