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Q9TTK8

- KCRU_BOVIN

UniProt

Q9TTK8 - KCRU_BOVIN

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Protein
Creatine kinase U-type, mitochondrial
Gene
CKMT1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa By similarity.

Catalytic activityi

ATP + creatine = ADP + phosphocreatine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei224 – 2241ATP By similarity
Binding sitei269 – 2691ATP By similarity
Binding sitei325 – 3251ATP By similarity
Binding sitei368 – 3681ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi161 – 1655ATP By similarity
Nucleotide bindingi353 – 3586ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. creatine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_207339. Creatine metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Creatine kinase U-type, mitochondrial (EC:2.7.3.2)
Alternative name(s):
Acidic-type mitochondrial creatine kinase
Short name:
Mia-CK
Ubiquitous mitochondrial creatine kinase
Short name:
U-MtCK
Gene namesi
Name:CKMT1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 21

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3939Mitochondrion By similarity
Add
BLAST
Chaini40 – 416377Creatine kinase U-type, mitochondrial
PRO_0000016589Add
BLAST

Proteomic databases

PaxDbiQ9TTK8.
PRIDEiQ9TTK8.

Interactioni

Subunit structurei

Exists as an octamer composed of four MTCK homodimers By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9TTK8.
SMRiQ9TTK8. Positions 39-412.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 13187Phosphagen kinase N-terminal
Add
BLAST
Domaini158 – 400243Phosphagen kinase C-terminal
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni40 – 6425Cardiolipin-binding By similarity
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG3869.
GeneTreeiENSGT00550000074561.
HOGENOMiHOG000232165.
HOVERGENiHBG001339.
InParanoidiQ9TTK8.
KOiK00933.
OMAiERHNGYN.
OrthoDBiEOG7XM2XW.
TreeFamiTF314214.

Family and domain databases

Gene3Di1.10.135.10. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR022415. ATP-guanido_PTrfase_AS.
IPR022414. ATP-guanido_PTrfase_cat.
IPR022413. ATP-guanido_PTrfase_N.
IPR014746. Gln_synth/guanido_kin_cat_dom.
[Graphical view]
PfamiPF00217. ATP-gua_Ptrans. 1 hit.
PF02807. ATP-gua_PtransN. 1 hit.
[Graphical view]
SUPFAMiSSF48034. SSF48034. 1 hit.
PROSITEiPS00112. PHOSPHAGEN_KINASE. 1 hit.
PS51510. PHOSPHAGEN_KINASE_C. 1 hit.
PS51509. PHOSPHAGEN_KINASE_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9TTK8-1 [UniParc]FASTAAdd to Basket

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MAGPFSRLLS ARPGLRLLAL AGAGSLAAGF LLRSEPVRAA SERRRLYPPS    50
AEYPDLRKHN NCMASHLTPA VYARLCDKTT PTGWTLDQCI QTGVDNPGHP 100
FIKTVGMVAG DEETYEVFAE LFDPVIQERH NGYDPRTMKH TTDLDASKIR 150
SGYFDERYVL SSRVRTGRSI RGLSLPPACT RAERREVERV VVDALSGLKG 200
DLAGRYYRLS EMTEAEQQQL IDDHFLFDKP VSPLLTAAGM ARDWPDARGI 250
WHNNEKSFLI WVNEEDHTRV ISMEKGGNMK KVFERFCRGL KEVERLIQER 300
GWEFMWNERL GYILTCPSNL GTGLRAGVHI KLPLLSKDSR FPKILENLRL 350
QKRGTGGVDT AATGSVFDIS NLDRLGKSEV ELVQLVIDGV NFLIDCERRL 400
ERGQDIRIPP PLPNKH 416
Length:416
Mass (Da):46,897
Last modified:May 1, 2000 - v1
Checksum:i283F2C9F49C9C176
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB003307 mRNA. Translation: BAA88431.1.
BC102422 mRNA. Translation: AAI02423.1.
RefSeqiNP_776700.1. NM_174275.2.
XP_005222173.1. XM_005222116.1.
XP_005222174.1. XM_005222117.1.
UniGeneiBt.49713.

Genome annotation databases

EnsembliENSBTAT00000009871; ENSBTAP00000009871; ENSBTAG00000007502.
GeneIDi281692.
KEGGibta:281692.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB003307 mRNA. Translation: BAA88431.1 .
BC102422 mRNA. Translation: AAI02423.1 .
RefSeqi NP_776700.1. NM_174275.2.
XP_005222173.1. XM_005222116.1.
XP_005222174.1. XM_005222117.1.
UniGenei Bt.49713.

3D structure databases

ProteinModelPortali Q9TTK8.
SMRi Q9TTK8. Positions 39-412.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q9TTK8.
PRIDEi Q9TTK8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000009871 ; ENSBTAP00000009871 ; ENSBTAG00000007502 .
GeneIDi 281692.
KEGGi bta:281692.

Organism-specific databases

CTDi 1159.

Phylogenomic databases

eggNOGi COG3869.
GeneTreei ENSGT00550000074561.
HOGENOMi HOG000232165.
HOVERGENi HBG001339.
InParanoidi Q9TTK8.
KOi K00933.
OMAi ERHNGYN.
OrthoDBi EOG7XM2XW.
TreeFami TF314214.

Enzyme and pathway databases

Reactomei REACT_207339. Creatine metabolism.

Miscellaneous databases

NextBioi 20805619.

Family and domain databases

Gene3Di 1.10.135.10. 1 hit.
3.30.590.10. 1 hit.
InterProi IPR022415. ATP-guanido_PTrfase_AS.
IPR022414. ATP-guanido_PTrfase_cat.
IPR022413. ATP-guanido_PTrfase_N.
IPR014746. Gln_synth/guanido_kin_cat_dom.
[Graphical view ]
Pfami PF00217. ATP-gua_Ptrans. 1 hit.
PF02807. ATP-gua_PtransN. 1 hit.
[Graphical view ]
SUPFAMi SSF48034. SSF48034. 1 hit.
PROSITEi PS00112. PHOSPHAGEN_KINASE. 1 hit.
PS51510. PHOSPHAGEN_KINASE_C. 1 hit.
PS51509. PHOSPHAGEN_KINASE_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Initiating ocular proteomics for cataloging bovine retinal proteins: microanalytical techniques permit the identification of proteins derived from a novel photoreceptor preparation."
    Komori N., Usukura J., Jackson K.W., Tobin S.L., Matsumoto H., Nishizawa Y.
    Exp. Eye Res. 69:195-212(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Retina.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiKCRU_BOVIN
AccessioniPrimary (citable) accession number: Q9TTK8
Secondary accession number(s): Q3ZCF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Mitochondrial creatine kinase binds cardiolipin By similarity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi