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Protein

Cyclin-dependent kinase-like 2

Gene

CDKL2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATPPROSITE-ProRule annotation1
Active sitei126Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase-like 2By similarity (EC:2.7.11.22)
Alternative name(s):
Serine/threonine-protein kinase KKIAMRE
Gene namesi
Name:CDKL2By similarity
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000858181 – 566Cyclin-dependent kinase-like 2Add BLAST566

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000002825

Structurei

3D structure databases

ProteinModelPortaliQ9TTK0
SMRiQ9TTK0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 287Protein kinasePROSITE-ProRule annotationAdd BLAST284

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi45 – 51[NKR]KIAxRE7

Domaini

The [NKR]KIAxRE motif seems to be a cyclin-binding region.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0593 Eukaryota
ENOG410XNSW LUCA
HOGENOMiHOG000233024
HOVERGENiHBG080204
InParanoidiQ9TTK0
KOiK08824

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q9TTK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKYENLGLV GEGSYGMVMK CRNKDSGRIV AIKKFLESDD DKMVKKIAMR
60 70 80 90 100
EIKLLKQLRH ENLVNLLEVC KKKKRWYLVF EFVDHTILDD LELFPNGLDD
110 120 130 140 150
QVVQKYLFQI INGIGFCHSH NIIHRDIKPE NILVSQSGVV KLCDFGFART
160 170 180 190 200
LAAPGEVYTD YVATRWYRAP ELLVGDVKYG KAVDVWAIGC LVTEMLMGEP
210 220 230 240 250
LFPGDSDIDQ LYLIMRCLGN LIPRHQELFY KNPVFAGVRL PEIKESEPLE
260 270 280 290 300
RRYPKLSEVV IDLAKKCLHV DPDKRPFCAE LLHHDFFQMD GFAERFSQEL
310 320 330 340 350
QMKVQKDARN ISLSKKSQNR KKEKEKDDSL GEERKTLVVQ DTNVDSKFKD
360 370 380 390 400
SKVFKIKGSK IDGEKVDKGN RAAVSMTVGP SHIKAVPSTS LRDCSNVSVD
410 420 430 440 450
HTRNPGMAIP PLTHNLSAVA PGINSGMGTI PGVQSYRVDE KTKKYCIPFV
460 470 480 490 500
KPNKHSPSGI YNMNVTTSVS SEKNLLQANK KRGEYSKTDV RLPELNYNHL
510 520 530 540 550
PELRALEGIA RNSRLIRKEN KILSESRIPS LAAIDLHTPN IAVHQVSGSP
560
LSDGSEADSP WMEHQH
Length:566
Mass (Da):64,053
Last modified:May 1, 2000 - v1
Checksum:i5D57595550902EA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029045 mRNA Translation: BAA88508.1
RefSeqiNP_001075468.1, NM_001081999.1
UniGeneiOcu.2407

Genome annotation databases

GeneIDi100008614
KEGGiocu:100008614

Similar proteinsi

Entry informationi

Entry nameiCDKL2_RABIT
AccessioniPrimary (citable) accession number: Q9TTK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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