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Protein

Olfactory receptor 1A1

Gene

OR1A1

Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1A1
Gene namesi
Name:OR1A1
OrganismiGorilla gorilla gorilla (Western lowland gorilla)
Taxonomic identifieri9595 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
Proteomesi
  • UP000001519 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence analysisAdd
BLAST
Transmembranei26 – 4924Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini50 – 578CytoplasmicSequence analysis
Transmembranei58 – 7922Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini80 – 10021ExtracellularSequence analysisAdd
BLAST
Transmembranei101 – 12020Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence analysisAdd
BLAST
Transmembranei140 – 15819Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini159 – 19537ExtracellularSequence analysisAdd
BLAST
Transmembranei196 – 21823Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini219 – 23517CytoplasmicSequence analysisAdd
BLAST
Transmembranei236 – 25823Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini259 – 27012ExtracellularSequence analysisAdd
BLAST
Transmembranei271 – 29020Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini291 – 30919CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Olfactory receptor 1A1PRO_0000150413Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation
Glycosylationi264 – 2641N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ9TU92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG017625.
InParanoidiQ9TU92.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9TU92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRENNQSSTL EFILLGVTGQ QEQEDFFYIL FLFIYPITLI GNLLIVLAIC
60 70 80 90 100
SDVHLHNPMY FLLANLSLVD IFFSSVTIPK MLANHLSGSK SISFGGCLTQ
110 120 130 140 150
MYFMIDLGNT DSYTLAAMAY DRAVAISRPL HYTTIMSPRS CIWLIAGSWV
160 170 180 190 200
IGNANALPHT LLTASLSFCG NQEVANFYCD ITPLLKLSCS DIHFHVKMMY
210 220 230 240 250
LGVGIFSVPL LCIIVSYIRV FSTVFQVPST KGVLKAFSTC GSHLTVVSLY
260 270 280 290 300
YGTVMGMYFR PLTNYSLKDA VITVMCTAVT PMLNPFIYSL RNRDMKAALQ

KLFNKRISS
Length:309
Mass (Da):34,494
Last modified:May 1, 2000 - v1
Checksum:iD9B189EF84E26CC9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF101751 Genomic DNA. Translation: AAF03332.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF101751 Genomic DNA. Translation: AAF03332.1.

3D structure databases

ProteinModelPortaliQ9TU92.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG017625.
InParanoidiQ9TU92.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Primate evolution of an olfactory receptor cluster: diversification by gene conversion and recent emergence of pseudogenes."
    Sharon D., Glusman G., Pilpel Y., Khen M., Gruetzner F., Haaf T., Lancet D.
    Genomics 61:24-36(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiOR1A1_GORGO
AccessioniPrimary (citable) accession number: Q9TU92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: May 1, 2000
Last modified: July 22, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.