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Protein

Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

Gene

COX4I1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide IV
Cytochrome c oxidase subunit IV isoform 1
Short name:
COX IV-1
Gene namesi
Name:COX4I1
Synonyms:COX4, COXIV
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 22MitochondrionAdd BLAST22
ChainiPRO_000000608723 – 169Cytochrome c oxidase subunit 4 isoform 1, mitochondrialAdd BLAST147

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29N6-acetyllysine; alternateBy similarity1
Modified residuei29N6-succinyllysine; alternateBy similarity1
Modified residuei53N6-acetyllysineBy similarity1
Modified residuei56PhosphoserineBy similarity1
Modified residuei60N6-acetyllysine; alternateBy similarity1
Modified residuei60N6-succinyllysine; alternateBy similarity1
Modified residuei67N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

PTM databases

iPTMnetiQ9TTT8

Structurei

3D structure databases

ProteinModelPortaliQ9TTT8
SMRiQ9TTT8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase IV family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000231486
HOVERGENiHBG051087
InParanoidiQ9TTT8
KOiK02263

Family and domain databases

CDDicd00922 Cyt_c_Oxidase_IV, 1 hit
Gene3Di1.10.442.10, 1 hit
InterProiView protein in InterPro
IPR013288 Cyt_c_oxidase_su4
IPR004203 Cyt_c_oxidase_su4_fam
IPR036639 Cyt_c_oxidase_su4_sf
PANTHERiPTHR10707 PTHR10707, 1 hit
PfamiView protein in Pfam
PF02936 COX4, 1 hit
PRINTSiPR01873 CYTCOXIDASE4
SUPFAMiSSF81406 SSF81406, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9TTT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPTRLLSFS GSRAISTSFC LRAHGSVVKS EDYALPSYVD RRDYPLPDVA
60 70 80 90 100
HVKQLSAGQK ALKEKEKAPW GSLTRDEKVE LYRIQFNESF AEMNRGTNEW
110 120 130 140 150
KTVVGTALFF IGFTALILIW EKHYVYGPIP HTFDKEWVAM QTKRMLDMKV
160
SPIQGFSAKW DYNKNEWRK
Length:169
Mass (Da):19,599
Last modified:May 1, 2000 - v1
Checksum:i0E5C08CF577FFB32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF198088 mRNA Translation: AAF13254.1
RefSeqiNP_001164353.1, NM_001170882.1
UniGeneiOcu.6273

Genome annotation databases

KEGGiocu:100327269

Similar proteinsi

Entry informationi

Entry nameiCOX41_RABIT
AccessioniPrimary (citable) accession number: Q9TTT8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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