Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Eukaryotic translation initiation factor 6

Gene

EIF6

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1-dependent protein kinase C activity.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 6UniRule annotation
Short name:
eIF-6UniRule annotation
Alternative name(s):
Imc-415 homolog
Gene namesi
Name:EIF6UniRule annotation
Synonyms:ITGB4BPUniRule annotation
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 13

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Nucleusnucleolus UniRule annotation

  • Note: Shuttles between cytoplasm and nucleus/nucleolus.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 245245Eukaryotic translation initiation factor 6PRO_0000259426Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei113 – 1131PhosphotyrosineBy similarity
Modified residuei165 – 1651PhosphothreonineUniRule annotationBy similarity
Modified residuei166 – 1661PhosphoserineUniRule annotationBy similarity
Modified residuei174 – 1741Phosphoserine; by CK1UniRule annotationBy similarity
Modified residuei175 – 1751Phosphoserine; by CK1UniRule annotationBy similarity
Modified residuei235 – 2351Phosphoserine; by PKCUniRule annotationBy similarity
Modified residuei239 – 2391PhosphoserineUniRule annotationBy similarity
Modified residuei243 – 2431PhosphoserineUniRule annotationBy similarity

Post-translational modificationi

Phosphorylation at Ser-174 and Ser-175 by CSNK1D/CK1 promotes nuclear export.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9TU47.
PRIDEiQ9TU47.

Interactioni

Subunit structurei

Monomer. Associates with the 60S ribosomal subunit. Interacts with RACK1.UniRule annotation

Protein-protein interaction databases

IntActiQ9TU47. 2 interactions.
STRINGi9913.ENSBTAP00000014966.

Structurei

3D structure databases

ProteinModelPortaliQ9TU47.
SMRiQ9TU47. Positions 1-224.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-6 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3185. Eukaryota.
COG1976. LUCA.
GeneTreeiENSGT00390000015972.
HOGENOMiHOG000230605.
HOVERGENiHBG001300.
InParanoidiQ9TU47.
KOiK03264.
OMAiNDWCAFT.
OrthoDBiEOG7V4B05.
TreeFamiTF105396.

Family and domain databases

HAMAPiMF_00032. eIF_6.
InterProiIPR002769. eIF6.
[Graphical view]
PANTHERiPTHR10784. PTHR10784. 1 hit.
PfamiPF01912. eIF-6. 1 hit.
[Graphical view]
PIRSFiPIRSF006413. IF-6. 1 hit.
SMARTiSM00654. eIF6. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00323. eIF-6. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9TU47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVRASFENN CEIGCFAKLT NSYCLVAIGG SENFYSVFEG ELAGTIPVVH
60 70 80 90 100
ASIAGCRIIG RMCVGNRHGL LVPNNTTDQE LQHIRNCLPD SVQIRRVEER
110 120 130 140 150
LSALGNVTTC NDYVALVHPD LDRETEEILA DVLKVEVFRQ TVADQVLVGS
160 170 180 190 200
YCVFSNQGGL VHPKTSIEDQ DELSSLLQVP LVAGTVNRGS EVIAAGMVVN
210 220 230 240
DWCAFCGLDT TSTELSVVES VFKLNEAQPS TIATSMRDSL IDSLT
Length:245
Mass (Da):26,513
Last modified:October 31, 2006 - v2
Checksum:iC62D76AD25402243
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti141 – 1411T → K in AAF00595 (PubMed:10879479).Curated
Sequence conflicti198 – 1981V → A in AAF00595 (PubMed:10879479).Curated
Sequence conflicti210 – 2101T → A in AAF00595 (PubMed:10879479).Curated
Sequence conflicti222 – 2243FKL → SKP in AAF00595 (PubMed:10879479).Curated
Sequence conflicti241 – 2411I → T in AAF00595 (PubMed:10879479).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF141872 mRNA. Translation: AAF00595.1.
BC109922 mRNA. Translation: AAI09923.1.
PIRiJC7273.
RefSeqiNP_777255.1. NM_174830.1.
XP_005214560.1. XM_005214503.3.
UniGeneiBt.4426.

Genome annotation databases

EnsembliENSBTAT00000014966; ENSBTAP00000014966; ENSBTAG00000011263.
GeneIDi286811.
KEGGibta:286811.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF141872 mRNA. Translation: AAF00595.1.
BC109922 mRNA. Translation: AAI09923.1.
PIRiJC7273.
RefSeqiNP_777255.1. NM_174830.1.
XP_005214560.1. XM_005214503.3.
UniGeneiBt.4426.

3D structure databases

ProteinModelPortaliQ9TU47.
SMRiQ9TU47. Positions 1-224.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9TU47. 2 interactions.
STRINGi9913.ENSBTAP00000014966.

Proteomic databases

PaxDbiQ9TU47.
PRIDEiQ9TU47.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000014966; ENSBTAP00000014966; ENSBTAG00000011263.
GeneIDi286811.
KEGGibta:286811.

Organism-specific databases

CTDi3692.

Phylogenomic databases

eggNOGiKOG3185. Eukaryota.
COG1976. LUCA.
GeneTreeiENSGT00390000015972.
HOGENOMiHOG000230605.
HOVERGENiHBG001300.
InParanoidiQ9TU47.
KOiK03264.
OMAiNDWCAFT.
OrthoDBiEOG7V4B05.
TreeFamiTF105396.

Family and domain databases

HAMAPiMF_00032. eIF_6.
InterProiIPR002769. eIF6.
[Graphical view]
PANTHERiPTHR10784. PTHR10784. 1 hit.
PfamiPF01912. eIF-6. 1 hit.
[Graphical view]
PIRSFiPIRSF006413. IF-6. 1 hit.
SMARTiSM00654. eIF6. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00323. eIF-6. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of bovine imc-415 cDNA from mammary gland."
    Ha S., Baik M., Choi Y.
    Biosci. Biotechnol. Biochem. 64:1052-1054(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Holstein.
    Tissue: Mammary gland.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Liver.

Entry informationi

Entry nameiIF6_BOVIN
AccessioniPrimary (citable) accession number: Q9TU47
Secondary accession number(s): Q2TBM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: June 8, 2016
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.