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Protein

Rho GDP-dissociation inhibitor 2

Gene

ARHGDIB

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Regulates reorganization of the actin cytoskeleton mediated by Rho family members.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiR-BTA-194840. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GDP-dissociation inhibitor 2
Short name:
Rho GDI 2
Alternative name(s):
D4-GDP-dissociation inhibitor
Short name:
D4-GDI
Ly-GDI
Rho-GDI beta
Gene namesi
Name:ARHGDIB
Synonyms:GDID4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB
  • extracellular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 200199Rho GDP-dissociation inhibitor 2PRO_0000219015Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylthreonineBy similarity
Modified residuei20 – 201N6-acetyllysineBy similarity
Modified residuei23 – 231PhosphotyrosineBy similarity
Modified residuei24 – 241N6-acetyllysineBy similarity
Modified residuei39 – 391N6-acetyllysineBy similarity
Modified residuei46 – 461N6-acetyllysineBy similarity
Modified residuei101 – 1011N6-acetyllysineBy similarity
Modified residuei123 – 1231N6-acetyllysineBy similarity
Modified residuei144 – 1441PhosphoserineBy similarity
Modified residuei174 – 1741N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9TU03.
PeptideAtlasiQ9TU03.
PRIDEiQ9TU03.

Interactioni

Subunit structurei

Interacts with RHOA. Interacts with RAC1. Interacts with RAC2. Interacts with CDC42.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007933.

Structurei

3D structure databases

ProteinModelPortaliQ9TU03.
SMRiQ9TU03. Positions 22-198.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Rho GDI family.Curated

Phylogenomic databases

eggNOGiKOG3205. Eukaryota.
ENOG4111K44. LUCA.
GeneTreeiENSGT00390000006233.
HOGENOMiHOG000175765.
HOVERGENiHBG000206.
InParanoidiQ9TU03.
KOiK12462.
OMAiQDHLTWE.
OrthoDBiEOG72JWH9.
TreeFamiTF105387.

Family and domain databases

Gene3Di2.70.50.30. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR000406. Rho_GDI.
IPR024792. RhoGDI_domain.
[Graphical view]
PANTHERiPTHR10980. PTHR10980. 1 hit.
PfamiPF02115. Rho_GDI. 1 hit.
[Graphical view]
PRINTSiPR00492. RHOGDI.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9TU03-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEKAPEPHV EEDDDELDGK LNYKPPPQKS LKELQEMDKD DESLTKYKKT
60 70 80 90 100
LLGDGPVVAD PTAPNVTVTR LTLVCESAPG PITMDLTGDL EALKKETFVL
110 120 130 140 150
KEGVEYRVKI NFKVNKDIVS GLKYVQHTYR TGVKVDKATF MVGSYGPRPE
160 170 180 190 200
EYEFLTPIEE APKGMLARGT YHNKSFFTDD DKHDHLTWEW NLSIKKDWTE
Length:200
Mass (Da):22,794
Last modified:January 23, 2007 - v3
Checksum:iEE8F1E38993AFDE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182001 mRNA. Translation: AAF00938.1.
BC102109 mRNA. Translation: AAI02110.1.
RefSeqiNP_786991.1. NM_175797.2.
UniGeneiBt.4757.

Genome annotation databases

EnsembliENSBTAT00000007933; ENSBTAP00000007933; ENSBTAG00000006039.
GeneIDi327676.
KEGGibta:327676.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182001 mRNA. Translation: AAF00938.1.
BC102109 mRNA. Translation: AAI02110.1.
RefSeqiNP_786991.1. NM_175797.2.
UniGeneiBt.4757.

3D structure databases

ProteinModelPortaliQ9TU03.
SMRiQ9TU03. Positions 22-198.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007933.

Proteomic databases

PaxDbiQ9TU03.
PeptideAtlasiQ9TU03.
PRIDEiQ9TU03.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000007933; ENSBTAP00000007933; ENSBTAG00000006039.
GeneIDi327676.
KEGGibta:327676.

Organism-specific databases

CTDi397.

Phylogenomic databases

eggNOGiKOG3205. Eukaryota.
ENOG4111K44. LUCA.
GeneTreeiENSGT00390000006233.
HOGENOMiHOG000175765.
HOVERGENiHBG000206.
InParanoidiQ9TU03.
KOiK12462.
OMAiQDHLTWE.
OrthoDBiEOG72JWH9.
TreeFamiTF105387.

Enzyme and pathway databases

ReactomeiR-BTA-194840. Rho GTPase cycle.

Family and domain databases

Gene3Di2.70.50.30. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR000406. Rho_GDI.
IPR024792. RhoGDI_domain.
[Graphical view]
PANTHERiPTHR10980. PTHR10980. 1 hit.
PfamiPF02115. Rho_GDI. 1 hit.
[Graphical view]
PRINTSiPR00492. RHOGDI.
SUPFAMiSSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of bovine low molecular weight GTPases (Rac1 and Rac2) and Rho GDP-dissociation inhibitor 2 (D4-GDI)."
    Davis A.R., Clements M.K., Bunger P.L., Siemsen D.W., Quinn M.T.
    Vet. Immunol. Immunopathol. 74:285-301(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiGDIR2_BOVIN
AccessioniPrimary (citable) accession number: Q9TU03
Secondary accession number(s): Q3ZCK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.