Reviewed, UniProtKB/Swiss-Prot Q9TTR7 (COT2_BOVIN)

Names and origin

Protein names

Recommended name:
    COUP transcription factor 2
      Short name=COUP-TF2
Alternative name(s):
    COUP transcription factor II
      Short name=COUP-TF II
    Nuclear receptor subfamily 2 group F member 2

Gene names

Name:	NR2F2
Synonyms:	TFCOUP2

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	414 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A By similarity.
Subunit structure	Binds DNA as a homodimer. Interacts with SQSTM1 By similarity.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the nuclear hormone receptor family. NR2 subfamily. Contains 1 nuclear receptor DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Receptor
Gene Ontology (GO)
Biological process	transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro steroid hormone receptor activity Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 414	414	COUP transcription factor 2		PRO_0000053605
Regions
	DNA binding	76 – 151	76	Nuclear receptor
	Zinc finger	79 – 99	21	NR C4-type
	Zinc finger	115 – 139	25	NR C4-type
	Region	337 – 414	78	Important for dimerization By similarity
	Compositional bias	71 – 75	5	Poly-Gln

Sequences

	Sequence		Length	Mass (Da)
	Q9TTR7-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: C24CB023C8A27F57	FASTA	414	45,557
	10 20 30 40 50 60 MAMVVSTWRD PQDEVPGSQG SQASQAPPVP GPPPGAPHTP QTPGQGGPAS TPAQTAAGGQ 70 80 90 100 110 120 GGPGGPGSDK QQQQQHIECV VCGDKSSGKH YGQFTCEGCK SFFKRSVRRN LSYTCRANRN 130 140 150 160 170 180 CPIDQHHRNQ CQYCRLKKCL KVGMRREAVQ RGRMPPTQPS HGQFALTNGD PLNCHSYLSG 190 200 210 220 230 240 YISLLLRAEP YPTSRFGSQC MQPNNIMGIE NICELAARML FSAVEWARNI PFFPDLQITD 250 260 270 280 290 300 QVALLRLTWS ELFVLNAAQC SMPLHVAPLL AAAGLHASPM SADRVVAFMD HIRIFQEQVE 310 320 330 340 350 360 KLKALHVDSA EYSCLKAIVL FTSDACGLSD VAHVESLQEK SQCALEEYVR SQYPNQPTRF 370 380 390 400 410 GKLLLRLPSL RTVSSSVIEQ LFFVRLVGKT PIETLIRDML LSGSSFNWPY MAIQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Walther N. Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Corpus luteum.
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Ascending colon.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ249441 mRNA. Translation: CAB55624.1. BC123677 mRNA. Translation: AAI23678.1.
IPI	IPI00695873.
PIR	JH0787.
RefSeq	NP_776827.1.
UniGene	Bt.53763
3D structure databases
SMR	Q9TTR7. Positions 77-157, 181-401.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9TTR7.
Genome annotation databases
Ensembl	ENSBTAT00000023969; ENSBTAP00000023969; ENSBTAG00000018007; Bos taurus. [Genome view]
GeneID	281945.
KEGG	bta:281945.
Organism-specific databases
CTD	281945.
Phylogenomic databases
eggNOG	maNOG09060.
HOVERGEN	Q9TTR7.
InParanoid	Q9TTR7.
OMA	KQPQHIE.
OrthoDB	EOG9RZ1JC.
Family and domain databases
InterPro	IPR003068. COUP_TF. IPR008946. Nucl_hormone_rcpt_ligand-bd. IPR000536. Nucl_hrmn_rcpt_lig-bd_core. IPR001723. Str_hrmn_rcpt. IPR013629. Znf_C4_C. IPR001628. Znf_hrmn_rcpt. IPR013088. Znf_NHR/GATA. [Graphical view]
Gene3D	G3DSA:1.10.565.10. Nucl_hrmn_rcpt_lig_bd. 1 hit. G3DSA:3.30.50.10. Znf_NHR/GATA. 1 hit.
Pfam	PF00104. Hormone_recep. 1 hit. PF00105. zf-C4. 1 hit. PF08420. zf-C4_C. 1 hit. [Graphical view]
PRINTS	PR01282. COUPTNFACTOR. PR00398. STRDHORMONER. PR00047. STROIDFINGER.
SMART	SM00430. HOLI. 1 hit. SM00399. ZnF_C4. 1 hit. [Graphical view]
PROSITE	PS00031. NUCLEAR_REC_DBD_1. 1 hit. PS51030. NUCLEAR_REC_DBD_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COT2_BOVIN

Accession

Primary (citable) accession number: Q9TTR7
Secondary accession number(s): Q08DL8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 2000
Last modified:	February 9, 2010
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)