UniProtKB - Q9TTD8 (PROP1_CANLF)
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Protein
Homeobox protein prophet of Pit-1
Gene
PROP1
Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Functioni
Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 69 – 128 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- beta-catenin binding Source: Ensembl
- chromatin binding Source: Ensembl
- protein C-terminus binding Source: Ensembl
- RNA polymerase II distal enhancer sequence-specific DNA binding Source: Ensembl
- transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding Source: Ensembl
- transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding Source: Ensembl
GO - Biological processi
- blood vessel development Source: Ensembl
- canonical Wnt signaling pathway Source: Ensembl
- cell migration Source: Ensembl
- dorsal/ventral pattern formation Source: Ensembl
- hypophysis morphogenesis Source: Ensembl
- hypothalamus cell differentiation Source: Ensembl
- negative regulation of apoptotic process Source: Ensembl
- somatotropin secreting cell differentiation Source: Ensembl
Keywordsi
Molecular function | DNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein prophet of Pit-1Short name: PROP-1 Alternative name(s): Pituitary-specific homeodomain factor |
Gene namesi | Name:PROP1 |
Organismi | Canis lupus familiaris (Dog) (Canis familiaris) |
Taxonomic identifieri | 9615 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:45014. PROP1. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000049268 | 1 – 226 | Homeobox protein prophet of Pit-1Add BLAST | 226 |
Proteomic databases
PaxDbi | Q9TTD8. |
Interactioni
GO - Molecular functioni
- beta-catenin binding Source: Ensembl
- protein C-terminus binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 9615.ENSCAFP00000000382. |
Structurei
3D structure databases
ProteinModelPortali | Q9TTD8. |
SMRi | Q9TTD8. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the paired homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0490. Eukaryota. ENOG410YIJ3. LUCA. |
GeneTreei | ENSGT00860000133740. |
HOGENOMi | HOG000115706. |
HOVERGENi | HBG053691. |
InParanoidi | Q9TTD8. |
KOi | K09327. |
OMAi | TCFPHPY. |
OrthoDBi | EOG091G0R1U. |
TreeFami | TF315976. |
Family and domain databases
CDDi | cd00086. homeodomain. 1 hit. |
InterProi | View protein in InterPro IPR009057. Homeobox-like_sf. IPR017970. Homeobox_CS. IPR001356. Homeobox_dom. |
Pfami | View protein in Pfam PF00046. Homeobox. 1 hit. |
SMARTi | View protein in SMART SM00389. HOX. 1 hit. |
SUPFAMi | SSF46689. SSF46689. 1 hit. |
PROSITEi | View protein in PROSITE PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q9TTD8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEAEGRSERG KQKKGRLCGS LWPDSYPAAG TLTSTVDVSP QPSKNLSGVG
60 70 80 90 100
VRRPRLSPQG GQRGRLHSRR RHRTTFNPGQ LEQLETAFGR NQYPDIWARE
110 120 130 140 150
GLARDTGLSE ARIQVWFQNR RAKQRKQERS LLQPLAHLSP ATFSGFLPES
160 170 180 190 200
PACPYSYPTP PPPMTCFPHP YNHALPSQPS TGGSFARPHQ SEDWYPTLHP
210 220
PPTGHLPCPP PPTMLPLSLE PPKSWN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF126157 Genomic DNA. Translation: AAF23266.1. |
RefSeqi | NP_001018643.1. NM_001020807.1. |
UniGenei | Cfa.24675. |
Genome annotation databases
Ensembli | ENSCAFT00000000419; ENSCAFP00000000382; ENSCAFG00000000268. |
GeneIDi | 474647. |
KEGGi | cfa:474647. |
Similar proteinsi
Entry informationi
Entry namei | PROP1_CANLF | |
Accessioni | Q9TTD8Primary (citable) accession number: Q9TTD8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2005 |
Last sequence update: | May 1, 2000 | |
Last modified: | March 28, 2018 | |
This is version 101 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |