Q9TTK0 (CDKL2_RABIT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cyclin-dependent kinase-like 2
EC=2.7.11.22

Alternative name(s):
Serine/threonine-protein kinase KKIAMRE

Gene names

Name:

CDKL2

Organism

Oryctolagus cuniculus (Rabbit) [Reference proteome]

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	566 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subcellular location	Cytoplasm. Nucleus.
Domain	The [NKR]KIAxRE motif seems to be a cyclin-binding region.
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: GOC
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cyclin-dependent protein serine/threonine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 566	566	Cyclin-dependent kinase-like 2		PRO_0000085818
Regions
	Domain	4 – 287	284	Protein kinase
	Nucleotide binding	10 – 18	9	ATP By similarity
	Motif	45 – 51	7	[NKR]KIAxRE
Sites
	Active site	126	1	Proton acceptor By similarity
	Binding site	33	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9TTK0 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 5D57595550902EA9	FASTA	566	64,053
	10 20 30 40 50 60 MEKYENLGLV GEGSYGMVMK CRNKDSGRIV AIKKFLESDD DKMVKKIAMR EIKLLKQLRH 70 80 90 100 110 120 ENLVNLLEVC KKKKRWYLVF EFVDHTILDD LELFPNGLDD QVVQKYLFQI INGIGFCHSH 130 140 150 160 170 180 NIIHRDIKPE NILVSQSGVV KLCDFGFART LAAPGEVYTD YVATRWYRAP ELLVGDVKYG 190 200 210 220 230 240 KAVDVWAIGC LVTEMLMGEP LFPGDSDIDQ LYLIMRCLGN LIPRHQELFY KNPVFAGVRL 250 260 270 280 290 300 PEIKESEPLE RRYPKLSEVV IDLAKKCLHV DPDKRPFCAE LLHHDFFQMD GFAERFSQEL 310 320 330 340 350 360 QMKVQKDARN ISLSKKSQNR KKEKEKDDSL GEERKTLVVQ DTNVDSKFKD SKVFKIKGSK 370 380 390 400 410 420 IDGEKVDKGN RAAVSMTVGP SHIKAVPSTS LRDCSNVSVD HTRNPGMAIP PLTHNLSAVA 430 440 450 460 470 480 PGINSGMGTI PGVQSYRVDE KTKKYCIPFV KPNKHSPSGI YNMNVTTSVS SEKNLLQANK 490 500 510 520 530 540 KRGEYSKTDV RLPELNYNHL PELRALEGIA RNSRLIRKEN KILSESRIPS LAAIDLHTPN 550 560 IAVHQVSGSP LSDGSEADSP WMEHQH

References

[1]	"Learning induces a CDC2-related protein kinase, KKIAMRE." Gomi H., Sun W., Finch C.E., Itohara S., Yoshimi K., Thompson R.F. J. Neurosci. 19:9530-9537(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB029045 mRNA. Translation: BAA88508.1.
RefSeq	NP_001075468.1. NM_001081999.1.
UniGene	Ocu.2407.
3D structure databases
ProteinModelPortal	Q9TTK0.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100008614.
Organism-specific databases
CTD	8999.
Phylogenomic databases
eggNOG	COG0515.
HOGENOM	HOG000233024.
HOVERGEN	HBG080204.
OrthoDB	EOG4X0MS0.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDKL2_RABIT

Accession

Primary (citable) accession number: Q9TTK0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program