Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9TTQ4

- CCL11_HORSE

UniProt

Q9TTQ4 - CCL11_HORSE

Protein

Eotaxin

Gene

CCL11

Organism
Equus caballus (Horse)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3 By similarity.By similarity

    GO - Biological processi

    1. cell chemotaxis Source: GOC
    2. immune response Source: InterPro
    3. inflammatory response Source: UniProtKB-KW

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Eotaxin
    Alternative name(s):
    C-C motif chemokine 11
    Small-inducible cytokine A11
    Gene namesi
    Name:CCL11
    Synonyms:SCYA11
    OrganismiEquus caballus (Horse)
    Taxonomic identifieri9796 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
    ProteomesiUP000002281: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323By similarityAdd
    BLAST
    Chaini24 – 10077EotaxinPRO_0000005194Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi32 ↔ 57By similarity
    Disulfide bondi33 ↔ 73By similarity
    Glycosylationi94 – 941O-linked (GalNAc...)By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ9TTQ4.
    SMRiQ9TTQ4. Positions 25-96.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG017871.
    KOiK16597.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9TTQ4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVSAALLCL LLTTAAFSTQ VLAQPVSIST VCCFNVASRK ISFQRLQSYR    50
    KITSSKCPQK AVIFKTKQAK KICADPKQKW VQDAMKYLDE NSRTTKYSSF 100
    Length:100
    Mass (Da):11,247
    Last modified:May 1, 2000 - v1
    Checksum:i11F08EC00E75D50B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ251188 mRNA. Translation: CAB61624.1.
    RefSeqiNP_001075340.1. NM_001081871.1.
    UniGeneiEca.12655.

    Genome annotation databases

    GeneIDi100033949.
    KEGGiecb:100033949.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ251188 mRNA. Translation: CAB61624.1 .
    RefSeqi NP_001075340.1. NM_001081871.1.
    UniGenei Eca.12655.

    3D structure databases

    ProteinModelPortali Q9TTQ4.
    SMRi Q9TTQ4. Positions 25-96.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100033949.
    KEGGi ecb:100033949.

    Organism-specific databases

    CTDi 6356.

    Phylogenomic databases

    HOVERGENi HBG017871.
    KOi K16597.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of equine chemokines eotaxin, monocyte chemoattractant protein (MCP)-1, MCP-2 and MCP-4, mRNA expression in tissues and induction by IL-4 in dermal fibroblasts."
      Benarafa C., Cunningham F.M., Hamblin A.S., Horohov D.W., Collins M.E.
      Vet. Immunol. Immunopathol. 76:283-298(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCCL11_HORSE
    AccessioniPrimary (citable) accession number: Q9TTQ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3