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Protein

Probable G-protein coupled receptor 83

Gene

GPR83

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor. Could be a neuropeptide Y receptor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-CFA-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 83
Alternative name(s):
Glucocorticoid-induced receptor
Gene namesi
Name:GPR83
Synonyms:GIR
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 21

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 7054ExtracellularSequence analysisAdd
BLAST
Transmembranei71 – 9121Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini92 – 10615CytoplasmicSequence analysisAdd
BLAST
Transmembranei107 – 12822Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini129 – 14416ExtracellularSequence analysisAdd
BLAST
Transmembranei145 – 16622Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini167 – 18519CytoplasmicSequence analysisAdd
BLAST
Transmembranei186 – 20722Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini208 – 23730ExtracellularSequence analysisAdd
BLAST
Transmembranei238 – 25922Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini260 – 29233CytoplasmicSequence analysisAdd
BLAST
Transmembranei293 – 31422Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini315 – 32612ExtracellularSequence analysisAdd
BLAST
Transmembranei327 – 34721Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini348 – 42275CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Chaini17 – 422406Probable G-protein coupled receptor 83PRO_0000012802Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi37 – 371N-linked (GlcNAc...)Sequence analysis
Glycosylationi45 – 451N-linked (GlcNAc...)Sequence analysis
Glycosylationi133 – 1331N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9TTQ9.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000039807.

Structurei

3D structure databases

ProteinModelPortaliQ9TTQ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118781.
HOVERGENiHBG051819.
InParanoidiQ9TTQ9.
KOiK04210.
OMAiNENFRIE.
OrthoDBiEOG091G0YEQ.
TreeFamiTF315303.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01012. NRPEPTIDEYR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9TTQ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRRGALLCL LPLLRAAERP EGRADEPGLE AALAGPNASH FFWSNYSFSD
60 70 80 90 100
WQNFVGRRRY GAESQNPTVK ALLVVAYSFI IVFSLFGNVL VCHVIFKNQR
110 120 130 140 150
MRSATSLFIV NLAVADILIT LLNTPFTLVR FVNSTWVFGK GMCHVSRFAQ
160 170 180 190 200
YCSLHVSALT LTAIAVDRHQ VIMHPLKPRI SITKGVIYIT VIWTMATFFS
210 220 230 240 250
LPHAICQKLF TFKYSEDIVR SLCLPDFPEP ADLFWKYLDL ATFILLYILP
260 270 280 290 300
LLIISVAYAR VAKKLWLCNT IGDVTTEQYL ALRRKKKKTI KMLMLVVVLF
310 320 330 340 350
ALCWFPLNCY VLLLSSKVIH TNNALYFAFH WFAMSSTCYN PFIYCWLNEN
360 370 380 390 400
FRIELKALLS MCQRLPKPQE ERPPSPVPSF RVAWTEKSNG RRVPPANNLL
410 420
LSSHLHSGKT DLSSVEPIVA MS
Length:422
Mass (Da):48,043
Last modified:May 1, 2000 - v1
Checksum:iC9C21DE85B9DFB67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y19224 mRNA. Translation: CAB57795.1.
RefSeqiNP_001003108.1. NM_001003108.1.
UniGeneiCfa.3560.

Genome annotation databases

EnsembliENSCAFT00000049808; ENSCAFP00000039807; ENSCAFG00000031257.
GeneIDi403699.
KEGGicfa:403699.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y19224 mRNA. Translation: CAB57795.1.
RefSeqiNP_001003108.1. NM_001003108.1.
UniGeneiCfa.3560.

3D structure databases

ProteinModelPortaliQ9TTQ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000039807.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ9TTQ9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000049808; ENSCAFP00000039807; ENSCAFG00000031257.
GeneIDi403699.
KEGGicfa:403699.

Organism-specific databases

CTDi10888.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118781.
HOVERGENiHBG051819.
InParanoidiQ9TTQ9.
KOiK04210.
OMAiNENFRIE.
OrthoDBiEOG091G0YEQ.
TreeFamiTF315303.

Enzyme and pathway databases

ReactomeiR-CFA-418555. G alpha (s) signalling events.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01012. NRPEPTIDEYR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR83_CANLF
AccessioniPrimary (citable) accession number: Q9TTQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.