PROP1

Functionⁱ

Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	69 – 128	HomeoboxPROSITE-ProRule annotationAdd BLAST		60

GO - Molecular functionⁱ

beta-catenin binding Source: Ensembl
chromatin binding Source: Ensembl
protein C-terminus binding Source: Ensembl
RNA polymerase II distal enhancer sequence-specific DNA binding Source: Ensembl
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding Source: Ensembl
transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding Source: Ensembl

Complete GO annotation...

GO - Biological processⁱ

blood vessel development Source: Ensembl
canonical Wnt signaling pathway Source: Ensembl
cell migration Source: Ensembl
dorsal/ventral pattern formation Source: Ensembl
hypophysis morphogenesis Source: Ensembl
hypothalamus cell differentiation Source: Ensembl
negative regulation of apoptotic process Source: Ensembl
somatotropin secreting cell differentiation Source: Ensembl

Complete GO annotation...

Keywordsⁱ

Molecular function	DNA-binding

Molecular function

DNA-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Homeobox protein prophet of Pit-1 Short name: PROP-1 Alternative name(s): Pituitary-specific homeodomain factor
Gene namesⁱ	Name:PROP1
Organismⁱ	Canis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifierⁱ	9615 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › Canis lupus
Proteomesⁱ	UP000002254 Componentⁱ: Chromosome 11

Subcellular locationⁱ

Nucleus
PROSITE-ProRule annotation
Manual assertion according to rulesⁱ
- PROSITE-ProRule:PRU00108

GO - Cellular componentⁱ

nucleus Source: UniProtKB-SubCell
transcription factor complex Source: Ensembl

Complete GO annotation...

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000049268	1 – 226	Homeobox protein prophet of Pit-1Add BLAST		226

Proteomic databases

PaxDbⁱ	Q9TTD8.

PaxDbⁱ

Q9TTD8.

Interactionⁱ

GO - Molecular functionⁱ

beta-catenin binding Source: Ensembl
protein C-terminus binding Source: Ensembl

Complete GO annotation...

Protein-protein interaction databases

STRINGⁱ	9615.ENSCAFP00000000382.

STRINGⁱ

9615.ENSCAFP00000000382.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9TTD8.
SMRⁱ	Q9TTD8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the paired homeobox family.Curated

Keywords - Domainⁱ

Homeobox

Phylogenomic databases

eggNOGⁱ	KOG0490. Eukaryota. ENOG410YIJ3. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00860000133740.
HOGENOMⁱ	HOG000115706.
HOVERGENⁱ	HBG053691.
InParanoidⁱ	Q9TTD8.
KEGG Orthology (KO) More...KOⁱ	K09327.
OMAⁱ	TCFPHPY.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0R1U.
TreeFamⁱ	TF315976.

Family and domain databases

InterProⁱ	View protein in InterPro IPR009057. Homeobox-like. IPR017970. Homeobox_CS. IPR001356. Homeobox_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046. Homeobox. 1 hit.
SMARTⁱ	View protein in SMART SM00389. HOX. 1 hit.
SUPFAMⁱ	SSF46689. SSF46689. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9TTD8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEAEGRSERG KQKKGRLCGS LWPDSYPAAG TLTSTVDVSP QPSKNLSGVG 
        60         70         80         90        100
VRRPRLSPQG GQRGRLHSRR RHRTTFNPGQ LEQLETAFGR NQYPDIWARE 
       110        120        130        140        150
GLARDTGLSE ARIQVWFQNR RAKQRKQERS LLQPLAHLSP ATFSGFLPES 
       160        170        180        190        200
PACPYSYPTP PPPMTCFPHP YNHALPSQPS TGGSFARPHQ SEDWYPTLHP 
       210        220 
PPTGHLPCPP PPTMLPLSLE PPKSWN

Length:226

Mass (Da):25,205

Last modified:May 1, 2000 - v1

Checksum:ⁱ650DD02B49F405B7

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF126157 Genomic DNA. Translation: AAF23266.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001018643.1. NM_001020807.1.
UniGeneⁱ	Cfa.24675.

Genome annotation databases

Ensemblⁱ	ENSCAFT00000000419; ENSCAFP00000000382; ENSCAFG00000000268.
GeneIDⁱ	474647.
KEGGⁱ	cfa:474647.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF126157 Genomic DNA. Translation: AAF23266.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001018643.1. NM_001020807.1.
UniGeneⁱ	Cfa.24675.

3D structure databases

ProteinModelPortalⁱ	Q9TTD8.
SMRⁱ	Q9TTD8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9615.ENSCAFP00000000382.

STRINGⁱ

9615.ENSCAFP00000000382.

Proteomic databases

PaxDbⁱ	Q9TTD8.

PaxDbⁱ

Q9TTD8.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSCAFT00000000419; ENSCAFP00000000382; ENSCAFG00000000268.
GeneIDⁱ	474647.
KEGGⁱ	cfa:474647.

Organism-specific databases

CTDⁱ	5626.

CTDⁱ

5626.

Phylogenomic databases

eggNOGⁱ	KOG0490. Eukaryota. ENOG410YIJ3. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00860000133740.
HOGENOMⁱ	HOG000115706.
HOVERGENⁱ	HBG053691.
InParanoidⁱ	Q9TTD8.
KEGG Orthology (KO) More...KOⁱ	K09327.
OMAⁱ	TCFPHPY.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0R1U.
TreeFamⁱ	TF315976.

Family and domain databases

InterProⁱ	View protein in InterPro IPR009057. Homeobox-like. IPR017970. Homeobox_CS. IPR001356. Homeobox_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046. Homeobox. 1 hit.
SMARTⁱ	View protein in SMART SM00389. HOX. 1 hit.
SUPFAMⁱ	SSF46689. SSF46689. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PROP1_CANLF
Accessionⁱ	Q9TTD8Primary (citable) accession number: Q9TTD8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
	Last sequence update:	May 1, 2000
	Last modified:	June 7, 2017
	This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9TTD8 (PROP1_CANLF)

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Homeobox protein prophet of Pit-1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ