Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9TTQ3 (CCL2_HORSE) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 2
Alternative name(s):
Monocyte chemoattractant protein 1
Monocyte chemotactic protein 1
Short name=MCP-1
Small-inducible cytokine A2
Gene names
Name:CCL2
Synonyms:MCP1, SCYA2
OrganismEquus caballus (Horse) [Reference proteome]
Taxonomic identifier9796 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus

Protein attributes

Sequence length99 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Chemotactic factor that attracts monocytes, but not neutrophils By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
   Biological processChemotaxis
Inflammatory response
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
Pyrrolidone carboxylic acid
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell chemotaxis

Inferred from electronic annotation. Source: GOC

immune response

Inferred from electronic annotation. Source: InterPro

inflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 9976C-C motif chemokine 2
PRO_0000005145

Amino acid modifications

Modified residue241Pyrrolidone carboxylic acid By similarity
Disulfide bond34 ↔ 59 By similarity
Disulfide bond35 ↔ 75 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9TTQ3 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: BA1448F79F3423D2

FASTA9910,790
        10         20         30         40         50         60 
MKVSAALLCL LLTAAAFSTQ VLAQPDAINS PVTCCYTFTG KKISSQRLGS YKRVTSSKCP 

        70         80         90 
KEAVIFKTIL AKEICADPEQ KWVQDAVKQL DKKAQTPKP 

« Hide

References

[1]"Cloning of equine chemokines eotaxin, monocyte chemoattractant protein (MCP)-1, MCP-2 and MCP-4, mRNA expression in tissues and induction by IL-4 in dermal fibroblasts."
Benarafa C., Cunningham F.M., Hamblin A.S., Horohov D.W., Collins M.E.
Vet. Immunol. Immunopathol. 76:283-298(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lung.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ251189 mRNA. Translation: CAB61625.1.
RefSeqNP_001075400.1. NM_001081931.1.
UniGeneEca.580.

3D structure databases

ProteinModelPortalQ9TTQ3.
SMRQ9TTQ3. Positions 24-98.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSECAT00000025681; ENSECAP00000021376; ENSECAG00000023949.
GeneID100034136.
KEGGecb:100034136.

Organism-specific databases

CTD6347.

Phylogenomic databases

eggNOGNOG140372.
GeneTreeENSGT00730000110714.
HOGENOMHOG000036686.
HOVERGENHBG017871.
KOK14624.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCCL2_HORSE
AccessionPrimary (citable) accession number: Q9TTQ3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: May 1, 2000
Last modified: March 19, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families