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Protein

Protein fosB

Gene

FOSB

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

FosB interacts with Jun proteins enhancing their DNA binding activity.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein fosB
Gene namesi
Name:FOSB
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338Protein fosBPRO_0000076475Add
BLAST

Proteomic databases

PaxDbiQ9TUB3.

Interactioni

Subunit structurei

Heterodimer.By similarity

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000006628.

Structurei

3D structure databases

ProteinModelPortaliQ9TUB3.
SMRiQ9TUB3. Positions 157-215.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini155 – 21864bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni157 – 18226Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni183 – 21129Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family. Fos subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
HOGENOMiHOG000234334.
HOVERGENiHBG005743.
InParanoidiQ9TUB3.
KOiK09029.

Family and domain databases

InterProiIPR000837. AP-1.
IPR004827. bZIP.
IPR029813. FosB.
[Graphical view]
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF3. PTHR23351:SF3. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9TUB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQAFPGDYD SGSRCSSSPS AESQYLSSVD SFGSPPTAAA SQECAGLGEM
60 70 80 90 100
PGSFVPTVTA ITTSQDLQWL VQPTLISSMA QSQGQPLASQ PPAVDPYDMP
110 120 130 140 150
GTSYSTPGMS GYSSGGASGS GGPSTSGTTS GPGPARPARA RLRRPREETL
160 170 180 190 200
TPEEEEKRRV RRERNKLAAA KCRNRRRELT DRLQAETDQL EEEKAELESE
210 220 230 240 250
IAELQKEKER LEFVLVAHKP GCKIPYEEGP GPGPLAEVRD LPGSASTKED
260 270 280 290 300
GFSWLLPPPP APPLPFQTSQ DAAPNLTASL FTHSEVQVLG DPFPVVNPSY
310 320 330
TSSFVLTCPE VSAFAGTQRP SGSDQPTDPL NSPSLLAL
Length:338
Mass (Da):35,924
Last modified:May 1, 2000 - v1
Checksum:iCDD2800870FE197A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095857 Genomic DNA. Translation: AAF01350.1.
RefSeqiNP_001013866.1. NM_001013844.1.
UniGeneiCfa.23480.

Genome annotation databases

GeneIDi484445.
KEGGicfa:484445.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095857 Genomic DNA. Translation: AAF01350.1.
RefSeqiNP_001013866.1. NM_001013844.1.
UniGeneiCfa.23480.

3D structure databases

ProteinModelPortaliQ9TUB3.
SMRiQ9TUB3. Positions 157-215.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000006628.

Proteomic databases

PaxDbiQ9TUB3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi484445.
KEGGicfa:484445.

Organism-specific databases

CTDi2354.

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
HOGENOMiHOG000234334.
HOVERGENiHBG005743.
InParanoidiQ9TUB3.
KOiK09029.

Family and domain databases

InterProiIPR000837. AP-1.
IPR004827. bZIP.
IPR029813. FosB.
[Graphical view]
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF3. PTHR23351:SF3. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genomic sequence of the canine fosB gene."
    Myeong H.K., Park C.K.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Sapsari.

Entry informationi

Entry nameiFOSB_CANLF
AccessioniPrimary (citable) accession number: Q9TUB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.