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Protein

C-C motif chemokine 2

Gene

CCL2

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Chemotactic factor that attracts monocytes, but not neutrophils.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 2
Alternative name(s):
Monocyte chemoattractant protein 1
Monocyte chemotactic protein 1
Short name:
MCP-1
Small-inducible cytokine A2
Gene namesi
Name:CCL2
Synonyms:MCP1, SCYA2
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Chromosome 11

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000000514524 – 99C-C motif chemokine 2Add BLAST76

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24Pyrrolidone carboxylic acidBy similarity1
Disulfide bondi34 ↔ 59By similarity
Disulfide bondi35 ↔ 75By similarity

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Expressioni

Gene expression databases

ExpressionAtlasiQ9TTQ3. differential.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ9TTQ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00860000133690.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiQ9TTQ3.
KOiK14624.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9TTQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVSAALLCL LLTAAAFSTQ VLAQPDAINS PVTCCYTFTG KKISSQRLGS
60 70 80 90
YKRVTSSKCP KEAVIFKTIL AKEICADPEQ KWVQDAVKQL DKKAQTPKP
Length:99
Mass (Da):10,790
Last modified:May 1, 2000 - v1
Checksum:iBA1448F79F3423D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251189 mRNA. Translation: CAB61625.1.
RefSeqiNP_001075400.1. NM_001081931.2.
UniGeneiEca.17895.
Eca.580.

Genome annotation databases

EnsembliENSECAT00000025681; ENSECAP00000021376; ENSECAG00000023949.
GeneIDi100034136.
KEGGiecb:100034136.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251189 mRNA. Translation: CAB61625.1.
RefSeqiNP_001075400.1. NM_001081931.2.
UniGeneiEca.17895.
Eca.580.

3D structure databases

ProteinModelPortaliQ9TTQ3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSECAT00000025681; ENSECAP00000021376; ENSECAG00000023949.
GeneIDi100034136.
KEGGiecb:100034136.

Organism-specific databases

CTDi6347.

Phylogenomic databases

GeneTreeiENSGT00860000133690.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiQ9TTQ3.
KOiK14624.

Gene expression databases

ExpressionAtlasiQ9TTQ3. differential.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCL2_HORSE
AccessioniPrimary (citable) accession number: Q9TTQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.