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Protein

Eotaxin

Gene

CCL11

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Attracts eosinophils in vitro but is not responsible for eosinophilia in the ovary.1 Publication

GO - Biological processi

  1. branching involved in mammary gland duct morphogenesis Source: Ensembl
  2. cytoskeleton organization Source: Ensembl
  3. eosinophil chemotaxis Source: Ensembl
  4. immune response Source: InterPro
  5. inflammatory response Source: UniProtKB-KW
  6. mammary duct terminal end bud growth Source: Ensembl
  7. positive regulation of actin filament polymerization Source: Ensembl
  8. positive regulation of angiogenesis Source: Ensembl
  9. positive regulation of cell migration Source: Ensembl
  10. positive regulation of endothelial cell proliferation Source: Ensembl
  11. positive regulation of Rac GTPase activity Source: Ensembl
  12. regulation of cell shape Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_321435. Chemokine receptors bind chemokines.

Names & Taxonomyi

Protein namesi
Recommended name:
Eotaxin
Alternative name(s):
C-C motif chemokine 11
Small-inducible cytokine A11
Gene namesi
Name:CCL11
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 19

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 9774EotaxinPRO_0000244408Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 57By similarity
Disulfide bondi33 ↔ 73By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ9TTS6.

Expressioni

Gene expression databases

ExpressionAtlasiQ9TTS6. baseline.

Structurei

3D structure databases

ProteinModelPortaliQ9TTS6.
SMRiQ9TTS6. Positions 25-96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiQ9TTS6.
KOiK16597.
OMAiGSKCPQK.
OrthoDBiEOG7C5MC2.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9TTS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVSAVLLCL LLTATLCSIQ VLAQPASIPT ICCFNMSKKK ISIQRLQSYR
60 70 80 90
KITSSKCPQK AVIFNTKQNK KICVDPQEKW VQNAMEYLNQ KSQTLKS
Length:97
Mass (Da):10,965
Last modified:April 30, 2000 - v1
Checksum:i9E65F23E1DDEB743
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132003 mRNA. Translation: CAB61617.1.
BC114735 mRNA. Translation: AAI14736.1.
RefSeqiNP_991342.1. NM_205773.2.
UniGeneiBt.24326.

Genome annotation databases

EnsembliENSBTAT00000005406; ENSBTAP00000005406; ENSBTAG00000004129.
GeneIDi404072.
KEGGibta:404072.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132003 mRNA. Translation: CAB61617.1.
BC114735 mRNA. Translation: AAI14736.1.
RefSeqiNP_991342.1. NM_205773.2.
UniGeneiBt.24326.

3D structure databases

ProteinModelPortaliQ9TTS6.
SMRiQ9TTS6. Positions 25-96.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ9TTS6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000005406; ENSBTAP00000005406; ENSBTAG00000004129.
GeneIDi404072.
KEGGibta:404072.

Organism-specific databases

CTDi6356.

Phylogenomic databases

GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiQ9TTS6.
KOiK16597.
OMAiGSKCPQK.
OrthoDBiEOG7C5MC2.
TreeFamiTF334888.

Enzyme and pathway databases

ReactomeiREACT_321435. Chemokine receptors bind chemokines.

Miscellaneous databases

NextBioi20817531.

Gene expression databases

ExpressionAtlasiQ9TTS6. baseline.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Bovine eotaxin (CCL11) -- an unusual member of the eotaxin group --attracts eosinophils in vitro but is not responsible for eosinophilia in the ovary."
    Vogel B., Klinder A., Sittig D., Aust G.
    Vet. Immunol. Immunopathol. 107:67-77(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Uterus.

Entry informationi

Entry nameiCCL11_BOVIN
AccessioniPrimary (citable) accession number: Q9TTS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2006
Last sequence update: April 30, 2000
Last modified: March 31, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.