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Protein

COUP transcription factor 1

Gene

NR2F1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi84 – 15976Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri87 – 10721NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri123 – 14725NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
COUP transcription factor 1
Short name:
COUP-TF1
Alternative name(s):
COUP transcription factor I
Short name:
COUP-TF I
Nuclear receptor subfamily 2 group F member 1
Gene namesi
Name:NR2F1
Synonyms:TFCOUP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 424424COUP transcription factor 1PRO_0000053601Add
BLAST

Proteomic databases

PaxDbiQ9TTR8.
PRIDEiQ9TTR8.

Interactioni

Subunit structurei

Binds DNA as dimer; homodimer and probable heterodimer with NR2F6. Interacts with COPS2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi160099. 1 interaction.
STRINGi9913.ENSBTAP00000023401.

Structurei

3D structure databases

ProteinModelPortaliQ9TTR8.
SMRiQ9TTR8. Positions 85-165.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi32 – 387Poly-Gly
Compositional biasi40 – 445Poly-Gln

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri87 – 10721NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri123 – 14725NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
HOGENOMiHOG000260820.
HOVERGENiHBG005606.
InParanoidiQ9TTR8.
KOiK08547.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR003068. COUP_TF.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01282. COUPTNFACTOR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9TTR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMVVSSWRD PQDDVAGGNP GGPNPAAQAA RGGGGGAGEQ QQQQAGSGAP
60 70 80 90 100
HTPQTPGQPG APATPGTAGD KGQGPPGSGQ SQQHIECVVC GDKSSGKHYG
110 120 130 140 150
QFTCEGCKSF FKRSVRRNLT YTCRANRNCP IDQHHRNQCQ YCRLKKCLKV
160 170 180 190 200
GMRREAVQRG RMPPTQPNPG QYALTNGDPL NGHCYLSGYI SLLLRAEPYP
210 220 230 240 250
TSRYGSQCMQ PNNIMGIENI CELAARLLFS AVEWARNIPF FPDLQITDQV
260 270 280 290 300
SLLRLTWSEL FVLNAAQCSM PLHVAPLLAA AGLHASPMSA DRVVAFMDHI
310 320 330 340 350
RIFQEQVEKL KALHVDSAEY SCLKAIVLFT SDACGLSDAA HIESLQEKSQ
360 370 380 390 400
CALEEYVRSQ YPNQPSRFGK LLLRLPSLRT VSSSVIEQLF FVRLVGKTPI
410 420
ETLIRDMLLS GSSFNWPYMS IQCS
Length:424
Mass (Da):46,284
Last modified:May 1, 2000 - v1
Checksum:i21B1829462CD5982
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249440 mRNA. Translation: CAB55623.1.
PIRiJH0786.
RefSeqiNP_786998.1. NM_175804.2.
UniGeneiBt.543.

Genome annotation databases

GeneIDi327684.
KEGGibta:327684.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249440 mRNA. Translation: CAB55623.1.
PIRiJH0786.
RefSeqiNP_786998.1. NM_175804.2.
UniGeneiBt.543.

3D structure databases

ProteinModelPortaliQ9TTR8.
SMRiQ9TTR8. Positions 85-165.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi160099. 1 interaction.
STRINGi9913.ENSBTAP00000023401.

Proteomic databases

PaxDbiQ9TTR8.
PRIDEiQ9TTR8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi327684.
KEGGibta:327684.

Organism-specific databases

CTDi7025.

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
HOGENOMiHOG000260820.
HOVERGENiHBG005606.
InParanoidiQ9TTR8.
KOiK08547.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR003068. COUP_TF.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01282. COUPTNFACTOR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Walther N.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiCOT1_BOVIN
AccessioniPrimary (citable) accession number: Q9TTR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.