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Protein
Submitted name:

N-type calcium channel alpha1B subunit

Gene

CACNA1B

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Calcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotationSAAS annotation

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Submitted name:
N-type calcium channel alpha1B subunitImported
Gene namesi
Name:CACNA1BImported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei97 – 11418HelicalSequence analysisAdd
BLAST
Transmembranei135 – 15622HelicalSequence analysisAdd
BLAST
Transmembranei168 – 18821HelicalSequence analysisAdd
BLAST
Transmembranei223 – 24523HelicalSequence analysisAdd
BLAST
Transmembranei300 – 32122HelicalSequence analysisAdd
BLAST
Transmembranei333 – 35523HelicalSequence analysisAdd
BLAST
Transmembranei484 – 50421HelicalSequence analysisAdd
BLAST
Transmembranei510 – 52718HelicalSequence analysisAdd
BLAST
Transmembranei548 – 56619HelicalSequence analysisAdd
BLAST
Transmembranei609 – 63123HelicalSequence analysisAdd
BLAST
Transmembranei687 – 70923HelicalSequence analysisAdd
BLAST
Transmembranei1144 – 116219HelicalSequence analysisAdd
BLAST
Transmembranei1182 – 120221HelicalSequence analysisAdd
BLAST
Transmembranei1214 – 123219HelicalSequence analysisAdd
BLAST
Transmembranei1275 – 129723HelicalSequence analysisAdd
BLAST
Transmembranei1387 – 141226HelicalSequence analysisAdd
BLAST
Transmembranei1468 – 148619HelicalSequence analysisAdd
BLAST
Transmembranei1498 – 152124HelicalSequence analysisAdd
BLAST
Transmembranei1533 – 155725HelicalSequence analysisAdd
BLAST
Transmembranei1578 – 160730HelicalSequence analysisAdd
BLAST
Transmembranei1676 – 169924HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ9TTA4.
PRIDEiQ9TTA4.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000045932.

Structurei

3D structure databases

ProteinModelPortaliQ9TTA4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1715 – 175036EF-handInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili712 – 73827Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG2301. Eukaryota.
ENOG410XNP6. LUCA.
HOVERGENiHBG050763.
KOiK04849.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR002048. EF_hand_dom.
IPR031649. GPHH_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005447. VDCC_N_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF161. PTHR10037:SF161. 3 hits.
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF16905. GPHH. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01631. NVDCCALPHA1.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]
PROSITEiPS50222. EF_HAND_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9TTA4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRFGDELGG RYGGPGGGER ARGGGAGVAG GPGPGGLQPG QRVLYKQSIA
60 70 80 90 100
QRARTMALYN PIPVKQNCFT VNRSLFVFSE DNVVRKYAKR ITEWPPFEYM
110 120 130 140 150
ILATIIANCI VLALEQHLPD GDKTPMSERL DDTEPYFIGI FCFEAGIKII
160 170 180 190 200
ALGFVLHKGS YLRNGWNVMD FVVVLTGILA TAGTDFDLRT LRAVRVLRPL
210 220 230 240 250
KLVSGIPSLQ VVLKSIMKAM VPLLQIGLLL FFAILMFAII GLEFYMGKFH
260 270 280 290 300
KACFPNSTDA DPVGDFPCGR EAPARLCEGD TECREYWAGP NFGITNFDNI
310 320 330 340 350
LFAILTVFQC ITMEGWTDIL YNTNDAAGNT WNWLYFLPLI IIGSFFMLNL
360 370 380 390 400
VLGVLSGEFA KERERVENRR AFLKLRRQQQ IERELNGYLE WIFKAEEVML
410 420 430 440 450
AEEDKNAEEK SPLDVLKRAA TKKSRNDLIH AEEGEDRFAD LCAVGSPFAR
460 470 480 490 500
ASLKSGKTES SSYFRRKEKM FRFFIRRLVK AQSFYWVVLC VVALNTLCVA
510 520 530 540 550
MVHYQQPQRL TTALYFAEFV FLGLFLTEMS LKMYGLGPRS YFRSSFNCFD
560 570 580 590 600
FGVIVGSIFE VVWAAIKPGT SFGISVLRAL RLLRIFKVTK YWSSLRNLVV
610 620 630 640 650
SLLNSMKSII SLLFLLFLFI VVFALLGMQL FGGQFNFQDE TPTTNFDTFP
660 670 680 690 700
AAILTVFQIL TGEDWNAVMY HGIESQGGVS KGMFSSVYFI VLTLFGNYTL
710 720 730 740 750
LNVFLAIAVD NLANAQELTK DEEEMEEAAN QKLALQKAKE VAEVSPMSAA
760 770 780 790 800
NISIAARQQN SAKARSVWEQ RASQLRLQNL RASCEALYSE MDPEERLRFA
810 820 830 840 850
TSRHLRPDMK THLDRPLVVE PGRDGARGPA GGKARPEGGE AGEGADPPRR
860 870 880 890 900
HHRHRDRDRD KAAAPAGEPD RADAPKAEGG EPGAREERAR PRRSRSKEAA
910 920 930 940 950
GPREARSERG RGLGPDGGRR HHRRGSPEEA AEREPRRHRA HRHAPEPSRE
960 970 980 990 1000
GAPGSKGERR ARHRGGSRAG PREAESGEEP SRRHRARHKA PPAHEEAEKE
1010 1020 1030 1040 1050
AEAEDRDKEP RNHQPRESHC DLEASVVIGV GPVHALPSTC LEKVEEQPED
1060 1070 1080 1090 1100
ADNQRNVTRM GSQPSDLSTA VRIPVTLTGP PGETTVVPSG NVDLESQAEG
1110 1120 1130 1140 1150
KKEVEADDVM RSGPRPIVPY SSMFCLSPTN LLRRFCHYIV TMQYFEMVIL
1160 1170 1180 1190 1200
VVIALSSIAL AAEDPVQTDS PRNNVLKYMD YIFTGVFTFE MVIKMIDLGL
1210 1220 1230 1240 1250
LLHPGAYFRD LWNILDFIVV SGALVAFAFS GSKGKDISTI KSLRVLRVLR
1260 1270 1280 1290 1300
PLKTIKRLPK LKAVFDCVVN SLKNVLNILI VYMLFMFIFA VIAVQLFKGK
1310 1320 1330 1340 1350
FFYCTDESKE LERDCRGQYL DYEKEEVEAQ PRQWKKYDFH YDNVLWALLT
1360 1370 1380 1390 1400
LFTVSTGEGW PMVLKHSVDA TYEEQGPSPG FRMELSIFYV VYFVVFPFFF
1410 1420 1430 1440 1450
VNIFVALIII TFQEQGDKVM SECSLEKNER ACIDFAISAK PLTRYMPQNK
1460 1470 1480 1490 1500
QSFQYKTWTF VVSPPFEYFI MAMIALNTVV LMMKFYDAPY EYELMLKCLN
1510 1520 1530 1540 1550
IVFTSMFSME CVLKVIAFGV LNYFRDAWNV FDFVTVLGSI TDILVTEIAN
1560 1570 1580 1590 1600
NFINLSFLRL FRAARLIKLL RQGYTIRILL WTFVQSFKAL PYVCLLIAML
1610 1620 1630 1640 1650
FFIYAIIGMQ VFGNIALDDD TSINRHNNFR TFLQALMLLF RSATGEAWHE
1660 1670 1680 1690 1700
IMLSCLSSRA CDELANATEC GSDFAYFYFV SFIFLCSFLM LNLFVAVIMD
1710 1720 1730 1740 1750
NFEYLTRDSS ILGPHHLDEF IRVWAEYDPA ACGRISYNDM FEMLKHMSPP
1760 1770 1780 1790 1800
LGLGKKCPAR VAYKRLVRMN MPISNDDMTV HFTSTLMALI RTALEIKLAP
1810 1820 1830 1840 1850
AGTKQHQCDA ELRKEISSVW ANLPQKTLDL LVPPHKPDEM TVGKVYAALM
1860 1870 1880 1890 1900
IFDFYKQNKT TRDQIHQAPG GLAQMGPVSL FHPLKATLEQ TQPAVLRGAR
1910 1920 1930 1940 1950
VFLRQKSSAS LSNGGAVQTQ EGGIKESVSW GTQRTQEVPC EVRTPLERGH
1960 1970 1980 1990 2000
STEIPVQTGK PAVDVQMQSM VLRGPDGEPQ PGLESQGRAA SMPRLAAETQ
2010 2020 2030 2040 2050
PPPDASPMKR SISTLAPQRP HVAHLCTAAL DRAPASQAAP PHHHRCHRRR
2060 2070 2080 2090 2100
DRKQKSLEKG PGLSADTDGA PYSTAGPGPP PPPGDGAAGC RRERRQERGR
2110 2120 2130 2140 2150
SQERRQPSSS SSEKQRFYSC DRFGGREPPQ PKPSLSSHPT SPTAGQEPGP
2160 2170 2180 2190 2200
PRQGSGSVNG SPLLSTSGAS TPGRGGRRQL PQTPLTPRPS ITYKTANSSP
2210 2220 2230 2240 2250
VHFAGAQTSL PAFSPGRLSR GLSEHNALLQ RDPLSQPLAP SSRIGSDPYL
2260 2270 2280 2290 2300
GQRLDSEAAA RTQLEDTLTF EEAVATNSGR SSRTSYVSSL TSQSHPLRRV
2310 2320 2330
PNGYHCTLGL SSGGGGRGRH SYHHPDQDHW C
Length:2,331
Mass (Da):260,562
Last modified:May 1, 2000 - v1
Checksum:i6A7F35C35C45EED8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF173882 mRNA. Translation: AAF24229.1.
RefSeqiNP_777057.1. NM_174632.2.
UniGeneiBt.286.

Genome annotation databases

GeneIDi282410.
KEGGibta:282410.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF173882 mRNA. Translation: AAF24229.1.
RefSeqiNP_777057.1. NM_174632.2.
UniGeneiBt.286.

3D structure databases

ProteinModelPortaliQ9TTA4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000045932.

Proteomic databases

PaxDbiQ9TTA4.
PRIDEiQ9TTA4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi282410.
KEGGibta:282410.

Organism-specific databases

CTDi774.

Phylogenomic databases

eggNOGiKOG2301. Eukaryota.
ENOG410XNP6. LUCA.
HOVERGENiHBG050763.
KOiK04849.

Miscellaneous databases

NextBioi20806192.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR002048. EF_hand_dom.
IPR031649. GPHH_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005447. VDCC_N_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF161. PTHR10037:SF161. 3 hits.
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF16905. GPHH. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01631. NVDCCALPHA1.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]
PROSITEiPS50222. EF_HAND_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Coexpression of cloned alpha(1B), beta(2a), and alpha(2)/delta subunits produces non-inactivating calcium currents similar to those found in bovine chromaffin cells."
    Cahill A.L., Hurley J.H., Fox A.P.
    J. Neurosci. 20:1685-1693(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9TTA4_BOVIN
AccessioniPrimary (citable) accession number: Q9TTA4
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: May 11, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.