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Q9TTQ3

- CCL2_HORSE

UniProt

Q9TTQ3 - CCL2_HORSE

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Protein
C-C motif chemokine 2
Gene
CCL2, MCP1, SCYA2
Organism
Equus caballus (Horse)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Chemotactic factor that attracts monocytes, but not neutrophils By similarity.

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. immune response Source: InterPro
  3. inflammatory response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 2
Alternative name(s):
Monocyte chemoattractant protein 1
Monocyte chemotactic protein 1
Short name:
MCP-1
Small-inducible cytokine A2
Gene namesi
Name:CCL2
Synonyms:MCP1, SCYA2
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
ProteomesiUP000002281: Chromosome 11

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 9976C-C motif chemokine 2
PRO_0000005145Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241Pyrrolidone carboxylic acid By similarity
Disulfide bondi34 ↔ 59 By similarity
Disulfide bondi35 ↔ 75 By similarity

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Structurei

3D structure databases

ProteinModelPortaliQ9TTQ3.
SMRiQ9TTQ3. Positions 24-98.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG140372.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
KOiK14624.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9TTQ3-1 [UniParc]FASTAAdd to Basket

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MKVSAALLCL LLTAAAFSTQ VLAQPDAINS PVTCCYTFTG KKISSQRLGS   50
YKRVTSSKCP KEAVIFKTIL AKEICADPEQ KWVQDAVKQL DKKAQTPKP 99
Length:99
Mass (Da):10,790
Last modified:May 1, 2000 - v1
Checksum:iBA1448F79F3423D2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ251189 mRNA. Translation: CAB61625.1.
RefSeqiNP_001075400.1. NM_001081931.1.
UniGeneiEca.580.

Genome annotation databases

EnsembliENSECAT00000025681; ENSECAP00000021376; ENSECAG00000023949.
GeneIDi100034136.
KEGGiecb:100034136.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ251189 mRNA. Translation: CAB61625.1 .
RefSeqi NP_001075400.1. NM_001081931.1.
UniGenei Eca.580.

3D structure databases

ProteinModelPortali Q9TTQ3.
SMRi Q9TTQ3. Positions 24-98.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSECAT00000025681 ; ENSECAP00000021376 ; ENSECAG00000023949 .
GeneIDi 100034136.
KEGGi ecb:100034136.

Organism-specific databases

CTDi 6347.

Phylogenomic databases

eggNOGi NOG140372.
GeneTreei ENSGT00730000110714.
HOGENOMi HOG000036686.
HOVERGENi HBG017871.
KOi K14624.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of equine chemokines eotaxin, monocyte chemoattractant protein (MCP)-1, MCP-2 and MCP-4, mRNA expression in tissues and induction by IL-4 in dermal fibroblasts."
    Benarafa C., Cunningham F.M., Hamblin A.S., Horohov D.W., Collins M.E.
    Vet. Immunol. Immunopathol. 76:283-298(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiCCL2_HORSE
AccessioniPrimary (citable) accession number: Q9TTQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: May 1, 2000
Last modified: March 19, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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