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Protein

Rho GDP-dissociation inhibitor 2

Gene

ARHGDIB

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Regulates reorganization of the actin cytoskeleton mediated by Rho family members.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-BTA-194840 Rho GTPase cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GDP-dissociation inhibitor 2
Short name:
Rho GDI 2
Alternative name(s):
D4-GDP-dissociation inhibitor
Short name:
D4-GDI
Ly-GDI
Rho-GDI beta
Gene namesi
Name:ARHGDIB
Synonyms:GDID4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Organism-specific databases

VGNCiVGNC:26102 ARHGDIB

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002190152 – 200Rho GDP-dissociation inhibitor 2Add BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineBy similarity1
Modified residuei20N6-acetyllysineBy similarity1
Modified residuei23PhosphotyrosineBy similarity1
Modified residuei24N6-acetyllysineBy similarity1
Modified residuei39N6-acetyllysineBy similarity1
Modified residuei46N6-acetyllysineBy similarity1
Modified residuei101N6-acetyllysineBy similarity1
Modified residuei123N6-acetyllysineBy similarity1
Modified residuei144PhosphoserineBy similarity1
Modified residuei174N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9TU03
PeptideAtlasiQ9TU03
PRIDEiQ9TU03

Expressioni

Gene expression databases

BgeeiENSBTAG00000006039

Interactioni

Subunit structurei

Interacts with RHOA. Interacts with RAC1. Interacts with RAC2. Interacts with CDC42.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007933

Structurei

3D structure databases

ProteinModelPortaliQ9TU03
SMRiQ9TU03
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Rho GDI family.Curated

Phylogenomic databases

eggNOGiKOG3205 Eukaryota
ENOG4111K44 LUCA
GeneTreeiENSGT00390000006233
HOGENOMiHOG000175765
HOVERGENiHBG000206
InParanoidiQ9TU03
KOiK12462
OMAiLTWEWNL
OrthoDBiEOG091G0MBU
TreeFamiTF105387

Family and domain databases

Gene3Di2.70.50.30, 1 hit
InterProiView protein in InterPro
IPR014756 Ig_E-set
IPR000406 Rho_GDI
IPR024792 RhoGDI_dom_sf
PANTHERiPTHR10980 PTHR10980, 1 hit
PfamiView protein in Pfam
PF02115 Rho_GDI, 1 hit
PRINTSiPR00492 RHOGDI
SUPFAMiSSF81296 SSF81296, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9TU03-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEKAPEPHV EEDDDELDGK LNYKPPPQKS LKELQEMDKD DESLTKYKKT
60 70 80 90 100
LLGDGPVVAD PTAPNVTVTR LTLVCESAPG PITMDLTGDL EALKKETFVL
110 120 130 140 150
KEGVEYRVKI NFKVNKDIVS GLKYVQHTYR TGVKVDKATF MVGSYGPRPE
160 170 180 190 200
EYEFLTPIEE APKGMLARGT YHNKSFFTDD DKHDHLTWEW NLSIKKDWTE
Length:200
Mass (Da):22,794
Last modified:January 23, 2007 - v3
Checksum:iEE8F1E38993AFDE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182001 mRNA Translation: AAF00938.1
BC102109 mRNA Translation: AAI02110.1
RefSeqiNP_786991.1, NM_175797.2
UniGeneiBt.4757

Genome annotation databases

EnsembliENSBTAT00000007933; ENSBTAP00000007933; ENSBTAG00000006039
GeneIDi327676
KEGGibta:327676

Similar proteinsi

Entry informationi

Entry nameiGDIR2_BOVIN
AccessioniPrimary (citable) accession number: Q9TU03
Secondary accession number(s): Q3ZCK4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 111 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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