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Protein

Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

Gene

COX4I1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide IV
Cytochrome c oxidase subunit IV isoform 1
Short name:
COX IV-1
Gene namesi
Name:COX4I1
Synonyms:COX4, COXIV
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2222MitochondrionAdd
BLAST
Chaini23 – 169147Cytochrome c oxidase subunit 4 isoform 1, mitochondrialPRO_0000006087Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei29 – 291N6-acetyllysine; alternateBy similarity
Modified residuei29 – 291N6-succinyllysine; alternateBy similarity
Modified residuei53 – 531N6-acetyllysineBy similarity
Modified residuei56 – 561PhosphoserineBy similarity
Modified residuei60 – 601N6-acetyllysine; alternateBy similarity
Modified residuei60 – 601N6-succinyllysine; alternateBy similarity
Modified residuei67 – 671N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

PTM databases

iPTMnetiQ9TTT8.

Structurei

3D structure databases

ProteinModelPortaliQ9TTT8.
SMRiQ9TTT8. Positions 26-169.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase IV family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000231486.
HOVERGENiHBG051087.
InParanoidiQ9TTT8.
KOiK02263.

Family and domain databases

CDDicd00922. Cyt_c_Oxidase_IV. 1 hit.
Gene3Di1.10.442.10. 1 hit.
InterProiIPR013288. Cyt_c_oxidase_su4.
IPR004203. Cyt_c_oxidase_su4_fam.
[Graphical view]
PANTHERiPTHR10707. PTHR10707. 1 hit.
PfamiPF02936. COX4. 1 hit.
[Graphical view]
PRINTSiPR01873. CYTCOXIDASE4.
SUPFAMiSSF81406. SSF81406. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9TTT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPTRLLSFS GSRAISTSFC LRAHGSVVKS EDYALPSYVD RRDYPLPDVA
60 70 80 90 100
HVKQLSAGQK ALKEKEKAPW GSLTRDEKVE LYRIQFNESF AEMNRGTNEW
110 120 130 140 150
KTVVGTALFF IGFTALILIW EKHYVYGPIP HTFDKEWVAM QTKRMLDMKV
160
SPIQGFSAKW DYNKNEWRK
Length:169
Mass (Da):19,599
Last modified:May 1, 2000 - v1
Checksum:i0E5C08CF577FFB32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF198088 mRNA. Translation: AAF13254.1.
RefSeqiNP_001164353.1. NM_001170882.1.
UniGeneiOcu.6273.

Genome annotation databases

GeneIDi100327269.
KEGGiocu:100327269.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF198088 mRNA. Translation: AAF13254.1.
RefSeqiNP_001164353.1. NM_001170882.1.
UniGeneiOcu.6273.

3D structure databases

ProteinModelPortaliQ9TTT8.
SMRiQ9TTT8. Positions 26-169.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ9TTT8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100327269.
KEGGiocu:100327269.

Organism-specific databases

CTDi1327.

Phylogenomic databases

HOGENOMiHOG000231486.
HOVERGENiHBG051087.
InParanoidiQ9TTT8.
KOiK02263.

Family and domain databases

CDDicd00922. Cyt_c_Oxidase_IV. 1 hit.
Gene3Di1.10.442.10. 1 hit.
InterProiIPR013288. Cyt_c_oxidase_su4.
IPR004203. Cyt_c_oxidase_su4_fam.
[Graphical view]
PANTHERiPTHR10707. PTHR10707. 1 hit.
PfamiPF02936. COX4. 1 hit.
[Graphical view]
PRINTSiPR01873. CYTCOXIDASE4.
SUPFAMiSSF81406. SSF81406. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOX41_RABIT
AccessioniPrimary (citable) accession number: Q9TTT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.