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Q9TTK0

- CDKL2_RABIT

UniProt

Q9TTK0 - CDKL2_RABIT

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Protein

Cyclin-dependent kinase-like 2

Gene

CDKL2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331ATPPROSITE-ProRule annotation
Active sitei126 – 1261Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase-like 2 (EC:2.7.11.22)
Alternative name(s):
Serine/threonine-protein kinase KKIAMRE
Gene namesi
Name:CDKL2
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 566566Cyclin-dependent kinase-like 2PRO_0000085818Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000002825.

Structurei

3D structure databases

ProteinModelPortaliQ9TTK0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 287284Protein kinasePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi45 – 517[NKR]KIAxRE

Domaini

The [NKR]KIAxRE motif seems to be a cyclin-binding region.

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
HOVERGENiHBG080204.
InParanoidiQ9TTK0.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9TTK0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKYENLGLV GEGSYGMVMK CRNKDSGRIV AIKKFLESDD DKMVKKIAMR
60 70 80 90 100
EIKLLKQLRH ENLVNLLEVC KKKKRWYLVF EFVDHTILDD LELFPNGLDD
110 120 130 140 150
QVVQKYLFQI INGIGFCHSH NIIHRDIKPE NILVSQSGVV KLCDFGFART
160 170 180 190 200
LAAPGEVYTD YVATRWYRAP ELLVGDVKYG KAVDVWAIGC LVTEMLMGEP
210 220 230 240 250
LFPGDSDIDQ LYLIMRCLGN LIPRHQELFY KNPVFAGVRL PEIKESEPLE
260 270 280 290 300
RRYPKLSEVV IDLAKKCLHV DPDKRPFCAE LLHHDFFQMD GFAERFSQEL
310 320 330 340 350
QMKVQKDARN ISLSKKSQNR KKEKEKDDSL GEERKTLVVQ DTNVDSKFKD
360 370 380 390 400
SKVFKIKGSK IDGEKVDKGN RAAVSMTVGP SHIKAVPSTS LRDCSNVSVD
410 420 430 440 450
HTRNPGMAIP PLTHNLSAVA PGINSGMGTI PGVQSYRVDE KTKKYCIPFV
460 470 480 490 500
KPNKHSPSGI YNMNVTTSVS SEKNLLQANK KRGEYSKTDV RLPELNYNHL
510 520 530 540 550
PELRALEGIA RNSRLIRKEN KILSESRIPS LAAIDLHTPN IAVHQVSGSP
560
LSDGSEADSP WMEHQH
Length:566
Mass (Da):64,053
Last modified:May 1, 2000 - v1
Checksum:i5D57595550902EA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029045 mRNA. Translation: BAA88508.1.
RefSeqiNP_001075468.1. NM_001081999.1.
UniGeneiOcu.2407.

Genome annotation databases

GeneIDi100008614.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029045 mRNA. Translation: BAA88508.1 .
RefSeqi NP_001075468.1. NM_001081999.1.
UniGenei Ocu.2407.

3D structure databases

ProteinModelPortali Q9TTK0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9986.ENSOCUP00000002825.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100008614.

Organism-specific databases

CTDi 8999.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000233024.
HOVERGENi HBG080204.
InParanoidi Q9TTK0.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Learning induces a CDC2-related protein kinase, KKIAMRE."
    Gomi H., Sun W., Finch C.E., Itohara S., Yoshimi K., Thompson R.F.
    J. Neurosci. 19:9530-9537(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCDKL2_RABIT
AccessioniPrimary (citable) accession number: Q9TTK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3