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Q9TTK8

- KCRU_BOVIN

UniProt

Q9TTK8 - KCRU_BOVIN

Protein

Creatine kinase U-type, mitochondrial

Gene

CKMT1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa By similarity.By similarity

    Catalytic activityi

    ATP + creatine = ADP + phosphocreatine.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei224 – 2241ATPPROSITE-ProRule annotation
    Binding sitei269 – 2691ATPPROSITE-ProRule annotation
    Binding sitei325 – 3251ATPPROSITE-ProRule annotation
    Binding sitei368 – 3681ATPPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi161 – 1655ATPPROSITE-ProRule annotation
    Nucleotide bindingi353 – 3586ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. creatine kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_207339. Creatine metabolism.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Creatine kinase U-type, mitochondrial (EC:2.7.3.2)
    Alternative name(s):
    Acidic-type mitochondrial creatine kinase
    Short name:
    Mia-CK
    Ubiquitous mitochondrial creatine kinase
    Short name:
    U-MtCK
    Gene namesi
    Name:CKMT1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 21

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3939MitochondrionBy similarityAdd
    BLAST
    Chaini40 – 416377Creatine kinase U-type, mitochondrialPRO_0000016589Add
    BLAST

    Proteomic databases

    PaxDbiQ9TTK8.
    PRIDEiQ9TTK8.

    Interactioni

    Subunit structurei

    Exists as an octamer composed of four MTCK homodimers.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9TTK8.
    SMRiQ9TTK8. Positions 39-412.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini45 – 13187Phosphagen kinase N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini158 – 400243Phosphagen kinase C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni40 – 6425Cardiolipin-bindingBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ATP:guanido phosphotransferase family.PROSITE-ProRule annotation
    Contains 1 phosphagen kinase C-terminal domain.PROSITE-ProRule annotation
    Contains 1 phosphagen kinase N-terminal domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG3869.
    GeneTreeiENSGT00550000074561.
    HOGENOMiHOG000232165.
    HOVERGENiHBG001339.
    InParanoidiQ9TTK8.
    KOiK00933.
    OMAiERHNGYN.
    OrthoDBiEOG7XM2XW.
    TreeFamiTF314214.

    Family and domain databases

    Gene3Di1.10.135.10. 1 hit.
    3.30.590.10. 1 hit.
    InterProiIPR022415. ATP-guanido_PTrfase_AS.
    IPR022414. ATP-guanido_PTrfase_cat.
    IPR022413. ATP-guanido_PTrfase_N.
    IPR014746. Gln_synth/guanido_kin_cat_dom.
    [Graphical view]
    PfamiPF00217. ATP-gua_Ptrans. 1 hit.
    PF02807. ATP-gua_PtransN. 1 hit.
    [Graphical view]
    SUPFAMiSSF48034. SSF48034. 1 hit.
    PROSITEiPS00112. PHOSPHAGEN_KINASE. 1 hit.
    PS51510. PHOSPHAGEN_KINASE_C. 1 hit.
    PS51509. PHOSPHAGEN_KINASE_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9TTK8-1 [UniParc]FASTAAdd to Basket

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    MAGPFSRLLS ARPGLRLLAL AGAGSLAAGF LLRSEPVRAA SERRRLYPPS    50
    AEYPDLRKHN NCMASHLTPA VYARLCDKTT PTGWTLDQCI QTGVDNPGHP 100
    FIKTVGMVAG DEETYEVFAE LFDPVIQERH NGYDPRTMKH TTDLDASKIR 150
    SGYFDERYVL SSRVRTGRSI RGLSLPPACT RAERREVERV VVDALSGLKG 200
    DLAGRYYRLS EMTEAEQQQL IDDHFLFDKP VSPLLTAAGM ARDWPDARGI 250
    WHNNEKSFLI WVNEEDHTRV ISMEKGGNMK KVFERFCRGL KEVERLIQER 300
    GWEFMWNERL GYILTCPSNL GTGLRAGVHI KLPLLSKDSR FPKILENLRL 350
    QKRGTGGVDT AATGSVFDIS NLDRLGKSEV ELVQLVIDGV NFLIDCERRL 400
    ERGQDIRIPP PLPNKH 416
    Length:416
    Mass (Da):46,897
    Last modified:May 1, 2000 - v1
    Checksum:i283F2C9F49C9C176
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB003307 mRNA. Translation: BAA88431.1.
    BC102422 mRNA. Translation: AAI02423.1.
    RefSeqiNP_776700.1. NM_174275.2.
    XP_005222173.1. XM_005222116.1.
    XP_005222174.1. XM_005222117.1.
    UniGeneiBt.49713.

    Genome annotation databases

    EnsembliENSBTAT00000009871; ENSBTAP00000009871; ENSBTAG00000007502.
    GeneIDi281692.
    KEGGibta:281692.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB003307 mRNA. Translation: BAA88431.1 .
    BC102422 mRNA. Translation: AAI02423.1 .
    RefSeqi NP_776700.1. NM_174275.2.
    XP_005222173.1. XM_005222116.1.
    XP_005222174.1. XM_005222117.1.
    UniGenei Bt.49713.

    3D structure databases

    ProteinModelPortali Q9TTK8.
    SMRi Q9TTK8. Positions 39-412.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q9TTK8.
    PRIDEi Q9TTK8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000009871 ; ENSBTAP00000009871 ; ENSBTAG00000007502 .
    GeneIDi 281692.
    KEGGi bta:281692.

    Organism-specific databases

    CTDi 1159.

    Phylogenomic databases

    eggNOGi COG3869.
    GeneTreei ENSGT00550000074561.
    HOGENOMi HOG000232165.
    HOVERGENi HBG001339.
    InParanoidi Q9TTK8.
    KOi K00933.
    OMAi ERHNGYN.
    OrthoDBi EOG7XM2XW.
    TreeFami TF314214.

    Enzyme and pathway databases

    Reactomei REACT_207339. Creatine metabolism.

    Miscellaneous databases

    NextBioi 20805619.

    Family and domain databases

    Gene3Di 1.10.135.10. 1 hit.
    3.30.590.10. 1 hit.
    InterProi IPR022415. ATP-guanido_PTrfase_AS.
    IPR022414. ATP-guanido_PTrfase_cat.
    IPR022413. ATP-guanido_PTrfase_N.
    IPR014746. Gln_synth/guanido_kin_cat_dom.
    [Graphical view ]
    Pfami PF00217. ATP-gua_Ptrans. 1 hit.
    PF02807. ATP-gua_PtransN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48034. SSF48034. 1 hit.
    PROSITEi PS00112. PHOSPHAGEN_KINASE. 1 hit.
    PS51510. PHOSPHAGEN_KINASE_C. 1 hit.
    PS51509. PHOSPHAGEN_KINASE_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Initiating ocular proteomics for cataloging bovine retinal proteins: microanalytical techniques permit the identification of proteins derived from a novel photoreceptor preparation."
      Komori N., Usukura J., Jackson K.W., Tobin S.L., Matsumoto H., Nishizawa Y.
      Exp. Eye Res. 69:195-212(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Retina.
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Ileum.

    Entry informationi

    Entry nameiKCRU_BOVIN
    AccessioniPrimary (citable) accession number: Q9TTK8
    Secondary accession number(s): Q3ZCF8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Mitochondrial creatine kinase binds cardiolipin.By similarity

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3