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Protein

Interleukin-18

Gene

IL18

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

ReactomeiR-BTA-448706. Interleukin-1 processing.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-18
Short name:
IL-18
Alternative name(s):
Interferon gamma-inducing factor
Short name:
IFN-gamma-inducing factor
Interleukin-1 gamma
Short name:
IL-1 gamma
Gene namesi
Name:IL18
Synonyms:IGIF
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 15

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 3636By similarityPRO_0000015337Add
BLAST
Chaini37 – 193157Interleukin-18PRO_0000015338Add
BLAST

Post-translational modificationi

The pro-IL-18 precursor is processed by CASP1 or CASP4 to yield the active form.By similarity

Proteomic databases

PaxDbiQ9TU73.
PRIDEiQ9TU73.

Expressioni

Gene expression databases

ExpressionAtlasiQ9TU73. baseline and differential.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000055793.

Structurei

3D structure databases

ProteinModelPortaliQ9TU73.
SMRiQ9TU73. Positions 37-193.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

eggNOGiENOG410J3U9. Eukaryota.
ENOG410ZGS8. LUCA.
GeneTreeiENSGT00390000001053.
HOGENOMiHOG000048723.
HOVERGENiHBG000388.
InParanoidiQ9TU73.
KOiK05482.
OMAiPVFEDMP.
OrthoDBiEOG7SR4NN.
TreeFamiTF336297.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR015529. IL-18.
IPR000975. IL-1_fam.
[Graphical view]
PANTHERiPTHR11326. PTHR11326. 1 hit.
PfamiPF00340. IL1. 1 hit.
[Graphical view]
PIRSFiPIRSF015162. Interleukin_18. 1 hit.
PRINTSiPR01933. INTRLEUKIN18.
SUPFAMiSSF50353. SSF50353. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9TU73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEQVEDYC ISFVEMKFIN NTLYFVAEND EDLESDHFGK LEPKLSIIRN
60 70 80 90 100
LNDQVLFINQ GNQPVFEDMP DSDCSDNAPQ TIFIIYMYKD SLTRGLAVTI
110 120 130 140 150
SVQCKKMSTL SCENKIVSFK EMNPPDNIDN EESDIIFFQR SVPGHDDKIQ
160 170 180 190
FESSLYKGYF LACKKENDLF KLILKKQDDN RDKSVMFTVQ NQN
Length:193
Mass (Da):22,347
Last modified:May 1, 2000 - v1
Checksum:i65720F199DEA49C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF124789 mRNA. Translation: AAF08686.1.
EU276078 mRNA. Translation: ABX72076.1.
BC102879 mRNA. Translation: AAI02880.1.
RefSeqiNP_776516.1. NM_174091.2.
UniGeneiBt.234.

Genome annotation databases

EnsembliENSBTAT00000065052; ENSBTAP00000055793; ENSBTAG00000000277.
GeneIDi281249.
KEGGibta:281249.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF124789 mRNA. Translation: AAF08686.1.
EU276078 mRNA. Translation: ABX72076.1.
BC102879 mRNA. Translation: AAI02880.1.
RefSeqiNP_776516.1. NM_174091.2.
UniGeneiBt.234.

3D structure databases

ProteinModelPortaliQ9TU73.
SMRiQ9TU73. Positions 37-193.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000055793.

Proteomic databases

PaxDbiQ9TU73.
PRIDEiQ9TU73.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000065052; ENSBTAP00000055793; ENSBTAG00000000277.
GeneIDi281249.
KEGGibta:281249.

Organism-specific databases

CTDi3606.

Phylogenomic databases

eggNOGiENOG410J3U9. Eukaryota.
ENOG410ZGS8. LUCA.
GeneTreeiENSGT00390000001053.
HOGENOMiHOG000048723.
HOVERGENiHBG000388.
InParanoidiQ9TU73.
KOiK05482.
OMAiPVFEDMP.
OrthoDBiEOG7SR4NN.
TreeFamiTF336297.

Enzyme and pathway databases

ReactomeiR-BTA-448706. Interleukin-1 processing.

Miscellaneous databases

NextBioi20805291.

Gene expression databases

ExpressionAtlasiQ9TU73. baseline and differential.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR015529. IL-18.
IPR000975. IL-1_fam.
[Graphical view]
PANTHERiPTHR11326. PTHR11326. 1 hit.
PfamiPF00340. IL1. 1 hit.
[Graphical view]
PIRSFiPIRSF015162. Interleukin_18. 1 hit.
PRINTSiPR01933. INTRLEUKIN18.
SUPFAMiSSF50353. SSF50353. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a cDNA encoding bovine interleukin-18 and analysis of IL-18 expression in macrophages and its IFN-gamma-inducing activity."
    Shoda L.K., Zarlenga D.S., Hirano A., Brown W.C.
    J. Interferon Cytokine Res. 19:1169-1177(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "U.S. veterinary immune reagent network: expressed bovine gene sequences."
    U.S. Veterinary Immune Reagent Network
    Hudgens T., Tompkins D., Baldwin C.L.
    Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Belted Galloway.
    Tissue: Peripheral blood.
  3. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiIL18_BOVIN
AccessioniPrimary (citable) accession number: Q9TU73
Secondary accession number(s): A9QWR6, Q3SZF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: January 20, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.