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Protein

Agouti-related protein

Gene

AGRP

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R. Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Agouti-related protein
Gene namesi
Name:AGRP
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 6

Subcellular locationi

  • Secreted By similarity
  • Golgi apparatus lumen By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000043404621 – 84By similarityAdd BLAST64
ChainiPRO_000000103685 – 134Agouti-related proteinAdd BLAST50

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi89 ↔ 104PROSITE-ProRule annotationBy similarity
Disulfide bondi96 ↔ 110PROSITE-ProRule annotationBy similarity
Disulfide bondi103 ↔ 121PROSITE-ProRule annotationBy similarity
Disulfide bondi107 ↔ 131PROSITE-ProRule annotationBy similarity
Disulfide bondi112 ↔ 119PROSITE-ProRule annotationBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei84 – 85Cleavage; by PCSK1By similarity2

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9TU18.

Expressioni

Gene expression databases

GenevisibleiQ9TU18. SS.

Interactioni

Subunit structurei

Interacts with melanocortin receptors MC3R, MC4R and MC5R.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000002994.

Structurei

3D structure databases

ProteinModelPortaliQ9TU18.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini89 – 131AgoutiPROSITE-ProRule annotationAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni113 – 115Interaction with melanocortin receptorsBy similarity3

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity

Sequence similaritiesi

Contains 1 agouti domain.PROSITE-ProRule annotation

Keywords - Domaini

Knottin, Signal

Phylogenomic databases

eggNOGiENOG410J14P. Eukaryota.
ENOG410Z66T. LUCA.
GeneTreeiENSGT00510000048590.
HOGENOMiHOG000033861.
HOVERGENiHBG050467.
InParanoidiQ9TU18.
KOiK05231.
OMAiMQGAQMG.
OrthoDBiEOG091G1506.
TreeFamiTF330729.

Family and domain databases

Gene3Di4.10.760.10. 1 hit.
InterProiIPR007733. Agouti.
IPR027300. Agouti_dom.
[Graphical view]
PANTHERiPTHR16551. PTHR16551. 1 hit.
PfamiPF05039. Agouti. 1 hit.
[Graphical view]
SMARTiSM00792. Agouti. 1 hit.
[Graphical view]
SUPFAMiSSF57055. SSF57055. 1 hit.
PROSITEiPS60024. AGOUTI_1. 1 hit.
PS51150. AGOUTI_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9TU18-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTTMLLSCA LLLAMPTMLG AQIGLAPLEG IGRLDQALFP ELQDLGLQPP
60 70 80 90 100
LKRTTAERAE EALLQQAEAK ALAEVLDPEG RKARSPRRCV RLHESCLGHQ
110 120 130
VPCCDPCATC YCRFFNAFCY CRKLGTATNP CSRT
Length:134
Mass (Da):14,681
Last modified:October 1, 2001 - v2
Checksum:iDA89AC087567889A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177762 Genomic DNA. Translation: AAF13865.2.
RefSeqiNP_001011693.1. NM_001011693.1.
XP_013853683.1. XM_013998229.1.
XP_013853684.1. XM_013998230.1.
UniGeneiSsc.483.

Genome annotation databases

EnsembliENSSSCT00000003073; ENSSSCP00000002994; ENSSSCG00000002775.
GeneIDi397275.
KEGGissc:397275.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177762 Genomic DNA. Translation: AAF13865.2.
RefSeqiNP_001011693.1. NM_001011693.1.
XP_013853683.1. XM_013998229.1.
XP_013853684.1. XM_013998230.1.
UniGeneiSsc.483.

3D structure databases

ProteinModelPortaliQ9TU18.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000002994.

Proteomic databases

PaxDbiQ9TU18.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000003073; ENSSSCP00000002994; ENSSSCG00000002775.
GeneIDi397275.
KEGGissc:397275.

Organism-specific databases

CTDi181.

Phylogenomic databases

eggNOGiENOG410J14P. Eukaryota.
ENOG410Z66T. LUCA.
GeneTreeiENSGT00510000048590.
HOGENOMiHOG000033861.
HOVERGENiHBG050467.
InParanoidiQ9TU18.
KOiK05231.
OMAiMQGAQMG.
OrthoDBiEOG091G1506.
TreeFamiTF330729.

Gene expression databases

GenevisibleiQ9TU18. SS.

Family and domain databases

Gene3Di4.10.760.10. 1 hit.
InterProiIPR007733. Agouti.
IPR027300. Agouti_dom.
[Graphical view]
PANTHERiPTHR16551. PTHR16551. 1 hit.
PfamiPF05039. Agouti. 1 hit.
[Graphical view]
SMARTiSM00792. Agouti. 1 hit.
[Graphical view]
SUPFAMiSSF57055. SSF57055. 1 hit.
PROSITEiPS60024. AGOUTI_1. 1 hit.
PS51150. AGOUTI_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAGRP_PIG
AccessioniPrimary (citable) accession number: Q9TU18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 1, 2001
Last modified: October 5, 2016
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.