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Q9TTS6

- CCL11_BOVIN

UniProt

Q9TTS6 - CCL11_BOVIN

Protein

Eotaxin

Gene

CCL11

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
  1. Functioni

    Attracts eosinophils in vitro but is not responsible for eosinophilia in the ovary.1 Publication

    GO - Biological processi

    1. branching involved in mammary gland duct morphogenesis Source: Ensembl
    2. cytoskeleton organization Source: Ensembl
    3. eosinophil chemotaxis Source: Ensembl
    4. immune response Source: InterPro
    5. inflammatory response Source: UniProtKB-KW
    6. mammary duct terminal end bud growth Source: Ensembl
    7. positive regulation of actin filament polymerization Source: Ensembl
    8. positive regulation of angiogenesis Source: Ensembl
    9. positive regulation of cell migration Source: Ensembl
    10. positive regulation of endothelial cell proliferation Source: Ensembl
    11. positive regulation of Rac GTPase activity Source: Ensembl
    12. regulation of cell shape Source: Ensembl

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Enzyme and pathway databases

    ReactomeiREACT_212617. Chemokine receptors bind chemokines.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Eotaxin
    Alternative name(s):
    C-C motif chemokine 11
    Small-inducible cytokine A11
    Gene namesi
    Name:CCL11
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 19

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 9774EotaxinPRO_0000244408Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi32 ↔ 57By similarity
    Disulfide bondi33 ↔ 73By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ9TTS6.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9TTS6.
    SMRiQ9TTS6. Positions 25-96.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    GeneTreeiENSGT00730000110714.
    HOGENOMiHOG000036686.
    HOVERGENiHBG017871.
    InParanoidiQ9TTS6.
    KOiK16597.
    OMAiQSYRRIT.
    OrthoDBiEOG7C5MC2.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9TTS6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVSAVLLCL LLTATLCSIQ VLAQPASIPT ICCFNMSKKK ISIQRLQSYR   50
    KITSSKCPQK AVIFNTKQNK KICVDPQEKW VQNAMEYLNQ KSQTLKS 97
    Length:97
    Mass (Da):10,965
    Last modified:May 1, 2000 - v1
    Checksum:i9E65F23E1DDEB743
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ132003 mRNA. Translation: CAB61617.1.
    BC114735 mRNA. Translation: AAI14736.1.
    RefSeqiNP_991342.1. NM_205773.2.
    UniGeneiBt.24326.

    Genome annotation databases

    EnsembliENSBTAT00000005406; ENSBTAP00000005406; ENSBTAG00000004129.
    GeneIDi404072.
    KEGGibta:404072.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ132003 mRNA. Translation: CAB61617.1 .
    BC114735 mRNA. Translation: AAI14736.1 .
    RefSeqi NP_991342.1. NM_205773.2.
    UniGenei Bt.24326.

    3D structure databases

    ProteinModelPortali Q9TTS6.
    SMRi Q9TTS6. Positions 25-96.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q9TTS6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000005406 ; ENSBTAP00000005406 ; ENSBTAG00000004129 .
    GeneIDi 404072.
    KEGGi bta:404072.

    Organism-specific databases

    CTDi 6356.

    Phylogenomic databases

    GeneTreei ENSGT00730000110714.
    HOGENOMi HOG000036686.
    HOVERGENi HBG017871.
    InParanoidi Q9TTS6.
    KOi K16597.
    OMAi QSYRRIT.
    OrthoDBi EOG7C5MC2.
    TreeFami TF334888.

    Enzyme and pathway databases

    Reactomei REACT_212617. Chemokine receptors bind chemokines.

    Miscellaneous databases

    NextBioi 20817531.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Bovine eotaxin (CCL11) -- an unusual member of the eotaxin group --attracts eosinophils in vitro but is not responsible for eosinophilia in the ovary."
      Vogel B., Klinder A., Sittig D., Aust G.
      Vet. Immunol. Immunopathol. 107:67-77(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Uterus.

    Entry informationi

    Entry nameiCCL11_BOVIN
    AccessioniPrimary (citable) accession number: Q9TTS6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3