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Protein

Homeobox protein prophet of Pit-1

Gene

PROP1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi69 – 128HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein prophet of Pit-1
Short name:
PROP-1
Alternative name(s):
Pituitary-specific homeodomain factor
Gene namesi
Name:PROP1
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 11

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000492681 – 226Homeobox protein prophet of Pit-1Add BLAST226

Proteomic databases

PaxDbiQ9TTD8.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000000382.

Structurei

3D structure databases

ProteinModelPortaliQ9TTD8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the paired homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
GeneTreeiENSGT00860000133740.
HOGENOMiHOG000115706.
HOVERGENiHBG053691.
InParanoidiQ9TTD8.
KOiK09327.
OMAiCFPHPYN.
OrthoDBiEOG091G0R1U.
TreeFamiTF315976.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9TTD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAEGRSERG KQKKGRLCGS LWPDSYPAAG TLTSTVDVSP QPSKNLSGVG
60 70 80 90 100
VRRPRLSPQG GQRGRLHSRR RHRTTFNPGQ LEQLETAFGR NQYPDIWARE
110 120 130 140 150
GLARDTGLSE ARIQVWFQNR RAKQRKQERS LLQPLAHLSP ATFSGFLPES
160 170 180 190 200
PACPYSYPTP PPPMTCFPHP YNHALPSQPS TGGSFARPHQ SEDWYPTLHP
210 220
PPTGHLPCPP PPTMLPLSLE PPKSWN
Length:226
Mass (Da):25,205
Last modified:May 1, 2000 - v1
Checksum:i650DD02B49F405B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126157 Genomic DNA. Translation: AAF23266.1.
RefSeqiNP_001018643.1. NM_001020807.1.
UniGeneiCfa.24675.

Genome annotation databases

EnsembliENSCAFT00000000419; ENSCAFP00000000382; ENSCAFG00000000268.
GeneIDi474647.
KEGGicfa:474647.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126157 Genomic DNA. Translation: AAF23266.1.
RefSeqiNP_001018643.1. NM_001020807.1.
UniGeneiCfa.24675.

3D structure databases

ProteinModelPortaliQ9TTD8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000000382.

Proteomic databases

PaxDbiQ9TTD8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000000419; ENSCAFP00000000382; ENSCAFG00000000268.
GeneIDi474647.
KEGGicfa:474647.

Organism-specific databases

CTDi5626.

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
GeneTreeiENSGT00860000133740.
HOGENOMiHOG000115706.
HOVERGENiHBG053691.
InParanoidiQ9TTD8.
KOiK09327.
OMAiCFPHPYN.
OrthoDBiEOG091G0R1U.
TreeFamiTF315976.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPROP1_CANLF
AccessioniPrimary (citable) accession number: Q9TTD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.