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Protein

Eotaxin

Gene

CCL11

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Attracts eosinophils in vitro but is not responsible for eosinophilia in the ovary.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Eotaxin
Alternative name(s):
C-C motif chemokine 11
Small-inducible cytokine A11
Gene namesi
Name:CCL11
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000024440824 – 97EotaxinAdd BLAST74

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 57By similarity
Disulfide bondi33 ↔ 73By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9TTS6.
PRIDEiQ9TTS6.

Expressioni

Gene expression databases

BgeeiENSBTAG00000004129.
ExpressionAtlasiQ9TTS6. baseline.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005406.

Structurei

3D structure databases

ProteinModelPortaliQ9TTS6.
SMRiQ9TTS6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1ST. Eukaryota.
ENOG410YXJU. LUCA.
GeneTreeiENSGT00860000133690.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiQ9TTS6.
KOiK16597.
OMAiGSKCPQK.
OrthoDBiEOG091G14KV.
TreeFamiTF334888.

Family and domain databases

InterProiView protein in InterPro
IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
PfamiView protein in Pfam
PF00048. IL8. 1 hit.
SMARTiView protein in SMART
SM00199. SCY. 1 hit.
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiView protein in PROSITE
PS00472. SMALL_CYTOKINES_CC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9TTS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVSAVLLCL LLTATLCSIQ VLAQPASIPT ICCFNMSKKK ISIQRLQSYR
60 70 80 90
KITSSKCPQK AVIFNTKQNK KICVDPQEKW VQNAMEYLNQ KSQTLKS
Length:97
Mass (Da):10,965
Last modified:May 1, 2000 - v1
Checksum:i9E65F23E1DDEB743
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132003 mRNA. Translation: CAB61617.1.
BC114735 mRNA. Translation: AAI14736.1.
RefSeqiNP_991342.1. NM_205773.2.
UniGeneiBt.24326.

Genome annotation databases

EnsembliENSBTAT00000005406; ENSBTAP00000005406; ENSBTAG00000004129.
GeneIDi404072.
KEGGibta:404072.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132003 mRNA. Translation: CAB61617.1.
BC114735 mRNA. Translation: AAI14736.1.
RefSeqiNP_991342.1. NM_205773.2.
UniGeneiBt.24326.

3D structure databases

ProteinModelPortaliQ9TTS6.
SMRiQ9TTS6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005406.

Proteomic databases

PaxDbiQ9TTS6.
PRIDEiQ9TTS6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000005406; ENSBTAP00000005406; ENSBTAG00000004129.
GeneIDi404072.
KEGGibta:404072.

Organism-specific databases

CTDi6356.

Phylogenomic databases

eggNOGiENOG410J1ST. Eukaryota.
ENOG410YXJU. LUCA.
GeneTreeiENSGT00860000133690.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiQ9TTS6.
KOiK16597.
OMAiGSKCPQK.
OrthoDBiEOG091G14KV.
TreeFamiTF334888.

Gene expression databases

BgeeiENSBTAG00000004129.
ExpressionAtlasiQ9TTS6. baseline.

Family and domain databases

InterProiView protein in InterPro
IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
PfamiView protein in Pfam
PF00048. IL8. 1 hit.
SMARTiView protein in SMART
SM00199. SCY. 1 hit.
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiView protein in PROSITE
PS00472. SMALL_CYTOKINES_CC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCCL11_BOVIN
AccessioniPrimary (citable) accession number: Q9TTS6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: May 1, 2000
Last modified: March 15, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.