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Protein

Adenylate kinase isoenzyme 6

Gene

AK6

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.UniRule annotation

Catalytic activityi

ATP + AMP = 2 ADP.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391AMPUniRule annotation
Binding sitei79 – 791ATPUniRule annotation
Binding sitei105 – 1051ATPUniRule annotation
Binding sitei109 – 1091ATPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 186ATPUniRule annotation
Nucleotide bindingi148 – 1492ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate kinase isoenzyme 6UniRule annotation (EC:2.7.4.3UniRule annotation)
Short name:
AK6UniRule annotation
Alternative name(s):
Coilin-interacting nuclear ATPase proteinUniRule annotation
Dual activity adenylate kinase/ATPaseUniRule annotation
Short name:
AK/ATPaseUniRule annotation
Gene namesi
Name:AK6UniRule annotation
Synonyms:CINAPUniRule annotation
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

  • Nucleusnucleoplasm UniRule annotation
  • NucleusCajal body UniRule annotation

  • Note: Displays widespread diffuse nucleoplasmic distribution but not detected in nucleoli. Detected in Cajal bodies but not in all cells.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 172172Adenylate kinase isoenzyme 6PRO_0000153898Add
BLAST

Interactioni

Subunit structurei

Monomer and homodimer. Interacts with COIL (via C-terminus).UniRule annotation

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000023998.

Structurei

3D structure databases

ProteinModelPortaliQ9TTU2.
SMRiQ9TTU2. Positions 1-172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni33 – 5624NMPbindUniRule annotationAdd
BLAST
Regioni108 – 11811LIDUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the adenylate kinase family. AK6 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG3347. Eukaryota.
COG1936. LUCA.
HOGENOMiHOG000224472.
HOVERGENiHBG052207.
InParanoidiQ9TTU2.
KOiK18532.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00039. Adenylate_kinase_AK6.
InterProiIPR020618. Adenyl_kinase_AK6.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9TTU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLPNILLTG TPGVGKTTLG KELASRSGLK YVNVGDLARE GELYDGFDEE
60 70 80 90 100
YNCPILDEDR VIDELDTQMR DGGVIVDYHG CDFFPERWFH IVFVLRTETS
110 120 130 140 150
VLYKRLETRG YSEKKLNDNI QCEIFQVLYE EAMESYKEEI VHQLPSNKPE
160 170
ELEENISQIL KWIEQWIKDH NS
Length:172
Mass (Da):20,079
Last modified:May 1, 2000 - v1
Checksum:iD3CED96756590873
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF195950 mRNA. Translation: AAF09498.1.
RefSeqiXP_008260533.1. XM_008262311.1.

Genome annotation databases

GeneIDi103349645.
KEGGiocu:103349645.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF195950 mRNA. Translation: AAF09498.1.
RefSeqiXP_008260533.1. XM_008262311.1.

3D structure databases

ProteinModelPortaliQ9TTU2.
SMRiQ9TTU2. Positions 1-172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000023998.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi103349645.
KEGGiocu:103349645.

Organism-specific databases

CTDi102157402.

Phylogenomic databases

eggNOGiKOG3347. Eukaryota.
COG1936. LUCA.
HOGENOMiHOG000224472.
HOVERGENiHBG052207.
InParanoidiQ9TTU2.
KOiK18532.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00039. Adenylate_kinase_AK6.
InterProiIPR020618. Adenyl_kinase_AK6.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The human T-cell leukemia virus type I (HTLV-I) X region encoded protein p13(II) interacts with cellular proteins."
    Hou X., Foley S., Cueto M., Robinson M.A.
    Virology 277:127-135(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: New Zealand white.

Entry informationi

Entry nameiKAD6_RABIT
AccessioniPrimary (citable) accession number: Q9TTU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 1, 2000
Last modified: November 11, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.