Q9TUA7 (OR1A1_PANTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 1A1

Gene names

Name:

OR1A1

Organism

Pan troglodytes (Chimpanzee) [Reference proteome]

Taxonomic identifier

9598 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Pan

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 309	309	Olfactory receptor 1A1		PRO_0000150414
Regions
	Topological domain	1 – 25	25	Extracellular Potential
	Transmembrane	26 – 49	24	Helical; Name=1; Potential
	Topological domain	50 – 57	8	Cytoplasmic Potential
	Transmembrane	58 – 79	22	Helical; Name=2; Potential
	Topological domain	80 – 100	21	Extracellular Potential
	Transmembrane	101 – 120	20	Helical; Name=3; Potential
	Topological domain	121 – 139	19	Cytoplasmic Potential
	Transmembrane	140 – 158	19	Helical; Name=4; Potential
	Topological domain	159 – 195	37	Extracellular Potential
	Transmembrane	196 – 218	23	Helical; Name=5; Potential
	Topological domain	219 – 235	17	Cytoplasmic Potential
	Transmembrane	236 – 258	23	Helical; Name=6; Potential
	Topological domain	259 – 270	12	Extracellular Potential
	Transmembrane	271 – 290	20	Helical; Name=7; Potential
	Topological domain	291 – 309	19	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Glycosylation	264	1	N-linked (GlcNAc...) Potential
	Disulfide bond	97 ↔ 189		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9TUA7 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: ED5D7E104DD17634	FASTA	309	34,544
	10 20 30 40 50 60 MRENNQSSTL EFILLGVTGQ QEQEDFFYIL FLFIYPITLI GNLLIVLAIC SDVHLHNPMY 70 80 90 100 110 120 FLLANLSLVD IFFSSVTIPK MLANHLLGSK SISFGGCLTQ MYFMIALGNT DSYILAAMAY 130 140 150 160 170 180 DRAVAISRPL HYTTIMSPRS CIWLIAGSWV IGNANALPHT LLTASLSFCG NQEVANFYCD 190 200 210 220 230 240 ITPLLKLSCS DIHFHVKMMY LGVGIFSVPL LCIIVSYIRV FSTVFQVPST KGVLKAFSTC 250 260 270 280 290 300 GSHLTVVSLY YGTVMGMYFR PLTNYSLKDA VITVMYTAVT PMLNPFIYSL RNRDVKAALR KLFNKRISS

References

[1]

"Primate evolution of an olfactory receptor cluster: diversification by gene conversion and recent emergence of pseudogenes." Sharon D., Glusman G., Pilpel Y., Khen M., Gruetzner F., Haaf T., Lancet D. Genomics 61:24-36(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF101732 Genomic DNA. Translation: AAF03317.1.
RefSeq	NP_001009115.1. NM_001009115.1.
UniGene	Ptr.6394.
3D structure databases
ProteinModelPortal	Q9TUA7.
ModBase	Search...
Protein-protein interaction databases
STRING	9598.ENSPTRP00000014611.
Protein family/group databases
GPCRDB	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSPTRT00000015791; ENSPTRP00000014611; ENSPTRG00000008560.
GeneID	468149.
KEGG	ptr:468149.
Organism-specific databases
CTD	8383.
Phylogenomic databases
eggNOG	NOG150319.
GeneTree	ENSGT00700000104519.
HOGENOM	HOG000041362.
HOVERGEN	HBG017625.
InParanoid	Q9TUA7.
KO	K04257.
OMA	DIHFHVK.
OrthoDB	EOG4V6ZH5.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PANTHER	PTHR24236. PTHR24236. 1 hit.
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20845849.

Entry information

Entry name

OR1A1_PANTR

Accession

Primary (citable) accession number: Q9TUA7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 21, 2003
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program