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Q9TTQ3

- CCL2_HORSE

UniProt

Q9TTQ3 - CCL2_HORSE

Protein

C-C motif chemokine 2

Gene

CCL2

Organism
Equus caballus (Horse)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Chemotactic factor that attracts monocytes, but not neutrophils.By similarity

    GO - Biological processi

    1. cell chemotaxis Source: GOC
    2. immune response Source: InterPro
    3. inflammatory response Source: UniProtKB-KW

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 2
    Alternative name(s):
    Monocyte chemoattractant protein 1
    Monocyte chemotactic protein 1
    Short name:
    MCP-1
    Small-inducible cytokine A2
    Gene namesi
    Name:CCL2
    Synonyms:MCP1, SCYA2
    OrganismiEquus caballus (Horse)
    Taxonomic identifieri9796 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
    ProteomesiUP000002281: Chromosome 11

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 9976C-C motif chemokine 2PRO_0000005145Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei24 – 241Pyrrolidone carboxylic acidBy similarity
    Disulfide bondi34 ↔ 59By similarity
    Disulfide bondi35 ↔ 75By similarity

    Keywords - PTMi

    Disulfide bond, Pyrrolidone carboxylic acid

    Structurei

    3D structure databases

    ProteinModelPortaliQ9TTQ3.
    SMRiQ9TTQ3. Positions 24-98.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG140372.
    GeneTreeiENSGT00730000110714.
    HOGENOMiHOG000036686.
    HOVERGENiHBG017871.
    KOiK14624.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9TTQ3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVSAALLCL LLTAAAFSTQ VLAQPDAINS PVTCCYTFTG KKISSQRLGS   50
    YKRVTSSKCP KEAVIFKTIL AKEICADPEQ KWVQDAVKQL DKKAQTPKP 99
    Length:99
    Mass (Da):10,790
    Last modified:May 1, 2000 - v1
    Checksum:iBA1448F79F3423D2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ251189 mRNA. Translation: CAB61625.1.
    RefSeqiNP_001075400.1. NM_001081931.1.
    UniGeneiEca.580.

    Genome annotation databases

    EnsembliENSECAT00000025681; ENSECAP00000021376; ENSECAG00000023949.
    GeneIDi100034136.
    KEGGiecb:100034136.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ251189 mRNA. Translation: CAB61625.1 .
    RefSeqi NP_001075400.1. NM_001081931.1.
    UniGenei Eca.580.

    3D structure databases

    ProteinModelPortali Q9TTQ3.
    SMRi Q9TTQ3. Positions 24-98.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSECAT00000025681 ; ENSECAP00000021376 ; ENSECAG00000023949 .
    GeneIDi 100034136.
    KEGGi ecb:100034136.

    Organism-specific databases

    CTDi 6347.

    Phylogenomic databases

    eggNOGi NOG140372.
    GeneTreei ENSGT00730000110714.
    HOGENOMi HOG000036686.
    HOVERGENi HBG017871.
    KOi K14624.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of equine chemokines eotaxin, monocyte chemoattractant protein (MCP)-1, MCP-2 and MCP-4, mRNA expression in tissues and induction by IL-4 in dermal fibroblasts."
      Benarafa C., Cunningham F.M., Hamblin A.S., Horohov D.W., Collins M.E.
      Vet. Immunol. Immunopathol. 76:283-298(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.

    Entry informationi

    Entry nameiCCL2_HORSE
    AccessioniPrimary (citable) accession number: Q9TTQ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3