Q9TTT8 (COX41_RABIT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

Alternative name(s):
Cytochrome c oxidase polypeptide IV
Cytochrome c oxidase subunit IV isoform 1
Short name=COX IV-1

Gene names

Name:	COX4I1
Synonyms:	COX4, COXIV

Organism

Oryctolagus cuniculus (Rabbit) [Reference proteome]

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	169 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Subcellular location	Mitochondrion inner membrane.
Sequence similarities	Belongs to the cytochrome c oxidase IV family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transit peptide
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 22	22	Mitochondrion
	Chain	23 – 169	147	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial		PRO_0000006087
Amino acid modifications
	Modified residue	53	1	N6-acetyllysine By similarity
	Modified residue	60	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9TTT8 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 0E5C08CF577FFB32	FASTA	169	19,599
	10 20 30 40 50 60 MLPTRLLSFS GSRAISTSFC LRAHGSVVKS EDYALPSYVD RRDYPLPDVA HVKQLSAGQK 70 80 90 100 110 120 ALKEKEKAPW GSLTRDEKVE LYRIQFNESF AEMNRGTNEW KTVVGTALFF IGFTALILIW 130 140 150 160 EKHYVYGPIP HTFDKEWVAM QTKRMLDMKV SPIQGFSAKW DYNKNEWRK

References

[1]	"Cloning and characterization of genes coxIV and coxVIa2 from the rabbit genome." Wu X., Hudson A.P. Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: New Zealand white.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF198088 mRNA. Translation: AAF13254.1.
RefSeq	NP_001164353.1. NM_001170882.1.
UniGene	Ocu.6273.
3D structure databases
ProteinModelPortal	Q9TTT8.
SMR	Q9TTT8. Positions 26-169.
ModBase	Search...
Protein-protein interaction databases
STRING	9986.ENSOCUP00000001489.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100327269.
Organism-specific databases
CTD	1327.
Phylogenomic databases
eggNOG	NOG276242.
HOGENOM	HOG000231486.
HOVERGEN	HBG051087.
OrthoDB	EOG48SGV7.
Family and domain databases
Gene3D	1.10.442.10. 1 hit.
InterPro	IPR013288. Cyt_c_oxidase_su4. IPR004203. Cyt_c_oxidase_su4_fam. [Graphical view]
Pfam	PF02936. COX4. 1 hit. [Graphical view]
PRINTS	PR01873. CYTCOXIDASE4.
SUPFAM	SSF81406. COX4. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COX41_RABIT

Accession

Primary (citable) accession number: Q9TTT8

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	May 1, 2000
Last modified:	April 3, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program